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The map label for this gene is pgcA [H]

Identifier: 169833362

GI number: 169833362

Start: 1484611

End: 1486329

Strand: Direct

Name: pgcA [H]

Synonym: SPH_1610

Alternate gene names: 169833362

Gene position: 1484611-1486329 (Clockwise)

Preceding gene: 169832492

Following gene: 169834179

Centisome position: 66.11

GC content: 43.22

Gene sequence:

>1719_bases
ATGTCTTACCAAGAAAATTACCAGAAATGGGTTGATTTTGTGGAGCTTCCTGACTACCTTCGTCAAGATTTGGAAAATAT
GGACGAAAAAACTAAGGAAGATGCCTTCTATACAAATCTTGAATTTGGTACTGCAGGTATGCGTGGCTTGGTTGGTGCTG
GTACAAACCGTATCAACATCTACGTTGTTCGCCAAGCTACTGAAGGATTGGCTCGTTTGATTGAGTCAAAAGGTGGAAAC
GAGAAAGAACGCGGTGTAGCAATTGCCTACGATAGCCGTCACTTCTCACCTGAGTTTGCCTTTGAATCTGCGGCAGTTCT
TGCTAAACACGGCATCAAATCTTACGTATTTGAAAGCCTTCGTCCAACTCCAGAACTATCATTTGCAGTTCGTCATCTCA
ACTGTTTCGCAGGTATCATGGTCACAGCCAGCCACAACCCTGCTCCATTTAACGGTTACAAGGTTTACGGTGAAGACGGT
GGACAAATGCCTCCACACGATGCGGACGCTTTGACTACTTATATCCGTGCAATCGAAAACCCATTTGCAGTTGAAGTTGC
TGATGTGGAAACTGAAAAAGCTTCTGGCTTGATTGAAGTTATCGGCGAAGCTGTTGACATAGAATACCTTAAAGAGGTTA
AGGACATAAACATCAACCCAGCCTTGATTGAAGAATTTGGTAAAGACATGAAGATTGTCTACACACCACTTCATGGTACT
GGTGAAATGTTGGCTCGTCGTGCTCTTGCCCAAGCAGGATTTGACTCTGTTCAAGTTGTTGAAGCGCAAGCAACTGCTGA
CCCAGACTTCTCAACTGTAACATCTCCAAACCCAGAAAGCCAAGCAGCCTTTGCCCTTGCTGAAGAACTTGGTCGTCAAG
TTGGTGCAGATGTTCTTGTCGCAACTGACCCAGACGCTGACCGTGTTGGTGTTGAAGTTCTTCAAAAAGATGGTAGCTAC
CTCAACCTTTCAGGTAACCAAATCGGTGCTATCATGGCTAAATACATCTTGGAAGCTCACAAAAACGCTGGAACTCTTCC
TGAAAATGCCGCTCTCTGCAAATCTATCGTTTCAACTGACTTGGTAACGAAGATTGCTGAAAGCTACGGCGCAACTATGT
TCAACGTCTTGACAGGTTTCAAATTTATCGCTGAAAAAATCCAAGAATTCGAAGAAAAACACAACCACACTTACATGATG
GGATTTGAAGAAAGCTTCGGTTACTTGATTAAACCATTTGTACGTGATAAAGATGCCATCCAAGCCGTTCTTGTCGTTGC
TGAACTTGCTGCCTACTACCGTTCTCGTGGTTTGACACTTGCTGACGGTATCGAAGAAATCTATAAAGAATATGGCTACT
ACGCAGAAAAAACAATCTCTGTTACTCTTTCAGGTGTCGATGGTGCTGAACAAATCAAAGCGATTATGGCTAAATTCCGC
AACAATGCTCCAAAAGAATGGAACGAAACAGCTATCACTGTCGTAGAAGACTTCAAGGCACAAACTGCTACTGTTGCTGA
CGGTACTGTTACAAACTTGACAACTCCTCCAAGTGATGTGTTGAAATACACACTTGCTGACGGTTCATGGATTGCCGTTC
GCCCTTCAGGTACAGAACCAAAAATCAAGTTCTACATTGCAGTTGTAGGGGAAACCAACGAAGAATCACAAGCTAAGATT
GCTAACATCGAAGCAGAAATCAATGCATTTGTAAAATAA

Upstream 100 bases:

>100_bases
TGGTTTGAAGAGATGTTCGAAGCAGATAAGGTTTTACTAAAACTAAAAAAAATGATATAATCAAACTGATTAAATGTTTT
AAAAATAAAGGAGAATTTGA

Downstream 100 bases:

>100_bases
AGACCTATAAAAGATGAGACCAACCAACCTCATCTTTTTTCGTATCAAATCTAAGCAATTTTAGAAACTTTATGGCATAC
TAGACTTATCAATGAAAGCG

Product: phosphoglucomutase/phosphomannomutase alpha/beta/subunit

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MSYQENYQKWVDFVELPDYLRQDLENMDEKTKEDAFYTNLEFGTAGMRGLVGAGTNRINIYVVRQATEGLARLIESKGGN
EKERGVAIAYDSRHFSPEFAFESAAVLAKHGIKSYVFESLRPTPELSFAVRHLNCFAGIMVTASHNPAPFNGYKVYGEDG
GQMPPHDADALTTYIRAIENPFAVEVADVETEKASGLIEVIGEAVDIEYLKEVKDININPALIEEFGKDMKIVYTPLHGT
GEMLARRALAQAGFDSVQVVEAQATADPDFSTVTSPNPESQAAFALAEELGRQVGADVLVATDPDADRVGVEVLQKDGSY
LNLSGNQIGAIMAKYILEAHKNAGTLPENAALCKSIVSTDLVTKIAESYGATMFNVLTGFKFIAEKIQEFEEKHNHTYMM
GFEESFGYLIKPFVRDKDAIQAVLVVAELAAYYRSRGLTLADGIEEIYKEYGYYAEKTISVTLSGVDGAEQIKAIMAKFR
NNAPKEWNETAITVVEDFKAQTATVADGTVTNLTTPPSDVLKYTLADGSWIAVRPSGTEPKIKFYIAVVGETNEESQAKI
ANIEAEINAFVK

Sequences:

>Translated_572_residues
MSYQENYQKWVDFVELPDYLRQDLENMDEKTKEDAFYTNLEFGTAGMRGLVGAGTNRINIYVVRQATEGLARLIESKGGN
EKERGVAIAYDSRHFSPEFAFESAAVLAKHGIKSYVFESLRPTPELSFAVRHLNCFAGIMVTASHNPAPFNGYKVYGEDG
GQMPPHDADALTTYIRAIENPFAVEVADVETEKASGLIEVIGEAVDIEYLKEVKDININPALIEEFGKDMKIVYTPLHGT
GEMLARRALAQAGFDSVQVVEAQATADPDFSTVTSPNPESQAAFALAEELGRQVGADVLVATDPDADRVGVEVLQKDGSY
LNLSGNQIGAIMAKYILEAHKNAGTLPENAALCKSIVSTDLVTKIAESYGATMFNVLTGFKFIAEKIQEFEEKHNHTYMM
GFEESFGYLIKPFVRDKDAIQAVLVVAELAAYYRSRGLTLADGIEEIYKEYGYYAEKTISVTLSGVDGAEQIKAIMAKFR
NNAPKEWNETAITVVEDFKAQTATVADGTVTNLTTPPSDVLKYTLADGSWIAVRPSGTEPKIKFYIAVVGETNEESQAKI
ANIEAEINAFVK
>Mature_571_residues
SYQENYQKWVDFVELPDYLRQDLENMDEKTKEDAFYTNLEFGTAGMRGLVGAGTNRINIYVVRQATEGLARLIESKGGNE
KERGVAIAYDSRHFSPEFAFESAAVLAKHGIKSYVFESLRPTPELSFAVRHLNCFAGIMVTASHNPAPFNGYKVYGEDGG
QMPPHDADALTTYIRAIENPFAVEVADVETEKASGLIEVIGEAVDIEYLKEVKDININPALIEEFGKDMKIVYTPLHGTG
EMLARRALAQAGFDSVQVVEAQATADPDFSTVTSPNPESQAAFALAEELGRQVGADVLVATDPDADRVGVEVLQKDGSYL
NLSGNQIGAIMAKYILEAHKNAGTLPENAALCKSIVSTDLVTKIAESYGATMFNVLTGFKFIAEKIQEFEEKHNHTYMMG
FEESFGYLIKPFVRDKDAIQAVLVVAELAAYYRSRGLTLADGIEEIYKEYGYYAEKTISVTLSGVDGAEQIKAIMAKFRN
NAPKEWNETAITVVEDFKAQTATVADGTVTNLTTPPSDVLKYTLADGSWIAVRPSGTEPKIKFYIAVVGETNEESQAKIA
NIEAEINAFVK

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=548, Percent_Identity=31.2043795620438, Blast_Score=269, Evalue=5e-72,
Organism=Homo sapiens, GI31377548, Length=570, Percent_Identity=31.4035087719298, Blast_Score=253, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71993870, Length=564, Percent_Identity=31.9148936170213, Blast_Score=238, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI71993878, Length=308, Percent_Identity=35.0649350649351, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323934, Length=565, Percent_Identity=32.0353982300885, Blast_Score=207, Evalue=3e-54,
Organism=Drosophila melanogaster, GI20129809, Length=574, Percent_Identity=30.1393728222997, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24651977, Length=477, Percent_Identity=31.2368972746331, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24653722, Length=557, Percent_Identity=29.443447037702, Blast_Score=219, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 62756; Mature: 62625

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQENYQKWVDFVELPDYLRQDLENMDEKTKEDAFYTNLEFGTAGMRGLVGAGTNRINI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHCCCCCEEEE
YVVRQATEGLARLIESKGGNEKERGVAIAYDSRHFSPEFAFESAAVLAKHGIKSYVFESL
EEEECHHHHHHHHHHHCCCCCHHCCEEEEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHC
RPTPELSFAVRHLNCFAGIMVTASHNPAPFNGYKVYGEDGGQMPPHDADALTTYIRAIEN
CCCCCHHHHHHHHHHHEEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCC
PFAVEVADVETEKASGLIEVIGEAVDIEYLKEVKDININPALIEEFGKDMKIVYTPLHGT
CCEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEECCCC
GEMLARRALAQAGFDSVQVVEAQATADPDFSTVTSPNPESQAAFALAEELGRQVGADVLV
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
ATDPDADRVGVEVLQKDGSYLNLSGNQIGAIMAKYILEAHKNAGTLPENAALCKSIVSTD
ECCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LVTKIAESYGATMFNVLTGFKFIAEKIQEFEEKHNHTYMMGFEESFGYLIKPFVRDKDAI
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHCCCHHHHHHHCCHHHH
QAVLVVAELAAYYRSRGLTLADGIEEIYKEYGYYAEKTISVTLSGVDGAEQIKAIMAKFR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEEEEEEECCCCHHHHHHHHHHHH
NNAPKEWNETAITVVEDFKAQTATVADGTVTNLTTPPSDVLKYTLADGSWIAVRPSGTEP
CCCCCCCCCCEEEEEHHCCCCEEEECCCCEECCCCCHHHHHEEEECCCCEEEEECCCCCC
KIKFYIAVVGETNEESQAKIANIEAEINAFVK
EEEEEEEEEECCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SYQENYQKWVDFVELPDYLRQDLENMDEKTKEDAFYTNLEFGTAGMRGLVGAGTNRINI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHCCCCCEEEE
YVVRQATEGLARLIESKGGNEKERGVAIAYDSRHFSPEFAFESAAVLAKHGIKSYVFESL
EEEECHHHHHHHHHHHCCCCCHHCCEEEEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHC
RPTPELSFAVRHLNCFAGIMVTASHNPAPFNGYKVYGEDGGQMPPHDADALTTYIRAIEN
CCCCCHHHHHHHHHHHEEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCC
PFAVEVADVETEKASGLIEVIGEAVDIEYLKEVKDININPALIEEFGKDMKIVYTPLHGT
CCEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEECCCC
GEMLARRALAQAGFDSVQVVEAQATADPDFSTVTSPNPESQAAFALAEELGRQVGADVLV
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
ATDPDADRVGVEVLQKDGSYLNLSGNQIGAIMAKYILEAHKNAGTLPENAALCKSIVSTD
ECCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LVTKIAESYGATMFNVLTGFKFIAEKIQEFEEKHNHTYMMGFEESFGYLIKPFVRDKDAI
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHCCCHHHHHHHCCHHHH
QAVLVVAELAAYYRSRGLTLADGIEEIYKEYGYYAEKTISVTLSGVDGAEQIKAIMAKFR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEEEEEEECCCCHHHHHHHHHHHH
NNAPKEWNETAITVVEDFKAQTATVADGTVTNLTTPPSDVLKYTLADGSWIAVRPSGTEP
CCCCCCCCCCEEEEEHHCCCCEEEECCCCEECCCCCHHHHHEEEECCCCEEEEECCCCCC
KIKFYIAVVGETNEESQAKIANIEAEINAFVK
EEEEEEEEEECCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]