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The map label for this gene is dprE1 [H]

Identifier: 169627297

GI number: 169627297

Start: 201545

End: 203068

Strand: Reverse

Name: dprE1 [H]

Synonym: MAB_0192c

Alternate gene names: 169627297

Gene position: 203068-201545 (Counterclockwise)

Preceding gene: 169627298

Following gene: 169627296

Centisome position: 4.01

GC content: 64.7

Gene sequence:

>1524_bases
ATGGCGCGTGCCAGTGGCCTTTGTCATCGCCCAGGGGACTGCGACAGTCATCAATTTCATCGTCCAGCGCGCGGTGATCT
TCCGAATCCGCTGAGCCGCTACGCTCAATTACCGATGACAACTCCGAAGTCTGAGCTACCTCTCACTCCGCGCGCCCTGA
CCGGGTTCGGCCGCACCGCACCCACCGTGGCGCATGTGCTCTCCACCCCGGACGTCGACGTCATTGCCGAGGCGGTGCGC
CAGGTGGCCGACGCGAGCTCCCACAGCCCCGCCCATCTGCGACGTGGCATCGTGGCGCGCGGTCTGGGCCGCTCCTACGG
CGACCACGCGTGCAACGGCGGCGGCATCGTCGTCGACATGACGCCGCTGAAGCGCGTGCACTCGATCAGCGCCGAGACCG
CGGTCGCGGACGTCGACGCGGGCGTAAGCCTGGATCAGCTGATGAAGGCCGCACTGCCGTTCGGCCTGTGGGTACCGGTG
CTGCCGGGCACCCGCCAGGTGACCGTGGGTGGGGCCATCGGCTCGGACATTCACGGCAAGAACCATCACAGCGCGGGCAG
CTTCGGCAACCACGTGCTGTCCATGGATCTGTTGATGGCCGACGGCGAGGTGCACACCATCACCCCTGACGGGCCCGCCA
GCGAGTTGTTCTGGGCCACCGTGGGCGGCAACGGTTTGACCGGCATCGTGGTGCGCGCCCGCATCGCCATGACTCGCACC
GAGACCGCGTATTTCATCGCCGACGGGGTGGCCACCCGCGACCTGGACGAGACCATCGCGGTGCACCAGGACGGCACCGA
GGACAACTACACCTATTCGAGCGCCTGGTTCGACCTCATCAACCCCCCGCCGAAGCTGGGCCGTGCCGCCGTCAGCCGGG
GAAGCCTGGCTAAGCTGGATCAGCTGCCGCCGAAGCTCGCCAAGGATCCGCTGAAGTTCAGTGCGCCACAGCTACCCGGA
TTGCCCGACCTCTTCCCGGTCAACTTCATGATCAAGCCGTCGCTCATGGCGATCGGCGAGGCGTTCTACCGGATGAGCGG
GAACTACCAGGGCAAGATCGTCAACCTGACGCAGTTCTATCACATGCTCGACATCACAACCGGATGGCAATACGCTTACG
GCCCAGCAGGTTTCGCCCAGCACCAATTCCTGGTCCCACCCGACGCACTTGAGGAATTCAAGGGCATCATCCGCTGGATC
CAGACCCAGGGCCAGTACTCGGCACTGAACGTCTTCAAGCTGTTCGGCCCGGGAAATAAAGCGCCACTGAGCTTCCCGAT
GAAGGGCTGGAACGTCGCGATGGACTTCCCGAACAAGCCCGGCGTCAACGAGTTCCTCAATGAACTGGACAATCGTGCGA
TGGAGTTCGGTGGGCGGGTCTACACCGCCAAGGATTCCCGGGTAAGCGCGGAGAAGTTCCACAGGATGTACCCGCGCGTC
GACGAGTGGATCGCCACCCGACGCAAGGCCGACCCACACGGTGTCTTTGCCTCCGACATGGCCCGCCGCCTCGAGCTGCT
CTAG

Upstream 100 bases:

>100_bases
GCCGGGCCCGGTTCATCGCGGTGATGGCGCTCTATGGCCTGACCTACGCCGTCCAGGTAGGCATCAATTACCTGTTTTAC
ATGCAGTTTGAGGACAAGCC

Downstream 100 bases:

>100_bases
AAAGGCTTTTGTAACAACATGATTGATGCCACGGGCAACCCCCAGACCATCCTGCTATTCGGCGGCACCTCGGAGATCGG
CCTCGCCATCGTCGAGCGCT

Product: oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MARASGLCHRPGDCDSHQFHRPARGDLPNPLSRYAQLPMTTPKSELPLTPRALTGFGRTAPTVAHVLSTPDVDVIAEAVR
QVADASSHSPAHLRRGIVARGLGRSYGDHACNGGGIVVDMTPLKRVHSISAETAVADVDAGVSLDQLMKAALPFGLWVPV
LPGTRQVTVGGAIGSDIHGKNHHSAGSFGNHVLSMDLLMADGEVHTITPDGPASELFWATVGGNGLTGIVVRARIAMTRT
ETAYFIADGVATRDLDETIAVHQDGTEDNYTYSSAWFDLINPPPKLGRAAVSRGSLAKLDQLPPKLAKDPLKFSAPQLPG
LPDLFPVNFMIKPSLMAIGEAFYRMSGNYQGKIVNLTQFYHMLDITTGWQYAYGPAGFAQHQFLVPPDALEEFKGIIRWI
QTQGQYSALNVFKLFGPGNKAPLSFPMKGWNVAMDFPNKPGVNEFLNELDNRAMEFGGRVYTAKDSRVSAEKFHRMYPRV
DEWIATRRKADPHGVFASDMARRLELL

Sequences:

>Translated_507_residues
MARASGLCHRPGDCDSHQFHRPARGDLPNPLSRYAQLPMTTPKSELPLTPRALTGFGRTAPTVAHVLSTPDVDVIAEAVR
QVADASSHSPAHLRRGIVARGLGRSYGDHACNGGGIVVDMTPLKRVHSISAETAVADVDAGVSLDQLMKAALPFGLWVPV
LPGTRQVTVGGAIGSDIHGKNHHSAGSFGNHVLSMDLLMADGEVHTITPDGPASELFWATVGGNGLTGIVVRARIAMTRT
ETAYFIADGVATRDLDETIAVHQDGTEDNYTYSSAWFDLINPPPKLGRAAVSRGSLAKLDQLPPKLAKDPLKFSAPQLPG
LPDLFPVNFMIKPSLMAIGEAFYRMSGNYQGKIVNLTQFYHMLDITTGWQYAYGPAGFAQHQFLVPPDALEEFKGIIRWI
QTQGQYSALNVFKLFGPGNKAPLSFPMKGWNVAMDFPNKPGVNEFLNELDNRAMEFGGRVYTAKDSRVSAEKFHRMYPRV
DEWIATRRKADPHGVFASDMARRLELL
>Mature_506_residues
ARASGLCHRPGDCDSHQFHRPARGDLPNPLSRYAQLPMTTPKSELPLTPRALTGFGRTAPTVAHVLSTPDVDVIAEAVRQ
VADASSHSPAHLRRGIVARGLGRSYGDHACNGGGIVVDMTPLKRVHSISAETAVADVDAGVSLDQLMKAALPFGLWVPVL
PGTRQVTVGGAIGSDIHGKNHHSAGSFGNHVLSMDLLMADGEVHTITPDGPASELFWATVGGNGLTGIVVRARIAMTRTE
TAYFIADGVATRDLDETIAVHQDGTEDNYTYSSAWFDLINPPPKLGRAAVSRGSLAKLDQLPPKLAKDPLKFSAPQLPGL
PDLFPVNFMIKPSLMAIGEAFYRMSGNYQGKIVNLTQFYHMLDITTGWQYAYGPAGFAQHQFLVPPDALEEFKGIIRWIQ
TQGQYSALNVFKLFGPGNKAPLSFPMKGWNVAMDFPNKPGVNEFLNELDNRAMEFGGRVYTAKDSRVSAEKFHRMYPRVD
EWIATRRKADPHGVFASDMARRLELL

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007173
- InterPro:   IPR016166
- InterPro:   IPR016168
- InterPro:   IPR006094 [H]

Pfam domain/function: PF04030 ALO; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 55171; Mature: 55039

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARASGLCHRPGDCDSHQFHRPARGDLPNPLSRYAQLPMTTPKSELPLTPRALTGFGRTA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCH
PTVAHVLSTPDVDVIAEAVRQVADASSHSPAHLRRGIVARGLGRSYGDHACNGGGIVVDM
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEC
TPLKRVHSISAETAVADVDAGVSLDQLMKAALPFGLWVPVLPGTRQVTVGGAIGSDIHGK
HHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHCCCCCEEECCCCCEEEEECCCCCCCCCCC
NHHSAGSFGNHVLSMDLLMADGEVHTITPDGPASELFWATVGGNGLTGIVVRARIAMTRT
CCCCCCCCCCCEEEEEEEEECCCEEEECCCCCCCCEEEEEECCCCCEEHHEEEHHHHEEC
ETAYFIADGVATRDLDETIAVHQDGTEDNYTYSSAWFDLINPPPKLGRAAVSRGSLAKLD
CCEEEEECCCCCCCCHHHHEEECCCCCCCEEEHHHHHCCCCCCHHHHHHHHCCCCHHHHH
QLPPKLAKDPLKFSAPQLPGLPDLFPVNFMIKPSLMAIGEAFYRMSGNYQGKIVNLTQFY
HCCHHHHCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCEEEEHHHHH
HMLDITTGWQYAYGPAGFAQHQFLVPPDALEEFKGIIRWIQTQGQYSALNVFKLFGPGNK
HHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCC
APLSFPMKGWNVAMDFPNKPGVNEFLNELDNRAMEFGGRVYTAKDSRVSAEKFHRMYPRV
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHCCHH
DEWIATRRKADPHGVFASDMARRLELL
HHHHHHHCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ARASGLCHRPGDCDSHQFHRPARGDLPNPLSRYAQLPMTTPKSELPLTPRALTGFGRTA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCH
PTVAHVLSTPDVDVIAEAVRQVADASSHSPAHLRRGIVARGLGRSYGDHACNGGGIVVDM
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEC
TPLKRVHSISAETAVADVDAGVSLDQLMKAALPFGLWVPVLPGTRQVTVGGAIGSDIHGK
HHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHCCCCCEEECCCCCEEEEECCCCCCCCCCC
NHHSAGSFGNHVLSMDLLMADGEVHTITPDGPASELFWATVGGNGLTGIVVRARIAMTRT
CCCCCCCCCCCEEEEEEEEECCCEEEECCCCCCCCEEEEEECCCCCEEHHEEEHHHHEEC
ETAYFIADGVATRDLDETIAVHQDGTEDNYTYSSAWFDLINPPPKLGRAAVSRGSLAKLD
CCEEEEECCCCCCCCHHHHEEECCCCCCCEEEHHHHHCCCCCCHHHHHHHHCCCCHHHHH
QLPPKLAKDPLKFSAPQLPGLPDLFPVNFMIKPSLMAIGEAFYRMSGNYQGKIVNLTQFY
HCCHHHHCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCEEEEHHHHH
HMLDITTGWQYAYGPAGFAQHQFLVPPDALEEFKGIIRWIQTQGQYSALNVFKLFGPGNK
HHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCC
APLSFPMKGWNVAMDFPNKPGVNEFLNELDNRAMEFGGRVYTAKDSRVSAEKFHRMYPRV
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHCCHH
DEWIATRRKADPHGVFASDMARRLELL
HHHHHHHCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]