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The map label for this gene is toxA [H]

Identifier: 169833837

GI number: 169833837

Start: 201209

End: 203326

Strand: Direct

Name: toxA [H]

Synonym: SPH_0232

Alternate gene names: 169833837

Gene position: 201209-203326 (Clockwise)

Preceding gene: 169833386

Following gene: 169833176

Centisome position: 8.96

GC content: 39.71

Gene sequence:

>2118_bases
ATGAATAAGAAAAAAATGATTTTAACAAGCCTAGCCAGCGTCGCTATCTTAGGGGCTGGTTTTGTTACGTCTCAGCCTAC
TTTTGTAAGAGCAGAAGAAGCTCCCGTAGCTAGTCAGTCTAAAGCTGAGAAAGACTATGATGCAGCAGTGAAAAAATCTG
AAGCTGCTAAGAAACATTACGAAGAAGCTAAAAAGAAAGCAAAAGAAGCTCAGAAAAAATATGATGAGGATCAGAAGAAA
ACTGAAGATAAGGCAGAGGCAGTTAAGAAAGCTGATGAAGAACTTCAAAAAGCGAATTTGGCAGTTCAAAAGGCGTATGT
AGAATATAGAGAAGCGAAAGATAAAGCTAGCGCTGAGAAAAAGATTGAAGAAGCAAAACGAAAACAAAAAGAAGCGAACA
AAAAATTTAATGAGGAGCAAGCAAAAGTAGTTCCTGAAGCAAAGGAGTTAGCTGCTACTAAACAAAAAGCGGAAAAAGCT
AAAAAAGACGCCGAAGTAGCTAAGGAAAAATATGATAAGGCAGTTCAAGAGGTAGAAGTAGAGAAAAATAAAATACTTGA
ACAAGATGCTGAAAACGAAAAGAAAATTGACGTACTTCAAAACAAAGTCGCTGATTTAGAAAAAGGAATTGCTCTTTATC
AAAACAAAGTCGCTGAATTAAATAAAGAAATTGCTAGACTTCAAAGCGATTTAAAAGATGCTGAAGAAAATAATGTAGAA
GACTATATTAAAGAAGGTTTAGAGCAAGCTATCGCTGATAAAAAAGCTGAATTAGCTACAACTCAACAAAACATAGATAA
AACTCAAAAAGATTTAGAGGATGCTGAATTAGAACTTGAAAAAGTATTAGCTACATTAGACCCTGAAGGTAAAACTCAAG
ATGAATTAGATAAAGAAGCTGCAGAAGATGCTAATATTGAAGCTCTTCAAAACAAAGTTGCTGATCTAGAAAACAAGGTT
GCTGAATTAGATAAAGAAGTTACTAGACTTCAAAGCGATTTAAAAGATGCTGAAGAAAACAATGTAGAAGACTACGTTAA
AGAAGGCTTAGAGAAAGCTCTTACTGATAAAAAAGTTGAATTAAATAATACTCAAAAAGCATTAGATACTGCTCAAAAAG
CATTAGATACTGCTCTTAATGAATTAGGTCCTGACGGTGATGAAGAAGAAACTCCAGCTCCAGCACCAAAACCAGAGCAA
CCAGCTGAACAACCAAAACCAGCGCCGGCTCCTCAACCAGCTCCAGCACCAAAACCAGAAAAAACAGATGATCAACAAGC
TGAAGAAGACTATGCTCGTAGATCAGAAGAAGAATATAACCGCTTGCCCCAACAGCAACCGCCAAAAGCAGAAAAACCAG
CTCCAGCACCAAAACCAGAGCAACCAGTTCCTGCACCAAAACCAGGTTGGAAACAAGAAAACGGTATGTGGTACTTCTAC
AATACTGATGGTTCAATGGCTACAGGTTGGCTCCAAAACAACGGTTCATGGTATTACCTCAACAGCAATGGCGCTATGGC
TACAGGTTGGCTCCAATACAATGGTTCATGGTATTACCTAAACGCTAACGGCGCTATGGCAACAGGTTGGGCTAAAGTCA
ACGGTTCATGGTACTACCTAAACGCTAATGGTGCTATGGCTACAGGTTGGCTCCAATACAACGATTCATGGTATTACCTA
AACGCTAACGGCGCTATGGCGACAGGATGGCTCCAATACAACGGTTCATGGTACTACCTCAACGCTAACGGTGCTATGGC
TACAGGTTGGGCTAAAGTCAACGGTTCATGGTACTACCTCAACGCTAATGGTGCTATGGCTACAGGTTGGCTCCAATACA
ACGGTTCATGGTATTACCTAAACGCTAACGGTGCTATGGCTACAGGTTGGGCTAAAGTCAACGGTTCATGGTACTACCTC
AACGCTAACGGTTCAATGGCAACAGGTTGGGTGAAAGATGGAGATACCTGGTACTATCTTGAAGCATCAGGTGCTATGAA
AGCAAGCCAATGGTTCAAAGTATCAGATAAATGGTACTATGTCAATGGTTTAGGTGCCCTTGCAGTCAACACAACTGTAG
ATGGCTATAAAGTCAATGCCAATGGTGAATGGGTTTAA

Upstream 100 bases:

>100_bases
ATAAAAATGTAATATAAAACATTTGACAAATATTTATGGGGGGAGTATACTTAATATAAGTATAGTCTAAAAATGACTAT
CAGAAAAGAGGTAAATTTAG

Downstream 100 bases:

>100_bases
GCCGATTAAATTAAATCATGTTAAGAACATTTGACATTTTAATTTTGAAACAAAGATAAGGTTCGATTGAATAGATTTAT
GTTCGTATTCTTTAGGTACC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 705; Mature: 705

Protein sequence:

>705_residues
MNKKKMILTSLASVAILGAGFVTSQPTFVRAEEAPVASQSKAEKDYDAAVKKSEAAKKHYEEAKKKAKEAQKKYDEDQKK
TEDKAEAVKKADEELQKANLAVQKAYVEYREAKDKASAEKKIEEAKRKQKEANKKFNEEQAKVVPEAKELAATKQKAEKA
KKDAEVAKEKYDKAVQEVEVEKNKILEQDAENEKKIDVLQNKVADLEKGIALYQNKVAELNKEIARLQSDLKDAEENNVE
DYIKEGLEQAIADKKAELATTQQNIDKTQKDLEDAELELEKVLATLDPEGKTQDELDKEAAEDANIEALQNKVADLENKV
AELDKEVTRLQSDLKDAEENNVEDYVKEGLEKALTDKKVELNNTQKALDTAQKALDTALNELGPDGDEEETPAPAPKPEQ
PAEQPKPAPAPQPAPAPKPEKTDDQQAEEDYARRSEEEYNRLPQQQPPKAEKPAPAPKPEQPVPAPKPGWKQENGMWYFY
NTDGSMATGWLQNNGSWYYLNSNGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGAMATGWLQYNDSWYYL
NANGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYL
NANGSMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGLGALAVNTTVDGYKVNANGEWV

Sequences:

>Translated_705_residues
MNKKKMILTSLASVAILGAGFVTSQPTFVRAEEAPVASQSKAEKDYDAAVKKSEAAKKHYEEAKKKAKEAQKKYDEDQKK
TEDKAEAVKKADEELQKANLAVQKAYVEYREAKDKASAEKKIEEAKRKQKEANKKFNEEQAKVVPEAKELAATKQKAEKA
KKDAEVAKEKYDKAVQEVEVEKNKILEQDAENEKKIDVLQNKVADLEKGIALYQNKVAELNKEIARLQSDLKDAEENNVE
DYIKEGLEQAIADKKAELATTQQNIDKTQKDLEDAELELEKVLATLDPEGKTQDELDKEAAEDANIEALQNKVADLENKV
AELDKEVTRLQSDLKDAEENNVEDYVKEGLEKALTDKKVELNNTQKALDTAQKALDTALNELGPDGDEEETPAPAPKPEQ
PAEQPKPAPAPQPAPAPKPEKTDDQQAEEDYARRSEEEYNRLPQQQPPKAEKPAPAPKPEQPVPAPKPGWKQENGMWYFY
NTDGSMATGWLQNNGSWYYLNSNGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGAMATGWLQYNDSWYYL
NANGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYL
NANGSMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGLGALAVNTTVDGYKVNANGEWV
>Mature_705_residues
MNKKKMILTSLASVAILGAGFVTSQPTFVRAEEAPVASQSKAEKDYDAAVKKSEAAKKHYEEAKKKAKEAQKKYDEDQKK
TEDKAEAVKKADEELQKANLAVQKAYVEYREAKDKASAEKKIEEAKRKQKEANKKFNEEQAKVVPEAKELAATKQKAEKA
KKDAEVAKEKYDKAVQEVEVEKNKILEQDAENEKKIDVLQNKVADLEKGIALYQNKVAELNKEIARLQSDLKDAEENNVE
DYIKEGLEQAIADKKAELATTQQNIDKTQKDLEDAELELEKVLATLDPEGKTQDELDKEAAEDANIEALQNKVADLENKV
AELDKEVTRLQSDLKDAEENNVEDYVKEGLEKALTDKKVELNNTQKALDTAQKALDTALNELGPDGDEEETPAPAPKPEQ
PAEQPKPAPAPQPAPAPKPEKTDDQQAEEDYARRSEEEYNRLPQQQPPKAEKPAPAPKPEQPVPAPKPGWKQENGMWYFY
NTDGSMATGWLQNNGSWYYLNSNGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGAMATGWLQYNDSWYYL
NANGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYL
NANGSMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGLGALAVNTTVDGYKVNANGEWV

Specific function: Only after the enteral delivery of the enterotoxin A may the characteristic disease called pseudomembranous colitis be induced [H]

COG id: COG5263

COG function: function code R; FOG: Glucan-binding domain (YG repeat)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 32 cell wall-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018337
- InterPro:   IPR007577
- InterPro:   IPR020974 [H]

Pfam domain/function: PF01473 CW_binding_1; PF04488 Gly_transf_sug; PF11713 Peptidase_C80 [H]

EC number: NA

Molecular weight: Translated: 78744; Mature: 78744

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKKMILTSLASVAILGAGFVTSQPTFVRAEEAPVASQSKAEKDYDAAVKKSEAAKKHY
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHH
EEAKKKAKEAQKKYDEDQKKTEDKAEAVKKADEELQKANLAVQKAYVEYREAKDKASAEK
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIEEAKRKQKEANKKFNEEQAKVVPEAKELAATKQKAEKAKKDAEVAKEKYDKAVQEVEV
HHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKNKILEQDAENEKKIDVLQNKVADLEKGIALYQNKVAELNKEIARLQSDLKDAEENNVE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
DYIKEGLEQAIADKKAELATTQQNIDKTQKDLEDAELELEKVLATLDPEGKTQDELDKEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AEDANIEALQNKVADLENKVAELDKEVTRLQSDLKDAEENNVEDYVKEGLEKALTDKKVE
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEE
LNNTQKALDTAQKALDTALNELGPDGDEEETPAPAPKPEQPAEQPKPAPAPQPAPAPKPE
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KTDDQQAEEDYARRSEEEYNRLPQQQPPKAEKPAPAPKPEQPVPAPKPGWKQENGMWYFY
CCCHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
NTDGSMATGWLQNNGSWYYLNSNGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYL
ECCCCEEEEEEECCCCEEEECCCCCEEEEEEEECCEEEEEECCCCEEECEEEECCEEEEE
NANGAMATGWLQYNDSWYYLNANGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYL
ECCCCEEEEEEEECCEEEEEECCCCEEEEEEEECCEEEEEECCCCEEECEEEECCEEEEE
NANGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGSMATGWVKDGDTWYYL
ECCCCEEEEEEEECCEEEEEECCCCEEECEEEECCEEEEEECCCCEEECEEECCCEEEEE
EASGAMKASQWFKVSDKWYYVNGLGALAVNTTVDGYKVNANGEWV
ECCCCCCCCCCEEECCCEEEEECCEEEEEEEECCCEEECCCCCCC
>Mature Secondary Structure
MNKKKMILTSLASVAILGAGFVTSQPTFVRAEEAPVASQSKAEKDYDAAVKKSEAAKKHY
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHH
EEAKKKAKEAQKKYDEDQKKTEDKAEAVKKADEELQKANLAVQKAYVEYREAKDKASAEK
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIEEAKRKQKEANKKFNEEQAKVVPEAKELAATKQKAEKAKKDAEVAKEKYDKAVQEVEV
HHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKNKILEQDAENEKKIDVLQNKVADLEKGIALYQNKVAELNKEIARLQSDLKDAEENNVE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
DYIKEGLEQAIADKKAELATTQQNIDKTQKDLEDAELELEKVLATLDPEGKTQDELDKEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AEDANIEALQNKVADLENKVAELDKEVTRLQSDLKDAEENNVEDYVKEGLEKALTDKKVE
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEE
LNNTQKALDTAQKALDTALNELGPDGDEEETPAPAPKPEQPAEQPKPAPAPQPAPAPKPE
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KTDDQQAEEDYARRSEEEYNRLPQQQPPKAEKPAPAPKPEQPVPAPKPGWKQENGMWYFY
CCCHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
NTDGSMATGWLQNNGSWYYLNSNGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYL
ECCCCEEEEEEECCCCEEEECCCCCEEEEEEEECCEEEEEECCCCEEECEEEECCEEEEE
NANGAMATGWLQYNDSWYYLNANGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYL
ECCCCEEEEEEEECCEEEEEECCCCEEEEEEEECCEEEEEECCCCEEECEEEECCEEEEE
NANGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGSMATGWVKDGDTWYYL
ECCCCEEEEEEEECCEEEEEECCCCEEECEEEECCEEEEEECCCCEEECEEECCCEEEEE
EASGAMKASQWFKVSDKWYYVNGLGALAVNTTVDGYKVNANGEWV
ECCCCCCCCCCEEECCCEEEEECCEEEEEEEECCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2109310; 2105276 [H]