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The map label for this gene is manA [H]

Identifier: 169833496

GI number: 169833496

Start: 778513

End: 779457

Strand: Direct

Name: manA [H]

Synonym: SPH_0837

Alternate gene names: 169833496

Gene position: 778513-779457 (Clockwise)

Preceding gene: 169833005

Following gene: 169833150

Centisome position: 34.67

GC content: 42.65

Gene sequence:

>945_bases
ATGTCAGAACCATTATTTTTACAATCAGTTATGCAAGAAAAAATCTGGGGTGGTACCAAGCTACGTGATGAGTTTGGCTA
CGACATCCCAAGTGAAAAAGTCGGAGAGTACTGGGCTATCTCAGCTCATCTAAATGGTGTTTCTAAAGTTGCCAATGGTC
GTTACGAGGGAACAGATCTTGCTACTTTGTATGCGGAACACCGTGAATTATTTGGCAATCGTCCAGAACCTGTATTTCCA
CTTTTGACCAAGATCCTCGATGCCAACGACTGGCTCAGTGTCCAAGTTCACCCAGACGATGCTTATGGACTCGAGCATGA
AGACGAACTTGGAAAAACAGAATGTTGGTACATCATTGCAGCAGATGAAGGTTCAGAGATTATCTACGGTCACAATGCCA
AGTCAAAAGAAGAACTCCGCCAGCAAATCGAGGACAAGAACTGGGATGACTTGTTGACCAAAGTCCCTGTTAAGGCTGGA
GATTTCTTCTATGTACCAAGTGGCACCATGCATGCTATCGGTACTGGCATCTTGATTCTTGAAACCCAACAGTCTAGTGA
TACAACTTACCGCGTCTATGACTTTGACCGAAAGGACGATAAGGGCAACTTGCGTGAACTTCACCTTGAAAAATCCATCG
ATGTTTTGAACATTGGCGAGCCAGCAAATAGCCGTCCTGTAACTGTTAAAGCAGATAATTTGCGTTCCACTTTACTTGTT
TCTAATGATTTCTTCGCAGTTTACAAGTGGGAAATCACTGGAAAAGTTGATTTTGAGAAGACAGCTGACTACAGCTTGTT
GAGTGTCTTGGCTGGTCAAGGTCAACTAACTGTTGACGGGAAAAACTATCCAATCCAAAAAGGGAGACACTTTATCCTAC
CAAGTGATGTTGAATCTTGGACTCTAGAAGGGCAAGATTTAGAATTAATTGTTAGTCATCCATAA

Upstream 100 bases:

>100_bases
TTATAAAATCTTCTCCCTGCTTTATAAGATGTAAAAAAGAGTTCAAATGGAACTCTTTTTTTGCTATAATGAGGGGAGAA
AAATCAGACAGGAGATTAAG

Downstream 100 bases:

>100_bases
AAAAGAAAGGACCTGAGTTCATTACTCAAGTCCTTTTGATTACATAAATTGGGCGATGAAGACCACGATGATGATTGGAA
TGACGAAACGAAGAAGGAAG

Product: mannose-6-phosphate isomerase, class I

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MSEPLFLQSVMQEKIWGGTKLRDEFGYDIPSEKVGEYWAISAHLNGVSKVANGRYEGTDLATLYAEHRELFGNRPEPVFP
LLTKILDANDWLSVQVHPDDAYGLEHEDELGKTECWYIIAADEGSEIIYGHNAKSKEELRQQIEDKNWDDLLTKVPVKAG
DFFYVPSGTMHAIGTGILILETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNIGEPANSRPVTVKADNLRSTLLV
SNDFFAVYKWEITGKVDFEKTADYSLLSVLAGQGQLTVDGKNYPIQKGRHFILPSDVESWTLEGQDLELIVSHP

Sequences:

>Translated_314_residues
MSEPLFLQSVMQEKIWGGTKLRDEFGYDIPSEKVGEYWAISAHLNGVSKVANGRYEGTDLATLYAEHRELFGNRPEPVFP
LLTKILDANDWLSVQVHPDDAYGLEHEDELGKTECWYIIAADEGSEIIYGHNAKSKEELRQQIEDKNWDDLLTKVPVKAG
DFFYVPSGTMHAIGTGILILETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNIGEPANSRPVTVKADNLRSTLLV
SNDFFAVYKWEITGKVDFEKTADYSLLSVLAGQGQLTVDGKNYPIQKGRHFILPSDVESWTLEGQDLELIVSHP
>Mature_313_residues
SEPLFLQSVMQEKIWGGTKLRDEFGYDIPSEKVGEYWAISAHLNGVSKVANGRYEGTDLATLYAEHRELFGNRPEPVFPL
LTKILDANDWLSVQVHPDDAYGLEHEDELGKTECWYIIAADEGSEIIYGHNAKSKEELRQQIEDKNWDDLLTKVPVKAGD
FFYVPSGTMHAIGTGILILETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNIGEPANSRPVTVKADNLRSTLLVS
NDFFAVYKWEITGKVDFEKTADYSLLSVLAGQGQLTVDGKNYPIQKGRHFILPSDVESWTLEGQDLELIVSHP

Specific function: Unknown

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR014628
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 35485; Mature: 35354

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPLFLQSVMQEKIWGGTKLRDEFGYDIPSEKVGEYWAISAHLNGVSKVANGRYEGTDL
CCCCHHHHHHHHHHHCCCCEEHHHHCCCCCHHHCCCEEEEEECCCCHHHHHCCCCCCCHH
ATLYAEHRELFGNRPEPVFPLLTKILDANDWLSVQVHPDDAYGLEHEDELGKTECWYIIA
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCEEEEEEE
ADEGSEIIYGHNAKSKEELRQQIEDKNWDDLLTKVPVKAGDFFYVPSGTMHAIGTGILIL
ECCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEEE
ETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNIGEPANSRPVTVKADNLRSTLLV
EECCCCCCEEEEEECCCCCCCCCCEEEEHHCCCCEEECCCCCCCCCEEEEECCCCEEEEE
SNDFFAVYKWEITGKVDFEKTADYSLLSVLAGQGQLTVDGKNYPIQKGRHFILPSDVESW
ECCEEEEEEEEEEEEECCCCCCCHHHHHHHCCCCEEEECCCCCCHHCCCEEEECCCCCCE
TLEGQDLELIVSHP
EECCCCEEEEEECC
>Mature Secondary Structure 
SEPLFLQSVMQEKIWGGTKLRDEFGYDIPSEKVGEYWAISAHLNGVSKVANGRYEGTDL
CCCHHHHHHHHHHHCCCCEEHHHHCCCCCHHHCCCEEEEEECCCCHHHHHCCCCCCCHH
ATLYAEHRELFGNRPEPVFPLLTKILDANDWLSVQVHPDDAYGLEHEDELGKTECWYIIA
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCEEEEEEE
ADEGSEIIYGHNAKSKEELRQQIEDKNWDDLLTKVPVKAGDFFYVPSGTMHAIGTGILIL
ECCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEEE
ETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNIGEPANSRPVTVKADNLRSTLLV
EECCCCCCEEEEEECCCCCCCCCCEEEEHHCCCCEEECCCCCCCCCEEEEECCCCEEEEE
SNDFFAVYKWEITGKVDFEKTADYSLLSVLAGQGQLTVDGKNYPIQKGRHFILPSDVESW
ECCEEEEEEEEEEEEECCCCCCCHHHHHHHCCCCEEEECCCCCCHHCCCEEEECCCCCCE
TLEGQDLELIVSHP
EECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8293960; 12397186 [H]