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The map label for this gene is yclK [H]

Identifier: 169824303

GI number: 169824303

Start: 668477

End: 669883

Strand: Direct

Name: yclK [H]

Synonym: FMG_0606

Alternate gene names: 169824303

Gene position: 668477-669883 (Clockwise)

Preceding gene: 169824302

Following gene: 169824304

Centisome position: 37.19

GC content: 30.28

Gene sequence:

>1407_bases
ATGAGTATTAAAAATAAAATAATGTATTCCTTTGTATTTTTAACAAGTATTACTGCGATAATACTTGTTATATTTTCGAT
TTATGCTACAAAGTTTTACTATTATTCCACAATGGAAGGTGTTCTGAACAACGAAATAAGATATTCTACAAATTTGTACA
GTTCCTACATGGCTGATTATGAATTAGATGAAGTAATCGCAGAAGATAAAAACCAATTTTATCGACAAACAGATTGTCAA
GTTCAAATTTTGGACAATAACCAAATTGTTGTATTTGATTCCATTGCAAGTCCCAATCTAGGAAAAAAAATAGAAACATC
TGATGTAGTAAACGCGGTAAATGGCCAAAGTGGTAGCTATACTGGAAAGGTCAGTTATTCTGATTCAAATATAATTTCAG
TATCCGTTCCATTAGAATCTCGTGGAAAACAAGTCGGAGTTTTAAGATACATTTCAAGTTTAAAAGACGTTGACAGAGCA
ATAAGAGTGAAGTCAGTTTCGTTTGCACTGTTTGGATTTTTAGTAATACTATTTAGTATTTTATTGAGCAAAATTCTAAC
AAAAAGTATTGTAAAGCCAATTAATAGTTTGGCAAAAACTGCTGAAAAAATGGCAAAGGGTAACATGGAAGTACGAGCAA
AAGAAAATAATACCGATGAAATTGGAAGATTAGGAATGACTTTGAATTTGTTAACGGATAATATCAACAAAAAAGAACAA
TTAAAAAATGAGTTTATTTCCAGTGTCTCACATGAATTGAGAACTCCATTAACTTCTATCAAAGGATGGGCACAAACGTT
AAAATACGATCCTTCGGATTTAGAAACAACTACAATGGGAATTGATATTATAGATAGTGAATGTGATAGACTGACAACTA
TGGTTGAAGAATTGCTTGATTTTTCAAGATTTACTTCCGGAAGAATTTCTATTGTAAAAAGAAAACAAAATCTAATAGAA
TTAGCTGAGCATATCAAAAATCAATTACTTCCTAAAGTTCGTTCCAAAGGCATTGATTTGATACTGAATTACGAAAGCCC
AGAACTAATTGCAACTTTTGATGAAGATAGAATCAAACAAGTTTTTATAAATATTTTGGACAATGCTATAAAATTCACAC
CGGATAAAGGAACAATAATTATTAATATTGAAAAAACTGAAAAATTTGCAGAAGTATCCATAATTGATACTGGAATTGGA
ATTTCGTTTGAAGAAATCGAATTAGTAACTGGTAAATTCTACAAAGGTTCCAATTCAAACTCACATGTTGGTTTGGGGCT
TTCTATTTGTGAAGAAATAGTAAAACTTCACAAAGGAGAGTTGATGATTAAATCTAAGATAGATGAAGGAACTACTGTTT
CATTCACATTGCCATTAGGAGATGATGAAAATGAAAAAGACAACTAG

Upstream 100 bases:

>100_bases
ACATGAGAAGATTGAGAAGTAAAATTGAAGAGGATTCAACTCATCCAAAATATATTGTTACGGTTTGGGGAGTTGGTTAC
AGATGGGAAAATAAAAAATA

Downstream 100 bases:

>100_bases
TATATTGATAGGTACGATTGTTTTGATATTATTGATTGTTTTTATAATGTTTAGAAATAAAGAACAATCAGCAGTCGAAA
ATGTAAAAGTTCCTGATAAT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSIKNKIMYSFVFLTSITAIILVIFSIYATKFYYYSTMEGVLNNEIRYSTNLYSSYMADYELDEVIAEDKNQFYRQTDCQ
VQILDNNQIVVFDSIASPNLGKKIETSDVVNAVNGQSGSYTGKVSYSDSNIISVSVPLESRGKQVGVLRYISSLKDVDRA
IRVKSVSFALFGFLVILFSILLSKILTKSIVKPINSLAKTAEKMAKGNMEVRAKENNTDEIGRLGMTLNLLTDNINKKEQ
LKNEFISSVSHELRTPLTSIKGWAQTLKYDPSDLETTTMGIDIIDSECDRLTTMVEELLDFSRFTSGRISIVKRKQNLIE
LAEHIKNQLLPKVRSKGIDLILNYESPELIATFDEDRIKQVFINILDNAIKFTPDKGTIIINIEKTEKFAEVSIIDTGIG
ISFEEIELVTGKFYKGSNSNSHVGLGLSICEEIVKLHKGELMIKSKIDEGTTVSFTLPLGDDENEKDN

Sequences:

>Translated_468_residues
MSIKNKIMYSFVFLTSITAIILVIFSIYATKFYYYSTMEGVLNNEIRYSTNLYSSYMADYELDEVIAEDKNQFYRQTDCQ
VQILDNNQIVVFDSIASPNLGKKIETSDVVNAVNGQSGSYTGKVSYSDSNIISVSVPLESRGKQVGVLRYISSLKDVDRA
IRVKSVSFALFGFLVILFSILLSKILTKSIVKPINSLAKTAEKMAKGNMEVRAKENNTDEIGRLGMTLNLLTDNINKKEQ
LKNEFISSVSHELRTPLTSIKGWAQTLKYDPSDLETTTMGIDIIDSECDRLTTMVEELLDFSRFTSGRISIVKRKQNLIE
LAEHIKNQLLPKVRSKGIDLILNYESPELIATFDEDRIKQVFINILDNAIKFTPDKGTIIINIEKTEKFAEVSIIDTGIG
ISFEEIELVTGKFYKGSNSNSHVGLGLSICEEIVKLHKGELMIKSKIDEGTTVSFTLPLGDDENEKDN
>Mature_467_residues
SIKNKIMYSFVFLTSITAIILVIFSIYATKFYYYSTMEGVLNNEIRYSTNLYSSYMADYELDEVIAEDKNQFYRQTDCQV
QILDNNQIVVFDSIASPNLGKKIETSDVVNAVNGQSGSYTGKVSYSDSNIISVSVPLESRGKQVGVLRYISSLKDVDRAI
RVKSVSFALFGFLVILFSILLSKILTKSIVKPINSLAKTAEKMAKGNMEVRAKENNTDEIGRLGMTLNLLTDNINKKEQL
KNEFISSVSHELRTPLTSIKGWAQTLKYDPSDLETTTMGIDIIDSECDRLTTMVEELLDFSRFTSGRISIVKRKQNLIEL
AEHIKNQLLPKVRSKGIDLILNYESPELIATFDEDRIKQVFINILDNAIKFTPDKGTIIINIEKTEKFAEVSIIDTGIGI
SFEEIELVTGKFYKGSNSNSHVGLGLSICEEIVKLHKGELMIKSKIDEGTTVSFTLPLGDDENEKDN

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=285, Percent_Identity=27.3684210526316, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=29.6296296296296, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790861, Length=395, Percent_Identity=24.3037974683544, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=25.8620689655172, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788713, Length=225, Percent_Identity=28.4444444444444, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=28.8135593220339, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789149, Length=249, Percent_Identity=29.718875502008, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI87081816, Length=355, Percent_Identity=24.5070422535211, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87082128, Length=325, Percent_Identity=23.3846153846154, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788549, Length=228, Percent_Identity=28.5087719298246, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790551, Length=307, Percent_Identity=23.1270358306189, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790346, Length=282, Percent_Identity=24.113475177305, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786783, Length=361, Percent_Identity=22.1606648199446, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI48994928, Length=238, Percent_Identity=24.3697478991597, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790300, Length=285, Percent_Identity=28.0701754385965, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787894, Length=350, Percent_Identity=22.8571428571429, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788279, Length=398, Percent_Identity=24.3718592964824, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789403, Length=283, Percent_Identity=25.7950530035336, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52557; Mature: 52426

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKNKIMYSFVFLTSITAIILVIFSIYATKFYYYSTMEGVLNNEIRYSTNLYSSYMADY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCC
ELDEVIAEDKNQFYRQTDCQVQILDNNQIVVFDSIASPNLGKKIETSDVVNAVNGQSGSY
HHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCE
TGKVSYSDSNIISVSVPLESRGKQVGVLRYISSLKDVDRAIRVKSVSFALFGFLVILFSI
EEEEEECCCCEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSKILTKSIVKPINSLAKTAEKMAKGNMEVRAKENNTDEIGRLGMTLNLLTDNINKKEQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHCCEEEEHHCCCCHHHH
LKNEFISSVSHELRTPLTSIKGWAQTLKYDPSDLETTTMGIDIIDSECDRLTTMVEELLD
HHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHH
FSRFTSGRISIVKRKQNLIELAEHIKNQLLPKVRSKGIDLILNYESPELIATFDEDRIKQ
HHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCHHHHHH
VFINILDNAIKFTPDKGTIIINIEKTEKFAEVSIIDTGIGISFEEIELVTGKFYKGSNSN
HHHHHHHHHHEECCCCCEEEEEEECCCCEEEEEEEECCCCCCHHHEEEEECCEECCCCCC
SHVGLGLSICEEIVKLHKGELMIKSKIDEGTTVSFTLPLGDDENEKDN
CEEEECHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SIKNKIMYSFVFLTSITAIILVIFSIYATKFYYYSTMEGVLNNEIRYSTNLYSSYMADY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCC
ELDEVIAEDKNQFYRQTDCQVQILDNNQIVVFDSIASPNLGKKIETSDVVNAVNGQSGSY
HHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCE
TGKVSYSDSNIISVSVPLESRGKQVGVLRYISSLKDVDRAIRVKSVSFALFGFLVILFSI
EEEEEECCCCEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSKILTKSIVKPINSLAKTAEKMAKGNMEVRAKENNTDEIGRLGMTLNLLTDNINKKEQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHCCEEEEHHCCCCHHHH
LKNEFISSVSHELRTPLTSIKGWAQTLKYDPSDLETTTMGIDIIDSECDRLTTMVEELLD
HHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHH
FSRFTSGRISIVKRKQNLIELAEHIKNQLLPKVRSKGIDLILNYESPELIATFDEDRIKQ
HHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCHHHHHH
VFINILDNAIKFTPDKGTIIINIEKTEKFAEVSIIDTGIGISFEEIELVTGKFYKGSNSN
HHHHHHHHHHEECCCCCEEEEEEECCCCEEEEEEEECCCCCCHHHEEEEECCEECCCCCC
SHVGLGLSICEEIVKLHKGELMIKSKIDEGTTVSFTLPLGDDENEKDN
CEEEECHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]