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The map label for this gene is thrC [H]

Identifier: 169824961

GI number: 169824961

Start: 1373321

End: 1374763

Strand: Direct

Name: thrC [H]

Synonym: FMG_1264

Alternate gene names: 169824961

Gene position: 1373321-1374763 (Clockwise)

Preceding gene: 169824941

Following gene: 169824962

Centisome position: 76.4

GC content: 30.08

Gene sequence:

>1443_bases
ATGAAATTTATTAGCACTAGGGATAATTCAATAACTATCGATTCTCAAGAAGTAATCTTCAATTGTATAAATGATGATAT
TTACGTTCCTTTGAATTTAGATAATTTGTACGATATTGATGTTCTTAGAGATATGACATATAACGAACTTGCTATATATA
TTTTGAAGCATTTTTTAACTGATATCGACGAAGATTCAATATCAAGCATTGTAAATAACGCTTACGATGGAGATGAGCCT
AATGTTTTTTTGAGAAAAACAAATGATAGATGCTACGTCGAACTTTTCAACAACAAAAGTCTATCTTATAGGGACTTGTC
ATTGAGTATTATCTCTAAATTTATAGATATTAATTTGAATAATAATGAAGATGTGAAAAACTTATACTTGTTCACAGCTT
CTACTGATATTTCTGTGTCTACGATTGAGAATTTCAAAAAGATGAACACAAAAGTTTTCGTGTTTTATCCAAATAATATC
TCAGATATCGAAAAATCAAAATTATTATCCACGCTTTCCGATAATATCTGTGCAATTGGCGTAGATGGTGATTTTTATGA
ATGTAAAAAATTGGTGGATAGTTTGATAAACGATTCTGATATCAAAAATTTGATTGCACAAAAAGAATCCGTGATTTCTA
CGTGCAATTCGTTGAATATAATCAGAGTTCTCACTCAAGTTATTTATTATTTTTACAGTTATGTGACTATGGTAAAATAC
GGAGAGATAGAAGCTGGAAAAAGAATCAACGTAAGTATTCCTACGGAAAATTTCGGCAATATAATGGCTTGTTTCTACGC
AAAAAGAATGGGACTTCCTATTAATAAAATAATTTGTGCGACAAAAACTCCATTGTCTTTCAAAAAATTCTTGGATACTG
GAGAATTTGTCTATGACGAAGTTTTCGGTGAAGAATCAACATCATTTGAAAGATTGGTCTTGGCAAACATCGAACGATTA
CTTCATCATTTGATAAATGATCACGAAAGAATTAGAGAGATTTTCACAGATTTTAGAGAAAACAATAAGTTTACTTTGTA
TCCAGAAGAACTCGAGAAATTAAGTTGTATCGAAACATACAGCTTGACAAGTGATGAGGTTAGTCAGAAAATTTTGAGAT
TATTCTTGGAATGTCAGTATCCATTATCTCCTCAAACCGCAACGGCTTCTCTCGCCTACGACAAATACGTTATCGATTCT
TATGATTACACGCCTTCAATAATTATGGCTACAACTTCTCCATATTCATCTACAGATAAGCTTTTGAAATCATTCGGATA
CAATGAAGATTTGGATATAAATATGGCTTTGGAAAAATTAAACTCTTTTATAAAATCGCCTATTCCCGATAATTTACAAA
ACATCAAAAAAATTGACACTAAAACTTTTAGTTCAACTGAAATCAAAGATATAGTTTACAAAAAAATACAAGAAATGAAT
TAA

Upstream 100 bases:

>100_bases
TTATATTTTCGGCATAATTTTACCTAAAATTAATCAAAATTTAAAAAGATTAACTTAAATCTCATAAAATGATATAATTA
GAATAATATTAGGAGGAAAT

Downstream 100 bases:

>100_bases
GCGGCGTAATTTTACGCTGCTTTTTGTTTTAAATAAATGATTAGCGGATATATATTTATATGAGTAAATTTGAAATAAAA
CAAGGGGGCATTATGAAAAA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MKFISTRDNSITIDSQEVIFNCINDDIYVPLNLDNLYDIDVLRDMTYNELAIYILKHFLTDIDEDSISSIVNNAYDGDEP
NVFLRKTNDRCYVELFNNKSLSYRDLSLSIISKFIDINLNNNEDVKNLYLFTASTDISVSTIENFKKMNTKVFVFYPNNI
SDIEKSKLLSTLSDNICAIGVDGDFYECKKLVDSLINDSDIKNLIAQKESVISTCNSLNIIRVLTQVIYYFYSYVTMVKY
GEIEAGKRINVSIPTENFGNIMACFYAKRMGLPINKIICATKTPLSFKKFLDTGEFVYDEVFGEESTSFERLVLANIERL
LHHLINDHERIREIFTDFRENNKFTLYPEELEKLSCIETYSLTSDEVSQKILRLFLECQYPLSPQTATASLAYDKYVIDS
YDYTPSIIMATTSPYSSTDKLLKSFGYNEDLDINMALEKLNSFIKSPIPDNLQNIKKIDTKTFSSTEIKDIVYKKIQEMN

Sequences:

>Translated_480_residues
MKFISTRDNSITIDSQEVIFNCINDDIYVPLNLDNLYDIDVLRDMTYNELAIYILKHFLTDIDEDSISSIVNNAYDGDEP
NVFLRKTNDRCYVELFNNKSLSYRDLSLSIISKFIDINLNNNEDVKNLYLFTASTDISVSTIENFKKMNTKVFVFYPNNI
SDIEKSKLLSTLSDNICAIGVDGDFYECKKLVDSLINDSDIKNLIAQKESVISTCNSLNIIRVLTQVIYYFYSYVTMVKY
GEIEAGKRINVSIPTENFGNIMACFYAKRMGLPINKIICATKTPLSFKKFLDTGEFVYDEVFGEESTSFERLVLANIERL
LHHLINDHERIREIFTDFRENNKFTLYPEELEKLSCIETYSLTSDEVSQKILRLFLECQYPLSPQTATASLAYDKYVIDS
YDYTPSIIMATTSPYSSTDKLLKSFGYNEDLDINMALEKLNSFIKSPIPDNLQNIKKIDTKTFSSTEIKDIVYKKIQEMN
>Mature_480_residues
MKFISTRDNSITIDSQEVIFNCINDDIYVPLNLDNLYDIDVLRDMTYNELAIYILKHFLTDIDEDSISSIVNNAYDGDEP
NVFLRKTNDRCYVELFNNKSLSYRDLSLSIISKFIDINLNNNEDVKNLYLFTASTDISVSTIENFKKMNTKVFVFYPNNI
SDIEKSKLLSTLSDNICAIGVDGDFYECKKLVDSLINDSDIKNLIAQKESVISTCNSLNIIRVLTQVIYYFYSYVTMVKY
GEIEAGKRINVSIPTENFGNIMACFYAKRMGLPINKIICATKTPLSFKKFLDTGEFVYDEVFGEESTSFERLVLANIERL
LHHLINDHERIREIFTDFRENNKFTLYPEELEKLSCIETYSLTSDEVSQKILRLFLECQYPLSPQTATASLAYDKYVIDS
YDYTPSIIMATTSPYSSTDKLLKSFGYNEDLDINMALEKLNSFIKSPIPDNLQNIKKIDTKTFSSTEIKDIVYKKIQEMN

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=401, Percent_Identity=28.927680798005, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI149193323, Length=440, Percent_Identity=22.7272727272727, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1786185, Length=373, Percent_Identity=24.6648793565684, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6319901, Length=467, Percent_Identity=23.982869379015, Blast_Score=125, Evalue=2e-29,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 55366; Mature: 55366

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFISTRDNSITIDSQEVIFNCINDDIYVPLNLDNLYDIDVLRDMTYNELAIYILKHFLT
CCCEECCCCEEEECHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCCHHHHHHHHHHHHHH
DIDEDSISSIVNNAYDGDEPNVFLRKTNDRCYVELFNNKSLSYRDLSLSIISKFIDINLN
CCCHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHEEECC
NNEDVKNLYLFTASTDISVSTIENFKKMNTKVFVFYPNNISDIEKSKLLSTLSDNICAIG
CCCCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEE
VDGDFYECKKLVDSLINDSDIKNLIAQKESVISTCNSLNIIRVLTQVIYYFYSYVTMVKY
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
GEIEAGKRINVSIPTENFGNIMACFYAKRMGLPINKIICATKTPLSFKKFLDTGEFVYDE
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHEEECCCCCHHHHHHHCCCHHHHHH
VFGEESTSFERLVLANIERLLHHLINDHERIREIFTDFRENNKFTLYPEELEKLSCIETY
HHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHH
SLTSDEVSQKILRLFLECQYPLSPQTATASLAYDKYVIDSYDYTPSIIMATTSPYSSTDK
CCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCEEEECCCCCCCCEEEEECCCCCHHHH
LLKSFGYNEDLDINMALEKLNSFIKSPIPDNLQNIKKIDTKTFSSTEIKDIVYKKIQEMN
HHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFISTRDNSITIDSQEVIFNCINDDIYVPLNLDNLYDIDVLRDMTYNELAIYILKHFLT
CCCEECCCCEEEECHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCCHHHHHHHHHHHHHH
DIDEDSISSIVNNAYDGDEPNVFLRKTNDRCYVELFNNKSLSYRDLSLSIISKFIDINLN
CCCHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHEEECC
NNEDVKNLYLFTASTDISVSTIENFKKMNTKVFVFYPNNISDIEKSKLLSTLSDNICAIG
CCCCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEE
VDGDFYECKKLVDSLINDSDIKNLIAQKESVISTCNSLNIIRVLTQVIYYFYSYVTMVKY
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
GEIEAGKRINVSIPTENFGNIMACFYAKRMGLPINKIICATKTPLSFKKFLDTGEFVYDE
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHEEECCCCCHHHHHHHCCCHHHHHH
VFGEESTSFERLVLANIERLLHHLINDHERIREIFTDFRENNKFTLYPEELEKLSCIETY
HHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHH
SLTSDEVSQKILRLFLECQYPLSPQTATASLAYDKYVIDSYDYTPSIIMATTSPYSSTDK
CCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCEEEECCCCCCCCEEEEECCCCCHHHH
LLKSFGYNEDLDINMALEKLNSFIKSPIPDNLQNIKKIDTKTFSSTEIKDIVYKKIQEMN
HHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]