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The map label for this gene is paaJ [C]

Identifier: 169627482

GI number: 169627482

Start: 374045

End: 375274

Strand: Direct

Name: paaJ [C]

Synonym: MAB_0378

Alternate gene names: 169627482

Gene position: 374045-375274 (Clockwise)

Preceding gene: 169627481

Following gene: 169627483

Centisome position: 7.38

GC content: 63.58

Gene sequence:

>1230_bases
ATGCCCCCAAAGGGATCGTCAAAGGTTTTGGAAAAGGTCTACGTCATCGGCGTCGGGATGACGAAATTCGAGAAACCCGG
ACGACGTGAGGGCTGGGACTACCCGGCCATGGCCAAGGAGTCGGGCACCAATGCACTGACCGACGCCGGCATCGATTACG
GCAAGGTGGAAGCCGCCTATGTCGGGTACTGCGCGGGGGAGTCCACCTCCGGCCAGCGGGCGGTGTATGAGCTCGGCATG
ACCGGTATCCCGGTCACCAACGTCAACAACAACTGTTCGACGGGTTCGACCGCGCTGTACAACGCCGCGCAGGCGATTCG
TGGCGGGCTCGCCGACGTCACCCTGGCGCTTGGTTTCGAGAAGATGCAGCCCGGCTCGTTGGGTGCCACCTTCACCGACC
GCGAGCAGCCGATGCAGCGACACATCGAGGCGCTCGCCGGGGTGTTCGATTTCGCTTTCCCGCCCGCGCCCTGGATGTTC
GGCGCGGCCGGGCGTGAGCACATGCAGAAGTACGGCACCACCGCCGAGCACTTCGCCAAGATCGGCTACAAGAACCACAA
GCATTCGGTGAACAACCCCTATGCCCAGTTCCAGGAGGAGTACACGCTCCAGGACATCTTGGATGCCAAGGAGATCTACG
CCCCGTTGACCAAGCTGCAGTGCTCGCCCACCTCCGACGGTTCGGGTGCCGCCATCTTGGCCTCGGAGCGATTCGTCGAG
CAGAACGGGCTCGGTGACCGTGCGGTGGAAATCGTCGGTCAGGCCATGACCACCGATATCCCGGGAACCCTGGAGTCCAA
GTCGGCGATCACCCTGGTCGGATTCGATATGGCCAAGCTTGCGGCGCAGAAAGTGTATGAGCAGGCTCAGATTTCGGCCG
ATGACGTCGATGTCATCGAGCTGCACGACTGCTTCTCGGCCAACGAGCTGATCACCTACGAGGCGCTTGGGCTGTGTGCC
GAGGGCGAAGGCGGCAAGCTGGTCGACAACGGCGACACCACCTACGGCGGCCGTTGGGTTGTCAACCCCTCGGGTGGCTT
GATCTCCAAGGGACACCCATTGGGTGCGACGGGGCTGGCGCAGTGCGCCGAACTCACCTGGCAGCTGCGCGGCGATGCCG
ACAAGCGTCAGGTGGCCAGTGCGTCCCAGAAGACTGGCGTGGCGCTGCAGCACAACCTCGGCCTCGGCGGTGCCTGCGTG
GTTACCGCCTACAAGCCGGCTAATCGCTGA

Upstream 100 bases:

>100_bases
CACGGACAATACATTTGTACTGGACCCTTACATTCAGGATAGAACGTATGTTACGTTGGCGAAGCCCCCATCGAAGTGTG
TGCAAAAGGAGCTTGTAACC

Downstream 100 bases:

>100_bases
AAGAGGCTGGCAGATAATGGCTGATACCCAGTACCCCTTCAACAACGACGGCCTGGATCAGTGGGGCGCCGAGGAGACCA
TCGAGGTCGACAAGGACCGC

Product: lipid-transfer protein

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MPPKGSSKVLEKVYVIGVGMTKFEKPGRREGWDYPAMAKESGTNALTDAGIDYGKVEAAYVGYCAGESTSGQRAVYELGM
TGIPVTNVNNNCSTGSTALYNAAQAIRGGLADVTLALGFEKMQPGSLGATFTDREQPMQRHIEALAGVFDFAFPPAPWMF
GAAGREHMQKYGTTAEHFAKIGYKNHKHSVNNPYAQFQEEYTLQDILDAKEIYAPLTKLQCSPTSDGSGAAILASERFVE
QNGLGDRAVEIVGQAMTTDIPGTLESKSAITLVGFDMAKLAAQKVYEQAQISADDVDVIELHDCFSANELITYEALGLCA
EGEGGKLVDNGDTTYGGRWVVNPSGGLISKGHPLGATGLAQCAELTWQLRGDADKRQVASASQKTGVALQHNLGLGGACV
VTAYKPANR

Sequences:

>Translated_409_residues
MPPKGSSKVLEKVYVIGVGMTKFEKPGRREGWDYPAMAKESGTNALTDAGIDYGKVEAAYVGYCAGESTSGQRAVYELGM
TGIPVTNVNNNCSTGSTALYNAAQAIRGGLADVTLALGFEKMQPGSLGATFTDREQPMQRHIEALAGVFDFAFPPAPWMF
GAAGREHMQKYGTTAEHFAKIGYKNHKHSVNNPYAQFQEEYTLQDILDAKEIYAPLTKLQCSPTSDGSGAAILASERFVE
QNGLGDRAVEIVGQAMTTDIPGTLESKSAITLVGFDMAKLAAQKVYEQAQISADDVDVIELHDCFSANELITYEALGLCA
EGEGGKLVDNGDTTYGGRWVVNPSGGLISKGHPLGATGLAQCAELTWQLRGDADKRQVASASQKTGVALQHNLGLGGACV
VTAYKPANR
>Mature_408_residues
PPKGSSKVLEKVYVIGVGMTKFEKPGRREGWDYPAMAKESGTNALTDAGIDYGKVEAAYVGYCAGESTSGQRAVYELGMT
GIPVTNVNNNCSTGSTALYNAAQAIRGGLADVTLALGFEKMQPGSLGATFTDREQPMQRHIEALAGVFDFAFPPAPWMFG
AAGREHMQKYGTTAEHFAKIGYKNHKHSVNNPYAQFQEEYTLQDILDAKEIYAPLTKLQCSPTSDGSGAAILASERFVEQ
NGLGDRAVEIVGQAMTTDIPGTLESKSAITLVGFDMAKLAAQKVYEQAQISADDVDVIELHDCFSANELITYEALGLCAE
GEGGKLVDNGDTTYGGRWVVNPSGGLISKGHPLGATGLAQCAELTWQLRGDADKRQVASASQKTGVALQHNLGLGGACVV
TAYKPANR

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=398, Percent_Identity=64.070351758794, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI302344760, Length=398, Percent_Identity=61.3065326633166, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI302344767, Length=327, Percent_Identity=65.7492354740061, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI302344762, Length=397, Percent_Identity=56.4231738035265, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI55956775, Length=355, Percent_Identity=53.8028169014084, Blast_Score=371, Evalue=1e-103,
Organism=Escherichia coli, GI1787663, Length=340, Percent_Identity=27.0588235294118, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17537653, Length=388, Percent_Identity=51.8041237113402, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24585051, Length=396, Percent_Identity=61.8686868686869, Blast_Score=496, Evalue=1e-141,
Organism=Drosophila melanogaster, GI19921506, Length=396, Percent_Identity=61.8686868686869, Blast_Score=496, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 43452; Mature: 43321

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPKGSSKVLEKVYVIGVGMTKFEKPGRREGWDYPAMAKESGTNALTDAGIDYGKVEAAY
CCCCCHHHHHHHHHHEECCHHHCCCCCCCCCCCCCCHHHCCCCCCHHHCCCCCCCEEEEE
VGYCAGESTSGQRAVYELGMTGIPVTNVNNNCSTGSTALYNAAQAIRGGLADVTLALGFE
EEEECCCCCCCCHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCHH
KMQPGSLGATFTDREQPMQRHIEALAGVFDFAFPPAPWMFGAAGREHMQKYGTTAEHFAK
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHCCCHHHHHH
IGYKNHKHSVNNPYAQFQEEYTLQDILDAKEIYAPLTKLQCSPTSDGSGAAILASERFVE
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEEEHHHHHH
QNGLGDRAVEIVGQAMTTDIPGTLESKSAITLVGFDMAKLAAQKVYEQAQISADDVDVIE
HCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEE
LHDCFSANELITYEALGLCAEGEGGKLVDNGDTTYGGRWVVNPSGGLISKGHPLGATGLA
ECCCCCCCCEEEEHHHEEEECCCCCEEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHH
QCAELTWQLRGDADKRQVASASQKTGVALQHNLGLGGACVVTAYKPANR
HHHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
PPKGSSKVLEKVYVIGVGMTKFEKPGRREGWDYPAMAKESGTNALTDAGIDYGKVEAAY
CCCCHHHHHHHHHHEECCHHHCCCCCCCCCCCCCCHHHCCCCCCHHHCCCCCCCEEEEE
VGYCAGESTSGQRAVYELGMTGIPVTNVNNNCSTGSTALYNAAQAIRGGLADVTLALGFE
EEEECCCCCCCCHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCHH
KMQPGSLGATFTDREQPMQRHIEALAGVFDFAFPPAPWMFGAAGREHMQKYGTTAEHFAK
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHCCCHHHHHH
IGYKNHKHSVNNPYAQFQEEYTLQDILDAKEIYAPLTKLQCSPTSDGSGAAILASERFVE
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEEEHHHHHH
QNGLGDRAVEIVGQAMTTDIPGTLESKSAITLVGFDMAKLAAQKVYEQAQISADDVDVIE
HCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEE
LHDCFSANELITYEALGLCAEGEGGKLVDNGDTTYGGRWVVNPSGGLISKGHPLGATGLA
ECCCCCCCCEEEEHHHEEEECCCCCEEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHH
QCAELTWQLRGDADKRQVASASQKTGVALQHNLGLGGACVVTAYKPANR
HHHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]