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The map label for this gene is mutM [H]

Identifier: 169833803

GI number: 169833803

Start: 987908

End: 988765

Strand: Direct

Name: mutM [H]

Synonym: SPH_1071

Alternate gene names: 169833803

Gene position: 987908-988765 (Clockwise)

Preceding gene: 169834294

Following gene: 169833367

Centisome position: 43.99

GC content: 43.59

Gene sequence:

>858_bases
ATGCCTGCTTCTTGTTTTACAGAAGGAGGACTTATGCCTGAATTACCTGAGGTTGAAACCGTTTGTCGTGGCTTAGAAAA
ATTGATTATAGGAAAGAAGATTTCGAGTATAGAAATTCGCTACCCCAAGATGATTAAGACGGATTTGGAAGAGTTTCAAA
GGGAATTGCCTAGTCAGATTATCGAGTCAATGGGACGTCGTGGAAAATATTTGCTTTTTTATCTGACAGACAAGGTCTTG
ATTTCCCATTTGCGGATGGAGGGCAAGTATTTTTACTATCCAGACCAAGGACCTGAACGCAAGCATGCCCATGTTTTCTT
TCATTTTGAAGATGGTGGCACGCTTGTTTATGAGGATGTTCGCAAGTTTGGAACCATGGAACTCTTGGTGCCTGACCTTT
TAGACGCCTACTTTATTTCTAAAAAATTAGGTCCTGAACCAAGCGAACAAGACTTTGATTTACAGGTCTTTCAATCTGCC
CTTGCCAAGTCCAAAAAGCCTATCAAATCCCATCTCCTAGACCAGACCTTGGTAGCTGGACTTGGCAATATCTATGTGGA
TGAGGTTCTCTGGCGAGCTCAGGTTCATCCAGCTAGATCTTCCCAGACTTTGACAGCAGAAGAAGCGACAGCTATTCATG
ACCAAACCATTGCTGTTTTGAGCCAGGCTGTTGAAAAAGGCGGTTCCACCATTCGGACCTATACCAATGCCTTTGGGGAA
GATGGAAGCATGCAGGATTTTCATCAGGTCTATGATAAGACTGGTCAAGAATGTGTACGCTGTGGTACCATCATTGAGAA
AATTCAACTAGGCGGACGAAGCACCCACTTTTGTCCAAACTGTCAAAGGAGGGACTGA

Upstream 100 bases:

>100_bases
TAGAAACCTGGGTCAAGGTCAAGAAAAACTGGCGCGATAAAAAGCTAGATTTGGCTGACTTTGGCTATAATGAAAAAGAA
TACTAAGTAGAGGTGGGCTC

Downstream 100 bases:

>100_bases
TGAGAAAAATCATCGGAATCACTGGGGGAATTGCCTCTGGTAAGTCAACTGTGACAAATTTTCTAAGACAGCAAGGCTTT
CAAGTAGTGGATGCCGACGC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MPASCFTEGGLMPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRELPSQIIESMGRRGKYLLFYLTDKVL
ISHLRMEGKYFYYPDQGPERKHAHVFFHFEDGGTLVYEDVRKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQSA
LAKSKKPIKSHLLDQTLVAGLGNIYVDEVLWRAQVHPARSSQTLTAEEATAIHDQTIAVLSQAVEKGGSTIRTYTNAFGE
DGSMQDFHQVYDKTGQECVRCGTIIEKIQLGGRSTHFCPNCQRRD

Sequences:

>Translated_285_residues
MPASCFTEGGLMPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRELPSQIIESMGRRGKYLLFYLTDKVL
ISHLRMEGKYFYYPDQGPERKHAHVFFHFEDGGTLVYEDVRKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQSA
LAKSKKPIKSHLLDQTLVAGLGNIYVDEVLWRAQVHPARSSQTLTAEEATAIHDQTIAVLSQAVEKGGSTIRTYTNAFGE
DGSMQDFHQVYDKTGQECVRCGTIIEKIQLGGRSTHFCPNCQRRD
>Mature_284_residues
PASCFTEGGLMPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRELPSQIIESMGRRGKYLLFYLTDKVLI
SHLRMEGKYFYYPDQGPERKHAHVFFHFEDGGTLVYEDVRKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQSAL
AKSKKPIKSHLLDQTLVAGLGNIYVDEVLWRAQVHPARSSQTLTAEEATAIHDQTIAVLSQAVEKGGSTIRTYTNAFGED
GSMQDFHQVYDKTGQECVRCGTIIEKIQLGGRSTHFCPNCQRRD

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=272, Percent_Identity=36.7647058823529, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1786932, Length=278, Percent_Identity=26.6187050359712, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 32332; Mature: 32201

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASCFTEGGLMPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRELPSQI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHH
IESMGRRGKYLLFYLTDKVLISHLRMEGKYFYYPDQGPERKHAHVFFHFEDGGTLVYEDV
HHHHCCCCCEEEEEEHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEEECCCCEEHHHHH
RKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQSALAKSKKPIKSHLLDQTLVAG
HHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LGNIYVDEVLWRAQVHPARSSQTLTAEEATAIHDQTIAVLSQAVEKGGSTIRTYTNAFGE
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHCCC
DGSMQDFHQVYDKTGQECVRCGTIIEKIQLGGRSTHFCPNCQRRD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PASCFTEGGLMPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRELPSQI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHH
IESMGRRGKYLLFYLTDKVLISHLRMEGKYFYYPDQGPERKHAHVFFHFEDGGTLVYEDV
HHHHCCCCCEEEEEEHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEEECCCCEEHHHHH
RKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQSALAKSKKPIKSHLLDQTLVAG
HHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LGNIYVDEVLWRAQVHPARSSQTLTAEEATAIHDQTIAVLSQAVEKGGSTIRTYTNAFGE
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHCCC
DGSMQDFHQVYDKTGQECVRCGTIIEKIQLGGRSTHFCPNCQRRD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]