Click here to switch to the map view.

The map label for this gene is lytC [H]

Identifier: 169823781

GI number: 169823781

Start: 106667

End: 107980

Strand: Direct

Name: lytC [H]

Synonym: FMG_0084

Alternate gene names: 169823781

Gene position: 106667-107980 (Clockwise)

Preceding gene: 169823780

Following gene: 169823782

Centisome position: 5.93

GC content: 36.91

Gene sequence:

>1314_bases
ATGTTAAAAAATCAATTGAAAAAGTTGACTGTAGCGGCGTTGGTTGCGGCGATGATTGTGCCAGCGGGTGTATCAAATGC
TGATAATCAACAAATTACAAGAATATCCGGTAAGGATAGAATCGCAACATCTGTAGAAATATCCAAATCAGCATACACTA
CATCAGAAAATGTTGTACTTGCAAGTGGATTCAACTTCGCAGATGCATTGTCAGCAGGTCAACTTGCATCAGCACTAGAT
GCACCACTTTTATTGTCATCACAAGATAAACTTGACTCACAAACAAAAAACGAAATCAATCGTTTGAAAGCGAAGAAAGT
TTTTGTTGTAGGTGGAGACAATGCAATCAGCAAAACTGGAATTGACAAAAACTTAAAATCAGAAAAGATTGACGTAACAA
GACTTGAAGGACAAGACAGATACTCAACATCCCAAAAAGTCATGGAAAAAACGAAAGAAATCATCAACCCAGAATATTTG
TTGATAGCAAGTGGGAAAAACTTCCCAGACGCACTAGCAGCGACAGGATTTTTTGTAAACCACAAATCAGTAATGGTACT
AAGTGACGGAGTAACATATCCACAATCTAATTTACAAGAAATCGCAATCGGTGGTAAAAACCAACTACCACTAAAAGGAT
TCACAGGAAAAAGAGTTTCCGGAAAAGACAGATACGAAACAGCACTCGAAATCGCAAAGCTATCATTTGACAAGAACAAC
AACGCAATCCTTGCAAGTGGACAAGTATTCGCAGATAGCTTGTCAGCAGTAAGCTTAACCAAAAAACACAACGCACCAAT
CATATTGACACAATCAAATAGCTTGACAGAAAACGCCAAGAAATATTTAAATGGCAAGAATGTGTTCATAGTTGGTGGGG
AAAAGACTGTTGTGAATGATATTTTGACTAGAAAAAAACCTGTTGTAAAGAAAGAAGATAAGAATTTGCACACAAAAACT
GGTCAATATTATTCTAGTTTGATTAGTAAAAAATTATCAAAATCAGAAGCAGACGCTAGTAATCAAGCGTATAATGTGAG
AATCGAAGGCGATCAATTGGTTGTATCGGGATATATGTTGTATTACAAGAAGATCGATTCATTCTTCGGTGGAGACAGCA
TTGGTCACAGCGTAAATCATTCTTTCAAGATTACAGACAAGACAGTTTTCAGAGCAGTGAGCGGTCTTGCAACACCAAGT
TATTTTAACAGAACTGAGTTTTTGAATTACTATAAATTGTGCAAGAACACAGGACTTGGTTTGGTGGTTACTGTGAAAAA
CGGCGTGGCTGTAAAAGTTGAAATAGCTTCATAA

Upstream 100 bases:

>100_bases
AAATCTCAAATTGGGTATAATAGTATTGAAGGCAAAATAATGGGAGAAATTCCGTTGTTTTATTAGAAATATCATAATAA
TGAATTTATGGAGGAGAAAT

Downstream 100 bases:

>100_bases
AATTTAGCTACAGGGGTGCAGGTTTTCCTGCACTCTTTTTTTGGTGCGATTTTTTGAAAAATCTTGGATAGGGTATAATA
ATGTTAAGTATAGGAGGAGT

Product: N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MLKNQLKKLTVAALVAAMIVPAGVSNADNQQITRISGKDRIATSVEISKSAYTTSENVVLASGFNFADALSAGQLASALD
APLLLSSQDKLDSQTKNEINRLKAKKVFVVGGDNAISKTGIDKNLKSEKIDVTRLEGQDRYSTSQKVMEKTKEIINPEYL
LIASGKNFPDALAATGFFVNHKSVMVLSDGVTYPQSNLQEIAIGGKNQLPLKGFTGKRVSGKDRYETALEIAKLSFDKNN
NAILASGQVFADSLSAVSLTKKHNAPIILTQSNSLTENAKKYLNGKNVFIVGGEKTVVNDILTRKKPVVKKEDKNLHTKT
GQYYSSLISKKLSKSEADASNQAYNVRIEGDQLVVSGYMLYYKKIDSFFGGDSIGHSVNHSFKITDKTVFRAVSGLATPS
YFNRTEFLNYYKLCKNTGLGLVVTVKNGVAVKVEIAS

Sequences:

>Translated_437_residues
MLKNQLKKLTVAALVAAMIVPAGVSNADNQQITRISGKDRIATSVEISKSAYTTSENVVLASGFNFADALSAGQLASALD
APLLLSSQDKLDSQTKNEINRLKAKKVFVVGGDNAISKTGIDKNLKSEKIDVTRLEGQDRYSTSQKVMEKTKEIINPEYL
LIASGKNFPDALAATGFFVNHKSVMVLSDGVTYPQSNLQEIAIGGKNQLPLKGFTGKRVSGKDRYETALEIAKLSFDKNN
NAILASGQVFADSLSAVSLTKKHNAPIILTQSNSLTENAKKYLNGKNVFIVGGEKTVVNDILTRKKPVVKKEDKNLHTKT
GQYYSSLISKKLSKSEADASNQAYNVRIEGDQLVVSGYMLYYKKIDSFFGGDSIGHSVNHSFKITDKTVFRAVSGLATPS
YFNRTEFLNYYKLCKNTGLGLVVTVKNGVAVKVEIAS
>Mature_437_residues
MLKNQLKKLTVAALVAAMIVPAGVSNADNQQITRISGKDRIATSVEISKSAYTTSENVVLASGFNFADALSAGQLASALD
APLLLSSQDKLDSQTKNEINRLKAKKVFVVGGDNAISKTGIDKNLKSEKIDVTRLEGQDRYSTSQKVMEKTKEIINPEYL
LIASGKNFPDALAATGFFVNHKSVMVLSDGVTYPQSNLQEIAIGGKNQLPLKGFTGKRVSGKDRYETALEIAKLSFDKNN
NAILASGQVFADSLSAVSLTKKHNAPIILTQSNSLTENAKKYLNGKNVFIVGGEKTVVNDILTRKKPVVKKEDKNLHTKT
GQYYSSLISKKLSKSEADASNQAYNVRIEGDQLVVSGYMLYYKKIDSFFGGDSIGHSVNHSFKITDKTVFRAVSGLATPS
YFNRTEFLNYYKLCKNTGLGLVVTVKNGVAVKVEIAS

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 47432; Mature: 47432

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNQLKKLTVAALVAAMIVPAGVSNADNQQITRISGKDRIATSVEISKSAYTTSENVVL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEEECCCEECCCCCEEE
ASGFNFADALSAGQLASALDAPLLLSSQDKLDSQTKNEINRLKAKKVFVVGGDNAISKTG
EECCCHHHHHCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCC
IDKNLKSEKIDVTRLEGQDRYSTSQKVMEKTKEIINPEYLLIASGKNFPDALAATGFFVN
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCEEEEE
HKSVMVLSDGVTYPQSNLQEIAIGGKNQLPLKGFTGKRVSGKDRYETALEIAKLSFDKNN
CCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCC
NAILASGQVFADSLSAVSLTKKHNAPIILTQSNSLTENAKKYLNGKNVFIVGGEKTVVND
CEEEECCCHHHHCHHHEEEECCCCCCEEEECCCCHHHHHHHHHCCCEEEEECCCHHHHHH
ILTRKKPVVKKEDKNLHTKTGQYYSSLISKKLSKSEADASNQAYNVRIEGDQLVVSGYML
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEHHHHH
YYKKIDSFFGGDSIGHSVNHSFKITDKTVFRAVSGLATPSYFNRTEFLNYYKLCKNTGLG
HHHHHHHHCCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCE
LVVTVKNGVAVKVEIAS
EEEEECCCEEEEEEECC
>Mature Secondary Structure
MLKNQLKKLTVAALVAAMIVPAGVSNADNQQITRISGKDRIATSVEISKSAYTTSENVVL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEEECCCEECCCCCEEE
ASGFNFADALSAGQLASALDAPLLLSSQDKLDSQTKNEINRLKAKKVFVVGGDNAISKTG
EECCCHHHHHCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCC
IDKNLKSEKIDVTRLEGQDRYSTSQKVMEKTKEIINPEYLLIASGKNFPDALAATGFFVN
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCEEEEE
HKSVMVLSDGVTYPQSNLQEIAIGGKNQLPLKGFTGKRVSGKDRYETALEIAKLSFDKNN
CCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCC
NAILASGQVFADSLSAVSLTKKHNAPIILTQSNSLTENAKKYLNGKNVFIVGGEKTVVND
CEEEECCCHHHHCHHHEEEECCCCCCEEEECCCCHHHHHHHHHCCCEEEEECCCHHHHHH
ILTRKKPVVKKEDKNLHTKTGQYYSSLISKKLSKSEADASNQAYNVRIEGDQLVVSGYML
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEHHHHH
YYKKIDSFFGGDSIGHSVNHSFKITDKTVFRAVSGLATPSYFNRTEFLNYYKLCKNTGLG
HHHHHHHHCCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCE
LVVTVKNGVAVKVEIAS
EEEEECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]