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The map label for this gene is phoP [H]

Identifier: 169824302

GI number: 169824302

Start: 667788

End: 668477

Strand: Direct

Name: phoP [H]

Synonym: FMG_0605

Alternate gene names: 169824302

Gene position: 667788-668477 (Clockwise)

Preceding gene: 169824301

Following gene: 169824303

Centisome position: 37.15

GC content: 31.59

Gene sequence:

>690_bases
ATGAGTATTAAAGTTCTTTTAGTAGAAGATGAAGATAATATTAGACAATTTACAAAAATAAATTTAGCAAGAGAAGGATT
TGAAATTTTGGAAGCGGATTCTGGAGAAAAAGGAGTAGAACTTGCAGAACTAAACAAACCAGATGTTGCAGTATTGGATA
TAATGCTTCCTGGAATTGACGGGTTTGAAGTATGCAAAATCCTAAGGAATAAATTTCCGAATATAGTTATCATAATGTTA
ACTGCAAAAACTCAAGATAACGATAAAATCGAAGGACTTGAGAGAGGCGCAGACGATTATTTGACAAAGCCTTTCAATCC
TCGCGAGTTGATACTTAGAATAAAATCTGTTTTAAGAAGAAGTCCTCAAAAACAAAATAATAGTCAAATTATTGAAGATG
AAACATTCAAGCTTGATATGTATTCGAGAACTTTTTATAAAAATGGCAAAGAAATTACATTAACTCCAACAGAACTTAGC
ATCATAAAACTTTTAATGCAAAACCCTGGAAAGGCAATTACTAGAGATGAATTGATGGATAAAGCATGGGGTGAAGATTT
TATTGGCGATGCAAAAATAGTAGATGTTAACATGAGAAGATTGAGAAGTAAAATTGAAGAGGATTCAACTCATCCAAAAT
ATATTGTTACGGTTTGGGGAGTTGGTTACAGATGGGAAAATAAAAAATAA

Upstream 100 bases:

>100_bases
CGACAAAAATTGTGAACAAGAGGTTGAAGATTTTCTTAACAATTATTTAAATCAATTGAATTAGCTAAATTATGGGTTAT
AATAATACATGAGGTGTGAT

Downstream 100 bases:

>100_bases
TGAGTATTAAAAATAAAATAATGTATTCCTTTGTATTTTTAACAAGTATTACTGCGATAATACTTGTTATATTTTCGATT
TATGCTACAAAGTTTTACTA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MSIKVLLVEDEDNIRQFTKINLAREGFEILEADSGEKGVELAELNKPDVAVLDIMLPGIDGFEVCKILRNKFPNIVIIML
TAKTQDNDKIEGLERGADDYLTKPFNPRELILRIKSVLRRSPQKQNNSQIIEDETFKLDMYSRTFYKNGKEITLTPTELS
IIKLLMQNPGKAITRDELMDKAWGEDFIGDAKIVDVNMRRLRSKIEEDSTHPKYIVTVWGVGYRWENKK

Sequences:

>Translated_229_residues
MSIKVLLVEDEDNIRQFTKINLAREGFEILEADSGEKGVELAELNKPDVAVLDIMLPGIDGFEVCKILRNKFPNIVIIML
TAKTQDNDKIEGLERGADDYLTKPFNPRELILRIKSVLRRSPQKQNNSQIIEDETFKLDMYSRTFYKNGKEITLTPTELS
IIKLLMQNPGKAITRDELMDKAWGEDFIGDAKIVDVNMRRLRSKIEEDSTHPKYIVTVWGVGYRWENKK
>Mature_228_residues
SIKVLLVEDEDNIRQFTKINLAREGFEILEADSGEKGVELAELNKPDVAVLDIMLPGIDGFEVCKILRNKFPNIVIIMLT
AKTQDNDKIEGLERGADDYLTKPFNPRELILRIKSVLRRSPQKQNNSQIIEDETFKLDMYSRTFYKNGKEITLTPTELSI
IKLLMQNPGKAITRDELMDKAWGEDFIGDAKIVDVNMRRLRSKIEEDSTHPKYIVTVWGVGYRWENKK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=38.6666666666667, Blast_Score=173, Evalue=7e-45,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=34.3891402714932, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=35.9307359307359, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=34.3478260869565, Blast_Score=148, Evalue=2e-37,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=36.1607142857143, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=34.3891402714932, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=34.2465753424658, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=33.1877729257642, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=32.8888888888889, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=32.2869955156951, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=34.5132743362832, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=31.1688311688312, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=31.2217194570136, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=29.2576419213974, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788550, Length=160, Percent_Identity=31.25, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1790299, Length=122, Percent_Identity=27.8688524590164, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788222, Length=117, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787473, Length=177, Percent_Identity=31.0734463276836, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26404; Mature: 26273

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKVLLVEDEDNIRQFTKINLAREGFEILEADSGEKGVELAELNKPDVAVLDIMLPGID
CCEEEEEEECCCHHHHHHHHHHHHHCHHHEECCCCCCCCEEECCCCCCEEEEEEEECCCC
GFEVCKILRNKFPNIVIIMLTAKTQDNDKIEGLERGADDYLTKPFNPRELILRIKSVLRR
HHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHC
SPQKQNNSQIIEDETFKLDMYSRTFYKNGKEITLTPTELSIIKLLMQNPGKAITRDELMD
CCCCCCCCCEECCCEEEEEEHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCHHHHHH
KAWGEDFIGDAKIVDVNMRRLRSKIEEDSTHPKYIVTVWGVGYRWENKK
HHCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCEEEEEECCCEEECCCC
>Mature Secondary Structure 
SIKVLLVEDEDNIRQFTKINLAREGFEILEADSGEKGVELAELNKPDVAVLDIMLPGID
CEEEEEEECCCHHHHHHHHHHHHHCHHHEECCCCCCCCEEECCCCCCEEEEEEEECCCC
GFEVCKILRNKFPNIVIIMLTAKTQDNDKIEGLERGADDYLTKPFNPRELILRIKSVLRR
HHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHC
SPQKQNNSQIIEDETFKLDMYSRTFYKNGKEITLTPTELSIIKLLMQNPGKAITRDELMD
CCCCCCCCCEECCCEEEEEEHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCHHHHHH
KAWGEDFIGDAKIVDVNMRRLRSKIEEDSTHPKYIVTVWGVGYRWENKK
HHCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCEEEEEECCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]