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The map label for this gene is uppS

Identifier: 169833071

GI number: 169833071

Start: 323732

End: 324490

Strand: Direct

Name: uppS

Synonym: SPH_0378

Alternate gene names: 169833071

Gene position: 323732-324490 (Clockwise)

Preceding gene: 169832824

Following gene: 169833499

Centisome position: 14.42

GC content: 44.01

Gene sequence:

>759_bases
ATGTTTGGATTTTTTAAGAAAGATAAGGCTGTGGAAGTAGAGGTTCCGACACAGGTTCCTGCTCATATCGGCATCATCAT
GGATGGCAATGGCCGTTGGGCTAAAAAACGTATGCAACCGCGAGTTTTTGGACATAAGGCGGGCATGGAAGCATTGCAAA
CCGTGACCAAGGCAGCCAACAAACTGGGCGTCAAGGTTATTACGGTCTATGCTTTTTCTACGGAAAACTGGACCCGTCCA
GATCAGGAAGTCAAGTTTATCATGAACTTGCCAGTAGAGTTTTATGATAATTATGTCCCGGAACTACATGCGAATAATGT
TAAGATTCAAATGATTGGGGAGACAGACCGCCTGCCTAAGCAAACCTTTGAAGCTTTAACCAAGGCTGAGGAATTGACTA
AGAACAACACAGGATTGATTCTTAATTTTGCTCTTAACTATGGTGGACGTGCTGAGATTACACAGGCGCTTAAGTTGATT
TCCCAGGATGTTTTAGATGCCAAAATCAATCCAGGTGACATCACAGAGGAATTGATTGGTAACTATCTCTTTACCCAGCA
TTTGCCTAAGGACTTACGAGACCCAGACTTGATTATCCGTACTAGTGGAGAATTGCGTTTGAGCAATTTCCTTCCATGGC
AGGGAGCCTATAGTGAGCTTTATTTTACGGACACCTTATGGCCTGATTTTGACGAAGCGGCCTTGCAGGAAGCTATTCTT
GCCTATAATCGTCGTCATCGCCGATTTGGAGGAGTTTAG

Upstream 100 bases:

>100_bases
AAAAATGGGCTTGGTGCCTGAGAATAAATAGCTTAGTGATAGAAGAAAATGGGGAAATATGGTATAATGAAACGATAGAT
TTTTGAATAGGAATAAGATC

Downstream 100 bases:

>100_bases
GAGGAAATATGACCCAGGATTTACAGAAAAGAACCTTGTTTGCAGGGATTGCCCTGGCTATTTTCCTACCAATTTTAATG
ATTGGGGGCCTCTTGCTTCA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFGHKAGMEALQTVTKAANKLGVKVITVYAFSTENWTRP
DQEVKFIMNLPVEFYDNYVPELHANNVKIQMIGETDRLPKQTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLI
SQDVLDAKINPGDITEELIGNYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYSELYFTDTLWPDFDEAALQEAIL
AYNRRHRRFGGV

Sequences:

>Translated_252_residues
MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFGHKAGMEALQTVTKAANKLGVKVITVYAFSTENWTRP
DQEVKFIMNLPVEFYDNYVPELHANNVKIQMIGETDRLPKQTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLI
SQDVLDAKINPGDITEELIGNYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYSELYFTDTLWPDFDEAALQEAIL
AYNRRHRRFGGV
>Mature_252_residues
MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFGHKAGMEALQTVTKAANKLGVKVITVYAFSTENWTRP
DQEVKFIMNLPVEFYDNYVPELHANNVKIQMIGETDRLPKQTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLI
SQDVLDAKINPGDITEELIGNYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYSELYFTDTLWPDFDEAALQEAIL
AYNRRHRRFGGV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=231, Percent_Identity=37.6623376623377, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI45580738, Length=231, Percent_Identity=37.6623376623377, Blast_Score=154, Evalue=6e-38,
Organism=Escherichia coli, GI1786371, Length=239, Percent_Identity=46.4435146443515, Blast_Score=229, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71993029, Length=228, Percent_Identity=35.9649122807018, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6319474, Length=217, Percent_Identity=36.8663594470046, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=236, Percent_Identity=33.4745762711864, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18857969, Length=233, Percent_Identity=36.9098712446352, Blast_Score=150, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_STRPN (Q97SR4)

Other databases:

- EMBL:   AE005672
- PIR:   F95030
- RefSeq:   NP_344799.1
- ProteinModelPortal:   Q97SR4
- SMR:   Q97SR4
- IntAct:   Q97SR4
- EnsemblBacteria:   EBSTRT00000025342
- GeneID:   930065
- GenomeReviews:   AE005672_GR
- KEGG:   spn:SP_0261
- TIGR:   SP_0261
- GeneTree:   EBGT00050000027110
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   PRK14830
- BioCyc:   SPNE170187-1:SP_0261-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28705; Mature: 28705

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 28-28

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFGHKAGMEALQTVTKAAN
CCCCCCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
KLGVKVITVYAFSTENWTRPDQEVKFIMNLPVEFYDNYVPELHANNVKIQMIGETDRLPK
HCCEEEEEEEEEECCCCCCCHHHHHHHCCCCHHHHHCCCCCCCCCCEEEEEECCCCCCHH
QTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLISQDVLDAKINPGDITEELIG
HHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
NYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYSELYFTDTLWPDFDEAALQEAIL
HHHHHHHCCHHCCCCCEEEECCCCEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHH
AYNRRHRRFGGV
HHHHHHHHCCCC
>Mature Secondary Structure
MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFGHKAGMEALQTVTKAAN
CCCCCCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
KLGVKVITVYAFSTENWTRPDQEVKFIMNLPVEFYDNYVPELHANNVKIQMIGETDRLPK
HCCEEEEEEEEEECCCCCCCHHHHHHHCCCCHHHHHCCCCCCCCCCEEEEEECCCCCCHH
QTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLISQDVLDAKINPGDITEELIG
HHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
NYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYSELYFTDTLWPDFDEAALQEAIL
HHHHHHHCCHHCCCCCEEEECCCCEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHH
AYNRRHRRFGGV
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916