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The map label for this gene is dnaX [H]

Identifier: 169833967

GI number: 169833967

Start: 889326

End: 890981

Strand: Direct

Name: dnaX [H]

Synonym: SPH_0968

Alternate gene names: 169833967

Gene position: 889326-890981 (Clockwise)

Preceding gene: 169832530

Following gene: 169834455

Centisome position: 39.6

GC content: 41.91

Gene sequence:

>1656_bases
ATGTATCAAGCACTTTATCGAAAATATAGAAGTCAAAACTTCTCCCAGTTAGTTGGTCAAGAAGTTGTGGCTAAGACTCT
TAAACAAGCGGTGGAGCAAGAGAAAATAAGTCACGCTTATCTTTTTTCTGGTCCTCGTGGAACGGGAAAAACCAGTGTTG
CTAAAATCTTTGCCAAGGCTATGAACTGTCCCAATCAAGTGGGTGGCGAACCTTGCAATAACTGCTATATTTGTCAAGCA
GTGACGGACGGTAGTTTAGAAGATGTCATTGAAATGGATGCAGCTTCTAATAATGGGGTAGATGAAATTCGCGAAATTCG
TGATAAATCTACCTATGCGCCTAGCCTTGCTCGTTATAAGATTTATATCATAGATGAGGTTCACATGCTGTCTACAGGGG
CTTTTAATGCCCTCCTAAAGACGTTGGAAGAACCAACACAGAATGTAGTCTTTATTTTGGCCACTACTGAATTGCACAAG
ATTCCTGCTACTATTCTATCCCGTGTGCAACGTTTTGAGTTTAAATCAATTAAGACACAGGATATTAAGGAACATATTCA
CTATATCTTAGAAAAAGAAAATATCAGTTCTGAACCAGAGGCTGTGGAAATCATTGCCAGACGGGCGGAAGGTGGAATGC
GGGACGCCTTGTCTATTTTGGATCAAGCCCTGAGTTTGACACAGGGAAATGAGCTGACGACTGCTATCTCTGAAGAAATT
ACTGGCACCATTAGCCTATCAGCCTTGGATGATTATGTGGCGGCCTTGTCTCAACAGGATGTTCCCAAAGCTTTGTCTTG
CTTGAATCTTCTTTTTGACAATGGTAAGAGCATGACTCGTTTTGTGACCGATCTTTTGCACTATTTAAGAGACTTGTTAA
TTGTTCAAACAGGGGGAGAAAATACTCATCATAGTTCAGTCTTTGTAGAAAATTTGGCACTTCCTCAAAAAAATCTGTTT
GAAATGATTCGCTTAGCAACAGTGAATTTAGCAGATATTAAGTCTAGTTTGCAGCCCAAGATTTATGCTGAAATGATGAC
CGTCCGTTTGGCGGAAATCAAGCCCGAACCAGCTCTATCAGGAGCGGTTGAAAATGAAATTGCTACGCTGAGACAGGAAG
TTGCCCGTCTCAAACAAGAGCTTTCTAATGCAGGTGCGGTTCCTAAACAAGTTGCACCAGCTCCTAGTCGACCAGCTACG
GGCAAAACAGTCTATCGTGTCGATCGCAATAAAGTGCAATCTATCTTACAAGAGGCCGTCGAAAATCCTGATTTAGCACG
TCAAAATCTAATTCGTTTGCAGAATGCCTGGGGAGAGGTAATTGAAAGTCTAGGTGGGCCGGACAAGGCTCTGCTAGTTG
GTTCTCAACCGGTTGCTGCCAATGAACACCATGCTATTCTTGCTTTTGAGTCTAACTTCAATGCTGGTCAAACTATGAAA
CGAGACAATCTCAATACCATGTTTGGTAATATCCTCAGTCAGGCGGCAGGTTTTTCACCTGAGATTTTAGCTATTTCCAT
GGAGGAATGGAAAGAAGTTCGCGCAGCCTTTTCAGCCAAAGCCAAATCTTCTCAAACTGAAAAAGAAGTAGAAGAAAGCC
TGATTCCAGAAGGATTTGAATTTTTGGCTGATAAAGTGAAGGTAGAGGAAGACTAA

Upstream 100 bases:

>100_bases
AGGATTACGATGCTATGGATCGAGATTATTTGGAACAATTTGTCGCTATTTTGCTTGAAAAGACAACATGGGACTTTACG
ATGTTTGAGGAAAAATCTTA

Downstream 100 bases:

>100_bases
AGAAAGATTTCATGATACAATAAGTTTATGAATAAACAACAATTTATTATTATGGCGCTATTTACAGCTGCTGAGACCTA
TTTTTTCAATGAAGCCTGGA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MYQALYRKYRSQNFSQLVGQEVVAKTLKQAVEQEKISHAYLFSGPRGTGKTSVAKIFAKAMNCPNQVGGEPCNNCYICQA
VTDGSLEDVIEMDAASNNGVDEIREIRDKSTYAPSLARYKIYIIDEVHMLSTGAFNALLKTLEEPTQNVVFILATTELHK
IPATILSRVQRFEFKSIKTQDIKEHIHYILEKENISSEPEAVEIIARRAEGGMRDALSILDQALSLTQGNELTTAISEEI
TGTISLSALDDYVAALSQQDVPKALSCLNLLFDNGKSMTRFVTDLLHYLRDLLIVQTGGENTHHSSVFVENLALPQKNLF
EMIRLATVNLADIKSSLQPKIYAEMMTVRLAEIKPEPALSGAVENEIATLRQEVARLKQELSNAGAVPKQVAPAPSRPAT
GKTVYRVDRNKVQSILQEAVENPDLARQNLIRLQNAWGEVIESLGGPDKALLVGSQPVAANEHHAILAFESNFNAGQTMK
RDNLNTMFGNILSQAAGFSPEILAISMEEWKEVRAAFSAKAKSSQTEKEVEESLIPEGFEFLADKVKVEED

Sequences:

>Translated_551_residues
MYQALYRKYRSQNFSQLVGQEVVAKTLKQAVEQEKISHAYLFSGPRGTGKTSVAKIFAKAMNCPNQVGGEPCNNCYICQA
VTDGSLEDVIEMDAASNNGVDEIREIRDKSTYAPSLARYKIYIIDEVHMLSTGAFNALLKTLEEPTQNVVFILATTELHK
IPATILSRVQRFEFKSIKTQDIKEHIHYILEKENISSEPEAVEIIARRAEGGMRDALSILDQALSLTQGNELTTAISEEI
TGTISLSALDDYVAALSQQDVPKALSCLNLLFDNGKSMTRFVTDLLHYLRDLLIVQTGGENTHHSSVFVENLALPQKNLF
EMIRLATVNLADIKSSLQPKIYAEMMTVRLAEIKPEPALSGAVENEIATLRQEVARLKQELSNAGAVPKQVAPAPSRPAT
GKTVYRVDRNKVQSILQEAVENPDLARQNLIRLQNAWGEVIESLGGPDKALLVGSQPVAANEHHAILAFESNFNAGQTMK
RDNLNTMFGNILSQAAGFSPEILAISMEEWKEVRAAFSAKAKSSQTEKEVEESLIPEGFEFLADKVKVEED
>Mature_551_residues
MYQALYRKYRSQNFSQLVGQEVVAKTLKQAVEQEKISHAYLFSGPRGTGKTSVAKIFAKAMNCPNQVGGEPCNNCYICQA
VTDGSLEDVIEMDAASNNGVDEIREIRDKSTYAPSLARYKIYIIDEVHMLSTGAFNALLKTLEEPTQNVVFILATTELHK
IPATILSRVQRFEFKSIKTQDIKEHIHYILEKENISSEPEAVEIIARRAEGGMRDALSILDQALSLTQGNELTTAISEEI
TGTISLSALDDYVAALSQQDVPKALSCLNLLFDNGKSMTRFVTDLLHYLRDLLIVQTGGENTHHSSVFVENLALPQKNLF
EMIRLATVNLADIKSSLQPKIYAEMMTVRLAEIKPEPALSGAVENEIATLRQEVARLKQELSNAGAVPKQVAPAPSRPAT
GKTVYRVDRNKVQSILQEAVENPDLARQNLIRLQNAWGEVIESLGGPDKALLVGSQPVAANEHHAILAFESNFNAGQTMK
RDNLNTMFGNILSQAAGFSPEILAISMEEWKEVRAAFSAKAKSSQTEKEVEESLIPEGFEFLADKVKVEED

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=287, Percent_Identity=26.4808362369338, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI31881687, Length=287, Percent_Identity=26.4808362369338, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI6677723, Length=215, Percent_Identity=26.9767441860465, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI194306571, Length=215, Percent_Identity=26.9767441860465, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI194306567, Length=215, Percent_Identity=26.9767441860465, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI31563534, Length=221, Percent_Identity=27.6018099547511, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1786676, Length=295, Percent_Identity=41.6949152542373, Blast_Score=250, Evalue=2e-67,
Organism=Escherichia coli, GI1787119, Length=232, Percent_Identity=27.5862068965517, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71986063, Length=300, Percent_Identity=26.3333333333333, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17554730, Length=220, Percent_Identity=24.0909090909091, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17541988, Length=216, Percent_Identity=26.8518518518519, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324039, Length=235, Percent_Identity=28.5106382978723, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322528, Length=302, Percent_Identity=23.841059602649, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324478, Length=217, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI18859927, Length=296, Percent_Identity=26.0135135135135, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19921076, Length=215, Percent_Identity=26.5116279069767, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17647857, Length=291, Percent_Identity=23.7113402061856, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 60868; Mature: 60868

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQALYRKYRSQNFSQLVGQEVVAKTLKQAVEQEKISHAYLFSGPRGTGKTSVAKIFAKA
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHH
MNCPNQVGGEPCNNCYICQAVTDGSLEDVIEMDAASNNGVDEIREIRDKSTYAPSLARYK
HCCCHHCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHEEE
IYIIDEVHMLSTGAFNALLKTLEEPTQNVVFILATTELHKIPATILSRVQRFEFKSIKTQ
EEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCHH
DIKEHIHYILEKENISSEPEAVEIIARRAEGGMRDALSILDQALSLTQGNELTTAISEEI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TGTISLSALDDYVAALSQQDVPKALSCLNLLFDNGKSMTRFVTDLLHYLRDLLIVQTGGE
CCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCC
NTHHSSVFVENLALPQKNLFEMIRLATVNLADIKSSLQPKIYAEMMTVRLAEIKPEPALS
CCCCHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHH
GAVENEIATLRQEVARLKQELSNAGAVPKQVAPAPSRPATGKTVYRVDRNKVQSILQEAV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHH
ENPDLARQNLIRLQNAWGEVIESLGGPDKALLVGSQPVAANEHHAILAFESNFNAGQTMK
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCC
RDNLNTMFGNILSQAAGFSPEILAISMEEWKEVRAAFSAKAKSSQTEKEVEESLIPEGFE
CCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHH
FLADKVKVEED
HHHHHHCCCCC
>Mature Secondary Structure
MYQALYRKYRSQNFSQLVGQEVVAKTLKQAVEQEKISHAYLFSGPRGTGKTSVAKIFAKA
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHH
MNCPNQVGGEPCNNCYICQAVTDGSLEDVIEMDAASNNGVDEIREIRDKSTYAPSLARYK
HCCCHHCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHEEE
IYIIDEVHMLSTGAFNALLKTLEEPTQNVVFILATTELHKIPATILSRVQRFEFKSIKTQ
EEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCHH
DIKEHIHYILEKENISSEPEAVEIIARRAEGGMRDALSILDQALSLTQGNELTTAISEEI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TGTISLSALDDYVAALSQQDVPKALSCLNLLFDNGKSMTRFVTDLLHYLRDLLIVQTGGE
CCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCC
NTHHSSVFVENLALPQKNLFEMIRLATVNLADIKSSLQPKIYAEMMTVRLAEIKPEPALS
CCCCHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHH
GAVENEIATLRQEVARLKQELSNAGAVPKQVAPAPSRPATGKTVYRVDRNKVQSILQEAV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHH
ENPDLARQNLIRLQNAWGEVIESLGGPDKALLVGSQPVAANEHHAILAFESNFNAGQTMK
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCC
RDNLNTMFGNILSQAAGFSPEILAISMEEWKEVRAAFSAKAKSSQTEKEVEESLIPEGFE
CCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHH
FLADKVKVEED
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]