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The map label for this gene is lytA [H]

Identifier: 169832565

GI number: 169832565

Start: 56407

End: 57363

Strand: Direct

Name: lytA [H]

Synonym: SPH_0067

Alternate gene names: 169832565

Gene position: 56407-57363 (Clockwise)

Preceding gene: 169833158

Following gene: 169833520

Centisome position: 2.51

GC content: 46.6

Gene sequence:

>957_bases
ATGGATATCGATAGAAACAGACTACGTACAGGCTTGCCCCAGGTTGGGGTGCAGCCTTATCGACAAGTACATGCTCACTC
AACAGGTAACCGCAACTCAACCGTACAGAATGAAGCGGATTATCACTATAGAAAGGACCCTGAACTAGGGTTCTTTTCAC
ATGTTGTCGGAAACGGCCGTGTCATGCAAGTAGGTCCTGTGAACAACGGAAGTTGGGATGTTGGGGGCGGTTGGAATACT
GAGAGTTACGCAGCGGTTGAACTGATTGAAAGCCATTCAACTAAAGAAGAGTTCATGACGGACTACCGCCTCTATATCGA
ATTGCTACGCAATCTAGCGGACGAAGCAGGCTTGCCGAAGACTCTTGATACAGACGACTTGGCAGGTATCAAGACGCATG
AATACTGTACCAATAACCAACCAAACAACCACTCAGACCATGTGGATCCATATCCATATCTTGCTAAATGGGGCATTAGC
CGTGAACAGTTTAAGCAAGACATCGAAAACGGCTTGAGCGCTGCAACAGGCTGGCAGAAAAATGGCACTGGCTACTGGTA
CGTACACTCAGACGGCTCTTATCCAAAAGATAAGTTTGAGAAAATCAACGGTACCTGGTATTATTTCGATGGCTCAGGCT
ATATGCTTTCAGACCGCTGGAAGAAGCACACAGACGGCAACTGGTACTACTTTGACCAATCAGGCGAAATGGCTACAGGC
TGGAAGAAAATCGCTGAGAAGTGGTACTATTTTGATGTAGAAGGTGCCATGAAGACAGGCTGGGTCAAGTACAAGGACAC
TTGGTACTACTTAGACGCTAAAGAAGGTGCTATGGTATCAAATGCCTTTATCCAGTCAGCAGACGGAACAGGCTGGTACT
ACCTCAAACCAGACGGAACGATGGCAGATAAACCAGAGTTCACAGTAGAGCCAGATGGCTTGATTACAGTAAAATAA

Upstream 100 bases:

>100_bases
GCTTACAAAATACAATATTAGCATGACTGACAAAGACTTAGACACCTTCGTAGAGTCAGCAGTGAAGCAGATGAATGACG
CATGGAAAGGACGATAGGGA

Downstream 100 bases:

>100_bases
ATAGAAAGGAAACTTTCTAAATTGTTCTTTCACCGCAGGCTCAGGCTTGCGGTTTTTTATTTGCTCTGATTTTTCAAAAA
AGTGCTTACTTGAAGAATAG

Product: lytic amidase (N-acetylmuramoyl-L-alanine amidase)

Products: NA

Alternate protein names: Cell wall hydrolase; Mucopeptide aminohydrolase; Murein hydrolase; N-acetylmuramoyl-L-alanine amidase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MDIDRNRLRTGLPQVGVQPYRQVHAHSTGNRNSTVQNEADYHYRKDPELGFFSHVVGNGRVMQVGPVNNGSWDVGGGWNT
ESYAAVELIESHSTKEEFMTDYRLYIELLRNLADEAGLPKTLDTDDLAGIKTHEYCTNNQPNNHSDHVDPYPYLAKWGIS
REQFKQDIENGLSAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATG
WKKIAEKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTMADKPEFTVEPDGLITVK

Sequences:

>Translated_318_residues
MDIDRNRLRTGLPQVGVQPYRQVHAHSTGNRNSTVQNEADYHYRKDPELGFFSHVVGNGRVMQVGPVNNGSWDVGGGWNT
ESYAAVELIESHSTKEEFMTDYRLYIELLRNLADEAGLPKTLDTDDLAGIKTHEYCTNNQPNNHSDHVDPYPYLAKWGIS
REQFKQDIENGLSAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATG
WKKIAEKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTMADKPEFTVEPDGLITVK
>Mature_318_residues
MDIDRNRLRTGLPQVGVQPYRQVHAHSTGNRNSTVQNEADYHYRKDPELGFFSHVVGNGRVMQVGPVNNGSWDVGGGWNT
ESYAAVELIESHSTKEEFMTDYRLYIELLRNLADEAGLPKTLDTDDLAGIKTHEYCTNNQPNNHSDHVDPYPYLAKWGIS
REQFKQDIENGLSAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATG
WKKIAEKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTMADKPEFTVEPDGLITVK

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Autolysin strictly depends on the presence of choline-containing

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 6 cell wall-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002502
- InterPro:   IPR018337 [H]

Pfam domain/function: PF01510 Amidase_2; PF01473 CW_binding_1 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 36511; Mature: 36511

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIDRNRLRTGLPQVGVQPYRQVHAHSTGNRNSTVQNEADYHYRKDPELGFFSHVVGNGR
CCCCHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCE
VMQVGPVNNGSWDVGGGWNTESYAAVELIESHSTKEEFMTDYRLYIELLRNLADEAGLPK
EEEEECCCCCCEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
TLDTDDLAGIKTHEYCTNNQPNNHSDHVDPYPYLAKWGISREQFKQDIENGLSAATGWQK
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCC
NGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATG
CCCEEEEEECCCCCCHHHHHHCCCEEEEECCCCEEECCCCCCCCCCCEEEECCCCCCHHH
WKKIAEKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGT
HHHHHHHEEEEEECCCHHCCEEEECCEEEEEECCCCCEEEHHHEECCCCCEEEEECCCCC
MADKPEFTVEPDGLITVK
CCCCCCEEECCCCEEEEC
>Mature Secondary Structure
MDIDRNRLRTGLPQVGVQPYRQVHAHSTGNRNSTVQNEADYHYRKDPELGFFSHVVGNGR
CCCCHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCE
VMQVGPVNNGSWDVGGGWNTESYAAVELIESHSTKEEFMTDYRLYIELLRNLADEAGLPK
EEEEECCCCCCEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
TLDTDDLAGIKTHEYCTNNQPNNHSDHVDPYPYLAKWGISREQFKQDIENGLSAATGWQK
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCC
NGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATG
CCCEEEEEECCCCCCHHHHHHCCCEEEEECCCCEEECCCCCCCCCCCEEEECCCCCCHHH
WKKIAEKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGT
HHHHHHHEEEEEECCCHHCCEEEECCEEEEEECCCCCEEEHHHEECCCCCEEEEECCCCC
MADKPEFTVEPDGLITVK
CCCCCCEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2875013; 11463916 [H]