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The map label for this gene is pkn1 [H]

Identifier: 169627474

GI number: 169627474

Start: 366012

End: 367295

Strand: Direct

Name: pkn1 [H]

Synonym: MAB_0370

Alternate gene names: 169627474

Gene position: 366012-367295 (Clockwise)

Preceding gene: 169627473

Following gene: 169627475

Centisome position: 7.22

GC content: 65.19

Gene sequence:

>1284_bases
ATGAGTCGTGATGAGTTGGCGCGCGACCTTGAGGCGGCGCGGATGCGGACGCTGACGATTACCGACCACGACGACGCCGA
GTTGCATCGCCAATACGACCCGCTGATGAGTCCGTTGGTGTGGGACTTGGCGCATATCGGGCAGCAAGAAGAGCTGTGGC
TGCTGCGCGGCGGAGATCCCCGCAGGCCGGGGATGCTGCCCGGTGAGATCGAGTCTCTGTATGACGCATTCCGTCATACC
CGGGCCAGCAGAGTGCAGCTACCGCTGTTGTCGCCGGCGCAGGCGCGCGCCTTCTGTCATGAGGTACGGGGCCGGGTCTT
GGACAGGCTTGAGGCGCTGCCTTCCGACGGTTCGGCCCGGGCAGAAGAGTTCGTGTACGCGATGGTGCTGAGCCATGAAC
ACCAACATGACGAAACTATGATGCAGGCCTTATCGATTCGCCATGGGGCCGCGCTGCTGGAGGCCGTCGACCCGGTGCCG
CCGGGGCGGCCCGGTGTCGCGGGAACCTCGGTGCTGGTACCGGAGGGGCCGTTCGTGCTGGGCGTCGACGCCGTTGACGA
GCCGTTCTCGCTGGACAACGAACGGCCGGCACATGTGGTGCATCTCAGGGGTTTCCGCATCGGCACGGTCCCGGTAACCA
ATGCCGAGTGGTTGGCATTCATGGCAGACGGCGGATATCGCCGTCAGGAACTTTGGACCGAGATCGGGTGGGCGCATCGG
TGTGCCGAAGCACTGACGGCGCCCAAGTTCTGGAACCAAGGCGGCACGCTCACCCGTTTCGGGCGCGAGCTACAGATCGT
GCCCGACGAACCGGTACAACATGTCACCTTTCACGAGGCGCAGGCCTACGCATCCTGGGCCGGGGCCCGGTTGCCGACAG
AGGCCGAGTGGGAGAAGGCGTGCGTGTGGGATCCGGAAATCGGTGCACGACGGCGGTTTCCGTGGGGTGCGGAGGCCCCG
GCCCGTGATCGGGCCAATCTCGGCGGCGGTGCGCTGGGGCCGGCGCCGGTAGGTGCGTATCCGGAGTCCGCATCGGCCTA
TGGTGCTGAACAGATGCTCGGCGATGTGTGGGAGTGGACGACGTCCCCGCTGCGGCCGTGGCCTGGATTCACCCCGATGA
TCTATCAGCAATACAGCGAACCGTTTTTTGACGGTGACTACCGTGTGCTGCGCGGGGGTTCATGGGCAGTGGCGCGCGAG
ATCATGCGGCCCAGCTTCCGGAATTGGGATCACCCGGTCCGGCGCCAGATCTTCAGTGGTCTTCGTCTGGCCTGGGATAT
CTAG

Upstream 100 bases:

>100_bases
TCTTGCTCGAACGAGTCGAGCAAGGTCGATGTCCGGCAGATGATTTCATCGACAATGTCACAGAATACGGTGTGGAGAAG
GCCTTTTCGGGGGCAATCGG

Downstream 100 bases:

>100_bases
CATGTGCCGTCATCTAGGCTGGCTGGGCGCGCCGCGTTCGTTGTCTTCGCTCATGCTTGAGCCCCCGCATGGGCTTGTGG
TGCAGTCATATTCACCACGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSRDELARDLEAARMRTLTITDHDDAELHRQYDPLMSPLVWDLAHIGQQEELWLLRGGDPRRPGMLPGEIESLYDAFRHT
RASRVQLPLLSPAQARAFCHEVRGRVLDRLEALPSDGSARAEEFVYAMVLSHEHQHDETMMQALSIRHGAALLEAVDPVP
PGRPGVAGTSVLVPEGPFVLGVDAVDEPFSLDNERPAHVVHLRGFRIGTVPVTNAEWLAFMADGGYRRQELWTEIGWAHR
CAEALTAPKFWNQGGTLTRFGRELQIVPDEPVQHVTFHEAQAYASWAGARLPTEAEWEKACVWDPEIGARRRFPWGAEAP
ARDRANLGGGALGPAPVGAYPESASAYGAEQMLGDVWEWTTSPLRPWPGFTPMIYQQYSEPFFDGDYRVLRGGSWAVARE
IMRPSFRNWDHPVRRQIFSGLRLAWDI

Sequences:

>Translated_427_residues
MSRDELARDLEAARMRTLTITDHDDAELHRQYDPLMSPLVWDLAHIGQQEELWLLRGGDPRRPGMLPGEIESLYDAFRHT
RASRVQLPLLSPAQARAFCHEVRGRVLDRLEALPSDGSARAEEFVYAMVLSHEHQHDETMMQALSIRHGAALLEAVDPVP
PGRPGVAGTSVLVPEGPFVLGVDAVDEPFSLDNERPAHVVHLRGFRIGTVPVTNAEWLAFMADGGYRRQELWTEIGWAHR
CAEALTAPKFWNQGGTLTRFGRELQIVPDEPVQHVTFHEAQAYASWAGARLPTEAEWEKACVWDPEIGARRRFPWGAEAP
ARDRANLGGGALGPAPVGAYPESASAYGAEQMLGDVWEWTTSPLRPWPGFTPMIYQQYSEPFFDGDYRVLRGGSWAVARE
IMRPSFRNWDHPVRRQIFSGLRLAWDI
>Mature_426_residues
SRDELARDLEAARMRTLTITDHDDAELHRQYDPLMSPLVWDLAHIGQQEELWLLRGGDPRRPGMLPGEIESLYDAFRHTR
ASRVQLPLLSPAQARAFCHEVRGRVLDRLEALPSDGSARAEEFVYAMVLSHEHQHDETMMQALSIRHGAALLEAVDPVPP
GRPGVAGTSVLVPEGPFVLGVDAVDEPFSLDNERPAHVVHLRGFRIGTVPVTNAEWLAFMADGGYRRQELWTEIGWAHRC
AEALTAPKFWNQGGTLTRFGRELQIVPDEPVQHVTFHEAQAYASWAGARLPTEAEWEKACVWDPEIGARRRFPWGAEAPA
RDRANLGGGALGPAPVGAYPESASAYGAEQMLGDVWEWTTSPLRPWPGFTPMIYQQYSEPFFDGDYRVLRGGSWAVAREI
MRPSFRNWDHPVRRQIFSGLRLAWDI

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI194248087, Length=243, Percent_Identity=31.2757201646091, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI257470975, Length=298, Percent_Identity=29.8657718120805, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI194248088, Length=260, Percent_Identity=29.6153846153846, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38202250, Length=315, Percent_Identity=28.8888888888889, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI257470977, Length=242, Percent_Identity=31.404958677686, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI226437577, Length=136, Percent_Identity=37.5, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20130397, Length=226, Percent_Identity=26.9911504424779, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 48002; Mature: 47870

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRDELARDLEAARMRTLTITDHDDAELHRQYDPLMSPLVWDLAHIGQQEELWLLRGGDP
CCHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
RRPGMLPGEIESLYDAFRHTRASRVQLPLLSPAQARAFCHEVRGRVLDRLEALPSDGSAR
CCCCCCCHHHHHHHHHHHHCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AEEFVYAMVLSHEHQHDETMMQALSIRHGAALLEAVDPVPPGRPGVAGTSVLVPEGPFVL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEE
GVDAVDEPFSLDNERPAHVVHLRGFRIGTVPVTNAEWLAFMADGGYRRQELWTEIGWAHR
EECCCCCCCCCCCCCCCEEEEEECEEEECEECCCCCEEEEEECCCCHHHHHHHHHHHHHH
CAEALTAPKFWNQGGTLTRFGRELQIVPDEPVQHVTFHEAQAYASWAGARLPTEAEWEKA
HHHHHHCCHHHCCCCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
CVWDPEIGARRRFPWGAEAPARDRANLGGGALGPAPVGAYPESASAYGAEQMLGDVWEWT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHC
TSPLRPWPGFTPMIYQQYSEPFFDGDYRVLRGGSWAVAREIMRPSFRNWDHPVRRQIFSG
CCCCCCCCCCCHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHC
LRLAWDI
CHHEECC
>Mature Secondary Structure 
SRDELARDLEAARMRTLTITDHDDAELHRQYDPLMSPLVWDLAHIGQQEELWLLRGGDP
CHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
RRPGMLPGEIESLYDAFRHTRASRVQLPLLSPAQARAFCHEVRGRVLDRLEALPSDGSAR
CCCCCCCHHHHHHHHHHHHCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AEEFVYAMVLSHEHQHDETMMQALSIRHGAALLEAVDPVPPGRPGVAGTSVLVPEGPFVL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEE
GVDAVDEPFSLDNERPAHVVHLRGFRIGTVPVTNAEWLAFMADGGYRRQELWTEIGWAHR
EECCCCCCCCCCCCCCCEEEEEECEEEECEECCCCCEEEEEECCCCHHHHHHHHHHHHHH
CAEALTAPKFWNQGGTLTRFGRELQIVPDEPVQHVTFHEAQAYASWAGARLPTEAEWEKA
HHHHHHCCHHHCCCCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
CVWDPEIGARRRFPWGAEAPARDRANLGGGALGPAPVGAYPESASAYGAEQMLGDVWEWT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHC
TSPLRPWPGFTPMIYQQYSEPFFDGDYRVLRGGSWAVAREIMRPSFRNWDHPVRRQIFSG
CCCCCCCCCCCHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHC
LRLAWDI
CHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]