The gene/protein map for NC_007760 is currently unavailable.
Definition Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence.
Accession NC_010397
Length 5,067,172

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The map label for this gene is serS

Identifier: 169627258

GI number: 169627258

Start: 149348

End: 150604

Strand: Direct

Name: serS

Synonym: MAB_0153

Alternate gene names: 169627258

Gene position: 149348-150604 (Clockwise)

Preceding gene: 169627257

Following gene: 169627259

Centisome position: 2.95

GC content: 64.12

Gene sequence:

>1257_bases
GTGATCGACCTCAAATTCCTGCGCGAAAACCCCGATGCGGTGCGTGCCTCACAGCGGCTGCGGGGCGAGGATCCGGCACT
CGTCGAGGTGCTGCTTGACGCCGACACGGCCCGGCGGGCGGCCATATCCACGGCCGATACGCTGCGCGCCGAGCAGAAGG
CGGCAAGCAAGAAGGTGGGCAAGGCGACGCCCGAGGAGCGCCCGGCACTCTTGGCGGCCGCCTCGGAACTCGCCGCACAG
GTCAAGTCGGCTGAAGCCGAGCAGGTAGTCACCGAGGCTGCGTTCACCGAGGCCCATAAGGCGATCAGCAATGTGGTGAT
CGACGGAGTTCCCGCTGGCGGCGAGCAGGACTTTGCGCTCCGCGAGTTGGTAGGCGAGCCACACCCGATCGAAAACCCAA
AGGACCATGTGGAATTGGGTGAGTCGCTGGGCCTGTTCGATATGGAACGCGGCGCAAAGGTATCCGGTGCGCGGTTCTAC
TTCCTCACCGGGTACGGCGCGCTGCTACAGCTGGGCTTGTTGCAGCTGGCGGTGCAGACCGCGGTGGCCAACGGCTTCAC
CCTGCTGATCCCGCCGGTACTGGTTAAGCCGGAAATCATGGGCGGCACGGGATTTTTGGGTGCACACGCCGATGAGGTGT
ACCACCTCGAGGAGGACGACCTCTATTTGGTTGGCACTTCGGAGGTGCCCATCGCCGGGTATCACTCCGGCGAAATCCTT
GATCTGAATAACGGGCCGCTGCGCTATGCGGGGTGGTCCAGCTGTTTCCGGCGTGAGGCCGGCAGTTACGGCAAGGACAC
CCGGGGCATCATCCGGGTACACCAGTTCGACAAGGTCGAGGCCTTTGTCTACTGCAAACCCGAAGACGCCGAGGCCGAGC
ATGAGAAGATCCTTGGCTGGGAACGGCAGATGCTGGGCCACATCGAGGTGCCCTACCGTGTGATCGATGTCGCGGCAGGC
GATTTGGGCTCATCCGCGGCCCGCAAGTTCGACTGTGAGGCGTGGGTTCCTACGCAGCGGGCATATCGCGAGCTGACCTC
CACCTCCAACTGCACGACATTCCAGGCACGGCGGTTGGCGGTGCGTTACCGGGATGAGAGCGGCAAGCCGCAGATCGCGG
CCACTCTCAACGGCACTCTCGCCACCACCCGATGGCTGGTGGCGATCCTGGAGAACCACCAGCAGCCCGATGGCAGCGTC
CGAGTCCCCACGGCGCTGGTGCCCTTCGTCGGTACCGAAGTGCTGGAGCCTAAATGA

Upstream 100 bases:

>100_bases
GCTCGACGCCGCGCGGATGTTCGGCAAGGACGGGTATCTGAGCCTGTTCGGTGCCTAATGGGTTGGCCGGGGTTTCCGGC
TCCCACGTAATGTTCAGCAG

Downstream 100 bases:

>100_bases
CCGAGATGTTCGAGGTCGAGCTGAACGAGCTCCGTACCTGGTTCGGCTTCGGAGTAGCCGGGAACTTCGCCGGCCATCTC
GAACAGGCCGGAGAGTCGGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MIDLKFLRENPDAVRASQRLRGEDPALVEVLLDADTARRAAISTADTLRAEQKAASKKVGKATPEERPALLAAASELAAQ
VKSAEAEQVVTEAAFTEAHKAISNVVIDGVPAGGEQDFALRELVGEPHPIENPKDHVELGESLGLFDMERGAKVSGARFY
FLTGYGALLQLGLLQLAVQTAVANGFTLLIPPVLVKPEIMGGTGFLGAHADEVYHLEEDDLYLVGTSEVPIAGYHSGEIL
DLNNGPLRYAGWSSCFRREAGSYGKDTRGIIRVHQFDKVEAFVYCKPEDAEAEHEKILGWERQMLGHIEVPYRVIDVAAG
DLGSSAARKFDCEAWVPTQRAYRELTSTSNCTTFQARRLAVRYRDESGKPQIAATLNGTLATTRWLVAILENHQQPDGSV
RVPTALVPFVGTEVLEPK

Sequences:

>Translated_418_residues
MIDLKFLRENPDAVRASQRLRGEDPALVEVLLDADTARRAAISTADTLRAEQKAASKKVGKATPEERPALLAAASELAAQ
VKSAEAEQVVTEAAFTEAHKAISNVVIDGVPAGGEQDFALRELVGEPHPIENPKDHVELGESLGLFDMERGAKVSGARFY
FLTGYGALLQLGLLQLAVQTAVANGFTLLIPPVLVKPEIMGGTGFLGAHADEVYHLEEDDLYLVGTSEVPIAGYHSGEIL
DLNNGPLRYAGWSSCFRREAGSYGKDTRGIIRVHQFDKVEAFVYCKPEDAEAEHEKILGWERQMLGHIEVPYRVIDVAAG
DLGSSAARKFDCEAWVPTQRAYRELTSTSNCTTFQARRLAVRYRDESGKPQIAATLNGTLATTRWLVAILENHQQPDGSV
RVPTALVPFVGTEVLEPK
>Mature_418_residues
MIDLKFLRENPDAVRASQRLRGEDPALVEVLLDADTARRAAISTADTLRAEQKAASKKVGKATPEERPALLAAASELAAQ
VKSAEAEQVVTEAAFTEAHKAISNVVIDGVPAGGEQDFALRELVGEPHPIENPKDHVELGESLGLFDMERGAKVSGARFY
FLTGYGALLQLGLLQLAVQTAVANGFTLLIPPVLVKPEIMGGTGFLGAHADEVYHLEEDDLYLVGTSEVPIAGYHSGEIL
DLNNGPLRYAGWSSCFRREAGSYGKDTRGIIRVHQFDKVEAFVYCKPEDAEAEHEKILGWERQMLGHIEVPYRVIDVAAG
DLGSSAARKFDCEAWVPTQRAYRELTSTSNCTTFQARRLAVRYRDESGKPQIAATLNGTLATTRWLVAILENHQQPDGSV
RVPTALVPFVGTEVLEPK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=460, Percent_Identity=32.8260869565217, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI225579074, Length=354, Percent_Identity=36.1581920903955, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI8923421, Length=335, Percent_Identity=37.3134328358209, Blast_Score=207, Evalue=2e-53,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=35.9628770301624, Blast_Score=238, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI17539260, Length=456, Percent_Identity=34.6491228070175, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17542084, Length=299, Percent_Identity=33.7792642140468, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320226, Length=442, Percent_Identity=33.2579185520362, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6321799, Length=350, Percent_Identity=33.4285714285714, Blast_Score=212, Evalue=8e-56,
Organism=Drosophila melanogaster, GI24581334, Length=469, Percent_Identity=34.1151385927505, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI17737985, Length=302, Percent_Identity=35.4304635761589, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_MYCA9 (B1MEI9)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001700907.1
- ProteinModelPortal:   B1MEI9
- SMR:   B1MEI9
- EnsemblBacteria:   EBMYCT00000005573
- GeneID:   5962696
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_0153
- GeneTree:   EBGT00050000016582
- HOGENOM:   HBG629391
- OMA:   PDGETDE
- ProtClustDB:   PRK05431
- BioCyc:   MABS561007:MAB_0153-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 45484; Mature: 45484

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 273-273 BINDING 280-280 BINDING 379-379

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MIDLKFLRENPDAVRASQRLRGEDPALVEVLLDADTARRAAISTADTLRAEQKAASKKVG
CCCEEEECCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
KATPEERPALLAAASELAAQVKSAEAEQVVTEAAFTEAHKAISNVVIDGVPAGGEQDFAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHH
RELVGEPHPIENPKDHVELGESLGLFDMERGAKVSGARFYFLTGYGALLQLGLLQLAVQT
HHHCCCCCCCCCCHHHHHHHHHCCCEECCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHH
AVANGFTLLIPPVLVKPEIMGGTGFLGAHADEVYHLEEDDLYLVGTSEVPIAGYHSGEIL
HHHCCEEEEECCEEECCEECCCCCCCCCCCCCEEEECCCCEEEEECCCCCEEECCCCCEE
DLNNGPLRYAGWSSCFRREAGSYGKDTRGIIRVHQFDKVEAFVYCKPEDAEAEHEKILGW
ECCCCCEEECCHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCHHHHHHHH
ERQMLGHIEVPYRVIDVAAGDLGSSAARKFDCEAWVPTQRAYRELTSTSNCTTFQARRLA
HHHHHCCCCCCEEEEEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHEEE
VRYRDESGKPQIAATLNGTLATTRWLVAILENHQQPDGSVRVPTALVPFVGTEVLEPK
EEEECCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHCCHHCCCC
>Mature Secondary Structure
MIDLKFLRENPDAVRASQRLRGEDPALVEVLLDADTARRAAISTADTLRAEQKAASKKVG
CCCEEEECCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
KATPEERPALLAAASELAAQVKSAEAEQVVTEAAFTEAHKAISNVVIDGVPAGGEQDFAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHH
RELVGEPHPIENPKDHVELGESLGLFDMERGAKVSGARFYFLTGYGALLQLGLLQLAVQT
HHHCCCCCCCCCCHHHHHHHHHCCCEECCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHH
AVANGFTLLIPPVLVKPEIMGGTGFLGAHADEVYHLEEDDLYLVGTSEVPIAGYHSGEIL
HHHCCEEEEECCEEECCEECCCCCCCCCCCCCEEEECCCCEEEEECCCCCEEECCCCCEE
DLNNGPLRYAGWSSCFRREAGSYGKDTRGIIRVHQFDKVEAFVYCKPEDAEAEHEKILGW
ECCCCCEEECCHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCHHHHHHHH
ERQMLGHIEVPYRVIDVAAGDLGSSAARKFDCEAWVPTQRAYRELTSTSNCTTFQARRLA
HHHHHCCCCCCEEEEEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHEEE
VRYRDESGKPQIAATLNGTLATTRWLVAILENHQQPDGSVRVPTALVPFVGTEVLEPK
EEEECCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA