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The map label for this gene is mepA [H]

Identifier: 169823904

GI number: 169823904

Start: 244145

End: 245455

Strand: Direct

Name: mepA [H]

Synonym: FMG_0207

Alternate gene names: 169823904

Gene position: 244145-245455 (Clockwise)

Preceding gene: 169823903

Following gene: 169823905

Centisome position: 13.58

GC content: 36.38

Gene sequence:

>1311_bases
ATGGGTAATGATAAATCTATTCGCGAGTTTGGAAAGTATGTTTTTCTGAATATTTTCGCGCAGATTGCTTTTTCTTGTTA
TACTTTGATGGATACTTATTTTGTTTCGTGGAAGTTAAAAGCGGACGGTTTGTCGGCTCTTAATATTGCATTTCCGATGT
TTTGCATTATTAACGGGATGGGTTTGATGATTGGTATTGGTGGTGGCATCAAGTATTCGATTTTTAAGAGTAAGGATATG
GATGATGATGCGAATACTATTTTCACGAATGCGGTGGTTTTGGGTGTTAGCATTGCTTGTTTGTTTGTGATTTCGGGGAT
GTTTTTCTCTGATAAACTGGTGAGGTTTTTGGGAGCGGACGATAGTATTTTCGAGATGACTAATACTTATTTGAGAGTGA
TGACGTTATTTGCGCCGGCTTTTTTTATGAATAATATTTTGCAGTGTTTTGTCAGAAATGACAGGAATCCAAGGTTATCG
ATGGCTGCGATGGTTATTGGTAGTATTTCGAATGTGATTTTGGATTATGTGTTTATTTTTCCGATGAATATGGGGATTTT
CGGGGCAATTTTTGCGACGGGTCTTGCTCCAATTATAAGTATGATGGTGATTGCTCCTTATATTATTGCGAGAAACAACG
GATTTCATTTAAACAAGAATATTTTTGATTTCCATAGTATTAGGGAGATTGTGTCGAAGGGGATGTTTGCTTTGTTGACG
GAGGCGACTTCTGCGAGTGTGATGTTCACTTTCAATATGATTATTCTAGGGATTTCTGGAAATGTCGGGGTGGCTAGTTT
CAGCATTATTACTGTGATTTCTTTGGTGGTTACAGCTATTTATACTGGTTTGTCGCAAGGTATTCAACCTTTGATTAGTC
ATTATTACGGAAAGAATGATGTTGAAAATGTGGGAAAAATTTTGAAGTATGCTGTTGTTGTACAAATTATGTTGTCGATT
TTAATTTACGGTGAGATTTATTTCAACGCGGATATTTTAGCGGCGTTTTACAACAAGGCGAATGATGTTTTGCTTCAAGA
TTACGCTGTGAGTGGCATGAAGATTTATTTTGTCGCGTGCTTTTTCATTGGTTTTAATATTGTGGTTTCGACTTATTTTA
CGTCAACTGAAAGATCAATTAAATCACAGGTGATTTCATTTGCGAGGGGATTTGTGATTATTATTCCTACGGCTTTGATT
TTATCGAAGATTTTTGCAATGACTGGCGTGTGGGCAGCGTATCCTGTGAGTGAATTTATTGTTTGCATGATGGCTATTGT
TTTATTTTTCAGAGAAAAGTCTGTGATATAA

Upstream 100 bases:

>100_bases
ACAGGGCGAGATATGGTATAATTATTTCATGGTTTGAAACGCGTCCATACACAAAGGCTATTGTGTGTGGACGTTTTATT
TTTTTATTGAAGGAGTTTTT

Downstream 100 bases:

>100_bases
TCAAGAGAGATTGGAGGATTTATGAAAGGAAATTACGAGACGATTGTTCATCCGTTGTCGCCTCTTTACGATGAGAATTC
CAAGATTTTGATTTTGGGTT

Product: Na+driven multidrug efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MGNDKSIREFGKYVFLNIFAQIAFSCYTLMDTYFVSWKLKADGLSALNIAFPMFCIINGMGLMIGIGGGIKYSIFKSKDM
DDDANTIFTNAVVLGVSIACLFVISGMFFSDKLVRFLGADDSIFEMTNTYLRVMTLFAPAFFMNNILQCFVRNDRNPRLS
MAAMVIGSISNVILDYVFIFPMNMGIFGAIFATGLAPIISMMVIAPYIIARNNGFHLNKNIFDFHSIREIVSKGMFALLT
EATSASVMFTFNMIILGISGNVGVASFSIITVISLVVTAIYTGLSQGIQPLISHYYGKNDVENVGKILKYAVVVQIMLSI
LIYGEIYFNADILAAFYNKANDVLLQDYAVSGMKIYFVACFFIGFNIVVSTYFTSTERSIKSQVISFARGFVIIIPTALI
LSKIFAMTGVWAAYPVSEFIVCMMAIVLFFREKSVI

Sequences:

>Translated_436_residues
MGNDKSIREFGKYVFLNIFAQIAFSCYTLMDTYFVSWKLKADGLSALNIAFPMFCIINGMGLMIGIGGGIKYSIFKSKDM
DDDANTIFTNAVVLGVSIACLFVISGMFFSDKLVRFLGADDSIFEMTNTYLRVMTLFAPAFFMNNILQCFVRNDRNPRLS
MAAMVIGSISNVILDYVFIFPMNMGIFGAIFATGLAPIISMMVIAPYIIARNNGFHLNKNIFDFHSIREIVSKGMFALLT
EATSASVMFTFNMIILGISGNVGVASFSIITVISLVVTAIYTGLSQGIQPLISHYYGKNDVENVGKILKYAVVVQIMLSI
LIYGEIYFNADILAAFYNKANDVLLQDYAVSGMKIYFVACFFIGFNIVVSTYFTSTERSIKSQVISFARGFVIIIPTALI
LSKIFAMTGVWAAYPVSEFIVCMMAIVLFFREKSVI
>Mature_435_residues
GNDKSIREFGKYVFLNIFAQIAFSCYTLMDTYFVSWKLKADGLSALNIAFPMFCIINGMGLMIGIGGGIKYSIFKSKDMD
DDANTIFTNAVVLGVSIACLFVISGMFFSDKLVRFLGADDSIFEMTNTYLRVMTLFAPAFFMNNILQCFVRNDRNPRLSM
AAMVIGSISNVILDYVFIFPMNMGIFGAIFATGLAPIISMMVIAPYIIARNNGFHLNKNIFDFHSIREIVSKGMFALLTE
ATSASVMFTFNMIILGISGNVGVASFSIITVISLVVTAIYTGLSQGIQPLISHYYGKNDVENVGKILKYAVVVQIMLSIL
IYGEIYFNADILAAFYNKANDVLLQDYAVSGMKIYFVACFFIGFNIVVSTYFTSTERSIKSQVISFARGFVIIIPTALIL
SKIFAMTGVWAAYPVSEFIVCMMAIVLFFREKSVI

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48347; Mature: 48216

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNDKSIREFGKYVFLNIFAQIAFSCYTLMDTYFVSWKLKADGLSALNIAFPMFCIINGM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCC
GLMIGIGGGIKYSIFKSKDMDDDANTIFTNAVVLGVSIACLFVISGMFFSDKLVRFLGAD
CEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DSIFEMTNTYLRVMTLFAPAFFMNNILQCFVRNDRNPRLSMAAMVIGSISNVILDYVFIF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
PMNMGIFGAIFATGLAPIISMMVIAPYIIARNNGFHLNKNIFDFHSIREIVSKGMFALLT
HHCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEECCCHHHHHHHHHHHHCCHHHHHH
EATSASVMFTFNMIILGISGNVGVASFSIITVISLVVTAIYTGLSQGIQPLISHYYGKND
HCCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VENVGKILKYAVVVQIMLSILIYGEIYFNADILAAFYNKANDVLLQDYAVSGMKIYFVAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHH
FFIGFNIVVSTYFTSTERSIKSQVISFARGFVIIIPTALILSKIFAMTGVWAAYPVSEFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHCCHHHHH
VCMMAIVLFFREKSVI
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GNDKSIREFGKYVFLNIFAQIAFSCYTLMDTYFVSWKLKADGLSALNIAFPMFCIINGM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCC
GLMIGIGGGIKYSIFKSKDMDDDANTIFTNAVVLGVSIACLFVISGMFFSDKLVRFLGAD
CEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DSIFEMTNTYLRVMTLFAPAFFMNNILQCFVRNDRNPRLSMAAMVIGSISNVILDYVFIF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
PMNMGIFGAIFATGLAPIISMMVIAPYIIARNNGFHLNKNIFDFHSIREIVSKGMFALLT
HHCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEECCCHHHHHHHHHHHHCCHHHHHH
EATSASVMFTFNMIILGISGNVGVASFSIITVISLVVTAIYTGLSQGIQPLISHYYGKND
HCCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VENVGKILKYAVVVQIMLSILIYGEIYFNADILAAFYNKANDVLLQDYAVSGMKIYFVAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHH
FFIGFNIVVSTYFTSTERSIKSQVISFARGFVIIIPTALILSKIFAMTGVWAAYPVSEFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHCCHHHHH
VCMMAIVLFFREKSVI
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA