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The map label for this gene is cadA [H]

Identifier: 169823752

GI number: 169823752

Start: 70772

End: 72583

Strand: Direct

Name: cadA [H]

Synonym: FMG_0055

Alternate gene names: 169823752

Gene position: 70772-72583 (Clockwise)

Preceding gene: 169823751

Following gene: 169823753

Centisome position: 3.94

GC content: 40.45

Gene sequence:

>1812_bases
ATGAACAAGGAAATTAAATTAACGATAGTTTCGGCTATTCTTTTTGCAATTGGATTTTTCATCGAACAACCTTACGTTAA
GCTTGCGGTGTTCGCTGTGAGTTATCTGATTGTGGGAATTCCAGTGATTAAGTTAGCGTTTTTGAATTTGAAAAACGGTC
AGTTATTTGACGAGAATTTTCTGATGATGATTGCAACTGTGGGTGCGTTTATCATTGGAGAATACGCAGAAGCTGTCGCT
GTTATGCTTTTTTATCAAATCGGGGAGATTTTTCAAGATAAGGCTGTTGGGAAATCTCGTGATTCAATCAAGGAATTGAT
GGATATTGCGCCTACTTTTGCGAATTTGAAAACGGAAGATGGCTACGACAAGGTGGATCCTTACGATGTGAGCGTGGGAG
ATATTATCGTGATTAAACCAGGAGAGAAAGTTCCGTTGGACTGCGTGGTAGTAGATGGAAGCTCCATGGTTGACACGAAG
GCGTTGACTGGAGAAAGTGTTCCAATCACAGTCGCAAAAGGCGAAGAGCTTTTGTCGGGTTACATCGTGGTGGACAAGGT
TTTAAATGCGAAAGTTACCAAGGATTTTGAAAACTCTGCAGTGACGAAGATTTTGGATTTGGTGGAAAATGCATCCAGCC
AAAAAAGTCAACAAGAAAAATTCATCACGAAATTTGCAAGAGTATACACTCCTGTTGTGGTATTTGTAGCAGCGGCTCTT
GCGATATTGATGCCTTTGATTTTGAAACAACCTTTCCAAGTGTGGTTGTATCGTGCGTTGACATTCCTTGTAATTTCGTG
TCCTTGCGCACTTGTAATCAGCGTTCCGTTGAGCTTTTTCTCAGGAATTGGCGCGAGCAGCAAGGCTGGGATTTTGGTCA
AAGGAAGTAACTACATCGAAAAGTTAGCAGAAACAGACACTGTTGTTATGGATAAAACTGGAACATTGACACAAGGCGTG
TTCAAAGTTGTAGAAGCAAAATCAGTTGGATTTTCAGATGAAGAAATGCTCCAATACGTTGCGAGTGCTGAGAAATCATC
CAACCATCCAATCGCACAATCGATTATTGATTATTATGGGGACAAAGAATATTTGAACTTGGACTCTGCAGAAAATATCG
CAGGCCAAGGGATACAAGCTGTGATAAATGGCAAACAAATCCTAGCGGGAAATGCGAAGCTTTTAAAAGATGTTGAATTT
GAACCGATTGACACTACAGACACTGTTGTCTACGTTGCAATCGATGGAAAATTTGCGGGATATATCAAAATCGCAGACAA
AATCAAACAAGATAGCGCACAAGCAATTGTTGATATGAAAAATGTCGGCATCAAAAAAACATACATGCTAACTGGTGATA
ATGAATCAGTAGCCAAATCAGTAGCAGAAAATCTTAAAATTGACGAATACAAATCCAAGCTACTTCCACAAGACAAGGTT
GAAATTGTAAAAGATTTGATAGAAAAGGGAAGAAAAGTGGCATTCGTAGGTGACGGAATCAACGATGCGCCAGTGCTTGC
ACTCAGTGATGTCGGAATTTCCATGGGACAAATCGGAAGCGATGCGGCAATTGAAGCGAGTGATGTCGTAATCATGACAG
ACGAGCTAACGAAAATCGCCCAAGCAATCAAAATCTCCAAGAAAACACTCAAAATCGCAAAACAAAACGCGTATTTTGCA
ATCGGTGTGAAAATAATTGTGCTAATATTATCGGCACTTGGACTTACAAACATGTGGGCTGCAATCTTCGCAGACGTCGG
AGTTACAGTGCTTGCTATTTTGAATTCATTCAGAGCTATGCGAGTTAGTTGA

Upstream 100 bases:

>100_bases
CAAAAATGGTGTTGGATGTAGAAGATGACAAGTTTGATACTGTTTTGGCGCAAGCAAAAGACATTATCAAATCAATTGAA
CCTTTAGTTGAAGTGAAATA

Downstream 100 bases:

>100_bases
GTAAAATCGAAATCTCATTTATACTAATCGTAAAGGAGATGATAAAATGAAAATAGTAGGCTATGTGTTTTTAGGAATAT
TTGCGATAGCACTCATTTAT

Product: putative cation-transporting P-type ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MNKEIKLTIVSAILFAIGFFIEQPYVKLAVFAVSYLIVGIPVIKLAFLNLKNGQLFDENFLMMIATVGAFIIGEYAEAVA
VMLFYQIGEIFQDKAVGKSRDSIKELMDIAPTFANLKTEDGYDKVDPYDVSVGDIIVIKPGEKVPLDCVVVDGSSMVDTK
ALTGESVPITVAKGEELLSGYIVVDKVLNAKVTKDFENSAVTKILDLVENASSQKSQQEKFITKFARVYTPVVVFVAAAL
AILMPLILKQPFQVWLYRALTFLVISCPCALVISVPLSFFSGIGASSKAGILVKGSNYIEKLAETDTVVMDKTGTLTQGV
FKVVEAKSVGFSDEEMLQYVASAEKSSNHPIAQSIIDYYGDKEYLNLDSAENIAGQGIQAVINGKQILAGNAKLLKDVEF
EPIDTTDTVVYVAIDGKFAGYIKIADKIKQDSAQAIVDMKNVGIKKTYMLTGDNESVAKSVAENLKIDEYKSKLLPQDKV
EIVKDLIEKGRKVAFVGDGINDAPVLALSDVGISMGQIGSDAAIEASDVVIMTDELTKIAQAIKISKKTLKIAKQNAYFA
IGVKIIVLILSALGLTNMWAAIFADVGVTVLAILNSFRAMRVS

Sequences:

>Translated_603_residues
MNKEIKLTIVSAILFAIGFFIEQPYVKLAVFAVSYLIVGIPVIKLAFLNLKNGQLFDENFLMMIATVGAFIIGEYAEAVA
VMLFYQIGEIFQDKAVGKSRDSIKELMDIAPTFANLKTEDGYDKVDPYDVSVGDIIVIKPGEKVPLDCVVVDGSSMVDTK
ALTGESVPITVAKGEELLSGYIVVDKVLNAKVTKDFENSAVTKILDLVENASSQKSQQEKFITKFARVYTPVVVFVAAAL
AILMPLILKQPFQVWLYRALTFLVISCPCALVISVPLSFFSGIGASSKAGILVKGSNYIEKLAETDTVVMDKTGTLTQGV
FKVVEAKSVGFSDEEMLQYVASAEKSSNHPIAQSIIDYYGDKEYLNLDSAENIAGQGIQAVINGKQILAGNAKLLKDVEF
EPIDTTDTVVYVAIDGKFAGYIKIADKIKQDSAQAIVDMKNVGIKKTYMLTGDNESVAKSVAENLKIDEYKSKLLPQDKV
EIVKDLIEKGRKVAFVGDGINDAPVLALSDVGISMGQIGSDAAIEASDVVIMTDELTKIAQAIKISKKTLKIAKQNAYFA
IGVKIIVLILSALGLTNMWAAIFADVGVTVLAILNSFRAMRVS
>Mature_603_residues
MNKEIKLTIVSAILFAIGFFIEQPYVKLAVFAVSYLIVGIPVIKLAFLNLKNGQLFDENFLMMIATVGAFIIGEYAEAVA
VMLFYQIGEIFQDKAVGKSRDSIKELMDIAPTFANLKTEDGYDKVDPYDVSVGDIIVIKPGEKVPLDCVVVDGSSMVDTK
ALTGESVPITVAKGEELLSGYIVVDKVLNAKVTKDFENSAVTKILDLVENASSQKSQQEKFITKFARVYTPVVVFVAAAL
AILMPLILKQPFQVWLYRALTFLVISCPCALVISVPLSFFSGIGASSKAGILVKGSNYIEKLAETDTVVMDKTGTLTQGV
FKVVEAKSVGFSDEEMLQYVASAEKSSNHPIAQSIIDYYGDKEYLNLDSAENIAGQGIQAVINGKQILAGNAKLLKDVEF
EPIDTTDTVVYVAIDGKFAGYIKIADKIKQDSAQAIVDMKNVGIKKTYMLTGDNESVAKSVAENLKIDEYKSKLLPQDKV
EIVKDLIEKGRKVAFVGDGINDAPVLALSDVGISMGQIGSDAAIEASDVVIMTDELTKIAQAIKISKKTLKIAKQNAYFA
IGVKIIVLILSALGLTNMWAAIFADVGVTVLAILNSFRAMRVS

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=595, Percent_Identity=27.8991596638655, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI55743073, Length=553, Percent_Identity=30.1989150090416, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI115529486, Length=309, Percent_Identity=29.4498381877023, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI48762687, Length=183, Percent_Identity=28.4153005464481, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI48762691, Length=183, Percent_Identity=28.4153005464481, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI48762689, Length=183, Percent_Identity=28.4153005464481, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI48762685, Length=183, Percent_Identity=28.4153005464481, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI48255959, Length=195, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI48255957, Length=195, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI48255955, Length=195, Percent_Identity=27.1794871794872, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI48255953, Length=195, Percent_Identity=27.1794871794872, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI48255947, Length=195, Percent_Identity=27.1794871794872, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI48255945, Length=195, Percent_Identity=27.1794871794872, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789879, Length=606, Percent_Identity=34.983498349835, Blast_Score=344, Evalue=1e-95,
Organism=Escherichia coli, GI1786691, Length=586, Percent_Identity=32.0819112627986, Blast_Score=266, Evalue=4e-72,
Organism=Escherichia coli, GI1786914, Length=532, Percent_Identity=26.1278195488722, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI2367363, Length=592, Percent_Identity=25.8445945945946, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17556548, Length=334, Percent_Identity=29.3413173652695, Blast_Score=119, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI193203354, Length=167, Percent_Identity=28.1437125748503, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193203356, Length=167, Percent_Identity=28.1437125748503, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17541776, Length=193, Percent_Identity=27.4611398963731, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995298, Length=222, Percent_Identity=26.5765765765766, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71995286, Length=222, Percent_Identity=26.5765765765766, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71995291, Length=222, Percent_Identity=26.5765765765766, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=546, Percent_Identity=31.5018315018315, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6319772, Length=472, Percent_Identity=26.9067796610169, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6321430, Length=551, Percent_Identity=23.7749546279492, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6321271, Length=188, Percent_Identity=31.9148936170213, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6321432, Length=184, Percent_Identity=30.9782608695652, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221329854, Length=415, Percent_Identity=26.7469879518072, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24668708, Length=123, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24668704, Length=123, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281366617, Length=123, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24668696, Length=123, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI161085803, Length=123, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281359543, Length=195, Percent_Identity=26.1538461538462, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI281359537, Length=195, Percent_Identity=26.1538461538462, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 65243; Mature: 65243

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKEIKLTIVSAILFAIGFFIEQPYVKLAVFAVSYLIVGIPVIKLAFLNLKNGQLFDENF
CCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEECCHH
LMMIATVGAFIIGEYAEAVAVMLFYQIGEIFQDKAVGKSRDSIKELMDIAPTFANLKTED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHCCCCCC
GYDKVDPYDVSVGDIIVIKPGEKVPLDCVVVDGSSMVDTKALTGESVPITVAKGEELLSG
CCCCCCCCEECCCCEEEECCCCCCCEEEEEECCCCCCCHHHCCCCCCEEEEECCHHHHHH
YIVVDKVLNAKVTKDFENSAVTKILDLVENASSQKSQQEKFITKFARVYTPVVVFVAAAL
HHHHHHHHCCHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AILMPLILKQPFQVWLYRALTFLVISCPCALVISVPLSFFSGIGASSKAGILVKGSNYIE
HHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHH
KLAETDTVVMDKTGTLTQGVFKVVEAKSVGFSDEEMLQYVASAEKSSNHPIAQSIIDYYG
HHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCC
DKEYLNLDSAENIAGQGIQAVINGKQILAGNAKLLKDVEFEPIDTTDTVVYVAIDGKFAG
CCCEECCCCCCHHHCCCHHHHCCCCEEEECCHHHHHCCCCCCCCCCCCEEEEEECCCEEE
YIKIADKIKQDSAQAIVDMKNVGIKKTYMLTGDNESVAKSVAENLKIDEYKSKLLPQDKV
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHCCCCHHH
EIVKDLIEKGRKVAFVGDGINDAPVLALSDVGISMGQIGSDAAIEASDVVIMTDELTKIA
HHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHHH
QAIKISKKTLKIAKQNAYFAIGVKIIVLILSALGLTNMWAAIFADVGVTVLAILNSFRAM
HHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
RVS
CCC
>Mature Secondary Structure
MNKEIKLTIVSAILFAIGFFIEQPYVKLAVFAVSYLIVGIPVIKLAFLNLKNGQLFDENF
CCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEECCHH
LMMIATVGAFIIGEYAEAVAVMLFYQIGEIFQDKAVGKSRDSIKELMDIAPTFANLKTED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHCCCCCC
GYDKVDPYDVSVGDIIVIKPGEKVPLDCVVVDGSSMVDTKALTGESVPITVAKGEELLSG
CCCCCCCCEECCCCEEEECCCCCCCEEEEEECCCCCCCHHHCCCCCCEEEEECCHHHHHH
YIVVDKVLNAKVTKDFENSAVTKILDLVENASSQKSQQEKFITKFARVYTPVVVFVAAAL
HHHHHHHHCCHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AILMPLILKQPFQVWLYRALTFLVISCPCALVISVPLSFFSGIGASSKAGILVKGSNYIE
HHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHH
KLAETDTVVMDKTGTLTQGVFKVVEAKSVGFSDEEMLQYVASAEKSSNHPIAQSIIDYYG
HHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCC
DKEYLNLDSAENIAGQGIQAVINGKQILAGNAKLLKDVEFEPIDTTDTVVYVAIDGKFAG
CCCEECCCCCCHHHCCCHHHHCCCCEEEECCHHHHHCCCCCCCCCCCCEEEEEECCCEEE
YIKIADKIKQDSAQAIVDMKNVGIKKTYMLTGDNESVAKSVAENLKIDEYKSKLLPQDKV
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHCCCCHHH
EIVKDLIEKGRKVAFVGDGINDAPVLALSDVGISMGQIGSDAAIEASDVVIMTDELTKIA
HHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHHH
QAIKISKKTLKIAKQNAYFAIGVKIIVLILSALGLTNMWAAIFADVGVTVLAILNSFRAM
HHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
RVS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]