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The map label for this gene is coaBC [H]

Identifier: 169824356

GI number: 169824356

Start: 722030

End: 723196

Strand: Direct

Name: coaBC [H]

Synonym: FMG_0659

Alternate gene names: 169824356

Gene position: 722030-723196 (Clockwise)

Preceding gene: 169824355

Following gene: 169824357

Centisome position: 40.17

GC content: 29.39

Gene sequence:

>1167_bases
ATGAATAAAAACATTCTTTTAGGAGTTACTGGAGGAATTGCTATTTACAAAGTTGTGGATGTTGTAAGTAGATTAAAAAA
ACTTGACTATAATATTAAAATCATTATGACGGATTCTGCTTGCGAATTTGTAAGTCCAATGACTTTTGAAACGATTGGAA
AATGCGATGTTAAAAACAAAATGTTTCACAATAATTCTCACAAGGTTGTTGAACATATAGAGCTTGCAAATTGGGCGGAT
TTGTTTATGATTGCACCAGCTAGTGCAAATACTATGGCTAAAATAAATTATGGTATAGCAGATGATTTATTATCTTCTAC
AGCACTAGCTTATACTAAACCTATAATGTTTTGTGTAAGCATGAATACTAATATGTTAAACAATCCTGCAACACAAAAGA
ATATCAAAGATTTGAAAGAAAAGGAACACTTAATTATAGATTCAAATAACGGAATGCTAGCTTGTAACACAAAAGGAGAC
GGAAGACTAAAAGAACCTTGGGAAATTGTCGAAGAAGTTGAAAAGTACTTTTGTAAAAAAGATTTAAAAGGTAAGAAAAT
TTTGATTACAGCCGGGGCTACAGTTGAAAGAATTGATCCTGTACGTTATATAACGAATGATTCCAGTGGTAAAATGGGAT
ATTCGATTGCTAAGAAAGCTTTTATGAGAGGTGCAGATGTAACAATTATTTCTGGGAAAACAACAGCAGAAAGTCCATAC
GGTGTTGAAAATATTAAAGTTGATTCTGCTATTGAAATGAAAGAAAAAATCGAAAGCTGCATTGAAAACTACGATTGCTT
AATTATGGCGGCAGCGGTAAGTGATTTTAAAGTAAAAAATAGAAAAGAATTAAAAATAAAAAAACAAGACGGCATCGATT
CATTAGAATTAGAAGAAAATCCAGATATTTTGAAATCATTAATTAAAAAAGAAAATCAAATCTTCATAGGATTTGCTGCA
GAAACAAATAATTTATTGGAAAATGCTAGGAAAAAATTAGATAAAAAAAATCTAGATTATATAGTATTAAACGATGTGTC
AAAAAAAGACATTGGATTTAATTCAGAATACAATAAAGTATCTGTAATTAGCAAGGACAATATATTAGATATTGAAAGAG
ATACAAAATTAAATATCGCAGATAGGATATTGGATTTGATAAAGTAG

Upstream 100 bases:

>100_bases
ATAGACGGAAAAGAAACTAAATTAAAAAAAGCAAAAGCCCAACCAGTTACTACAGCTTTGGAAGAAGTTATGGAAAAGAA
GGTTTGGGAAGATAAATCAA

Downstream 100 bases:

>100_bases
GTAAACATGTATATTGATGTTATTTTTAGAAATAAATCGAAGATGACTAACAGGCTGTACTCTTATCATTCGAATGAAGA
AGTTGAAGTTGGAATGAGAG

Product: phosphopantothenate-cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNKNILLGVTGGIAIYKVVDVVSRLKKLDYNIKIIMTDSACEFVSPMTFETIGKCDVKNKMFHNNSHKVVEHIELANWAD
LFMIAPASANTMAKINYGIADDLLSSTALAYTKPIMFCVSMNTNMLNNPATQKNIKDLKEKEHLIIDSNNGMLACNTKGD
GRLKEPWEIVEEVEKYFCKKDLKGKKILITAGATVERIDPVRYITNDSSGKMGYSIAKKAFMRGADVTIISGKTTAESPY
GVENIKVDSAIEMKEKIESCIENYDCLIMAAAVSDFKVKNRKELKIKKQDGIDSLELEENPDILKSLIKKENQIFIGFAA
ETNNLLENARKKLDKKNLDYIVLNDVSKKDIGFNSEYNKVSVISKDNILDIERDTKLNIADRILDLIK

Sequences:

>Translated_388_residues
MNKNILLGVTGGIAIYKVVDVVSRLKKLDYNIKIIMTDSACEFVSPMTFETIGKCDVKNKMFHNNSHKVVEHIELANWAD
LFMIAPASANTMAKINYGIADDLLSSTALAYTKPIMFCVSMNTNMLNNPATQKNIKDLKEKEHLIIDSNNGMLACNTKGD
GRLKEPWEIVEEVEKYFCKKDLKGKKILITAGATVERIDPVRYITNDSSGKMGYSIAKKAFMRGADVTIISGKTTAESPY
GVENIKVDSAIEMKEKIESCIENYDCLIMAAAVSDFKVKNRKELKIKKQDGIDSLELEENPDILKSLIKKENQIFIGFAA
ETNNLLENARKKLDKKNLDYIVLNDVSKKDIGFNSEYNKVSVISKDNILDIERDTKLNIADRILDLIK
>Mature_388_residues
MNKNILLGVTGGIAIYKVVDVVSRLKKLDYNIKIIMTDSACEFVSPMTFETIGKCDVKNKMFHNNSHKVVEHIELANWAD
LFMIAPASANTMAKINYGIADDLLSSTALAYTKPIMFCVSMNTNMLNNPATQKNIKDLKEKEHLIIDSNNGMLACNTKGD
GRLKEPWEIVEEVEKYFCKKDLKGKKILITAGATVERIDPVRYITNDSSGKMGYSIAKKAFMRGADVTIISGKTTAESPY
GVENIKVDSAIEMKEKIESCIENYDCLIMAAAVSDFKVKNRKELKIKKQDGIDSLELEENPDILKSLIKKENQIFIGFAA
ETNNLLENARKKLDKKNLDYIVLNDVSKKDIGFNSEYNKVSVISKDNILDIERDTKLNIADRILDLIK

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=175, Percent_Identity=32.5714285714286, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI87082301, Length=380, Percent_Identity=38.4210526315789, Blast_Score=263, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17560194, Length=147, Percent_Identity=37.4149659863946, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6322762, Length=189, Percent_Identity=32.8042328042328, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=29.1005291005291, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43544; Mature: 43544

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKNILLGVTGGIAIYKVVDVVSRLKKLDYNIKIIMTDSACEFVSPMTFETIGKCDVKNK
CCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCHHHHCCCCCCHH
MFHNNSHKVVEHIELANWADLFMIAPASANTMAKINYGIADDLLSSTALAYTKPIMFCVS
HHCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHCCEEEEEE
MNTNMLNNPATQKNIKDLKEKEHLIIDSNNGMLACNTKGDGRLKEPWEIVEEVEKYFCKK
CCCCCCCCCCHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHC
DLKGKKILITAGATVERIDPVRYITNDSSGKMGYSIAKKAFMRGADVTIISGKTTAESPY
CCCCCEEEEECCCCHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCC
GVENIKVDSAIEMKEKIESCIENYDCLIMAAAVSDFKVKNRKELKIKKQDGIDSLELEEN
CCCEEEECHHHHHHHHHHHHHCCCCEEEEEEEHHHHCCCCCCEEEEECCCCCCCEECCCC
PDILKSLIKKENQIFIGFAAETNNLLENARKKLDKKNLDYIVLNDVSKKDIGFNSEYNKV
HHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEE
SVISKDNILDIERDTKLNIADRILDLIK
EEEECCCEEECCCCCCCCHHHHHHHHHC
>Mature Secondary Structure
MNKNILLGVTGGIAIYKVVDVVSRLKKLDYNIKIIMTDSACEFVSPMTFETIGKCDVKNK
CCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCHHHHCCCCCCHH
MFHNNSHKVVEHIELANWADLFMIAPASANTMAKINYGIADDLLSSTALAYTKPIMFCVS
HHCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHCCEEEEEE
MNTNMLNNPATQKNIKDLKEKEHLIIDSNNGMLACNTKGDGRLKEPWEIVEEVEKYFCKK
CCCCCCCCCCHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHC
DLKGKKILITAGATVERIDPVRYITNDSSGKMGYSIAKKAFMRGADVTIISGKTTAESPY
CCCCCEEEEECCCCHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCC
GVENIKVDSAIEMKEKIESCIENYDCLIMAAAVSDFKVKNRKELKIKKQDGIDSLELEEN
CCCEEEECHHHHHHHHHHHHHCCCCEEEEEEEHHHHCCCCCCEEEEECCCCCCCEECCCC
PDILKSLIKKENQIFIGFAAETNNLLENARKKLDKKNLDYIVLNDVSKKDIGFNSEYNKV
HHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEE
SVISKDNILDIERDTKLNIADRILDLIK
EEEECCCEEECCCCCCCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]