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The map label for this gene is cysK [H]

Identifier: 169834032

GI number: 169834032

Start: 2217371

End: 2218297

Strand: Direct

Name: cysK [H]

Synonym: SPH_2408

Alternate gene names: 169834032

Gene position: 2217371-2218297 (Clockwise)

Preceding gene: 169832597

Following gene: 169834041

Centisome position: 98.74

GC content: 41.21

Gene sequence:

>927_bases
ATGTCTATTTATAACAACATTACTGAATTAATCGGTCAAACACCAATTGTTAAACTTAACAACATCGTGCCAGAAGGTGC
TGCAGACGTCTATATAAAGCTTGAAGCATTTAATCCTGGTTCATCTGTAAAAGACCGTATTGCCCTTAGCATGATTGAAA
AAGCTGAACAAGATGGTATTCTGAAACCTGGTTCTACTATTGTTGAAGCAACAAGTGGAAACACTGGTATTGGACTTTCA
TGGGTAGGTGCTGCTAAAGGGTATAAAGTCGTCATCGTTATGCCTGAAACTATGAGTGTAGAACGACGTAAAATTATCCA
AGCTTATGGTGCTGAACTCGTCCTAACTCCTGGTAGCGAGGGAATGAAAGGTGCTATTGCTAAGGCTCAAGAAATCGCTG
CTGAACGTGATGGTTTCCTTCCTCTTCAATTTGACAATCCAGCTAATCCAGAAGTACACGAAAGAACAACAGGAGCTGAG
ATACTAGCTGCTTTCGGTAAAGATGGATTAGATGCCTTTGTTGCTGGAGTAGGTACCGGTGGAACGATTTCTGGTGTTTC
TCATGCACTCAAATCAGAAAATTCTAACATTCAAGTTTTTGCAGTAGAAGCAGATGAATCTGCTATTCTATCTGGTGAAA
AACCCGGTCCTCACAAAATTCAAGGTATCTCAGCTGGATTTATTCCTGATACACTTGATACTAAAGCCTATGATGGTATC
GTTCGTGTAACATCAGATGACGCTCTTGCACTCGGACGTGAAATTGGTGGAAAAGAAGGCTTCCTTGTAGGGATTTCCTC
AGCTGCAGCTATCTACGGAGCCATCGAGGTTGCCAAAAAATTAGGTACAGGTAAAAAAGTCCTTGCTCTAGCACCAGATA
ACGGTGAACGTTATCTCTCTACAGCACTCTATGAATTTGAAGTTTAG

Upstream 100 bases:

>100_bases
ATGATATATAGAAATCCTATCGCTTCGATAGGATTTCTATATTTTACAAATGGTATAGATAGCGTTATACTAAAGATATC
TTATACAAAGAGGTATTCAT

Downstream 100 bases:

>100_bases
TCTCCTAAATACAATTGGCCCTTATTATAGGGCTTTTTATTTTTACCTTGAAAATAGGAAGCTCTCCCTATAAGGATCGA
CTGCATACAAAAAAGGAAGC

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVKDRIALSMIEKAEQDGILKPGSTIVEATSGNTGIGLS
WVGAAKGYKVVIVMPETMSVERRKIIQAYGAELVLTPGSEGMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAE
ILAAFGKDGLDAFVAGVGTGGTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPHKIQGISAGFIPDTLDTKAYDGI
VRVTSDDALALGREIGGKEGFLVGISSAAAIYGAIEVAKKLGTGKKVLALAPDNGERYLSTALYEFEV

Sequences:

>Translated_308_residues
MSIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVKDRIALSMIEKAEQDGILKPGSTIVEATSGNTGIGLS
WVGAAKGYKVVIVMPETMSVERRKIIQAYGAELVLTPGSEGMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAE
ILAAFGKDGLDAFVAGVGTGGTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPHKIQGISAGFIPDTLDTKAYDGI
VRVTSDDALALGREIGGKEGFLVGISSAAAIYGAIEVAKKLGTGKKVLALAPDNGERYLSTALYEFEV
>Mature_307_residues
SIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVKDRIALSMIEKAEQDGILKPGSTIVEATSGNTGIGLSW
VGAAKGYKVVIVMPETMSVERRKIIQAYGAELVLTPGSEGMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAEI
LAAFGKDGLDAFVAGVGTGGTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPHKIQGISAGFIPDTLDTKAYDGIV
RVTSDDALALGREIGGKEGFLVGISSAAAIYGAIEVAKKLGTGKKVLALAPDNGERYLSTALYEFEV

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=313, Percent_Identity=37.0607028753994, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI295821200, Length=313, Percent_Identity=37.0607028753994, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI4557415, Length=313, Percent_Identity=37.0607028753994, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI11345492, Length=198, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788754, Length=314, Percent_Identity=50, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI2367138, Length=300, Percent_Identity=39.6666666666667, Blast_Score=217, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI17535051, Length=302, Percent_Identity=46.0264900662252, Blast_Score=265, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=48.6928104575163, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=45.3333333333333, Blast_Score=247, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI32566674, Length=295, Percent_Identity=45.4237288135593, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=42.809364548495, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17534315, Length=318, Percent_Identity=38.9937106918239, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=43.4579439252336, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25147552, Length=316, Percent_Identity=35.4430379746835, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=40.5172413793103, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321594, Length=318, Percent_Identity=37.4213836477987, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6321449, Length=334, Percent_Identity=34.4311377245509, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24643623, Length=310, Percent_Identity=37.741935483871, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI20129101, Length=310, Percent_Identity=37.741935483871, Blast_Score=187, Evalue=7e-48,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32120; Mature: 31989

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVKDRIALSMIEKAEQDGI
CCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCC
LKPGSTIVEATSGNTGIGLSWVGAAKGYKVVIVMPETMSVERRKIIQAYGAELVLTPGSE
CCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCEEEECCCCC
GMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAEILAAFGKDGLDAFVAGVGTG
CCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCHHHHHHHHCCCCHHHHHHCCCCC
GTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPHKIQGISAGFIPDTLDTKAYDGI
CCHHHHHHHHHCCCCCEEEEEEECCCCEEECCCCCCCCEEEEEECCCCCCCCCCHHHCCE
VRVTSDDALALGREIGGKEGFLVGISSAAAIYGAIEVAKKLGTGKKVLALAPDNGERYLS
EEEECCCHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHH
TALYEFEV
HEEEEECC
>Mature Secondary Structure 
SIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVKDRIALSMIEKAEQDGI
CHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCC
LKPGSTIVEATSGNTGIGLSWVGAAKGYKVVIVMPETMSVERRKIIQAYGAELVLTPGSE
CCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCEEEECCCCC
GMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAEILAAFGKDGLDAFVAGVGTG
CCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCHHHHHHHHCCCCHHHHHHCCCCC
GTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPHKIQGISAGFIPDTLDTKAYDGI
CCHHHHHHHHHCCCCCEEEEEEECCCCEEECCCCCCCCEEEEEECCCCCCCCCCHHHCCE
VRVTSDDALALGREIGGKEGFLVGISSAAAIYGAIEVAKKLGTGKKVLALAPDNGERYLS
EEEECCCHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHH
TALYEFEV
HEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA