| Definition | Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_010397 |
| Length | 5,067,172 |
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The map label for this gene is yhdF [H]
Identifier: 169627269
GI number: 169627269
Start: 158566
End: 159339
Strand: Direct
Name: yhdF [H]
Synonym: MAB_0164
Alternate gene names: 169627269
Gene position: 158566-159339 (Clockwise)
Preceding gene: 169627266
Following gene: 169627270
Centisome position: 3.13
GC content: 66.54
Gene sequence:
>774_bases GTGAACCTCACTGACTTCCAGTCGCTCTACGATCTGTCCGGGCGCACGGCCATCGTCACCGGGGGTACCCGGGGAATCGG CTACGCGATCGCTGAGGCACTCGGTGCCTGTGGGGCATCGGTGGTGGTGTCGAGCCGCAAATCCGATGCCTGTACCGCCG CGGCGAAGGAACTGCACGACAAGGGGTATCGGGCGCTGGGTGTGCCCGCCCACATGGGCGAGCTGGGCGATATCGACGCC CTGGTGACTGCCACGGTCGACGAGTACGGCGGTGTCGACATCGTGGTCAACGCGGCTGCTAACCCCGTGGCTCAGCCTAT GGGCAGCTACACCCCCGAGGCGCTGGGCAAGTCGTTCGACGTCAACGTGCGCGGGCCGGTGTTCCTGGTGCAGGCCGCGC TGCCGCACCTGACCGCCAGCGAGCATGCGTCGGTGCTCAATGTGGTGTCGGTGGCGGCGTTCCAGTATGTGCCCATGCTC TCGATGTACGCGGCGATGAAGGCGACACTCATGTCGTTCACCCGGTCGATGGCGGCCGAATACACGGCTCGCGGTATCCG GGTGAACGCGCTGGCGCCTGGCACCGTCGACACCTACATGCTGCAGCAGAACCCGCAGGAGATCATCGACGCGATGGCCG CACAGTCCTTCATGGGCAGGGTGGCGCACACCGACGAAATGATCGGCCCTGCGCTGCTGCTGTTGTCGGACGCGGGTTCG TTCATCACCGGGCAGGTGATCGTCGCCGACGGCGGGGGCGGGGTGCAGCGCTAG
Upstream 100 bases:
>100_bases GCCGAGAGATGTGCCACGATATCGGGGATGGTCACCGGCTCGGTCGGAATCGTCACCGTTCCAGTCTGCCCGGCGACGTC AACCGAATAGAGTGCCGAGC
Downstream 100 bases:
>100_bases ACGGGTATCCGGTGTGCAAGCCGGACCGCCAGCGCTAGGCTCGTCACGTGGAGCCTGTCTATGGAACCGTGATCGGGCTT GCCCGCACCGTCTGGGCGAT
Product: short chain dehydrogenase/reductase
Products: D-Gluconate; Nicotinamide adenine dinucleotide phosphate [C]
Alternate protein names: NA
Number of amino acids: Translated: 257; Mature: 257
Protein sequence:
>257_residues MNLTDFQSLYDLSGRTAIVTGGTRGIGYAIAEALGACGASVVVSSRKSDACTAAAKELHDKGYRALGVPAHMGELGDIDA LVTATVDEYGGVDIVVNAAANPVAQPMGSYTPEALGKSFDVNVRGPVFLVQAALPHLTASEHASVLNVVSVAAFQYVPML SMYAAMKATLMSFTRSMAAEYTARGIRVNALAPGTVDTYMLQQNPQEIIDAMAAQSFMGRVAHTDEMIGPALLLLSDAGS FITGQVIVADGGGGVQR
Sequences:
>Translated_257_residues MNLTDFQSLYDLSGRTAIVTGGTRGIGYAIAEALGACGASVVVSSRKSDACTAAAKELHDKGYRALGVPAHMGELGDIDA LVTATVDEYGGVDIVVNAAANPVAQPMGSYTPEALGKSFDVNVRGPVFLVQAALPHLTASEHASVLNVVSVAAFQYVPML SMYAAMKATLMSFTRSMAAEYTARGIRVNALAPGTVDTYMLQQNPQEIIDAMAAQSFMGRVAHTDEMIGPALLLLSDAGS FITGQVIVADGGGGVQR >Mature_257_residues MNLTDFQSLYDLSGRTAIVTGGTRGIGYAIAEALGACGASVVVSSRKSDACTAAAKELHDKGYRALGVPAHMGELGDIDA LVTATVDEYGGVDIVVNAAANPVAQPMGSYTPEALGKSFDVNVRGPVFLVQAALPHLTASEHASVLNVVSVAAFQYVPML SMYAAMKATLMSFTRSMAAEYTARGIRVNALAPGTVDTYMLQQNPQEIIDAMAAQSFMGRVAHTDEMIGPALLLLSDAGS FITGQVIVADGGGGVQR
Specific function: Catalyzes A Reversible Reduction Of 5-Ketoglutanate To Form D-Gluconate. Dependent On Nadp, Almost Inactive With NAD. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=36.734693877551, Blast_Score=145, Evalue=4e-35, Organism=Homo sapiens, GI5031737, Length=243, Percent_Identity=31.6872427983539, Blast_Score=121, Evalue=5e-28, Organism=Homo sapiens, GI126723750, Length=248, Percent_Identity=29.8387096774194, Blast_Score=116, Evalue=2e-26, Organism=Homo sapiens, GI33667109, Length=188, Percent_Identity=36.7021276595745, Blast_Score=115, Evalue=5e-26, Organism=Homo sapiens, GI126723191, Length=181, Percent_Identity=38.121546961326, Blast_Score=115, Evalue=5e-26, Organism=Homo sapiens, GI19923817, Length=252, Percent_Identity=28.968253968254, Blast_Score=109, Evalue=2e-24, Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=32.6530612244898, Blast_Score=96, Evalue=3e-20, Organism=Homo sapiens, GI10190704, Length=246, Percent_Identity=30.4878048780488, Blast_Score=92, Evalue=3e-19, Organism=Homo sapiens, GI40254992, Length=238, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=9e-18, Organism=Homo sapiens, GI66933014, Length=145, Percent_Identity=32.4137931034483, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=27.6679841897233, Blast_Score=78, Evalue=7e-15, Organism=Homo sapiens, GI59889578, Length=227, Percent_Identity=27.3127753303965, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI302344755, Length=107, Percent_Identity=37.3831775700935, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI31542939, Length=204, Percent_Identity=28.4313725490196, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI7706318, Length=200, Percent_Identity=25.5, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI4503301, Length=224, Percent_Identity=25.8928571428571, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI226371731, Length=191, Percent_Identity=27.7486910994764, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI40254986, Length=194, Percent_Identity=29.3814432989691, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI210032110, Length=207, Percent_Identity=26.5700483091787, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI4557649, Length=205, Percent_Identity=26.8292682926829, Blast_Score=66, Evalue=3e-11, Organism=Escherichia coli, GI1790717, Length=247, Percent_Identity=28.3400809716599, Blast_Score=114, Evalue=9e-27, Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=30.1587301587302, Blast_Score=104, Evalue=5e-24, Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=30.8300395256917, Blast_Score=103, Evalue=1e-23, Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=29.3388429752066, Blast_Score=100, Evalue=8e-23, Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=31.7073170731707, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=30.6451612903226, Blast_Score=99, Evalue=3e-22, Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=28.6821705426357, Blast_Score=94, Evalue=9e-21, Organism=Escherichia coli, GI1786812, Length=256, Percent_Identity=28.515625, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI1788459, Length=240, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=2e-15, Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=28.8, Blast_Score=69, Evalue=4e-13, Organism=Escherichia coli, GI1787820, Length=220, Percent_Identity=24.0909090909091, Blast_Score=66, Evalue=2e-12, Organism=Escherichia coli, GI2367365, Length=246, Percent_Identity=28.0487804878049, Blast_Score=64, Evalue=7e-12, Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=36.2903225806452, Blast_Score=144, Evalue=5e-35, Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=32, Blast_Score=120, Evalue=5e-28, Organism=Caenorhabditis elegans, GI17538480, Length=267, Percent_Identity=31.8352059925094, Blast_Score=107, Evalue=6e-24, Organism=Caenorhabditis elegans, GI17562910, Length=260, Percent_Identity=32.3076923076923, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=28.4, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17544670, Length=262, Percent_Identity=27.0992366412214, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=30.6513409961686, Blast_Score=98, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=30.3370786516854, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=30.6772908366534, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=29.4354838709677, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI193204405, Length=261, Percent_Identity=31.0344827586207, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI17563726, Length=257, Percent_Identity=30.3501945525292, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17551412, Length=272, Percent_Identity=30.1470588235294, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17562904, Length=267, Percent_Identity=29.5880149812734, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI72000259, Length=257, Percent_Identity=30.7392996108949, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=28.9156626506024, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17565030, Length=268, Percent_Identity=30.2238805970149, Blast_Score=91, Evalue=8e-19, Organism=Caenorhabditis elegans, GI17562906, Length=260, Percent_Identity=30, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=30.3846153846154, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=29.5454545454545, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17562908, Length=263, Percent_Identity=30.7984790874525, Blast_Score=87, Evalue=8e-18, Organism=Caenorhabditis elegans, GI17538486, Length=262, Percent_Identity=27.0992366412214, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17562990, Length=258, Percent_Identity=29.0697674418605, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17559104, Length=258, Percent_Identity=26.7441860465116, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=29.5546558704453, Blast_Score=85, Evalue=5e-17, Organism=Caenorhabditis elegans, GI17536025, Length=252, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17538182, Length=263, Percent_Identity=27.3764258555133, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17561272, Length=250, Percent_Identity=28.8, Blast_Score=74, Evalue=7e-14, Organism=Caenorhabditis elegans, GI71982365, Length=194, Percent_Identity=28.3505154639175, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17536651, Length=255, Percent_Identity=28.2352941176471, Blast_Score=71, Evalue=7e-13, Organism=Caenorhabditis elegans, GI17508895, Length=194, Percent_Identity=23.7113402061856, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI193203115, Length=193, Percent_Identity=25.9067357512953, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI193203117, Length=197, Percent_Identity=25.3807106598985, Blast_Score=64, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=247, Percent_Identity=25.9109311740891, Blast_Score=80, Evalue=4e-16, Organism=Saccharomyces cerevisiae, GI6322226, Length=196, Percent_Identity=33.1632653061224, Blast_Score=70, Evalue=5e-13, Organism=Saccharomyces cerevisiae, GI6323882, Length=196, Percent_Identity=28.0612244897959, Blast_Score=70, Evalue=5e-13, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=35.3413654618474, Blast_Score=144, Evalue=8e-35, Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=33.4677419354839, Blast_Score=98, Evalue=6e-21, Organism=Drosophila melanogaster, GI24643142, Length=253, Percent_Identity=29.2490118577075, Blast_Score=91, Evalue=9e-19, Organism=Drosophila melanogaster, GI21357041, Length=245, Percent_Identity=27.7551020408163, Blast_Score=88, Evalue=7e-18, Organism=Drosophila melanogaster, GI24644337, Length=252, Percent_Identity=27.7777777777778, Blast_Score=85, Evalue=6e-17, Organism=Drosophila melanogaster, GI21357673, Length=198, Percent_Identity=31.3131313131313, Blast_Score=84, Evalue=6e-17, Organism=Drosophila melanogaster, GI28571526, Length=245, Percent_Identity=27.3469387755102, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI24644339, Length=250, Percent_Identity=26, Blast_Score=82, Evalue=5e-16, Organism=Drosophila melanogaster, GI17737361, Length=248, Percent_Identity=27.8225806451613, Blast_Score=80, Evalue=2e-15, Organism=Drosophila melanogaster, GI24639444, Length=244, Percent_Identity=27.0491803278689, Blast_Score=75, Evalue=3e-14, Organism=Drosophila melanogaster, GI21358495, Length=193, Percent_Identity=26.4248704663212, Blast_Score=75, Evalue=3e-14, Organism=Drosophila melanogaster, GI24640492, Length=202, Percent_Identity=20.7920792079208, Blast_Score=67, Evalue=8e-12, Organism=Drosophila melanogaster, GI24640442, Length=207, Percent_Identity=28.9855072463768, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI24665243, Length=208, Percent_Identity=25, Blast_Score=65, Evalue=4e-11, Organism=Drosophila melanogaster, GI116007236, Length=197, Percent_Identity=25.3807106598985, Blast_Score=65, Evalue=6e-11, Organism=Drosophila melanogaster, GI221331218, Length=203, Percent_Identity=25.1231527093596, Blast_Score=64, Evalue=8e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.69 [C]
Molecular weight: Translated: 26634; Mature: 26634
Theoretical pI: Translated: 4.80; Mature: 4.80
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 4.7 %Met (Translated Protein) 5.4 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 4.7 %Met (Mature Protein) 5.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNLTDFQSLYDLSGRTAIVTGGTRGIGYAIAEALGACGASVVVSSRKSDACTAAAKELHD CCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCHHEEEECCCCHHHHHHHHHHHH KGYRALGVPAHMGELGDIDALVTATVDEYGGVDIVVNAAANPVAQPMGSYTPEALGKSFD CCCEEECCCHHCCCCCCHHHHHEEHHHHCCCEEEEEECCCCCHHHHCCCCCHHHCCCCCC VNVRGPVFLVQAALPHLTASEHASVLNVVSVAAFQYVPMLSMYAAMKATLMSFTRSMAAE CCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH YTARGIRVNALAPGTVDTYMLQQNPQEIIDAMAAQSFMGRVAHTDEMIGPALLLLSDAGS HHHCCEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC FITGQVIVADGGGGVQR EEEEEEEEEECCCCCCC >Mature Secondary Structure MNLTDFQSLYDLSGRTAIVTGGTRGIGYAIAEALGACGASVVVSSRKSDACTAAAKELHD CCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCHHEEEECCCCHHHHHHHHHHHH KGYRALGVPAHMGELGDIDALVTATVDEYGGVDIVVNAAANPVAQPMGSYTPEALGKSFD CCCEEECCCHHCCCCCCHHHHHEEHHHHCCCEEEEEECCCCCHHHHCCCCCHHHCCCCCC VNVRGPVFLVQAALPHLTASEHASVLNVVSVAAFQYVPMLSMYAAMKATLMSFTRSMAAE CCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH YTARGIRVNALAPGTVDTYMLQQNPQEIIDAMAAQSFMGRVAHTDEMIGPALLLLSDAGS HHHCCEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC FITGQVIVADGGGGVQR EEEEEEEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NAD+; NADH; NADP+; NADPH [C]
Metal ions: Mn2+ [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 0.02 {NADP+}} 20 {D-gluconate}} 0.006 {NADPH}} 0.9 {5-keto-D-gluconate}} [C]
Substrates: 5-Dehydro-D-gluconate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]
Specific reaction: 5-Dehydro-D-gluconate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced <==> D-Gluconate + Nicotinamide adenine dinucleotide phosphate [C]
General reaction: Redox reaction [C]
Inhibitor: Cd2+; Cs2+; Cu2+; Divalent metal ions; Hg2+; Ni2+; p-Chloromercuribenzoate; Sn2+; Sulfhydryl reagents [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9579061; 9384377 [H]