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The map label for this gene is treR [H]

Identifier: 169833147

GI number: 169833147

Start: 1858336

End: 1859046

Strand: Direct

Name: treR [H]

Synonym: SPH_2001

Alternate gene names: 169833147

Gene position: 1858336-1859046 (Clockwise)

Preceding gene: 169832540

Following gene: 169833559

Centisome position: 82.75

GC content: 41.49

Gene sequence:

>711_bases
ATGAAGAAATACCAACAATTATTTAAGCAAATCCAAGAAACCATTCAAAACGAGACTTACGCTGTCGGAGATTTCCTTCC
TAGCGAGCACGACCTTATGGAGCAATATCAAGTGAGTCGTGATACCGTCCGAAAGGCCCTGTCTCTCCTCCAAGAGGAAG
GATTGATCAAAAAGATAAGAGGGCAAGGTTCTCAAGTCGTCAAAGAAGAAACCGTCAATTTCCCTGTATCCAACCTAACC
AGCTACCAAGAACTAGTTAAAGAACTTGGACTGCGCTCTAAAACCAACGTGGTCAGTCTGGACAAGATTATTATTGATAA
AAAATCCTCACTGATAACCGGTTTCCCAGAGTTTCGGATGGTTTGGAAGGTGGTCCGCCAGCGTGTGGTGGATGATCTGG
TATCCGTTCTGGATACAGACTATCTGGATATGGAACTAATTCCAAATCTCACTCGCCAAATTGCTGAGCAGTCTATCTAT
TCTTATATAGAAAATGGCCTCAAACTCCTTATTGATTATGCTCAGAAGGAAATCACCATTGACCACTCAAGCGACCGAGA
CAAGATTCTCATGGACATTGGCAAAGACCCTTATGTCGTTTCGATTAAATCAAAAGTCTATCTCCAAGACGGACGCCAAT
TTCAGTTTACCGAAAGTCGCCATAAGTTAGAAAAATTTAGATTTGTAGATTTTGCAAAACGCAAGAAATAA

Upstream 100 bases:

>100_bases
TATAAAAAGGGTGTTTTTTTGTAAATTTTCTAGCACTTGTATGGTAAAATAGATACAGGTGTTCATTAAACTAGACTAAA
AACCTATTTAAGCAGGCAAA

Downstream 100 bases:

>100_bases
AAGACTGAGACACCAGATCTCAGCCTTTTTCGGCTCTATAATATTTGTAGTGGGTAACCCCCCTATGGATATTATGGAGC
CTATTTTGTGTAGAAAAAAA

Product: trehalose operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKKYQQLFKQIQETIQNETYAVGDFLPSEHDLMEQYQVSRDTVRKALSLLQEEGLIKKIRGQGSQVVKEETVNFPVSNLT
SYQELVKELGLRSKTNVVSLDKIIIDKKSSLITGFPEFRMVWKVVRQRVVDDLVSVLDTDYLDMELIPNLTRQIAEQSIY
SYIENGLKLLIDYAQKEITIDHSSDRDKILMDIGKDPYVVSIKSKVYLQDGRQFQFTESRHKLEKFRFVDFAKRKK

Sequences:

>Translated_236_residues
MKKYQQLFKQIQETIQNETYAVGDFLPSEHDLMEQYQVSRDTVRKALSLLQEEGLIKKIRGQGSQVVKEETVNFPVSNLT
SYQELVKELGLRSKTNVVSLDKIIIDKKSSLITGFPEFRMVWKVVRQRVVDDLVSVLDTDYLDMELIPNLTRQIAEQSIY
SYIENGLKLLIDYAQKEITIDHSSDRDKILMDIGKDPYVVSIKSKVYLQDGRQFQFTESRHKLEKFRFVDFAKRKK
>Mature_236_residues
MKKYQQLFKQIQETIQNETYAVGDFLPSEHDLMEQYQVSRDTVRKALSLLQEEGLIKKIRGQGSQVVKEETVNFPVSNLT
SYQELVKELGLRSKTNVVSLDKIIIDKKSSLITGFPEFRMVWKVVRQRVVDDLVSVLDTDYLDMELIPNLTRQIAEQSIY
SYIENGLKLLIDYAQKEITIDHSSDRDKILMDIGKDPYVVSIKSKVYLQDGRQFQFTESRHKLEKFRFVDFAKRKK

Specific function: Repressor for the trehalose operon (treP and treA). Binds trehalose-6-phosphate, which probably acts as an inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=235, Percent_Identity=31.9148936170213, Blast_Score=105, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR012770
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27608; Mature: 27608

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYQQLFKQIQETIQNETYAVGDFLPSEHDLMEQYQVSRDTVRKALSLLQEEGLIKKIR
CCHHHHHHHHHHHHHCCCCEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
GQGSQVVKEETVNFPVSNLTSYQELVKELGLRSKTNVVSLDKIIIDKKSSLITGFPEFRM
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHCCCHHHHH
VWKVVRQRVVDDLVSVLDTDYLDMELIPNLTRQIAEQSIYSYIENGLKLLIDYAQKEITI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
DHSSDRDKILMDIGKDPYVVSIKSKVYLQDGRQFQFTESRHKLEKFRFVDFAKRKK
CCCCCCCHHHHCCCCCCEEEEEECEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKYQQLFKQIQETIQNETYAVGDFLPSEHDLMEQYQVSRDTVRKALSLLQEEGLIKKIR
CCHHHHHHHHHHHHHCCCCEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
GQGSQVVKEETVNFPVSNLTSYQELVKELGLRSKTNVVSLDKIIIDKKSSLITGFPEFRM
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHCCCHHHHH
VWKVVRQRVVDDLVSVLDTDYLDMELIPNLTRQIAEQSIYSYIENGLKLLIDYAQKEITI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
DHSSDRDKILMDIGKDPYVVSIKSKVYLQDGRQFQFTESRHKLEKFRFVDFAKRKK
CCCCCCCHHHHCCCCCCEEEEEECEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8917076; 8969503; 9384377; 7651129; 8755887 [H]