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The map label for this gene is pbpA [H]

Identifier: 169627142

GI number: 169627142

Start: 33199

End: 34713

Strand: Reverse

Name: pbpA [H]

Synonym: MAB_0035c

Alternate gene names: 169627142

Gene position: 34713-33199 (Counterclockwise)

Preceding gene: 169627143

Following gene: 169627141

Centisome position: 0.69

GC content: 66.14

Gene sequence:

>1515_bases
ATGAACACGTCGATCCGCCGGGTATCGCTGGCTGTCATGGGACTGGTCGTACTGCTGCTGGCCAATGCCACCATCACCCA
GGTGTTTACGGCGCCGGGCCTACGCGCCGATCCCCGCAACCAGCGGATCCTGCTCGACGAGTATTCGCGCCAGCGGGGGC
AGATTTCGGCGAGTGGGCAGCTGCTGGCATCCTCGGTGGCCACCGACAGCCGTTTCCGCTTTCTCCGGCAGTACGCCGAC
CCCGAGGTGTACGCGCCGGTCACCGGGTTCTATTCACTCAATTACTCGAGCACCGGACTGGAACGCGCCGAGGACACCAT
GCTCAACGGGTCCGATCCGCGCCTCTTCGGGCGCCGGCTCGCGGACTTCTTCACCGGCCGGGACCCACGTGGCGGCAGCG
TGGTGACCACCATCCGGCCCGATGTGCAGCAAGCCGCCTATGACGCCATGCACCGCGGCTGCAAGGACGGCTGCCGCGGG
GCTGTGGTGGCACTGGAGCCCTCCACCGGAAAGATTCTCGCGATGGTCTCCACTCCCTCCTACGACCCGAACCTGCTCGC
CAGTCAGGATCCCGAGAAGGAGAACGCTGCCTGGAAGCGGCTGACGGAAGACCCGGCGCAGCCGATGCTGAACCGCGCCA
TCGCGCAGACCTACCCACCCGGGTCCACCTTCAAGGTGATCACCACCGCCGCCGCGCTAGCCGACGGCAAGACGGTCAAC
ACCGAGGTGACCGCGTCGCCGACGATCTTCCTGCCGGGCAGCAACGCAACCTTGGAGAACTACAACCGGGCCTCCTGCGG
CGGCGGTGATACCACCTCCTTGAAGGAGGCGTTCGCACGTTCCTGCAACACCGCCTTCGCCAAGTTGGGCGCTGAACAAC
TCAAGCGCGACAAGCTGGTCAAAGCCGCACAGGCGTTCGGTCTCGACCGCGAGCTCGACTCCATTCCGCTCCAAGTGGCT
ACCTCCACCGTCGGACCGATGTCCGACGACGCCGCCGTCGCCATGTCGAGCATCGGGCAAAAGGATGTCGCCATGACCCC
GCTGCAGAACGCGATGGTTGCCGCGGCCGTCGCCAACAAGGGCGTGCTGATGCAGCCGCACCTGGTCGATAGCCTTAAGG
GCCCAGACCTTTCGAATCTGTCCACCACCACCCCGGATGACATCGGCCAAGCCGTGACACCCGCTATCGCGAACACATTG
ACCGAACTGATGATTGCCTCAGAACAGCGCACCGCACAGACCGGTGCCCTCCCCGGCGTACAGATCGCTTCCAAGACCGG
CACCGCCGAGCACGGCACCGATCCGCGCAACACCCCGCCGCACGCGTGGTACATCGCCTTCGCGCCGGCTCAGGGCACGA
CAACCGATCCTCAGGCCACGGCGGTCACTCCCAAGGTGGCCATCGCCGTCCTCGTCGAAGATGGCGGAGACCGTGCCCTG
GCGGCCACCGGCGGCTCCGTCGCCGCACCCATTGGGCGGCAGGTCATTGCCGCAGCACTACAGGGGGCCTCATGA

Upstream 100 bases:

>100_bases
TGCGCATTTCACATATCGCACGCCGGCCACTGAGTCCACACGCTTCCTCATCGCCCGCCGCCCCGCTCGCGGAGGCCCGC
ACGGAACTGATCGACCGCGT

Downstream 100 bases:

>100_bases
CCGTTCGTGTGGGAGAAACGCTCTCAGGCCGTTACCGGTTGCAACGACTCATCGCGACCGGCGGTATGGGCCAGGTCTGG
GAGGGTACCGACAGCCGGCT

Product: penicillin-binding protein PbpA

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MNTSIRRVSLAVMGLVVLLLANATITQVFTAPGLRADPRNQRILLDEYSRQRGQISASGQLLASSVATDSRFRFLRQYAD
PEVYAPVTGFYSLNYSSTGLERAEDTMLNGSDPRLFGRRLADFFTGRDPRGGSVVTTIRPDVQQAAYDAMHRGCKDGCRG
AVVALEPSTGKILAMVSTPSYDPNLLASQDPEKENAAWKRLTEDPAQPMLNRAIAQTYPPGSTFKVITTAAALADGKTVN
TEVTASPTIFLPGSNATLENYNRASCGGGDTTSLKEAFARSCNTAFAKLGAEQLKRDKLVKAAQAFGLDRELDSIPLQVA
TSTVGPMSDDAAVAMSSIGQKDVAMTPLQNAMVAAAVANKGVLMQPHLVDSLKGPDLSNLSTTTPDDIGQAVTPAIANTL
TELMIASEQRTAQTGALPGVQIASKTGTAEHGTDPRNTPPHAWYIAFAPAQGTTTDPQATAVTPKVAIAVLVEDGGDRAL
AATGGSVAAPIGRQVIAAALQGAS

Sequences:

>Translated_504_residues
MNTSIRRVSLAVMGLVVLLLANATITQVFTAPGLRADPRNQRILLDEYSRQRGQISASGQLLASSVATDSRFRFLRQYAD
PEVYAPVTGFYSLNYSSTGLERAEDTMLNGSDPRLFGRRLADFFTGRDPRGGSVVTTIRPDVQQAAYDAMHRGCKDGCRG
AVVALEPSTGKILAMVSTPSYDPNLLASQDPEKENAAWKRLTEDPAQPMLNRAIAQTYPPGSTFKVITTAAALADGKTVN
TEVTASPTIFLPGSNATLENYNRASCGGGDTTSLKEAFARSCNTAFAKLGAEQLKRDKLVKAAQAFGLDRELDSIPLQVA
TSTVGPMSDDAAVAMSSIGQKDVAMTPLQNAMVAAAVANKGVLMQPHLVDSLKGPDLSNLSTTTPDDIGQAVTPAIANTL
TELMIASEQRTAQTGALPGVQIASKTGTAEHGTDPRNTPPHAWYIAFAPAQGTTTDPQATAVTPKVAIAVLVEDGGDRAL
AATGGSVAAPIGRQVIAAALQGAS
>Mature_504_residues
MNTSIRRVSLAVMGLVVLLLANATITQVFTAPGLRADPRNQRILLDEYSRQRGQISASGQLLASSVATDSRFRFLRQYAD
PEVYAPVTGFYSLNYSSTGLERAEDTMLNGSDPRLFGRRLADFFTGRDPRGGSVVTTIRPDVQQAAYDAMHRGCKDGCRG
AVVALEPSTGKILAMVSTPSYDPNLLASQDPEKENAAWKRLTEDPAQPMLNRAIAQTYPPGSTFKVITTAAALADGKTVN
TEVTASPTIFLPGSNATLENYNRASCGGGDTTSLKEAFARSCNTAFAKLGAEQLKRDKLVKAAQAFGLDRELDSIPLQVA
TSTVGPMSDDAAVAMSSIGQKDVAMTPLQNAMVAAAVANKGVLMQPHLVDSLKGPDLSNLSTTTPDDIGQAVTPAIANTL
TELMIASEQRTAQTGALPGVQIASKTGTAEHGTDPRNTPPHAWYIAFAPAQGTTTDPQATAVTPKVAIAVLVEDGGDRAL
AATGGSVAAPIGRQVIAAALQGAS

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=364, Percent_Identity=27.1978021978022, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786272, Length=442, Percent_Identity=26.0180995475113, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 52848; Mature: 52848

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSIRRVSLAVMGLVVLLLANATITQVFTAPGLRADPRNQRILLDEYSRQRGQISASGQ
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCEEEHHHHHHHCCCCCCCCH
LLASSVATDSRFRFLRQYADPEVYAPVTGFYSLNYSSTGLERAEDTMLNGSDPRLFGRRL
HHHHHHCCHHHHHHHHHHCCCCEEECEEEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHH
ADFFTGRDPRGGSVVTTIRPDVQQAAYDAMHRGCKDGCRGAVVALEPSTGKILAMVSTPS
HHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCC
YDPNLLASQDPEKENAAWKRLTEDPAQPMLNRAIAQTYPPGSTFKVITTAAALADGKTVN
CCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCCCC
TEVTASPTIFLPGSNATLENYNRASCGGGDTTSLKEAFARSCNTAFAKLGAEQLKRDKLV
EEEECCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
KAAQAFGLDRELDSIPLQVATSTVGPMSDDAAVAMSSIGQKDVAMTPLQNAMVAAAVANK
HHHHHHCCCCCHHCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC
GVLMQPHLVDSLKGPDLSNLSTTTPDDIGQAVTPAIANTLTELMIASEQRTAQTGALPGV
CEEECCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCC
QIASKTGTAEHGTDPRNTPPHAWYIAFAPAQGTTTDPQATAVTPKVAIAVLVEDGGDRAL
EEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEECCCCEEEEEEEECCCCEEE
AATGGSVAAPIGRQVIAAALQGAS
EECCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTSIRRVSLAVMGLVVLLLANATITQVFTAPGLRADPRNQRILLDEYSRQRGQISASGQ
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCEEEHHHHHHHCCCCCCCCH
LLASSVATDSRFRFLRQYADPEVYAPVTGFYSLNYSSTGLERAEDTMLNGSDPRLFGRRL
HHHHHHCCHHHHHHHHHHCCCCEEECEEEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHH
ADFFTGRDPRGGSVVTTIRPDVQQAAYDAMHRGCKDGCRGAVVALEPSTGKILAMVSTPS
HHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCC
YDPNLLASQDPEKENAAWKRLTEDPAQPMLNRAIAQTYPPGSTFKVITTAAALADGKTVN
CCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCCCC
TEVTASPTIFLPGSNATLENYNRASCGGGDTTSLKEAFARSCNTAFAKLGAEQLKRDKLV
EEEECCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
KAAQAFGLDRELDSIPLQVATSTVGPMSDDAAVAMSSIGQKDVAMTPLQNAMVAAAVANK
HHHHHHCCCCCHHCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC
GVLMQPHLVDSLKGPDLSNLSTTTPDDIGQAVTPAIANTLTELMIASEQRTAQTGALPGV
CEEECCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCC
QIASKTGTAEHGTDPRNTPPHAWYIAFAPAQGTTTDPQATAVTPKVAIAVLVEDGGDRAL
EEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEECCCCEEEEEEEECCCCEEE
AATGGSVAAPIGRQVIAAALQGAS
EECCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA