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The map label for this gene is pth [H]

Identifier: 169833645

GI number: 169833645

Start: 4382

End: 4951

Strand: Direct

Name: pth [H]

Synonym: SPH_0005

Alternate gene names: 169833645

Gene position: 4382-4951 (Clockwise)

Preceding gene: 169834529

Following gene: 169833013

Centisome position: 0.2

GC content: 33.68

Gene sequence:

>570_bases
ATGACCAAATTACTTGTAGGCTTGGGAAATCCAGGGGATAAATATTTTGAAACAAAACACAATGTTGGTTTTATGTTGAT
TGATCAACTAGCGAAGAAACAGAATGTCACTTTTACACACGATAAGATATTTCAAGCTGACCTAGCATCCTTTTTCCTAA
ATGGAGAAAAAATTTATCTGGTTAAACCAACGACCTTTATGAATGAAAGTGGAAAAGCAGTTCATGCTTTATTAACTTAC
TATGGTTTGGATATTGACGATTTACTTATCATTTACGATGATCTTGACATGGAAGTTGGGAAAATTCGTTTAAGAGCAAA
AGGCTCAGCAGGTGGTCATAATGGTATCAAGTCTATTATTCAACATATAGGAACTCAGGTCTTTAACCGTGTTAAGATTG
GAATTGGAAGACCTAAAAATGGTATGTCAGTTGTTCATCATGTTTTGAGTAAGTTTGACAGGGATGATTATATCGGTATT
TTACAGTCTGTTGACAAAGTTGACGATTCTGTAAACTACTATTTACAAGAGAAAAATTTTGAGAAAACAATGCAGAGGTA
TAACGGATAA

Upstream 100 bases:

>100_bases
GATATCATGGAATTCCGCTTTAATGTCTAAAAATTAATAAATGGTGTCAATTAGGTTGGAAAAAAATTCCAACCCTTTTG
GCTTTTGAAAGGAAAAATAA

Downstream 100 bases:

>100_bases
ATGGTGACCTTATTAGATTTATTCTCAGAAAATGATCAGATTAAAAAATGGCATCAAAATTTAACAGATAAGAAAAGACA
ACTAATACTTGGTTTATCAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIFQADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTY
YGLDIDDLLIIYDDLDMEVGKIRLRAKGSAGGHNGIKSIIQHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGI
LQSVDKVDDSVNYYLQEKNFEKTMQRYNG

Sequences:

>Translated_189_residues
MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIFQADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTY
YGLDIDDLLIIYDDLDMEVGKIRLRAKGSAGGHNGIKSIIQHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGI
LQSVDKVDDSVNYYLQEKNFEKTMQRYNG
>Mature_188_residues
TKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIFQADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTYY
GLDIDDLLIIYDDLDMEVGKIRLRAKGSAGGHNGIKSIIQHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGIL
QSVDKVDDSVNYYLQEKNFEKTMQRYNG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=178, Percent_Identity=32.0224719101124, Blast_Score=116, Evalue=1e-26,
Organism=Escherichia coli, GI1787455, Length=176, Percent_Identity=35.7954545454545, Blast_Score=105, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321983, Length=153, Percent_Identity=28.7581699346405, Blast_Score=71, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21391; Mature: 21260

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIFQADLASFFLNGEKIYL
CCEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHCCCEECHHHHHHHHHHHHHCCCCEEEE
VKPTTFMNESGKAVHALLTYYGLDIDDLLIIYDDLDMEVGKIRLRAKGSAGGHNGIKSII
ECCCCEECCCCHHHHHHHHHHCCCHHHEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHH
QHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGILQSVDKVDDSVNYYLQEKNF
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
EKTMQRYNG
HHHHHHHCC
>Mature Secondary Structure 
TKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIFQADLASFFLNGEKIYL
CEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHCCCEECHHHHHHHHHHHHHCCCCEEEE
VKPTTFMNESGKAVHALLTYYGLDIDDLLIIYDDLDMEVGKIRLRAKGSAGGHNGIKSII
ECCCCEECCCCHHHHHHHHHHCCCHHHEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHH
QHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGILQSVDKVDDSVNYYLQEKNF
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
EKTMQRYNG
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA