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The map label for this gene is pepQ [H]

Identifier: 169832959

GI number: 169832959

Start: 1572160

End: 1573242

Strand: Direct

Name: pepQ [H]

Synonym: SPH_1703

Alternate gene names: 169832959

Gene position: 1572160-1573242 (Clockwise)

Preceding gene: 169833947

Following gene: 169834026

Centisome position: 70.01

GC content: 43.86

Gene sequence:

>1083_bases
ATGTCTAAATTACAACAAATCCTAACATATCTTGAATCAGAAAAACTAGACGTCGCTGTCGTATCTGACCCCGTCACAAT
CAATTACCTCACTGGTTTTTACAGTGATCCCCATGAACGCCAAATGTTCCTCTTTGTCCTAGCAGATCAGGAACCTCTCC
TCTTTGTCCCAGCTCTTGAAGTAGAACGTGCAAGTAGCACCGTTTCCTTCCCAGTAGTGGGCTATGTCGATTCTGAAAAT
CCATGGCAAAAAATCAAACATGCTCTTCCACAACTTGACTTCAAACGTGTCGCTGTTGAGTTTGACAATCTCATCTTGAC
CAAATACCATGGTTTGAAAACAGTTTTTGAGACTGCTGAGTTTGACAACCTCACTCCTCGTATCCAACGCATGCGCCTCA
TCAAATCAGCTGATGAAGTGCAAAAAATGATGGTTGCAGGTCTTTATGCTGACAAGGCTGTTCATGTTGGTTTTGACAAT
ATTTCTCTTGATAAGACTGAGACAGATATCATCGCACAAATTGACTTTGCCATGAAACGTGAAGGTTACGAAATGAGCTT
TGATACCATGGTCTTGACTGGTGATAATGCTGCGAATCCACACGGCATTCCAGCAGCTAATAAGGTTGAAAATGATGCTC
TTCTCCTCTTTGACCTGGGTGTTCTGGTCAATGGCTATGCGTCAGATATGACTCGTACAGTCGCTGTCGGCAAACCAGAC
CAATTCAAGAAAGATATTTACAACTTGACTCTTGAAGCCCAACAAGCTGCTCTTGACTTTATCAAGCCAGGTGTGACTGC
TCATGAAGTGGACCGCGCTGCCCGTGAGGTCATCGAAAAAGCTGGTTATGGTGAGTACTTCAACCACCGTCTCGGGCATG
GTATCGGTATGGATGTCCATGAATTCCCATCTATCATGGAAGGAAACGACATGGTCATCGAAGAAGGCATGTGCTTCTCT
GTTGAACCAGGTATCTATATCCCTGGTAAAGTCGGTGTTCGTATTGAAGACTGCGGTGTTGTTACCAAGGATGGCTTCGA
CCTCTTTACAAGCACCAGCAAAGATTTGCTTTATTTTGATTAA

Upstream 100 bases:

>100_bases
TCCGTTATCTTGTCGGAGTTTTTTGTCTTTTCTTTTACCCTTCTCCCTTGCATTTTCTCTCATTTTTTGCCAAAATAGAG
GGGTAGAAAGAAGGTAGCAT

Downstream 100 bases:

>100_bases
ACTATATAGCCCCTATGCTTTCCTTTCAAAATATCTAGGGGCTATTTTATTGTCATTTTTCTGCTATTATGCTAAAGAAA
TTGGCTGCAGTAATCTAACC

Product: Xaa-Pro dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFLFVLADQEPLLFVPALEVERASSTVSFPVVGYVDSEN
PWQKIKHALPQLDFKRVAVEFDNLILTKYHGLKTVFETAEFDNLTPRIQRMRLIKSADEVQKMMVAGLYADKAVHVGFDN
ISLDKTETDIIAQIDFAMKREGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFDLGVLVNGYASDMTRTVAVGKPD
QFKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAAREVIEKAGYGEYFNHRLGHGIGMDVHEFPSIMEGNDMVIEEGMCFS
VEPGIYIPGKVGVRIEDCGVVTKDGFDLFTSTSKDLLYFD

Sequences:

>Translated_360_residues
MSKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFLFVLADQEPLLFVPALEVERASSTVSFPVVGYVDSEN
PWQKIKHALPQLDFKRVAVEFDNLILTKYHGLKTVFETAEFDNLTPRIQRMRLIKSADEVQKMMVAGLYADKAVHVGFDN
ISLDKTETDIIAQIDFAMKREGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFDLGVLVNGYASDMTRTVAVGKPD
QFKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAAREVIEKAGYGEYFNHRLGHGIGMDVHEFPSIMEGNDMVIEEGMCFS
VEPGIYIPGKVGVRIEDCGVVTKDGFDLFTSTSKDLLYFD
>Mature_359_residues
SKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFLFVLADQEPLLFVPALEVERASSTVSFPVVGYVDSENP
WQKIKHALPQLDFKRVAVEFDNLILTKYHGLKTVFETAEFDNLTPRIQRMRLIKSADEVQKMMVAGLYADKAVHVGFDNI
SLDKTETDIIAQIDFAMKREGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFDLGVLVNGYASDMTRTVAVGKPDQ
FKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAAREVIEKAGYGEYFNHRLGHGIGMDVHEFPSIMEGNDMVIEEGMCFSV
EPGIYIPGKVGVRIEDCGVVTKDGFDLFTSTSKDLLYFD

Specific function: Strict dipeptidase active on Xaa-Pro dipeptides, except Gly-Pro and Pro-Pro [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=293, Percent_Identity=26.2798634812287, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI93141226, Length=162, Percent_Identity=35.1851851851852, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI264681563, Length=187, Percent_Identity=32.0855614973262, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI40385867, Length=204, Percent_Identity=25.4901960784314, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788728, Length=245, Percent_Identity=38.7755102040816, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789275, Length=259, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786364, Length=233, Percent_Identity=27.4678111587983, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17509539, Length=239, Percent_Identity=29.2887029288703, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320922, Length=254, Percent_Identity=23.2283464566929, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322999, Length=174, Percent_Identity=32.7586206896552, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19920384, Length=252, Percent_Identity=26.984126984127, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21355531, Length=226, Percent_Identity=26.1061946902655, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 40273; Mature: 40142

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFLFVLADQEPLLFVPALE
CHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCCCCCCCCEEEEEEEECCCCEEEEECCC
VERASSTVSFPVVGYVDSENPWQKIKHALPQLDFKRVAVEFDNLILTKYHGLKTVFETAE
HHCCCCEEEEEEEEEECCCCHHHHHHHHCCCCCHHHHHEECCCEEEEECCCHHHHHHHHC
FDNLTPRIQRMRLIKSADEVQKMMVAGLYADKAVHVGFDNISLDKTETDIIAQIDFAMKR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCEEEEEHHHHHC
EGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFDLGVLVNGYASDMTRTVAVGKPD
CCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCHHHHCEEEEECCCCH
QFKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAAREVIEKAGYGEYFNHRLGHGIGMDVH
HHHHHHHHEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHH
EFPSIMEGNDMVIEEGMCFSVEPGIYIPGKVGVRIEDCGVVTKDGFDLFTSTSKDLLYFD
HCCHHHCCCCEEEECCCEEEECCCEEECCCCCEEEECCCEEECCCCHHCCCCCCCEEEEC
>Mature Secondary Structure 
SKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFLFVLADQEPLLFVPALE
HHHHHHHHHHHCCCCEEEEECCCEEEEEEECCCCCCCCCEEEEEEEECCCCEEEEECCC
VERASSTVSFPVVGYVDSENPWQKIKHALPQLDFKRVAVEFDNLILTKYHGLKTVFETAE
HHCCCCEEEEEEEEEECCCCHHHHHHHHCCCCCHHHHHEECCCEEEEECCCHHHHHHHHC
FDNLTPRIQRMRLIKSADEVQKMMVAGLYADKAVHVGFDNISLDKTETDIIAQIDFAMKR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCEEEEEHHHHHC
EGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFDLGVLVNGYASDMTRTVAVGKPD
CCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCHHHHCEEEEECCCCH
QFKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAAREVIEKAGYGEYFNHRLGHGIGMDVH
HHHHHHHHEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHH
EFPSIMEGNDMVIEEGMCFSVEPGIYIPGKVGVRIEDCGVVTKDGFDLFTSTSKDLLYFD
HCCHHHCCCCEEEECCCEEEECCCEEECCCCCEEEECCCEEECCCCHHCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10075426 [H]