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The map label for this gene is guaD [H]

Identifier: 169627158

GI number: 169627158

Start: 48482

End: 48982

Strand: Reverse

Name: guaD [H]

Synonym: MAB_0053c

Alternate gene names: 169627158

Gene position: 48982-48482 (Counterclockwise)

Preceding gene: 169627159

Following gene: 169627155

Centisome position: 0.97

GC content: 63.07

Gene sequence:

>501_bases
ATGGACTTCGCACAACGAACCATCGACCTCGCACGACGTAACGTCGAGGAGGGCGGTCGACCCTTTGCCACCATCATCGT
CAAGGACGGCGCTGTACTCGCCGAGAGCCCCAACAGAGTTGCCCAGACCAACGATCCCACCGCACATGCCGAGATCCTGG
CCATCCGTGAGGCCTGCACCAGGCTGGGCACCGAGCATCTGGCCGGCAGCACCATATTCATCCTGGCCCTACCGTGCCCC
ATGTGCCTGGGTGCGCTCTACTACTGCTCGCCTGACGAGGTCGTCTTCTTGACCACCCGCGAGGCCTATCAACCGCACTA
TGTCGACGATCGAAAGTACTTCGAGTTCAACACCTTCTATGGCGAGTTCGCCAAACCCTGGGACCGGCGGCGGCTGCCCA
TGCACTATCAGGCCCGCGACGACGCCGTCGACGTCTACCGGCTATGGCAGGAACGCAACGGCGGCAATCGCCACGTCGCC
GGAGCACCCACCGCCACCTGA

Upstream 100 bases:

>100_bases
GACGGCGGGTATCGCGCGGTCGTCACCCTCGATGGTAAGTACCTGCCAACGGTGCCCTTCTGATCGGTCACCAATCTTCG
AGTCCCACATAAGGAATCCC

Downstream 100 bases:

>100_bases
CGCCGATACCGCGCACTGCCGTCAGCCGGTCGTCAATTCACAAATCACGACCGGGATTTGCCTATCGGTATTGCGCTGGT
ATCCGTCGTAACCGGGGAAC

Product: cytidine/deoxycytidylate deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MDFAQRTIDLARRNVEEGGRPFATIIVKDGAVLAESPNRVAQTNDPTAHAEILAIREACTRLGTEHLAGSTIFILALPCP
MCLGALYYCSPDEVVFLTTREAYQPHYVDDRKYFEFNTFYGEFAKPWDRRRLPMHYQARDDAVDVYRLWQERNGGNRHVA
GAPTAT

Sequences:

>Translated_166_residues
MDFAQRTIDLARRNVEEGGRPFATIIVKDGAVLAESPNRVAQTNDPTAHAEILAIREACTRLGTEHLAGSTIFILALPCP
MCLGALYYCSPDEVVFLTTREAYQPHYVDDRKYFEFNTFYGEFAKPWDRRRLPMHYQARDDAVDVYRLWQERNGGNRHVA
GAPTAT
>Mature_166_residues
MDFAQRTIDLARRNVEEGGRPFATIIVKDGAVLAESPNRVAQTNDPTAHAEILAIREACTRLGTEHLAGSTIFILALPCP
MCLGALYYCSPDEVVFLTTREAYQPHYVDDRKYFEFNTFYGEFAKPWDRRRLPMHYQARDDAVDVYRLWQERNGGNRHVA
GAPTAT

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=94, Percent_Identity=32.9787234042553, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554608, Length=154, Percent_Identity=32.4675324675325, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17555996, Length=144, Percent_Identity=31.25, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 18839; Mature: 18839

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFAQRTIDLARRNVEEGGRPFATIIVKDGAVLAESPNRVAQTNDPTAHAEILAIREACT
CCHHHHHHHHHHHHHHHCCCEEEEEEEECCEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
RLGTEHLAGSTIFILALPCPMCLGALYYCSPDEVVFLTTREAYQPHYVDDRKYFEFNTFY
HHCHHHHCCCEEEEEECCHHHHHHHEEEECCCCEEEEEECCCCCCCCCCCCEEEEEECCC
GEFAKPWDRRRLPMHYQARDDAVDVYRLWQERNGGNRHVAGAPTAT
CCCCCCHHHCCCCCEECCCCCHHHHHHHHHHCCCCCEEECCCCCCC
>Mature Secondary Structure
MDFAQRTIDLARRNVEEGGRPFATIIVKDGAVLAESPNRVAQTNDPTAHAEILAIREACT
CCHHHHHHHHHHHHHHHCCCEEEEEEEECCEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
RLGTEHLAGSTIFILALPCPMCLGALYYCSPDEVVFLTTREAYQPHYVDDRKYFEFNTFY
HHCHHHHCCCEEEEEECCHHHHHHHEEEECCCCEEEEEECCCCCCCCCCCCEEEEEECCC
GEFAKPWDRRRLPMHYQARDDAVDVYRLWQERNGGNRHVAGAPTAT
CCCCCCHHHCCCCCEECCCCCHHHHHHHHHHCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]