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The map label for this gene is gltR [H]

Identifier: 169627266

GI number: 169627266

Start: 156299

End: 157189

Strand: Direct

Name: gltR [H]

Synonym: MAB_0161

Alternate gene names: 169627266

Gene position: 156299-157189 (Clockwise)

Preceding gene: 169627265

Following gene: 169627269

Centisome position: 3.08

GC content: 62.85

Gene sequence:

>891_bases
ATGGAGCTCAGTGACATCACGCATTTCCTCGCGGTCGCCGAGGCCGGCGGTATTTCGCATGCGTCGAAGCGACTGCACAC
CGTGCAGTCGAACGTCAGCACCCACATCAAGGCACTGGAGGACGAGCTCGGAGTGGAGCTGTTTCGTCGGCATGCCCGGG
GCATGGCCCTGACCAACGCGGGTGAGGCCTTTCTGCCGTATGCGGAGCGCATCACGGCGTTGCTGAGAGAAGCCACTCAG
GTGGTCGGCGATGAGGCCGAACCCACCGGGACACTGGCGATCGGGTCCATGGAAACCACCGCGGGACTGCGGCTACCAGG
TGTCCTGGCCGCATTTGCGGCTGCGTGTCCGCGGGTGGATTTCACCCTCGCCACGGGCACCACTGCCGAGCTGATCGACA
TGGTGACCGATCGTCGACTGGATGGTGCCTTTGTCTGCGGGCCCATCGAGAATGATTCGTTGACAACGGATTTAGCATTT
GTGGAAGAGTTGGTCCTGCTGACGGCCCAGCGGCACACGGAGATCAGCGAAGTCTTCGGCGCACCCACCAGGATGCTCGT
CTTTCGCAATGGATGTTCCTATCGCGCTCGGCTGCAGCAGATCTTCACCGAGCAGGGCGTTGATCCTCAAGTCCTCGAAT
TCGGTAGCCTTGAAGGAATATTGGGTTGCGTTGCGGCAGATATGGGTGTCTCCCTGCTGCCGGCCGGAGTCGTCAGCGCC
TCGCAGCGTGCGACGCTGCTACGTATGCATCCGTTGCCCCCGATGCGGGCCCGCGTGGAAACGGTGTTCGTCCGTCGCGC
CGATGCGGCTCTTTCACCGGCCATGGCGCAGTTCCTGCGTGAGCTACAGCGTGCCGATACGCCGGTCGTGCTGCGATCGG
TGGCGCCGTGA

Upstream 100 bases:

>100_bases
CGAAAATGGCCCTCAGGATTGGTCTTTCGGCTTCGGACACGCGCAGTACGTGACCGGTGAGCTCGCAGTGCCCGCCGCAG
GCGCATGATTGACTTCGGCT

Downstream 100 bases:

>100_bases
TCACTCGTAGCGGCCGTATCCGGTGATCCCGGAATCGTCGGCGGCCACGTAGGTAGATAAACCCACGCCGCGGCCTTCCC
CGCCACCGACGGTGGTGAGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MELSDITHFLAVAEAGGISHASKRLHTVQSNVSTHIKALEDELGVELFRRHARGMALTNAGEAFLPYAERITALLREATQ
VVGDEAEPTGTLAIGSMETTAGLRLPGVLAAFAAACPRVDFTLATGTTAELIDMVTDRRLDGAFVCGPIENDSLTTDLAF
VEELVLLTAQRHTEISEVFGAPTRMLVFRNGCSYRARLQQIFTEQGVDPQVLEFGSLEGILGCVAADMGVSLLPAGVVSA
SQRATLLRMHPLPPMRARVETVFVRRADAALSPAMAQFLRELQRADTPVVLRSVAP

Sequences:

>Translated_296_residues
MELSDITHFLAVAEAGGISHASKRLHTVQSNVSTHIKALEDELGVELFRRHARGMALTNAGEAFLPYAERITALLREATQ
VVGDEAEPTGTLAIGSMETTAGLRLPGVLAAFAAACPRVDFTLATGTTAELIDMVTDRRLDGAFVCGPIENDSLTTDLAF
VEELVLLTAQRHTEISEVFGAPTRMLVFRNGCSYRARLQQIFTEQGVDPQVLEFGSLEGILGCVAADMGVSLLPAGVVSA
SQRATLLRMHPLPPMRARVETVFVRRADAALSPAMAQFLRELQRADTPVVLRSVAP
>Mature_296_residues
MELSDITHFLAVAEAGGISHASKRLHTVQSNVSTHIKALEDELGVELFRRHARGMALTNAGEAFLPYAERITALLREATQ
VVGDEAEPTGTLAIGSMETTAGLRLPGVLAAFAAACPRVDFTLATGTTAELIDMVTDRRLDGAFVCGPIENDSLTTDLAF
VEELVLLTAQRHTEISEVFGAPTRMLVFRNGCSYRARLQQIFTEQGVDPQVLEFGSLEGILGCVAADMGVSLLPAGVVSA
SQRATLLRMHPLPPMRARVETVFVRRADAALSPAMAQFLRELQRADTPVVLRSVAP

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787806, Length=291, Percent_Identity=35.3951890034364, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI87082132, Length=292, Percent_Identity=29.1095890410959, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI157672245, Length=281, Percent_Identity=28.4697508896797, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788296, Length=245, Percent_Identity=30.6122448979592, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI145693105, Length=287, Percent_Identity=25.0871080139373, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788481, Length=287, Percent_Identity=24.7386759581882, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790399, Length=252, Percent_Identity=24.6031746031746, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI2367136, Length=294, Percent_Identity=24.4897959183673, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787601, Length=294, Percent_Identity=23.1292517006803, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790208, Length=254, Percent_Identity=28.740157480315, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787530, Length=232, Percent_Identity=23.7068965517241, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788887, Length=247, Percent_Identity=27.9352226720648, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789639, Length=153, Percent_Identity=30.718954248366, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788297, Length=240, Percent_Identity=24.5833333333333, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31807; Mature: 31807

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELSDITHFLAVAEAGGISHASKRLHTVQSNVSTHIKALEDELGVELFRRHARGMALTNA
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
GEAFLPYAERITALLREATQVVGDEAEPTGTLAIGSMETTAGLRLPGVLAAFAAACPRVD
CCHHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCE
FTLATGTTAELIDMVTDRRLDGAFVCGPIENDSLTTDLAFVEELVLLTAQRHTEISEVFG
EEEECCCHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
APTRMLVFRNGCSYRARLQQIFTEQGVDPQVLEFGSLEGILGCVAADMGVSLLPAGVVSA
CCEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHH
SQRATLLRMHPLPPMRARVETVFVRRADAALSPAMAQFLRELQRADTPVVLRSVAP
HHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCCCC
>Mature Secondary Structure
MELSDITHFLAVAEAGGISHASKRLHTVQSNVSTHIKALEDELGVELFRRHARGMALTNA
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
GEAFLPYAERITALLREATQVVGDEAEPTGTLAIGSMETTAGLRLPGVLAAFAAACPRVD
CCHHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCE
FTLATGTTAELIDMVTDRRLDGAFVCGPIENDSLTTDLAFVEELVLLTAQRHTEISEVFG
EEEECCCHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
APTRMLVFRNGCSYRARLQQIFTEQGVDPQVLEFGSLEGILGCVAADMGVSLLPAGVVSA
CCEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHH
SQRATLLRMHPLPPMRARVETVFVRRADAALSPAMAQFLRELQRADTPVVLRSVAP
HHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]