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The map label for this gene is tcmR [H]

Identifier: 169627353

GI number: 169627353

Start: 251072

End: 251665

Strand: Reverse

Name: tcmR [H]

Synonym: MAB_0248c

Alternate gene names: 169627353

Gene position: 251665-251072 (Counterclockwise)

Preceding gene: 169627359

Following gene: 169627352

Centisome position: 4.97

GC content: 66.16

Gene sequence:

>594_bases
ATGCGACCAGCCAGCGGCCTGCGCGAGCAGAAGAAGTCGGAGACCAAACTGGCCTTGAGTCGTGCGGCCCTGGAACTTGC
GCTCGACCGGGGCGACCTGGCCGCGGTGACGGTCGACGACATCGCCGACGCGGTGCGCGTCTCGGCGCGCACCTTTCGTA
ACTACTTCACCAGCAAGGAAGACGCCGTGCTGTTCTCGCTGCGCGGGATCGAAGACAATGCCGTGGCGCTGCTGCGTCAG
CGCCCCCAGCACGAGCACGTTGTCGACTCCCTGGAGGCCGTCATGCTGGACCTGGCGACCTCCGAAGCCTTCAGTACCAC
CGTGGCTGTCACCCGGCTATCCGCGCAGAATCCAGGGCTGGCGGCGCACGACGCCGCCCGGTCCGAAGACGTGGGAACCG
TCGTGCTGACGGAAGTCAGCCGACGCGCCGGGCTCGATCCCGACGTAGATCTGTATCCGCGGCTGGTCTGCAATGCCGCG
TATGCGGTCCTGGCCACGGTCATCCAGCTCGCGGTATCCGGTTCCAAGCTTTCCAAAGACCCCGGAGCCCTTGTGGCCCA
GGGGTTTCAACGACTACGTGACGGCCTGGCATGA

Upstream 100 bases:

>100_bases
TCTTGGTGCTCCCGGCCTCACCGCGACGCCGGATATACCCGTAGAACGTTTCCGTATTTGGAAAAGTTTCCCAATTTGGA
AGGTTTGTTACCATGACCAC

Downstream 100 bases:

>100_bases
CGGTGCGGGCGGAACGGATCGATGCGGGCGCGGTGGTGCTCCGCAAGGCTTGTGACGCCGACCGCGACGGGCTGATCGAG
ATCATGACGGATCGCGAGGT

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Tetracenomycin C transcriptional repressor [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MRPASGLREQKKSETKLALSRAALELALDRGDLAAVTVDDIADAVRVSARTFRNYFTSKEDAVLFSLRGIEDNAVALLRQ
RPQHEHVVDSLEAVMLDLATSEAFSTTVAVTRLSAQNPGLAAHDAARSEDVGTVVLTEVSRRAGLDPDVDLYPRLVCNAA
YAVLATVIQLAVSGSKLSKDPGALVAQGFQRLRDGLA

Sequences:

>Translated_197_residues
MRPASGLREQKKSETKLALSRAALELALDRGDLAAVTVDDIADAVRVSARTFRNYFTSKEDAVLFSLRGIEDNAVALLRQ
RPQHEHVVDSLEAVMLDLATSEAFSTTVAVTRLSAQNPGLAAHDAARSEDVGTVVLTEVSRRAGLDPDVDLYPRLVCNAA
YAVLATVIQLAVSGSKLSKDPGALVAQGFQRLRDGLA
>Mature_197_residues
MRPASGLREQKKSETKLALSRAALELALDRGDLAAVTVDDIADAVRVSARTFRNYFTSKEDAVLFSLRGIEDNAVALLRQ
RPQHEHVVDSLEAVMLDLATSEAFSTTVAVTRLSAQNPGLAAHDAARSEDVGTVVLTEVSRRAGLDPDVDLYPRLVCNAA
YAVLATVIQLAVSGSKLSKDPGALVAQGFQRLRDGLA

Specific function: Represses transcription of the divergently oriented tcmR and tcmA (tetracenomycin C resistance and export) genes by binding to an intergenic operator region. This binding is inhibited by tetracenomycin C [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 21069; Mature: 21069

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPASGLREQKKSETKLALSRAALELALDRGDLAAVTVDDIADAVRVSARTFRNYFTSKE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCC
DAVLFSLRGIEDNAVALLRQRPQHEHVVDSLEAVMLDLATSEAFSTTVAVTRLSAQNPGL
CEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
AAHDAARSEDVGTVVLTEVSRRAGLDPDVDLYPRLVCNAAYAVLATVIQLAVSGSKLSKD
CHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PGALVAQGFQRLRDGLA
CHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRPASGLREQKKSETKLALSRAALELALDRGDLAAVTVDDIADAVRVSARTFRNYFTSKE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCC
DAVLFSLRGIEDNAVALLRQRPQHEHVVDSLEAVMLDLATSEAFSTTVAVTRLSAQNPGL
CEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
AAHDAARSEDVGTVVLTEVSRRAGLDPDVDLYPRLVCNAAYAVLATVIQLAVSGSKLSKD
CHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PGALVAQGFQRLRDGLA
CHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1592819; 1592820 [H]