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The map label for this gene is mro [H]

Identifier: 169834454

GI number: 169834454

Start: 149945

End: 150982

Strand: Direct

Name: mro [H]

Synonym: SPH_0172

Alternate gene names: 169834454

Gene position: 149945-150982 (Clockwise)

Preceding gene: 169832904

Following gene: 169832930

Centisome position: 6.68

GC content: 45.18

Gene sequence:

>1038_bases
ATGAAAGCATACACAGAGCGTGTATTTGGAAATGTTGAGGGCGAGGATGTCTTGGCCTATCGATTTGAGACAGACGGTGG
CTACCAACTTGAGGTTATGACTTATGGTGCGACCATCTTGCGCTATGTCGCACCTGACAAGGCTGGAAATTTTGCCAATG
TTATCTTGGGATTTGATGACTTTGATAGTTATGTAGGCAATAGTCCCAAGCATGGAGCAAGTGTAGGTCCTGTAGCGGGT
CGTATTGCAGGTGCGACCTTTGAGCTCAATGGTAAGACCTATGACCTTGAGGTTAATAATGCTAGCAACTGTAATCACAG
TGGTTCAACTGGTTGGGATTCCAGCTTGTTTGAAGTTGAAGAAGTAAGCGATCATGGCTTGACTCTCTACACAGAGCGTA
CAGATGGGACAGGAGGGTTCCCTGGAAATCTCAAGATTTGGATCAGTTATCACTTGGAAGAAACTGGTGCCTATGAAATT
AGCTACAAGGTAACGACCGATCAGGATACGCTGGTCAATCCAACCAACCACAGCTATTTCAACTTGTCTGGTGATTTCAC
GCAGACGATTGACCGTCATGTCTTCCAACTAAACACAGAGGGCATTTACTCAATCACTCCTGACGGTGTTCCTGCCAAAA
CTCCAGAAGCCAACCGTGATGTGGTCAAACACATCTACAATGGTACCTTGTTGAAGGATATCTTTGCAGAAGAAGATGAG
CAAATCCAGCTGGCATCAGGTTTGGATCACCCATTTGCCCTTCCTGTAGGCCATGACAATGCTGGATTCCTTTATGACCA
AAATTCAGGTCGCTTCCTGCTTTTCAAGACAGAAGCTCCTTGCTTTGTGGTCTACACAGCAAACTTTGTGGATGAAAGTG
TCATCATAGGAGGTCAGCCAATGCTACAGCACAATGGGATTGCTCTTGAAGCGCAAGCTTTACCAGATGCCATTCACAGT
GACCTTAAAGGCCAAGTCATTCTTAAAGCTGGTCAAACCTTCACCAGTAAGACACGTTATGAACTTGTTGTGAAATAA

Upstream 100 bases:

>100_bases
TTCTTGACAAGAGGATTTGTAAATTATCAGATAAACCATAGATTGTCAGTACGCTTTCTATGGTTTGTTTGCTTGAGAGA
AATAGTAAAAGGAGAACAGA

Downstream 100 bases:

>100_bases
AAAAGCTGGTCAAAAAGTCTTTAAAATTAAAATAACGCATATTGTCAGGTGATGAAAAGTTTGATACTATGCGTTTTATT
ATGAAATGATTTACTTTATC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKAYTERVFGNVEGEDVLAYRFETDGGYQLEVMTYGATILRYVAPDKAGNFANVILGFDDFDSYVGNSPKHGASVGPVAG
RIAGATFELNGKTYDLEVNNASNCNHSGSTGWDSSLFEVEEVSDHGLTLYTERTDGTGGFPGNLKIWISYHLEETGAYEI
SYKVTTDQDTLVNPTNHSYFNLSGDFTQTIDRHVFQLNTEGIYSITPDGVPAKTPEANRDVVKHIYNGTLLKDIFAEEDE
QIQLASGLDHPFALPVGHDNAGFLYDQNSGRFLLFKTEAPCFVVYTANFVDESVIIGGQPMLQHNGIALEAQALPDAIHS
DLKGQVILKAGQTFTSKTRYELVVK

Sequences:

>Translated_345_residues
MKAYTERVFGNVEGEDVLAYRFETDGGYQLEVMTYGATILRYVAPDKAGNFANVILGFDDFDSYVGNSPKHGASVGPVAG
RIAGATFELNGKTYDLEVNNASNCNHSGSTGWDSSLFEVEEVSDHGLTLYTERTDGTGGFPGNLKIWISYHLEETGAYEI
SYKVTTDQDTLVNPTNHSYFNLSGDFTQTIDRHVFQLNTEGIYSITPDGVPAKTPEANRDVVKHIYNGTLLKDIFAEEDE
QIQLASGLDHPFALPVGHDNAGFLYDQNSGRFLLFKTEAPCFVVYTANFVDESVIIGGQPMLQHNGIALEAQALPDAIHS
DLKGQVILKAGQTFTSKTRYELVVK
>Mature_345_residues
MKAYTERVFGNVEGEDVLAYRFETDGGYQLEVMTYGATILRYVAPDKAGNFANVILGFDDFDSYVGNSPKHGASVGPVAG
RIAGATFELNGKTYDLEVNNASNCNHSGSTGWDSSLFEVEEVSDHGLTLYTERTDGTGGFPGNLKIWISYHLEETGAYEI
SYKVTTDQDTLVNPTNHSYFNLSGDFTQTIDRHVFQLNTEGIYSITPDGVPAKTPEANRDVVKHIYNGTLLKDIFAEEDE
QIQLASGLDHPFALPVGHDNAGFLYDQNSGRFLLFKTEAPCFVVYTANFVDESVIIGGQPMLQHNGIALEAQALPDAIHS
DLKGQVILKAGQTFTSKTRYELVVK

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=353, Percent_Identity=30.3116147308782, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1786971, Length=338, Percent_Identity=26.3313609467456, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17557428, Length=318, Percent_Identity=24.5283018867925, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI115533334, Length=318, Percent_Identity=24.5283018867925, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6322004, Length=343, Percent_Identity=26.530612244898, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319493, Length=343, Percent_Identity=26.2390670553936, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324399, Length=344, Percent_Identity=24.4186046511628, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24659048, Length=368, Percent_Identity=29.8913043478261, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24583720, Length=337, Percent_Identity=27.893175074184, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24668278, Length=319, Percent_Identity=27.5862068965517, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24668282, Length=356, Percent_Identity=27.247191011236, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24641876, Length=369, Percent_Identity=24.9322493224932, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37854; Mature: 37854

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAYTERVFGNVEGEDVLAYRFETDGGYQLEVMTYGATILRYVAPDKAGNFANVILGFDD
CCCCHHHHHCCCCCCEEEEEEEECCCCEEEEEEECCCEEEEEECCCCCCCEEEEEEECCH
FDSYVGNSPKHGASVGPVAGRIAGATFELNGKTYDLEVNNASNCNHSGSTGWDSSLFEVE
HHHHHCCCCCCCCCCCCCHHEEECEEEEECCEEEEEEECCCCCCCCCCCCCCCCCCEEEE
EVSDHGLTLYTERTDGTGGFPGNLKIWISYHLEETGAYEISYKVTTDQDTLVNPTNHSYF
ECCCCCEEEEEECCCCCCCCCCCEEEEEEEEECCCCCEEEEEEEECCCCCEECCCCCCEE
NLSGDFTQTIDRHVFQLNTEGIYSITPDGVPAKTPEANRDVVKHIYNGTLLKDIFAEEDE
EECCCHHHHHCCEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCC
QIQLASGLDHPFALPVGHDNAGFLYDQNSGRFLLFKTEAPCFVVYTANFVDESVIIGGQP
EEEEECCCCCCEEEECCCCCCCEEEECCCCEEEEEECCCCEEEEEEECCCCCEEEECCCC
MLQHNGIALEAQALPDAIHSDLKGQVILKAGQTFTSKTRYELVVK
EEECCCEEEEHHHCCHHHHCCCCCEEEEEECCCCCCCCEEEEEEC
>Mature Secondary Structure
MKAYTERVFGNVEGEDVLAYRFETDGGYQLEVMTYGATILRYVAPDKAGNFANVILGFDD
CCCCHHHHHCCCCCCEEEEEEEECCCCEEEEEEECCCEEEEEECCCCCCCEEEEEEECCH
FDSYVGNSPKHGASVGPVAGRIAGATFELNGKTYDLEVNNASNCNHSGSTGWDSSLFEVE
HHHHHCCCCCCCCCCCCCHHEEECEEEEECCEEEEEEECCCCCCCCCCCCCCCCCCEEEE
EVSDHGLTLYTERTDGTGGFPGNLKIWISYHLEETGAYEISYKVTTDQDTLVNPTNHSYF
ECCCCCEEEEEECCCCCCCCCCCEEEEEEEEECCCCCEEEEEEEECCCCCEECCCCCCEE
NLSGDFTQTIDRHVFQLNTEGIYSITPDGVPAKTPEANRDVVKHIYNGTLLKDIFAEEDE
EECCCHHHHHCCEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCC
QIQLASGLDHPFALPVGHDNAGFLYDQNSGRFLLFKTEAPCFVVYTANFVDESVIIGGQP
EEEEECCCCCCEEEECCCCCCCEEEECCCCEEEEEECCCCEEEEEEECCCCCEEEECCCC
MLQHNGIALEAQALPDAIHSDLKGQVILKAGQTFTSKTRYELVVK
EEECCCEEEEHHHCCHHHHCCCCCEEEEEECCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]