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The map label for this gene is purC [H]

Identifier: 169833896

GI number: 169833896

Start: 123746

End: 124453

Strand: Direct

Name: purC [H]

Synonym: SPH_0150

Alternate gene names: 169833896

Gene position: 123746-124453 (Clockwise)

Preceding gene: 169833323

Following gene: 169834279

Centisome position: 5.51

GC content: 39.97

Gene sequence:

>708_bases
ATGTCAAAACAATTGATCTATTCGGGAAAAGCTAAAGATATCTATACAACTGAGGATGAAAATCTTATTATTTCAACTTA
CAAGGACCAGGCGACTGCTTTCAACGGTGTCAAGAAGGAGCAGATTGCAGGTAAGGGAGTCTTGAATAATCAGATCTCAT
CTTTTATTTTTGAGAAATTAAATGCGGCTGGTGTGGCGACTCACTTTGTGGAGAAACTTTCAGACACGGAACAACTCAAT
AAAAAGGTTAAGATTATTCCTTTGGAAGTCGTGCTCCGCAACTATACTGCTGGTTCCTTTTCAAAACGTTTTGGTGTGGA
TGAGGGAATCGCCTTGGAGACTCCGATTGTCGAATTTTACTACAAAAATGATGATTTGGATGATCCATTTATCAATGATG
AGCATGTGAAATTCCTACAGATTGCGGATGACCAGCAGATTGCCTACTTGAAGGAAGAAACGCGTCGTATCAATGAACTA
TTGAAAGTCTGGTTTGCTGAGATTGGGCTTAAATTGATTGACTTTAAGCTAGAGTTCGGTTTTGACAAGGATGGCAAGAT
TATCTTGGCAGACGAATTTTCACCAGATAACTGCCGCTTGTGGGATGCTGATGGCAACCACATGGATAAGGATGTTTTCC
GTAGAGGATTGGGAGAACTAACCGACGTTTATGAGATTGTTTGGGAAAAGTTGCAGGAATTGAAATAA

Upstream 100 bases:

>100_bases
CAATTTTTGAAAAACATCTGCTATTTATTCGGTTAAATTCTTGTGTTTTTTGGTTTTTGTGGTAAAATGTGCTCAAGTAA
TACGAAAGGCGAACTTTAAA

Downstream 100 bases:

>100_bases
TCTGTTTGCAATGGAAAACCTTCGTCTCTCAACTAAAAGGACTCAGGCTGAAAAGGTCCCCCAGACCTTTTCACTCTGTA
GAGAACTAGGTGAACTAACC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLN
KKVKIIPLEVVLRNYTAGSFSKRFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINEL
LKVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTDVYEIVWEKLQELK

Sequences:

>Translated_235_residues
MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLN
KKVKIIPLEVVLRNYTAGSFSKRFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINEL
LKVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTDVYEIVWEKLQELK
>Mature_234_residues
SKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNK
KVKIIPLEVVLRNYTAGSFSKRFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINELL
KVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTDVYEIVWEKLQELK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=242, Percent_Identity=33.8842975206612, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI5453539, Length=242, Percent_Identity=33.8842975206612, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI119220559, Length=249, Percent_Identity=32.5301204819277, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1788820, Length=233, Percent_Identity=43.3476394849785, Blast_Score=197, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17531275, Length=222, Percent_Identity=34.2342342342342, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319326, Length=234, Percent_Identity=28.2051282051282, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18860083, Length=222, Percent_Identity=34.6846846846847, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24583917, Length=222, Percent_Identity=30.6306306306306, Blast_Score=104, Evalue=6e-23,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27033; Mature: 26902

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNNQISSFIFEKL
CCCCEEECCCCCCEEECCCCCEEEEECCCHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHH
NAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRFGVDEGIALETPIVEFY
HHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCCCHHHCCCCCCCEECCCEEEEE
YKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINELLKVWFAEIGLKLIDFKLEFG
ECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEC
FDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTDVYEIVWEKLQELK
CCCCCCEEEEECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNNQISSFIFEKL
CCCEEECCCCCCEEECCCCCEEEEECCCHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHH
NAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRFGVDEGIALETPIVEFY
HHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCCCHHHCCCCCCCEECCCEEEEE
YKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINELLKVWFAEIGLKLIDFKLEFG
ECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEC
FDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTDVYEIVWEKLQELK
CCCCCCEEEEECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA