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The map label for this gene is hemH [H]

Identifier: 169833370

GI number: 169833370

Start: 1025207

End: 1026301

Strand: Direct

Name: hemH [H]

Synonym: SPH_1111

Alternate gene names: 169833370

Gene position: 1025207-1026301 (Clockwise)

Preceding gene: 169832663

Following gene: 169834119

Centisome position: 45.65

GC content: 37.81

Gene sequence:

>1095_bases
ATGAAAAAAGCAATTTTAATGATGACCTTCGGTTCACCAGAAGAGATTACCTTTGAAGGTGTAGCTGATTTTTTCACAAA
TATTCGTCGTGGGGTGAGACCCCAAGACCACGAGATTCAGACTCTCTATGATAATTATGTACGAATTGGAGGCACGCCTC
TGCAAAAAATTACCCGTCAAGAGGTTGCCTTGGTAGAAGCTAGGCTGGGGAATGAATACAGTGTCTACTTTGCTAATAAG
TTTTCCAGTCCCTTTATTCCAGATGTGATCGGTCAAATGGAAGCAGACGGAATTGAACAGTGTATTTGCTTGATTTTGGA
GCCCCATTATTCTTTCTACTCTGTCATGGGCTATGAAAAATTTTTAGAAAGCAAACAAATTCAATTTTTGGTCATTAAGG
ACTGGTATCAGGAAGAAGCGCTCTTAAACTATTGGGTAGATGAAATTGCTAAGATTTTAAAAGAAGAAGTAAAGCAAGAC
AGCTGTAAAGTCATCTTTTCAGCCCATAGTGTGCCCATTTTTGCCTTGGACTTTGGTGATCCTTATATAGACCAAATTTT
CGAAAATAGCAAGCTAGTCGCTGAAAAACTGGGCTTGAGTTCAGAACAATATACCAACACTTGGCAGAGTGAGAGTGATA
TTGGTATTCCATGGATTAAACCAGATGTTTTGGAGTATCTCAGAGAACAGACAGAACATCCAGACCATTATATTTTTGTA
CCTATTAGTTTCATCAGTGAGCATATTGAGGTCTTGTTTGACAATGATGTAGAATGTTATGACTTATGCCAGGAATTTGG
GGTAAACTACCATCGTCCACCAATGCCAAATACAGATTCTCGTTTGATTGATGCTTTGGTCAATACAGTTAGAGTCAATG
AAAATCAAGAGTTTAAGGAATTTCTCCCAGAAGAAGAGACCTTTGATGAGTTAGTTCCTTCAGACGAGACGAAAAACATT
TTAGCTGAATCTGAAGATTTACAAATGCCAGAATTTGTGAAAAAACTGATTGAGAAAAAAGGGCGGGAGAATGTTAAGAT
GCCTTATCTTATCAAAAAAATGTTTGAAAAAGCAGGCAAGTTACCCAAAGAGTAA

Upstream 100 bases:

>100_bases
AACAAAAGACAGAAGATTGAGAATGTCCCTATGTTAGCGTTTACTTATCGATGAATTAATGATAAAATAAACTTGATAAA
AACATCACAAGGAAGCAGTC

Downstream 100 bases:

>100_bases
AGAAAAAAGGATTTAGCTTTGCGCTAGATCCTTTTAATCGATTATTTTTTCTCAAGGAGAGCTTTTATTTCTTGAAGGAC
TTCCAATTCGGTTGGTTTTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIGGTPLQKITRQEVALVEARLGNEYSVYFANK
FSSPFIPDVIGQMEADGIEQCICLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWVDEIAKILKEEVKQD
SCKVIFSAHSVPIFALDFGDPYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFV
PISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKEFLPEEETFDELVPSDETKNI
LAESEDLQMPEFVKKLIEKKGRENVKMPYLIKKMFEKAGKLPKE

Sequences:

>Translated_364_residues
MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIGGTPLQKITRQEVALVEARLGNEYSVYFANK
FSSPFIPDVIGQMEADGIEQCICLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWVDEIAKILKEEVKQD
SCKVIFSAHSVPIFALDFGDPYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFV
PISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKEFLPEEETFDELVPSDETKNI
LAESEDLQMPEFVKKLIEKKGRENVKMPYLIKKMFEKAGKLPKE
>Mature_364_residues
MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIGGTPLQKITRQEVALVEARLGNEYSVYFANK
FSSPFIPDVIGQMEADGIEQCICLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWVDEIAKILKEEVKQD
SCKVIFSAHSVPIFALDFGDPYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFV
PISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKEFLPEEETFDELVPSDETKNI
LAESEDLQMPEFVKKLIEKKGRENVKMPYLIKKMFEKAGKLPKE

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=321, Percent_Identity=26.4797507788162, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI60499021, Length=321, Percent_Identity=26.4797507788162, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324750, Length=274, Percent_Identity=26.2773722627737, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17864156, Length=325, Percent_Identity=27.3846153846154, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45552018, Length=172, Percent_Identity=33.1395348837209, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 42444; Mature: 42444

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIGGTPLQKITRQ
CCCEEEEEECCCCCCEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
EVALVEARLGNEYSVYFANKFSSPFIPDVIGQMEADGIEQCICLILEPHYSFYSVMGYEK
HHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHH
FLESKQIQFLVIKDWYQEEALLNYWVDEIAKILKEEVKQDSCKVIFSAHSVPIFALDFGD
HHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCCEEEEEECCC
PYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFV
HHHHHHHCCCHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEE
PISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKE
EHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
FLPEEETFDELVPSDETKNILAESEDLQMPEFVKKLIEKKGRENVKMPYLIKKMFEKAGK
HCCCHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCC
LPKE
CCCC
>Mature Secondary Structure
MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIGGTPLQKITRQ
CCCEEEEEECCCCCCEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
EVALVEARLGNEYSVYFANKFSSPFIPDVIGQMEADGIEQCICLILEPHYSFYSVMGYEK
HHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHH
FLESKQIQFLVIKDWYQEEALLNYWVDEIAKILKEEVKQDSCKVIFSAHSVPIFALDFGD
HHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCCEEEEEECCC
PYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFV
HHHHHHHCCCHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEE
PISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKE
EHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
FLPEEETFDELVPSDETKNILAESEDLQMPEFVKKLIEKKGRENVKMPYLIKKMFEKAGK
HCCCHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCC
LPKE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA