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The map label for this gene is ahpC [H]

Identifier: 169824343

GI number: 169824343

Start: 710186

End: 710749

Strand: Direct

Name: ahpC [H]

Synonym: FMG_0646

Alternate gene names: 169824343

Gene position: 710186-710749 (Clockwise)

Preceding gene: 169824342

Following gene: 169824345

Centisome position: 39.51

GC content: 31.91

Gene sequence:

>564_bases
ATGTCATTAATTAAAAAACACGTTGAAGAATTTAAAGTTCCTGCTTATCACAATGAAGAACTTACAGAAGTTTCTAGTGA
AGATTTAAAAGGTCACTGGTCATTGTTGTTCTTCTATCCAGGAGATTTTACATTTGTTTGTCCTACTGAATTAGAAGACT
TACAAAACTTATACTCAGAATTTAAAGAATTAAACTGTGAAATTTATTCTATCTCTACAGATTCAGAATTTGTTCACAAG
GCATGGCATGATAAATCTGAAAAGATTAAAAAAATCCAATATCCAATGTTATCAGATAGAGCATTTGCTTTATCAAAACA
ATTTGGAGTTTTAAAAGAAGCTGACGGTCAAAGTCAAAGAGGTGCTTTCTTAATCAATCCTGATTTAGATGTTGTATTAT
ACGAAGTATCTGCTGATGGAATTGGTAGAAATGCACATGAATTATTAAGAAAACTACAAGCTGCACAATATGTTGATAAA
TACGGTGATCAAGTTTGTCCAGCTAACTGGGCACCTGGTCAAGACACTTTAAAACCAGGAATTGACCTAGTAGGTAACTT
ATAA

Upstream 100 bases:

>100_bases
ATTGCTCGAAAATATATTACAAACTATTAAACGAAACTTGTAATCATTACAAAATGTGGTATAATTAAATTATAAATCAA
ATAAGAAAGGATGATTATTT

Downstream 100 bases:

>100_bases
ATAACAAAACTAGCTGTAAAATTACAGCTAGTTTTTTAAATTATTTTCAATTTCTATAATATCTTTTAAGAATTGAGATG
AATCAACTTCAACAGAATTT

Product: alkyl hydroperoxide reductase

Products: NA

Alternate protein names: Alkyl hydroperoxide reductase protein C22; General stress protein 22; Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MSLIKKHVEEFKVPAYHNEELTEVSSEDLKGHWSLLFFYPGDFTFVCPTELEDLQNLYSEFKELNCEIYSISTDSEFVHK
AWHDKSEKIKKIQYPMLSDRAFALSKQFGVLKEADGQSQRGAFLINPDLDVVLYEVSADGIGRNAHELLRKLQAAQYVDK
YGDQVCPANWAPGQDTLKPGIDLVGNL

Sequences:

>Translated_187_residues
MSLIKKHVEEFKVPAYHNEELTEVSSEDLKGHWSLLFFYPGDFTFVCPTELEDLQNLYSEFKELNCEIYSISTDSEFVHK
AWHDKSEKIKKIQYPMLSDRAFALSKQFGVLKEADGQSQRGAFLINPDLDVVLYEVSADGIGRNAHELLRKLQAAQYVDK
YGDQVCPANWAPGQDTLKPGIDLVGNL
>Mature_186_residues
SLIKKHVEEFKVPAYHNEELTEVSSEDLKGHWSLLFFYPGDFTFVCPTELEDLQNLYSEFKELNCEIYSISTDSEFVHKA
WHDKSEKIKKIQYPMLSDRAFALSKQFGVLKEADGQSQRGAFLINPDLDVVLYEVSADGIGRNAHELLRKLQAAQYVDKY
GDQVCPANWAPGQDTLKPGIDLVGNL

Specific function: Directly reduces organic hydroperoxides in its reduced dithiol form [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=184, Percent_Identity=41.8478260869565, Blast_Score=147, Evalue=5e-36,
Organism=Homo sapiens, GI5802974, Length=179, Percent_Identity=40.2234636871508, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI32483377, Length=172, Percent_Identity=41.2790697674419, Blast_Score=140, Evalue=6e-34,
Organism=Homo sapiens, GI4505591, Length=167, Percent_Identity=40.7185628742515, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI32455266, Length=167, Percent_Identity=40.7185628742515, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI32455264, Length=167, Percent_Identity=40.7185628742515, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI5453549, Length=189, Percent_Identity=38.0952380952381, Blast_Score=127, Evalue=4e-30,
Organism=Homo sapiens, GI33188454, Length=85, Percent_Identity=43.5294117647059, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI4758638, Length=173, Percent_Identity=28.3236994219653, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786822, Length=187, Percent_Identity=47.0588235294118, Blast_Score=200, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI32565831, Length=183, Percent_Identity=41.5300546448087, Blast_Score=151, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI193204376, Length=183, Percent_Identity=41.5300546448087, Blast_Score=151, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17554494, Length=180, Percent_Identity=39.4444444444444, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI25153706, Length=162, Percent_Identity=28.3950617283951, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=185, Percent_Identity=35.6756756756757, Blast_Score=117, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6320661, Length=181, Percent_Identity=34.2541436464088, Blast_Score=116, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319407, Length=162, Percent_Identity=31.4814814814815, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17157991, Length=180, Percent_Identity=40, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24641739, Length=180, Percent_Identity=40, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21357347, Length=167, Percent_Identity=39.5209580838323, Blast_Score=136, Evalue=9e-33,
Organism=Drosophila melanogaster, GI17738015, Length=184, Percent_Identity=36.9565217391304, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24656348, Length=183, Percent_Identity=38.2513661202186, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17864676, Length=183, Percent_Identity=38.2513661202186, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17975518, Length=156, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652434, Length=156, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652436, Length=156, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581278, Length=154, Percent_Identity=26.6233766233766, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017559
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 21291; Mature: 21160

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIKKHVEEFKVPAYHNEELTEVSSEDLKGHWSLLFFYPGDFTFVCPTELEDLQNLYSE
CHHHHHHHHHHCCCCCCCHHHHHHCHHCCCCEEEEEEEECCCEEEECCHHHHHHHHHHHH
FKELNCEIYSISTDSEFVHKAWHDKSEKIKKIQYPMLSDRAFALSKQFGVLKEADGQSQR
HHHCCCEEEEECCCHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCC
GAFLINPDLDVVLYEVSADGIGRNAHELLRKLQAAQYVDKYGDQVCPANWAPGQDTLKPG
CEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
IDLVGNL
HHHHCCC
>Mature Secondary Structure 
SLIKKHVEEFKVPAYHNEELTEVSSEDLKGHWSLLFFYPGDFTFVCPTELEDLQNLYSE
HHHHHHHHHHCCCCCCCHHHHHHCHHCCCCEEEEEEEECCCEEEECCHHHHHHHHHHHH
FKELNCEIYSISTDSEFVHKAWHDKSEKIKKIQYPMLSDRAFALSKQFGVLKEADGQSQR
HHHCCCEEEEECCCHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCC
GAFLINPDLDVVLYEVSADGIGRNAHELLRKLQAAQYVDKYGDQVCPANWAPGQDTLKPG
CEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
IDLVGNL
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8180695; 8012595 [H]