Click here to switch to the map view.

The map label for this gene is tpx [H]

Identifier: 169824829

GI number: 169824829

Start: 1231674

End: 1232180

Strand: Direct

Name: tpx [H]

Synonym: FMG_1132

Alternate gene names: 169824829

Gene position: 1231674-1232180 (Clockwise)

Preceding gene: 169824807

Following gene: 169824839

Centisome position: 68.52

GC content: 31.76

Gene sequence:

>507_bases
ATGGACAAAAGACAAGAAACAACATTTGCAAACAACCCTGTAACATTATTAGGAACTAAAGTAAAAGTAGGAGATAAAGC
TCAAGATTTCACTTGCTTAAACGCAGAATTAAAACCAGTAAAATTATCTGATTATGACGGAAAGAAAAAATTAATTTCTG
TAGTACCATCAATCGATACTGGCGTTTGCGAATTCCAAACAAAAGAATTCAACAAAAAAGCTAGTGAATTTGACAACACA
ATTATATTTACAATTAGTTGTGATTTGCCATTTGCACAATCAAGATTCTGTGCAGCTGAAGGAATCGACAATCTAATAGT
CCTAAGCGATCACAAAGATTTAGATTTCGGTTTGAAATACGGTTTCGTTATGGAAGAATTCCGTCTTCTTAACAGAGGTA
TCGTAATTTTAGATGAAAACAACGAAGTTAAATACGTTGAATATGTAAAAGAAAATACAAATCATCCTGATTACGACAAA
GCTATAGAAGCCTTAAAATCACTTTAA

Upstream 100 bases:

>100_bases
ATAATTGTAGCTAAACTCATTAATATCAACTCCTATTGTTTATATGAATAATTTTTTGGGTATAAACTTTTGTGAATGAA
AATATAAGGAGGTCTATAAC

Downstream 100 bases:

>100_bases
TAAATTATATCATACAAAAAATCGATAATACTTTCGAAAAGTATACAAAATATTAAAGATTAATAAACAAAAATCTCGTA
ACCGATTTTTCGATTACGAG

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MDKRQETTFANNPVTLLGTKVKVGDKAQDFTCLNAELKPVKLSDYDGKKKLISVVPSIDTGVCEFQTKEFNKKASEFDNT
IIFTISCDLPFAQSRFCAAEGIDNLIVLSDHKDLDFGLKYGFVMEEFRLLNRGIVILDENNEVKYVEYVKENTNHPDYDK
AIEALKSL

Sequences:

>Translated_168_residues
MDKRQETTFANNPVTLLGTKVKVGDKAQDFTCLNAELKPVKLSDYDGKKKLISVVPSIDTGVCEFQTKEFNKKASEFDNT
IIFTISCDLPFAQSRFCAAEGIDNLIVLSDHKDLDFGLKYGFVMEEFRLLNRGIVILDENNEVKYVEYVKENTNHPDYDK
AIEALKSL
>Mature_168_residues
MDKRQETTFANNPVTLLGTKVKVGDKAQDFTCLNAELKPVKLSDYDGKKKLISVVPSIDTGVCEFQTKEFNKKASEFDNT
IIFTISCDLPFAQSRFCAAEGIDNLIVLSDHKDLDFGLKYGFVMEEFRLLNRGIVILDENNEVKYVEYVKENTNHPDYDK
AIEALKSL

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=166, Percent_Identity=42.7710843373494, Blast_Score=149, Evalue=1e-37,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 19027; Mature: 19027

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRQETTFANNPVTLLGTKVKVGDKAQDFTCLNAELKPVKLSDYDGKKKLISVVPSIDT
CCCCCCCEECCCCEEEEEEEEEECCCCCCEEEECCCCCEEEECCCCCHHHHHHHCCCCCC
GVCEFQTKEFNKKASEFDNTIIFTISCDLPFAQSRFCAAEGIDNLIVLSDHKDLDFGLKY
CEEEEEHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCHH
GFVMEEFRLLNRGIVILDENNEVKYVEYVKENTNHPDYDKAIEALKSL
HHHHHHHHHHHCCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MDKRQETTFANNPVTLLGTKVKVGDKAQDFTCLNAELKPVKLSDYDGKKKLISVVPSIDT
CCCCCCCEECCCCEEEEEEEEEECCCCCCEEEECCCCCEEEECCCCCHHHHHHHCCCCCC
GVCEFQTKEFNKKASEFDNTIIFTISCDLPFAQSRFCAAEGIDNLIVLSDHKDLDFGLKY
CEEEEEHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCHH
GFVMEEFRLLNRGIVILDENNEVKYVEYVKENTNHPDYDKAIEALKSL
HHHHHHHHHHHCCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA