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The map label for this gene is phoP [H]

Identifier: 169833990

GI number: 169833990

Start: 2076334

End: 2077041

Strand: Direct

Name: phoP [H]

Synonym: SPH_2269

Alternate gene names: 169833990

Gene position: 2076334-2077041 (Clockwise)

Preceding gene: 169832852

Following gene: 169834271

Centisome position: 92.46

GC content: 41.24

Gene sequence:

>708_bases
ATGACAAAACAAGTCTTATTAGTGGATGATGAAGAACACATTCTGAAATTGCTTTACTACCATTTAAGTAAGGAAGGCTT
TTCTACTCAATTGGTTACAAATGGACGGAAGGCCTTAGCTTTGGCAGAAACAGAACCCTTTGATTTTATCTTGCTTGATA
TCATGTTACCACAATTAGATGGCATGGAAGTTTGTAAGCGGCTGAGAGCCAAAGGCGTCAAAACTCCAATTATGATGGTT
TCTGCGAAAAGTGATGAATTTGATAAGGTTTTGGCCTTGGAATTAGGGGCTGATGACTACCTGACCAAGCCTTTTAGCCC
TAGAGAATTGCTGGCGCGTGTCAAGGCTGTCCTCAGGCGAACTAAAGGAGAACAAGAAGGAGATGATTCAGATAATATCG
CTGACGATTCTTGGCTATTTGGGACCTTGAAAGTATACCCTGAGCGTCATGAAGTCTACAAGGCGAATAAGTTACTGAGT
TTGACCCCAAAAGAATTTGAACTCTTGCTCTATCTTATGAAACATCCCAACATGACACTGACTAGAGAGCGTCTTTTGGA
ACGTATCTGGGGGTATGACTTTGGGCAGGAAACACGTTTGGTGGACGTTCATATTGGTAAGTTGAGGGAAAAAATTGAAG
ACAATCCTAAAGCCCCTCAATTTATTCGAACCATTCGGGGTTATGGTTATAAGTTCAAGGAGTTATAG

Upstream 100 bases:

>100_bases
GTTTGACCAGATACTAGTCTTGATAGGCAAATTTAATCTGATTTAGCAATGTTAGGATTTCTGATAATTGTGTTATAATG
TTACCAATAGGAGATAATAG

Downstream 100 bases:

>100_bases
ATGAAACGCTACCTTCAATTTTGGCTAGTCAATCTAAGTGTTAGCCTCATTCTGATTGCAGGGATGGCATTAACTTGGAT
CAGTAAAGGCATCGGTCTCT

Product: alkaline phosphatase synthesis transcriptional regulatory protein PhoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MTKQVLLVDDEEHILKLLYYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGMEVCKRLRAKGVKTPIMMV
SAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLS
LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL

Sequences:

>Translated_235_residues
MTKQVLLVDDEEHILKLLYYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGMEVCKRLRAKGVKTPIMMV
SAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLS
LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL
>Mature_234_residues
TKQVLLVDDEEHILKLLYYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGMEVCKRLRAKGVKTPIMMVS
AKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLSL
TPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=39.3013100436681, Blast_Score=180, Evalue=6e-47,
Organism=Escherichia coli, GI1788394, Length=232, Percent_Identity=37.5, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1786599, Length=236, Percent_Identity=37.2881355932203, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=36.1233480176211, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=35.8078602620087, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=37.719298245614, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI1790860, Length=235, Percent_Identity=37.0212765957447, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1789402, Length=231, Percent_Identity=33.7662337662338, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=33.920704845815, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=34.3478260869565, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=36.0169491525424, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1790863, Length=237, Percent_Identity=29.957805907173, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=30.3030303030303, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787375, Length=231, Percent_Identity=28.1385281385281, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788550, Length=162, Percent_Identity=31.4814814814815, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790437, Length=208, Percent_Identity=25, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=35.2941176470588, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790299, Length=123, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=103, Percent_Identity=33.0097087378641, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27279; Mature: 27148

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQVLLVDDEEHILKLLYYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLD
CCCCEEEECCHHHHHHHHHHHHCCCCCCCCEEECCCEEEEEECCCCCCEEEEEHHHCCCC
GMEVCKRLRAKGVKTPIMMVSAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRR
HHHHHHHHHHCCCCCCEEEEECCCCCCHHEEEEEECCCHHCCCCCCHHHHHHHHHHHHHH
TKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLSLTPKEFELLLYLMKHPNMTL
HCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHCCEEECCHHHHHHHHHHHHCCCCCH
TRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL
HHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHCCEECCCC
>Mature Secondary Structure 
TKQVLLVDDEEHILKLLYYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLD
CCCEEEECCHHHHHHHHHHHHCCCCCCCCEEECCCEEEEEECCCCCCEEEEEHHHCCCC
GMEVCKRLRAKGVKTPIMMVSAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRR
HHHHHHHHHHCCCCCCEEEEECCCCCCHHEEEEEECCCHHCCCCCCHHHHHHHHHHHHHH
TKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLSLTPKEFELLLYLMKHPNMTL
HCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHCCEEECCHHHHHHHHHHHHCCCCCH
TRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL
HHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]