Click here to switch to the map view.

The map label for this gene is pdp [H]

Identifier: 169832459

GI number: 169832459

Start: 866750

End: 868027

Strand: Direct

Name: pdp [H]

Synonym: SPH_0941

Alternate gene names: 169832459

Gene position: 866750-868027 (Clockwise)

Preceding gene: 169832916

Following gene: 169832792

Centisome position: 38.6

GC content: 42.88

Gene sequence:

>1278_bases
ATGAGAGCAGTTGATTTAATCCAAAAAAAACGAGACGGTCAAGAACTGACTTCAAGTGAAATTGAATGGCTGATAGAAGG
CTATGTATCAGGAACTGTTCCTGATTATCAGATGTCTGCCTTTGCTATGGCTGTTTATTTTAAAGGAATGACGACTCGAG
AAATCTCTGATTTAACGATGAATATGGTTAAGACTGGGCAAGAGTTTGACCTGTCAGCCATTGATGGTGTGAAAGTTGAC
AAGCATTCTACTGGTGGTGTCGGCGATAAGGTAACCTTGATTTTAGCTCCTCTTGTTGCTAGCTTCGGTGTGCCTGTAGC
AAAAATGAGTGGTCGTGGTCTTGGCCATACAGGCGGAACAATTGATAAATTGGAGTCCATTAAGGGCTATCAAGTAGAAC
GTAGTCAAGAGGATTTTATTCGTCAGGTTCAGGATATTGGAGTATCTGTCATTGGGCAATCAGACCAGCTGGTCAAAGCA
GATAAGCTTCTCTATGCCCTTCGTGATGTGACCGCAACTGTCGACACGATTCCTTTGATTGCGAGTTCGGTGATGAGCAA
GAAAATTGCGGCAGGGGCGGATGCTATTTTGCTAGACGTGACTGTCGGTGAGGGTGCCTTCATGAAGACGGTTGATGAGG
CGCGTGAGTTGGCTCAAACTATGGTAGATCTTGGTAAGGTTGTTGGACGGAAGACAGTAGCAGTGATTACGGATATGAGC
CAGCCTTTGGGACGAGCGATTGGAAATCGTCTGGAAATCCTTGAAGCATTGGAGATTTTGCAAGGTCAAGGACGTCAGGA
TATTACCCACTTTATTTGTGAATTGGCTCAAATTATGCTTGGTTTGGCAAATGTTAACAAAACTGTTGAAGAAGTTCGCC
AACATCTTGAAAATGGTCAAGCACTGGCTAAGTTTGAGGAAATGGTGCAAGCCCAAGGTGGAGACTTGGAAGACCTCTAT
CGTCCTGTAAATGTAGCTCATGTGGTGGAAATCCCTGCTCAGGAAACGGGTGTCATTTCAGCTCTTCCAGCTATGGACTT
TGGTCTTTATGCCATGAGGCTGGGTGCTGGTCGTGCAGTTAAGTCTGATGTCTTGGACTATGAAACAGGAATTGTTTTTG
AAAAGAAGATTGGAGACTCCGTTCAAAAGGGTGAAATTGTTGCAAAAGTATACACAAATGGAAAAATTTCTCCTCAGCTA
GTTACAGATTTTCAAAAATATGTTAAAATAAATGATAGGGTGCAAAGTTTACGAGAAATTATAGAAACCATCTCATAA

Upstream 100 bases:

>100_bases
AAGGAGCTCCAAGTGCCAAGTCTAAGATGGAAGATGTGTTTGGCAATTGTGAAATCCTTAAAAAAGACAAGGGATACTAT
ATCCTTAGAAGTGTGAAAGA

Downstream 100 bases:

>100_bases
ACCGCAGGAGAATCCGAATATGAAATTAAATAAATATATCGATCATACGCTTTTAAAACAAGATGCAAAGAAAAAACAAA
TTGATAGTTTGTTGTCTGAG

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MRAVDLIQKKRDGQELTSSEIEWLIEGYVSGTVPDYQMSAFAMAVYFKGMTTREISDLTMNMVKTGQEFDLSAIDGVKVD
KHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTIDKLESIKGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKA
DKLLYALRDVTATVDTIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELAQTMVDLGKVVGRKTVAVITDMS
QPLGRAIGNRLEILEALEILQGQGRQDITHFICELAQIMLGLANVNKTVEEVRQHLENGQALAKFEEMVQAQGGDLEDLY
RPVNVAHVVEIPAQETGVISALPAMDFGLYAMRLGAGRAVKSDVLDYETGIVFEKKIGDSVQKGEIVAKVYTNGKISPQL
VTDFQKYVKINDRVQSLREIIETIS

Sequences:

>Translated_425_residues
MRAVDLIQKKRDGQELTSSEIEWLIEGYVSGTVPDYQMSAFAMAVYFKGMTTREISDLTMNMVKTGQEFDLSAIDGVKVD
KHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTIDKLESIKGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKA
DKLLYALRDVTATVDTIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELAQTMVDLGKVVGRKTVAVITDMS
QPLGRAIGNRLEILEALEILQGQGRQDITHFICELAQIMLGLANVNKTVEEVRQHLENGQALAKFEEMVQAQGGDLEDLY
RPVNVAHVVEIPAQETGVISALPAMDFGLYAMRLGAGRAVKSDVLDYETGIVFEKKIGDSVQKGEIVAKVYTNGKISPQL
VTDFQKYVKINDRVQSLREIIETIS
>Mature_425_residues
MRAVDLIQKKRDGQELTSSEIEWLIEGYVSGTVPDYQMSAFAMAVYFKGMTTREISDLTMNMVKTGQEFDLSAIDGVKVD
KHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTIDKLESIKGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKA
DKLLYALRDVTATVDTIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELAQTMVDLGKVVGRKTVAVITDMS
QPLGRAIGNRLEILEALEILQGQGRQDITHFICELAQIMLGLANVNKTVEEVRQHLENGQALAKFEEMVQAQGGDLEDLY
RPVNVAHVVEIPAQETGVISALPAMDFGLYAMRLGAGRAVKSDVLDYETGIVFEKKIGDSVQKGEIVAKVYTNGKISPQL
VTDFQKYVKINDRVQSLREIIETIS

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=430, Percent_Identity=37.6744186046512, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI4503445, Length=430, Percent_Identity=37.6744186046512, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI166158922, Length=430, Percent_Identity=37.6744186046512, Blast_Score=262, Evalue=4e-70,
Organism=Escherichia coli, GI1790842, Length=400, Percent_Identity=39.25, Blast_Score=270, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46168; Mature: 46168

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVDLIQKKRDGQELTSSEIEWLIEGYVSGTVPDYQMSAFAMAVYFKGMTTREISDLTM
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
NMVKTGQEFDLSAIDGVKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGT
HHHHCCCCCCCHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLESIKGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKADKLLYALRDVTATVDTIPLI
HHHHHHCCCCCCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELAQTMVDLGKVVGRKTVAVITDMS
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHH
QPLGRAIGNRLEILEALEILQGQGRQDITHFICELAQIMLGLANVNKTVEEVRQHLENGQ
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ALAKFEEMVQAQGGDLEDLYRPVNVAHVVEIPAQETGVISALPAMDFGLYAMRLGAGRAV
HHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
KSDVLDYETGIVFEKKIGDSVQKGEIVAKVYTNGKISPQLVTDFQKYVKINDRVQSLREI
HHHHHHHHCCEEEEHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IETIS
HHHCC
>Mature Secondary Structure
MRAVDLIQKKRDGQELTSSEIEWLIEGYVSGTVPDYQMSAFAMAVYFKGMTTREISDLTM
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
NMVKTGQEFDLSAIDGVKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGT
HHHHCCCCCCCHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLESIKGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKADKLLYALRDVTATVDTIPLI
HHHHHHCCCCCCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELAQTMVDLGKVVGRKTVAVITDMS
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHH
QPLGRAIGNRLEILEALEILQGQGRQDITHFICELAQIMLGLANVNKTVEEVRQHLENGQ
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ALAKFEEMVQAQGGDLEDLYRPVNVAHVVEIPAQETGVISALPAMDFGLYAMRLGAGRAV
HHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
KSDVLDYETGIVFEKKIGDSVQKGEIVAKVYTNGKISPQLVTDFQKYVKINDRVQSLREI
HHHHHHHHCCEEEEHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IETIS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA