| Definition | Streptococcus pneumoniae Hungary19A-6, complete genome. |
|---|---|
| Accession | NC_010380 |
| Length | 2,245,615 |
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The map label for this gene is polA [H]
Identifier: 169833568
GI number: 169833568
Start: 105855
End: 108488
Strand: Direct
Name: polA [H]
Synonym: SPH_0131
Alternate gene names: 169833568
Gene position: 105855-108488 (Clockwise)
Preceding gene: 169834138
Following gene: 169832658
Centisome position: 4.71
GC content: 44.0
Gene sequence:
>2634_bases ATGGATAAGAAAAAATTATTATTGATTGATGGGTCTTCTGTAGCTTTTCGGGCGTTTTTTGCGCTGTATCAGCAGTTGGA CCGTTTTAAGAATGCGGCTGGTTTGCATACCAATGCGATTTATGGTTTCCAGTTGATGTTGAGTCATTTGTTGGAGCGGG TTGAGCCGAGTCATATTTTGGTGGCTTTTGATGCGGGAAAGACGACCTTCCGGACAGAGATGTATGCGGACTATAAGGGT GGTCGGGCCAAGACTCCTGATGAGTTTCGTGAGCAATTTCCTTTCATTCGTGAGTTGCTGGATCATATGGGGATTCGTCA CTATGAGCTGGCTCAGTATGAGGCGGATGACATCATTGGGACGCTGGATAAGCTAGCAGAGCAGGATGGTTTTGATATTA CCATTGTCAGTGGGGACAAGGATTTGATTCAGCTGACGGATGAGCATACGGTGGTTGAAATTTCCAAGAAAGGTGTGGCT GAGTTTGAGGCCTTTACGCCAGATTACCTCATGGAAGAAATGGGCCTCACACCAGCTCAGTTTATCGATCTCAAGGCGCT CATGGGTGATAAGTCGGATAATATCCCTGGGGTGACCAAAGTCGGTGAAAAGACGGGTATTAAGCTCTTGCTGGAGCATG GTTCGCTTGAGGGGATTTATGAAAATATTGATGGAATGAAGACTTCTAAGATGAAGGAAAATCTCATCAATGACAAGGAA CAGGCCTTTTTGTCTAAAACACTAGCGACCATTGATACCAAGGCACCGATTGCGATTGGTTTAGAGGACTTGGTCTATAG TGGTCCAGATGTTGAAAATCTTGGGAAATTTTACGATGAGATGGGCTTCAAACAGCTCAAGCAGGCTTTAAATGTGTCGT CAGCTGATGTGGCTAAGGGTTTAGATTTTACTATTGTTGACCAAATCAGTCAAGATATGCTGAGTGAAGAGTCTATCTTC CACTTTGAGCTTTTTGGTGAGAATTACCATACGGATAATTTGGTTGGATTTGCCTGGTCTTGTGAGGATAAGCTCTATGC CACAGACAAGCTTGAGCTGTTGCAAGACCCGATTTTCAAGGATTTCTTAGAAAAAACATCTCTGAGAGTTTATGACTTTA AGAAGGTTAAAGTTCTTTTGCAACGTTTTGGTGTGGATTTGCAGGCGCCTGCTTTTGACATCCGTTTGGCTAAATACCTC CTTTCGACTGTGGAGGACAATGAAATTGCGACCATCGCTAGTCTTTATGGTCAGACTTACTTGGTTGATGATGAAACTTT CTACGGTAAGGGTGTTAAAAAGGCCATTCCTGAACGTGAGAAATTCTTGGAACACTTAGCTTGTAAACTTGCTGTTTTGG TAGAAACAGAGCCTATTTTACTTGAAAAACTCAGCGAAAATGGGCAATTAGAGCTTCTTTATGATATGGAGCAACCTCTG GCTTTTGTCCTTGCCAAGATGGAAATTGCTGGGATTATGGTCAAGAAAGAGACCTTGCTTGAGATGCAGGCTGAAAATGA GCTTGTCATTGAAAAACTGACTCAAGAGATTTACGAGCTGGCTGGTGAGGAGTTTAATGTCAACTCGCCTAAGCAGTTGG GCGTGCTTCTCTTTGAGAAATTGGGACTTCCTCTAGAATACACTAAGAAAACCAAGACAGGTTATTCGACAGCAGTGGAT GTGTTGGAGCGTCTCGCTCCTATTGCTCCGATTGTTAAGAAAATCCTGGATTACCGTCAAATTGCTAAGATTCAATCTAC TTATGTAATTGGCTTGCAGGACTGGATTTTGGCTGATGGAAAGATTCATACTCGCTATGTGCAGGATTTGACCCAGACCG GGCGTTTGTCTAGTGTGGATCCAAACTTGCAAAATATTCCTGCCCGATTGGAACAGGGGCGCTTGATTCGGAAGGCTTTT GTGCCAGAGTGGGAGGATAGTGTGCTACTCAGCTCTGACTATTCACAGATTGAATTGCGCGTTTTGGCGCATATTTCTAA GGATGAGCACTTGATTAAGGCCTTCCAAGAGGGGGCAGATATCCATACTTCGACAGCCATGCGGGTCTTTGGCATTGAGC GTCCTGATGATGTGACTGCAAACGACCGTCGCAATGCCAAGGCAGTTAACTTTGGAGTGGTTTATGGGATTTCAGACTTT GGCTTGTCTAATAATTTGGGAATTAGTCGTAAGGAAGCCAAAGCCTACATTGATACCTACTTTGAACGTTTTCCAGGTAT TAAAAACTACATGGATGAAGTGGTGCGGGAGGCGCGTGATAAGAGCTATGTAGAGACCCTCTTTAAGCGTCGCCGTGAGT TGCCAGATATCAATTCGCGCAACTTCAATATTCGTGGTTTTGCGGAGCGAACTGCTATCAACTCACCTATCCAGGGTTCG GCAGCAGATATTCTCAAGATTGCCATGATTCAGCTGGATAAAGCCTTGGTTGCAGGTGGTTATCAGACTAAGATGCTGTT ACAAGTGCACGATGAAATCGTCCTTGAAGTGCCTAAATCTGAATTGGTAGAGATGAAAAAATTGGTGAAACAAACCATGG AAGAAGCCATTCAACTCAGTGTTCCTCTTATCGCAGATGAGAATGAAGGGGCAACCTGGTACGAGGCTAAATAA
Upstream 100 bases:
>100_bases GATTCTCTGGCTCTATCTATTTATTCGGAAAAAGTTTGAAAAATACTTGCTCTAGCTCTTCCCAATGGTATTTTTTGATT CTTTCCTTTATAATGGGTGT
Downstream 100 bases:
>100_bases AAAGGGGGCTAGTCCTCCTTTTTTGTAGTAGAATTCTGCAAACCTTTTCAAAATATGCTATACTGATGAAAAAGGAGGAT TTCTATGAGTCAAGAATTTA
Product: DNA polymerase I
Products: NA
Alternate protein names: POL I [H]
Number of amino acids: Translated: 877; Mature: 877
Protein sequence:
>877_residues MDKKKLLLIDGSSVAFRAFFALYQQLDRFKNAAGLHTNAIYGFQLMLSHLLERVEPSHILVAFDAGKTTFRTEMYADYKG GRAKTPDEFREQFPFIRELLDHMGIRHYELAQYEADDIIGTLDKLAEQDGFDITIVSGDKDLIQLTDEHTVVEISKKGVA EFEAFTPDYLMEEMGLTPAQFIDLKALMGDKSDNIPGVTKVGEKTGIKLLLEHGSLEGIYENIDGMKTSKMKENLINDKE QAFLSKTLATIDTKAPIAIGLEDLVYSGPDVENLGKFYDEMGFKQLKQALNVSSADVAKGLDFTIVDQISQDMLSEESIF HFELFGENYHTDNLVGFAWSCEDKLYATDKLELLQDPIFKDFLEKTSLRVYDFKKVKVLLQRFGVDLQAPAFDIRLAKYL LSTVEDNEIATIASLYGQTYLVDDETFYGKGVKKAIPEREKFLEHLACKLAVLVETEPILLEKLSENGQLELLYDMEQPL AFVLAKMEIAGIMVKKETLLEMQAENELVIEKLTQEIYELAGEEFNVNSPKQLGVLLFEKLGLPLEYTKKTKTGYSTAVD VLERLAPIAPIVKKILDYRQIAKIQSTYVIGLQDWILADGKIHTRYVQDLTQTGRLSSVDPNLQNIPARLEQGRLIRKAF VPEWEDSVLLSSDYSQIELRVLAHISKDEHLIKAFQEGADIHTSTAMRVFGIERPDDVTANDRRNAKAVNFGVVYGISDF GLSNNLGISRKEAKAYIDTYFERFPGIKNYMDEVVREARDKSYVETLFKRRRELPDINSRNFNIRGFAERTAINSPIQGS AADILKIAMIQLDKALVAGGYQTKMLLQVHDEIVLEVPKSELVEMKKLVKQTMEEAIQLSVPLIADENEGATWYEAK
Sequences:
>Translated_877_residues MDKKKLLLIDGSSVAFRAFFALYQQLDRFKNAAGLHTNAIYGFQLMLSHLLERVEPSHILVAFDAGKTTFRTEMYADYKG GRAKTPDEFREQFPFIRELLDHMGIRHYELAQYEADDIIGTLDKLAEQDGFDITIVSGDKDLIQLTDEHTVVEISKKGVA EFEAFTPDYLMEEMGLTPAQFIDLKALMGDKSDNIPGVTKVGEKTGIKLLLEHGSLEGIYENIDGMKTSKMKENLINDKE QAFLSKTLATIDTKAPIAIGLEDLVYSGPDVENLGKFYDEMGFKQLKQALNVSSADVAKGLDFTIVDQISQDMLSEESIF HFELFGENYHTDNLVGFAWSCEDKLYATDKLELLQDPIFKDFLEKTSLRVYDFKKVKVLLQRFGVDLQAPAFDIRLAKYL LSTVEDNEIATIASLYGQTYLVDDETFYGKGVKKAIPEREKFLEHLACKLAVLVETEPILLEKLSENGQLELLYDMEQPL AFVLAKMEIAGIMVKKETLLEMQAENELVIEKLTQEIYELAGEEFNVNSPKQLGVLLFEKLGLPLEYTKKTKTGYSTAVD VLERLAPIAPIVKKILDYRQIAKIQSTYVIGLQDWILADGKIHTRYVQDLTQTGRLSSVDPNLQNIPARLEQGRLIRKAF VPEWEDSVLLSSDYSQIELRVLAHISKDEHLIKAFQEGADIHTSTAMRVFGIERPDDVTANDRRNAKAVNFGVVYGISDF GLSNNLGISRKEAKAYIDTYFERFPGIKNYMDEVVREARDKSYVETLFKRRRELPDINSRNFNIRGFAERTAINSPIQGS AADILKIAMIQLDKALVAGGYQTKMLLQVHDEIVLEVPKSELVEMKKLVKQTMEEAIQLSVPLIADENEGATWYEAK >Mature_877_residues MDKKKLLLIDGSSVAFRAFFALYQQLDRFKNAAGLHTNAIYGFQLMLSHLLERVEPSHILVAFDAGKTTFRTEMYADYKG GRAKTPDEFREQFPFIRELLDHMGIRHYELAQYEADDIIGTLDKLAEQDGFDITIVSGDKDLIQLTDEHTVVEISKKGVA EFEAFTPDYLMEEMGLTPAQFIDLKALMGDKSDNIPGVTKVGEKTGIKLLLEHGSLEGIYENIDGMKTSKMKENLINDKE QAFLSKTLATIDTKAPIAIGLEDLVYSGPDVENLGKFYDEMGFKQLKQALNVSSADVAKGLDFTIVDQISQDMLSEESIF HFELFGENYHTDNLVGFAWSCEDKLYATDKLELLQDPIFKDFLEKTSLRVYDFKKVKVLLQRFGVDLQAPAFDIRLAKYL LSTVEDNEIATIASLYGQTYLVDDETFYGKGVKKAIPEREKFLEHLACKLAVLVETEPILLEKLSENGQLELLYDMEQPL AFVLAKMEIAGIMVKKETLLEMQAENELVIEKLTQEIYELAGEEFNVNSPKQLGVLLFEKLGLPLEYTKKTKTGYSTAVD VLERLAPIAPIVKKILDYRQIAKIQSTYVIGLQDWILADGKIHTRYVQDLTQTGRLSSVDPNLQNIPARLEQGRLIRKAF VPEWEDSVLLSSDYSQIELRVLAHISKDEHLIKAFQEGADIHTSTAMRVFGIERPDDVTANDRRNAKAVNFGVVYGISDF GLSNNLGISRKEAKAYIDTYFERFPGIKNYMDEVVREARDKSYVETLFKRRRELPDINSRNFNIRGFAERTAINSPIQGS AADILKIAMIQLDKALVAGGYQTKMLLQVHDEIVLEVPKSELVEMKKLVKQTMEEAIQLSVPLIADENEGATWYEAK
Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity [H]
COG id: COG0749
COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 5'-3' exonuclease domain [H]
Homologues:
Organism=Homo sapiens, GI112420958, Length=443, Percent_Identity=33.6343115124154, Blast_Score=216, Evalue=6e-56, Organism=Homo sapiens, GI139394648, Length=703, Percent_Identity=27.1692745376956, Blast_Score=213, Evalue=7e-55, Organism=Escherichia coli, GI1790294, Length=948, Percent_Identity=38.1856540084388, Blast_Score=520, Evalue=1e-148, Organism=Escherichia coli, GI226510970, Length=230, Percent_Identity=30.8695652173913, Blast_Score=115, Evalue=9e-27, Organism=Caenorhabditis elegans, GI86563272, Length=375, Percent_Identity=30.4, Blast_Score=166, Evalue=4e-41, Organism=Drosophila melanogaster, GI17933644, Length=433, Percent_Identity=34.1801385681293, Blast_Score=228, Evalue=1e-59,
Paralogues:
None
Copy number: 400 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002562 - InterPro: IPR020046 - InterPro: IPR020045 - InterPro: IPR002421 - InterPro: IPR020047 - InterPro: IPR019760 - InterPro: IPR001098 - InterPro: IPR018320 - InterPro: IPR002298 - InterPro: IPR008918 - InterPro: IPR012337 [H]
Pfam domain/function: PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]
EC number: =2.7.7.7 [H]
Molecular weight: Translated: 99267; Mature: 99267
Theoretical pI: Translated: 4.73; Mature: 4.73
Prosite motif: PS00447 DNA_POLYMERASE_A
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDKKKLLLIDGSSVAFRAFFALYQQLDRFKNAAGLHTNAIYGFQLMLSHLLERVEPSHIL CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEE VAFDAGKTTFRTEMYADYKGGRAKTPDEFREQFPFIRELLDHMGIRHYELAQYEADDIIG EEEECCCCEEEHHHEECCCCCCCCCCHHHHHHCHHHHHHHHHCCCCEEEHHHHHHHHHHH TLDKLAEQDGFDITIVSGDKDLIQLTDEHTVVEISKKGVAEFEAFTPDYLMEEMGLTPAQ HHHHHHCCCCCEEEEECCCCCEEEECCCCEEEEECCCCCHHHHHCCHHHHHHHHCCCHHH FIDLKALMGDKSDNIPGVTKVGEKTGIKLLLEHGSLEGIYENIDGMKTSKMKENLINDKE HHHHHHHHCCCCCCCCCCHHCCCCCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHCCHHH QAFLSKTLATIDTKAPIAIGLEDLVYSGPDVENLGKFYDEMGFKQLKQALNVSSADVAKG HHHHHHHHHHHCCCCCCEECHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC LDFTIVDQISQDMLSEESIFHFELFGENYHTDNLVGFAWSCEDKLYATDKLELLQDPIFK CCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEECCCCEECCHHHHHHHCHHHH DFLEKTSLRVYDFKKVKVLLQRFGVDLQAPAFDIRLAKYLLSTVEDNEIATIASLYGQTY HHHHHCCCEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCEE LVDDETFYGKGVKKAIPEREKFLEHLACKLAVLVETEPILLEKLSENGQLELLYDMEQPL EECCCCHHCCCHHHHCCHHHHHHHHHHHHHHEEECCCHHHHHHHCCCCCEEEEECCHHHH AFVLAKMEIAGIMVKKETLLEMQAENELVIEKLTQEIYELAGEEFNVNSPKQLGVLLFEK HHHHHHHHHHHHEEHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH LGLPLEYTKKTKTGYSTAVDVLERLAPIAPIVKKILDYRQIAKIQSTYVIGLQDWILADG HCCCHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEEHHHHEECC KIHTRYVQDLTQTGRLSSVDPNLQNIPARLEQGRLIRKAFVPEWEDSVLLSSDYSQIELR CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCHHHHHHCCCCCCCCEEEECCCHHHHHH VLAHISKDEHLIKAFQEGADIHTSTAMRVFGIERPDDVTANDRRNAKAVNFGVVYGISDF HHHHCCCCHHHHHHHHCCCCCCHHHHEEEEECCCCCCCCCCCCCCCEEEEEEEEEECHHC GLSNNLGISRKEAKAYIDTYFERFPGIKNYMDEVVREARDKSYVETLFKRRRELPDINSR CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC NFNIRGFAERTAINSPIQGSAADILKIAMIQLDKALVAGGYQTKMLLQVHDEIVLEVPKS CCEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCHH ELVEMKKLVKQTMEEAIQLSVPLIADENEGATWYEAK HHHHHHHHHHHHHHHHHHEECCEEEECCCCCCEEECC >Mature Secondary Structure MDKKKLLLIDGSSVAFRAFFALYQQLDRFKNAAGLHTNAIYGFQLMLSHLLERVEPSHIL CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEE VAFDAGKTTFRTEMYADYKGGRAKTPDEFREQFPFIRELLDHMGIRHYELAQYEADDIIG EEEECCCCEEEHHHEECCCCCCCCCCHHHHHHCHHHHHHHHHCCCCEEEHHHHHHHHHHH TLDKLAEQDGFDITIVSGDKDLIQLTDEHTVVEISKKGVAEFEAFTPDYLMEEMGLTPAQ HHHHHHCCCCCEEEEECCCCCEEEECCCCEEEEECCCCCHHHHHCCHHHHHHHHCCCHHH FIDLKALMGDKSDNIPGVTKVGEKTGIKLLLEHGSLEGIYENIDGMKTSKMKENLINDKE HHHHHHHHCCCCCCCCCCHHCCCCCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHCCHHH QAFLSKTLATIDTKAPIAIGLEDLVYSGPDVENLGKFYDEMGFKQLKQALNVSSADVAKG HHHHHHHHHHHCCCCCCEECHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC LDFTIVDQISQDMLSEESIFHFELFGENYHTDNLVGFAWSCEDKLYATDKLELLQDPIFK CCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEECCCCEECCHHHHHHHCHHHH DFLEKTSLRVYDFKKVKVLLQRFGVDLQAPAFDIRLAKYLLSTVEDNEIATIASLYGQTY HHHHHCCCEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCEE LVDDETFYGKGVKKAIPEREKFLEHLACKLAVLVETEPILLEKLSENGQLELLYDMEQPL EECCCCHHCCCHHHHCCHHHHHHHHHHHHHHEEECCCHHHHHHHCCCCCEEEEECCHHHH AFVLAKMEIAGIMVKKETLLEMQAENELVIEKLTQEIYELAGEEFNVNSPKQLGVLLFEK HHHHHHHHHHHHEEHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH LGLPLEYTKKTKTGYSTAVDVLERLAPIAPIVKKILDYRQIAKIQSTYVIGLQDWILADG HCCCHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEEHHHHEECC KIHTRYVQDLTQTGRLSSVDPNLQNIPARLEQGRLIRKAFVPEWEDSVLLSSDYSQIELR CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCHHHHHHCCCCCCCCEEEECCCHHHHHH VLAHISKDEHLIKAFQEGADIHTSTAMRVFGIERPDDVTANDRRNAKAVNFGVVYGISDF HHHHCCCCHHHHHHHHCCCCCCHHHHEEEEECCCCCCCCCCCCCCCEEEEEEEEEECHHC GLSNNLGISRKEAKAYIDTYFERFPGIKNYMDEVVREARDKSYVETLFKRRRELPDINSR CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC NFNIRGFAERTAINSPIQGSAADILKIAMIQLDKALVAGGYQTKMLLQVHDEIVLEVPKS CCEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCHH ELVEMKKLVKQTMEEAIQLSVPLIADENEGATWYEAK HHHHHHHHHHHHHHHHHHEECCEEEECCCCCCEEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11463916 [H]