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The map label for this gene is gluP [H]

Identifier: 169627133

GI number: 169627133

Start: 25546

End: 26409

Strand: Direct

Name: gluP [H]

Synonym: MAB_0026

Alternate gene names: 169627133

Gene position: 25546-26409 (Clockwise)

Preceding gene: 169627132

Following gene: 169627137

Centisome position: 0.5

GC content: 68.63

Gene sequence:

>864_bases
ATGGCTCATCCCGGTCAGGTCCCGGTCTACGGGTGCGCTTGGCACCCGGACCGGGCCACCGCGGTGCGCTGCGTGCGGTG
CGGGCGCCCCGTGTGTCCGGCCTGCATGCGGTCGGCGCCCGTGGGGCAGCAGTGTGTCGAATGCGTCCAGCAGGGCGCCA
AGTCGGTGCGCCAGGTCAAGCCGCTGCAGCAGGTGCGAGCCTGGATCACCTGGGCGCTGATTGCCGTCAACGTCCTGGTG
TACACGGCGACGGTGTCCGATGGCGTGGGCGGCGATGTCACGGGCAGCCAGCTATTCCGGGAGCTGGTGTTGTACCTGCC
CTGGGTGGCCCAGGGTGAACTGTGGCGGACCGTCACGACGGGCTTCTTGCATCTGGGTCTGATGCATATCGCCGTCAACA
TGCTGTCGCTGGCCATGATCGGACCGGGCCTTGAGCGGGCGTTCGGCGGCCAGCGGTATGCGGCGATCTATGGCACCGCA
TTGCTCGGCAGTAGCGCCGCGGCCATGTGGCTCAGCCCAAACGCCGTGGTAGCAGGAGCATCGGGCGCCATCTATGGCCT
GCTGGGTGCGGCGCTCGTGTTGTCTCTGCGCGAGCGGCTGAACCCGCAGACCATCATCATCGTGCTGCTGCTCAACATCG
GCCTGAGCATCTCGCTGCCGGGCATCTCGCTGGCCGGGCACATGGGTGGGCTGCTGTTCGGCGTGCTCAGCGCGGGCGCG
CTGCTGTACTACCGCGAGGTGTGCCGGGGCATAGGCATGCCCGACCTCGCGCGCAAGGCGTCGACACCGTGGGTGCTGGC
GGCCGTGGTGGCCGCGCTCTCGGTCGCCCTGATCATGGCGAAGGTGCTGGCCTACGCGGGTTGA

Upstream 100 bases:

>100_bases
ACAGCAGGTCGTCGACTCCATCGCCTCCACCGCCGTCGATCGCGGCGACCGTCCCACCGAGGATGTCGTGATCAACTCGA
TCACCATCAGCTAGGTCTCG

Downstream 100 bases:

>100_bases
GTCACGGCAGAACAAGCCGCACCGTGCAGGCTCATAACGGGTGAGCTCGAGGCCTGTTATCGGGTAGCGGTGATGAAGTA
GGCGTCGGACCACAGCGAGG

Product: rhomboid family protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MAHPGQVPVYGCAWHPDRATAVRCVRCGRPVCPACMRSAPVGQQCVECVQQGAKSVRQVKPLQQVRAWITWALIAVNVLV
YTATVSDGVGGDVTGSQLFRELVLYLPWVAQGELWRTVTTGFLHLGLMHIAVNMLSLAMIGPGLERAFGGQRYAAIYGTA
LLGSSAAAMWLSPNAVVAGASGAIYGLLGAALVLSLRERLNPQTIIIVLLLNIGLSISLPGISLAGHMGGLLFGVLSAGA
LLYYREVCRGIGMPDLARKASTPWVLAAVVAALSVALIMAKVLAYAG

Sequences:

>Translated_287_residues
MAHPGQVPVYGCAWHPDRATAVRCVRCGRPVCPACMRSAPVGQQCVECVQQGAKSVRQVKPLQQVRAWITWALIAVNVLV
YTATVSDGVGGDVTGSQLFRELVLYLPWVAQGELWRTVTTGFLHLGLMHIAVNMLSLAMIGPGLERAFGGQRYAAIYGTA
LLGSSAAAMWLSPNAVVAGASGAIYGLLGAALVLSLRERLNPQTIIIVLLLNIGLSISLPGISLAGHMGGLLFGVLSAGA
LLYYREVCRGIGMPDLARKASTPWVLAAVVAALSVALIMAKVLAYAG
>Mature_286_residues
AHPGQVPVYGCAWHPDRATAVRCVRCGRPVCPACMRSAPVGQQCVECVQQGAKSVRQVKPLQQVRAWITWALIAVNVLVY
TATVSDGVGGDVTGSQLFRELVLYLPWVAQGELWRTVTTGFLHLGLMHIAVNMLSLAMIGPGLERAFGGQRYAAIYGTAL
LGSSAAAMWLSPNAVVAGASGAIYGLLGAALVLSLRERLNPQTIIIVLLLNIGLSISLPGISLAGHMGGLLFGVLSAGAL
LYYREVCRGIGMPDLARKASTPWVLAAVVAALSVALIMAKVLAYAG

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 30129; Mature: 29998

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHPGQVPVYGCAWHPDRATAVRCVRCGRPVCPACMRSAPVGQQCVECVQQGAKSVRQVK
CCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHH
PLQQVRAWITWALIAVNVLVYTATVSDGVGGDVTGSQLFRELVLYLPWVAQGELWRTVTT
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHH
GFLHLGLMHIAVNMLSLAMIGPGLERAFGGQRYAAIYGTALLGSSAAAMWLSPNAVVAGA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCEEEECC
SGAIYGLLGAALVLSLRERLNPQTIIIVLLLNIGLSISLPGISLAGHMGGLLFGVLSAGA
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHH
LLYYREVCRGIGMPDLARKASTPWVLAAVVAALSVALIMAKVLAYAG
HHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AHPGQVPVYGCAWHPDRATAVRCVRCGRPVCPACMRSAPVGQQCVECVQQGAKSVRQVK
CCCCCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHH
PLQQVRAWITWALIAVNVLVYTATVSDGVGGDVTGSQLFRELVLYLPWVAQGELWRTVTT
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHH
GFLHLGLMHIAVNMLSLAMIGPGLERAFGGQRYAAIYGTALLGSSAAAMWLSPNAVVAGA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCEEEECC
SGAIYGLLGAALVLSLRERLNPQTIIIVLLLNIGLSISLPGISLAGHMGGLLFGVLSAGA
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHH
LLYYREVCRGIGMPDLARKASTPWVLAAVVAALSVALIMAKVLAYAG
HHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]