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The map label for this gene is betA [C]

Identifier: 169627355

GI number: 169627355

Start: 252103

End: 253692

Strand: Direct

Name: betA [C]

Synonym: MAB_0250

Alternate gene names: 169627355

Gene position: 252103-253692 (Clockwise)

Preceding gene: 169627354

Following gene: 169627356

Centisome position: 4.98

GC content: 63.65

Gene sequence:

>1590_bases
ATGGTTGAGGACCTTGCCGCTGACTTTGTCATTGTGGGCGCGGGATCGGCGGGAGCACCGCTGGCCACCCGGCTCTCCGA
ACGGACCAACGATCAGGTGCTGGTCCTGGAGGCCGGCCCCAAGGACAAGGACATGGGAATCCACATTCCCGCTGCATTCT
CGAAGCTTTTCCGCAGCGATGTCGACTGGGACTACTTGACCGAGCCCCAACCTCAGTTGAACAACCGTCAAATCTATTGG
CCGCGAGGCAAGACGCTCGGCGGGTCGTCGTCGATGAACGCGATGATGTGGGTCCGTGGCTTCGCGGCGGACTATGACGA
CTGGGCGCAGGTGGCGGGCGAGCAATGGTCGTTCGCGAACATCGCGCCCTATTTCAAGCGCATCGAAGCTGTGGAAGGCG
CCACCGAGAGCGACGAGGGTACCGACGGCGCGCTGAAAATCTCCAAGCAGCGCAGTCCTCGTTCGAGCACCGCGGCGTGG
CTGGAGGCGGTGAAGGAAGCCGGGTTTGATGTCGAGCGAGCCAATACTCCTGAGCCCAAGGGGTTCTCGGAGACCATGGT
GTGCCAGCACGGTGGTCGCCGATGGAGCACCGCGGATGGCTATCTCAAACCCGGTCTACGGCGGCGCAACCTGAACGTGG
TCACCGACGCCCAGGCGCGCCGGGTGCTGTTCGACGGCATCCGCGCCGTGGGCGTTGAGTATGTGCGCGACGGCATCACC
CATACCGTCCACGCGCGGCGCGAGGTCATTCTGAGTGGAGGCGCCATCAATTCGCCCCAACTGCTGATGCTTTCGGGTAT
CGGCGAGGCCACGCGATTGGGTGAGCTCGGAATTCCGGTCGTGCACGACGCGCCACAGGTGGGTCAGAACTTGCTCGATC
ACCTGTGTTGCCCGGTGGGTTATGCGGTGAAGTCGGATTCGTTGTTCGGCGCGGAGAAGCCGCTTCAGCTCGCCAACTAC
TTCCTGCGGCATCGGGGCATGCTCACCTCGAATGTCGGTGAAGCATATGGGTTTTTGCGCAGTCACCCCAATCTCACCCT
GCCGGACCTCGAGTTGATCTTCGCGCCCGCCCCGTTCTTCGACGAAGGCATCGGTGTGGCCACCGAACACGCCATTGTGA
TGGGCCCGATCTTGCTCAAGCCGGAAAGCAGCGGCGAGATCACCTTGACGTCACCCGATCCGCTGGCCAAGCCGCGTATC
GACCCTCGCTACCTGAGCGATCCGGCCGGACGAGACCGTGCTGCCATGATGTTCGGGCTGCGGACCACCGCGCGCATTGC
CGAGACACCGTCGATGCGCGCGGTACTGGGCAAGATCCTGCGTCCCCGGAATCCCAGCGACGATCTGGAGGAGACACTCG
TGGCCGCGCTGGAGAACAACTCGCATACGCTGTATCACCCGGTCGGGACCTGCCGGATGGGTGCGGACGATGCCAGCGTG
GTGACGCCGGATCTCACCGTGCGCGGCGTGCAGGGACTGCGGGTGGTCGACGCGTCGGTGATTCCCAGCCTCATCCGCGG
GCACACCCATGCGCCGTCGGTGCTGCTTGGTGAGAAGGCCGCAGATCTCATACTTTCTCCACAACCGTGA

Upstream 100 bases:

>100_bases
AACGCACGGAGCCGCGGCGAGACGGCCGCCGCCGCCCGAAGTGGGACGCCCTGTACCAGAAGCTGCCCCACATGCTGTCC
AGTCCGCTACCGTCCCATTC

Downstream 100 bases:

>100_bases
AACCGAATCTCGTCCGCCTGCGTCTAACTCGGTAAAGCCATTGCCAGGAGTTAGCGGAGGGGAACCATGACCGATCCGTT
CGGGGTACGCACCGAGGAGC

Product: GMC-type oxidoreductase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDKDMGIHIPAAFSKLFRSDVDWDYLTEPQPQLNNRQIYW
PRGKTLGGSSSMNAMMWVRGFAADYDDWAQVAGEQWSFANIAPYFKRIEAVEGATESDEGTDGALKISKQRSPRSSTAAW
LEAVKEAGFDVERANTPEPKGFSETMVCQHGGRRWSTADGYLKPGLRRRNLNVVTDAQARRVLFDGIRAVGVEYVRDGIT
HTVHARREVILSGGAINSPQLLMLSGIGEATRLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVKSDSLFGAEKPLQLANY
FLRHRGMLTSNVGEAYGFLRSHPNLTLPDLELIFAPAPFFDEGIGVATEHAIVMGPILLKPESSGEITLTSPDPLAKPRI
DPRYLSDPAGRDRAAMMFGLRTTARIAETPSMRAVLGKILRPRNPSDDLEETLVAALENNSHTLYHPVGTCRMGADDASV
VTPDLTVRGVQGLRVVDASVIPSLIRGHTHAPSVLLGEKAADLILSPQP

Sequences:

>Translated_529_residues
MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDKDMGIHIPAAFSKLFRSDVDWDYLTEPQPQLNNRQIYW
PRGKTLGGSSSMNAMMWVRGFAADYDDWAQVAGEQWSFANIAPYFKRIEAVEGATESDEGTDGALKISKQRSPRSSTAAW
LEAVKEAGFDVERANTPEPKGFSETMVCQHGGRRWSTADGYLKPGLRRRNLNVVTDAQARRVLFDGIRAVGVEYVRDGIT
HTVHARREVILSGGAINSPQLLMLSGIGEATRLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVKSDSLFGAEKPLQLANY
FLRHRGMLTSNVGEAYGFLRSHPNLTLPDLELIFAPAPFFDEGIGVATEHAIVMGPILLKPESSGEITLTSPDPLAKPRI
DPRYLSDPAGRDRAAMMFGLRTTARIAETPSMRAVLGKILRPRNPSDDLEETLVAALENNSHTLYHPVGTCRMGADDASV
VTPDLTVRGVQGLRVVDASVIPSLIRGHTHAPSVLLGEKAADLILSPQP
>Mature_529_residues
MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDKDMGIHIPAAFSKLFRSDVDWDYLTEPQPQLNNRQIYW
PRGKTLGGSSSMNAMMWVRGFAADYDDWAQVAGEQWSFANIAPYFKRIEAVEGATESDEGTDGALKISKQRSPRSSTAAW
LEAVKEAGFDVERANTPEPKGFSETMVCQHGGRRWSTADGYLKPGLRRRNLNVVTDAQARRVLFDGIRAVGVEYVRDGIT
HTVHARREVILSGGAINSPQLLMLSGIGEATRLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVKSDSLFGAEKPLQLANY
FLRHRGMLTSNVGEAYGFLRSHPNLTLPDLELIFAPAPFFDEGIGVATEHAIVMGPILLKPESSGEITLTSPDPLAKPRI
DPRYLSDPAGRDRAAMMFGLRTTARIAETPSMRAVLGKILRPRNPSDDLEETLVAALENNSHTLYHPVGTCRMGADDASV
VTPDLTVRGVQGLRVVDASVIPSLIRGHTHAPSVLLGEKAADLILSPQP

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=534, Percent_Identity=41.0112359550562, Blast_Score=362, Evalue=1e-100,
Organism=Escherichia coli, GI1786503, Length=539, Percent_Identity=36.9202226345083, Blast_Score=308, Evalue=8e-85,
Organism=Caenorhabditis elegans, GI17532301, Length=546, Percent_Identity=36.6300366300366, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24642048, Length=573, Percent_Identity=35.0785340314136, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI45551458, Length=562, Percent_Identity=35.4092526690391, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI45549471, Length=562, Percent_Identity=35.4092526690391, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24642042, Length=569, Percent_Identity=35.676625659051, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24642055, Length=580, Percent_Identity=35.6896551724138, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24650267, Length=561, Percent_Identity=33.8680926916221, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI18859995, Length=562, Percent_Identity=35.0533807829181, Blast_Score=269, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24642059, Length=565, Percent_Identity=32.5663716814159, Blast_Score=269, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24642037, Length=569, Percent_Identity=34.9736379613357, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24642035, Length=570, Percent_Identity=34.3859649122807, Blast_Score=265, Evalue=7e-71,
Organism=Drosophila melanogaster, GI24642039, Length=565, Percent_Identity=33.6283185840708, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI17137792, Length=556, Percent_Identity=33.0935251798561, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24642051, Length=561, Percent_Identity=32.7985739750446, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI18859993, Length=566, Percent_Identity=32.8621908127208, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24645930, Length=580, Percent_Identity=28.6206896551724, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24642057, Length=593, Percent_Identity=28.1618887015177, Blast_Score=151, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 57351; Mature: 57351

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDKDMGIHIPAAFSKLFRSD
CCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCEEECHHHHHHHHHCC
VDWDYLTEPQPQLNNRQIYWPRGKTLGGSSSMNAMMWVRGFAADYDDWAQVAGEQWSFAN
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEHHHCCCHHHHHHHCCCCCCCCH
IAPYFKRIEAVEGATESDEGTDGALKISKQRSPRSSTAAWLEAVKEAGFDVERANTPEPK
HHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
GFSETMVCQHGGRRWSTADGYLKPGLRRRNLNVVTDAQARRVLFDGIRAVGVEYVRDGIT
CCCHHHHHHCCCCCCCCCCCCCCCCCEECCCCEEECHHHHHHHHHHHHHHHHHHHHHCHH
HTVHARREVILSGGAINSPQLLMLSGIGEATRLGELGIPVVHDAPQVGQNLLDHLCCPVG
HHHHHCEEEEEECCCCCCCCEEEEECCCCHHHHCCCCCCEECCCHHHHHHHHHHHHCCCC
YAVKSDSLFGAEKPLQLANYFLRHRGMLTSNVGEAYGFLRSHPNLTLPDLELIFAPAPFF
CEECCCCCCCCCCHHHHHHHHHHHCCCHHCCHHHHHHHHHCCCCCCCCCCEEEEECCCCC
DEGIGVATEHAIVMGPILLKPESSGEITLTSPDPLAKPRIDPRYLSDPAGRDRAAMMFGL
CCCCCCCCCCEEEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHEHH
RTTARIAETPSMRAVLGKILRPRNPSDDLEETLVAALENNSHTLYHPVGTCRMGADDASV
HHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCCEEECCCCCCE
VTPDLTVRGVQGLRVVDASVIPSLIRGHTHAPSVLLGEKAADLILSPQP
ECCCCEEECCCCEEEECHHHHHHHHCCCCCCCCEEECCCCCCCEECCCC
>Mature Secondary Structure
MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDKDMGIHIPAAFSKLFRSD
CCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCEEECHHHHHHHHHCC
VDWDYLTEPQPQLNNRQIYWPRGKTLGGSSSMNAMMWVRGFAADYDDWAQVAGEQWSFAN
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEHHHCCCHHHHHHHCCCCCCCCH
IAPYFKRIEAVEGATESDEGTDGALKISKQRSPRSSTAAWLEAVKEAGFDVERANTPEPK
HHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
GFSETMVCQHGGRRWSTADGYLKPGLRRRNLNVVTDAQARRVLFDGIRAVGVEYVRDGIT
CCCHHHHHHCCCCCCCCCCCCCCCCCEECCCCEEECHHHHHHHHHHHHHHHHHHHHHCHH
HTVHARREVILSGGAINSPQLLMLSGIGEATRLGELGIPVVHDAPQVGQNLLDHLCCPVG
HHHHHCEEEEEECCCCCCCCEEEEECCCCHHHHCCCCCCEECCCHHHHHHHHHHHHCCCC
YAVKSDSLFGAEKPLQLANYFLRHRGMLTSNVGEAYGFLRSHPNLTLPDLELIFAPAPFF
CEECCCCCCCCCCHHHHHHHHHHHCCCHHCCHHHHHHHHHCCCCCCCCCCEEEEECCCCC
DEGIGVATEHAIVMGPILLKPESSGEITLTSPDPLAKPRIDPRYLSDPAGRDRAAMMFGL
CCCCCCCCCCEEEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHEHH
RTTARIAETPSMRAVLGKILRPRNPSDDLEETLVAALENNSHTLYHPVGTCRMGADDASV
HHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCCEEECCCCCCE
VTPDLTVRGVQGLRVVDASVIPSLIRGHTHAPSVLLGEKAADLILSPQP
ECCCCEEECCCCEEEECHHHHHHHHCCCCCCCCEEECCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]