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The map label for this gene is gyrA [H]

Identifier: 169823703

GI number: 169823703

Start: 6649

End: 9069

Strand: Direct

Name: gyrA [H]

Synonym: FMG_0006

Alternate gene names: 169823703

Gene position: 6649-9069 (Clockwise)

Preceding gene: 169823702

Following gene: 169823704

Centisome position: 0.37

GC content: 36.72

Gene sequence:

>2421_bases
ATGACAGAAAGAAAACTCAATATAAAACCAGCTGATTTGAAAAGAGAAATGGAAAGTGCATATTTGGATTATTCTATGAG
TGTAATTGTATCTCGTGCGCTTCCAGATGTAAGAGACGGATTGAAACCTGTTCACAGACGTATAATTTACGGAATGCAAC
AACAAGGATTGTTCCCAGATAGAAAATACTCCAAGTCCGCAAGACTTGTAGGGGAAGTAATGGGTAAATATCACCCTCAC
GGTGACAGTGCAATCTACGATGCAGTTGTAAGACTTGCACAAGATTTCAACATGAGATATCCACTTGTAGATGGTCAAGG
TAACTTCGGTTCAATCGATGGTGACGGAGCTGCGGCACCTCGTTACACGGAGTTACGTATGGACAAACTTGCACTTGAAA
TGTTGCGTGACATCAACAAAGACACTGTTGATTTCCAAGACAACTACGACGGTGAAGAACAAGAACCAGTTGTACTTCCA
TCAAGATTTCCAAATTTAATCGTAAATGGATCCAGTGGTATCGCTGTTGGTATGGCGACAAATATGGCTCCACACAATTT
GGGAGAAACAATTGATGCGCTAATAGCAACGATTGACAATCCAAATATAACAATTGAAGAATTGATGAAATACATCAAGG
CTCCTGATTTTCCGACAGGTGGAAACATCATGGGACTTGAAGAAGTCAAGAACGCATACACAACAGGACGTGGAAAAGTT
AGACTAAGAGCAGAAGCTAGAATCGAGGAATCAAAGGGCAGATTCAAAATCATCGTCACAGAAATTCCTTACCAAGTCAA
CAAATCCAATTTAATCAAAAAAATCGCAGATCTTGTAAAACAAAAGAAAATAGAAGGCATCAGCGATTTGAGAGATGAAT
CAGACAGAAAAGGTATGAGAATTGTCATCGAAACAAAAAGAGATGCCAATCCAAATATCGTGCTTAACAATTTGTACAAA
TACACTCAAATGCAAACTACATTTGGGATAATTAACCTTGCCCTTGTAAATGGCGTTCCAAAAGTTTTGACATTGAAACA
ATTAATCGACCATTATCTTGTTCACCAAGAAATAGTCGTTAGAAGAAGAACGCAATTCGATTTGAACAAGGCGAAGGCGA
GAATTCATATTGTTGAAGGATTGTTAAAAGCAATCGACAATATCGATGAAATTATCCACATTATCAGAACAAGTTATGAT
GATGCGCTCGAAAAATTGATGGAAAGATTTGGTTTTTCAGAAATCCAAGCACAAGCAATCTTGGACATGAGACTTAAAAG
ATTACAAGGTTTGGAAAAAGAAAAACTACAAAATGAATTTGACGAATTGAGCGCTTTGATTGAAAAATTGACAGAAATTT
TGAATAACAGACACATGTTGTTAGAAATAATCAAAGACGAATTATCAGAAATTAGAACAAAATACGCAGACGATAGAAGA
ACTAAAATTCTACGAGATGACGGAGATTTTGAAGACATGGAACTTTTGGAAGAAGAAGACATGTTCATCACTATCACTAA
CAAAGGCTACATCAAACGAATTTCAACTGATGCATACAAGGTTCAACACAGAGGTGGCCGAGGCGTGAATGCTATGGGAA
TGAAAGACGGAGATTTCATCAAAGATATGTTCGCAACTACAACTCACCAAGATTTGTTGTTCTTCACTAATAAAGGAAAA
GTTTACTCACTAAAAGCTTACGAAGTGCCAGAAGCAAGCCGTACAGCGAGAGGTTCCAACATCATCAATCTTATCCAAAT
AGATGCTGACGAAAATGTTACACAAGTTTTGGCATTGGATAAGGAAAAAGAAAACGACCAATTTATAATATTTATCACTA
AAAAAGGCAAAGTGAAGAAGACTTCGTTGAGTTTGTACGAAAATATCAGAAAAACTGGTATCATAGCTATCAAATTCGAT
GAGGGCGACGAGCTTATCGATGTGAAACTTGTCGAAAAGAATGAAGAAGTAATTATCGTCACTAAAAAAGGAATGAGTTT
GCAATTTAATGTGGATCAATTGAGAGATTTATCGAGAAATGCCATCGGAGTAAAGGCTATTACTCTTAACAAAGACGATG
AGGTTATTTCATTTGATTTGGTAAAAGACAATGAATTCTTGGCAGTTATCAGTGAAAATGGTTACGGTAAGAAGACTGAA
CTATCCAACTACACTACTCAAAATAGAGGTGGAAAAGGTATCAGAACTTACAAGATCGCCAAGAAAACAGGAGATGTAGC
GTGTGCGAAGGCATTGAAAAAAGACGACGAGATTCTTTTGATTAGCAAACAAGCTGAGGTTATCAGAATAAAAGCAGAAG
GAATATCTACACTTTCAAGAAATACATCTGGGGTATTGTTGAAAAATACAGATAAGGGCGAAGATGCAATAGTAGCTGTA
GCTAAATATTTTGAAGAATAA

Upstream 100 bases:

>100_bases
CACATTCGATGTTTTGATGGGAGACAATGTAGAACCAAGAAGAGAATTTATAGAACAAAACGCTGTTTATGCACAAAACA
TTGACGCTTAGGAGAATAAT

Downstream 100 bases:

>100_bases
GGAGAAAATTATGCAATTAAATTACGATATAGTCACAAAAGACGAGATAATTGTGCGTGTTCAAGGTGATTTGGACATCA
ATACTTGTGACGAATTCAGA

Product: DNA gyrase A subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 806; Mature: 805

Protein sequence:

>806_residues
MTERKLNIKPADLKREMESAYLDYSMSVIVSRALPDVRDGLKPVHRRIIYGMQQQGLFPDRKYSKSARLVGEVMGKYHPH
GDSAIYDAVVRLAQDFNMRYPLVDGQGNFGSIDGDGAAAPRYTELRMDKLALEMLRDINKDTVDFQDNYDGEEQEPVVLP
SRFPNLIVNGSSGIAVGMATNMAPHNLGETIDALIATIDNPNITIEELMKYIKAPDFPTGGNIMGLEEVKNAYTTGRGKV
RLRAEARIEESKGRFKIIVTEIPYQVNKSNLIKKIADLVKQKKIEGISDLRDESDRKGMRIVIETKRDANPNIVLNNLYK
YTQMQTTFGIINLALVNGVPKVLTLKQLIDHYLVHQEIVVRRRTQFDLNKAKARIHIVEGLLKAIDNIDEIIHIIRTSYD
DALEKLMERFGFSEIQAQAILDMRLKRLQGLEKEKLQNEFDELSALIEKLTEILNNRHMLLEIIKDELSEIRTKYADDRR
TKILRDDGDFEDMELLEEEDMFITITNKGYIKRISTDAYKVQHRGGRGVNAMGMKDGDFIKDMFATTTHQDLLFFTNKGK
VYSLKAYEVPEASRTARGSNIINLIQIDADENVTQVLALDKEKENDQFIIFITKKGKVKKTSLSLYENIRKTGIIAIKFD
EGDELIDVKLVEKNEEVIIVTKKGMSLQFNVDQLRDLSRNAIGVKAITLNKDDEVISFDLVKDNEFLAVISENGYGKKTE
LSNYTTQNRGGKGIRTYKIAKKTGDVACAKALKKDDEILLISKQAEVIRIKAEGISTLSRNTSGVLLKNTDKGEDAIVAV
AKYFEE

Sequences:

>Translated_806_residues
MTERKLNIKPADLKREMESAYLDYSMSVIVSRALPDVRDGLKPVHRRIIYGMQQQGLFPDRKYSKSARLVGEVMGKYHPH
GDSAIYDAVVRLAQDFNMRYPLVDGQGNFGSIDGDGAAAPRYTELRMDKLALEMLRDINKDTVDFQDNYDGEEQEPVVLP
SRFPNLIVNGSSGIAVGMATNMAPHNLGETIDALIATIDNPNITIEELMKYIKAPDFPTGGNIMGLEEVKNAYTTGRGKV
RLRAEARIEESKGRFKIIVTEIPYQVNKSNLIKKIADLVKQKKIEGISDLRDESDRKGMRIVIETKRDANPNIVLNNLYK
YTQMQTTFGIINLALVNGVPKVLTLKQLIDHYLVHQEIVVRRRTQFDLNKAKARIHIVEGLLKAIDNIDEIIHIIRTSYD
DALEKLMERFGFSEIQAQAILDMRLKRLQGLEKEKLQNEFDELSALIEKLTEILNNRHMLLEIIKDELSEIRTKYADDRR
TKILRDDGDFEDMELLEEEDMFITITNKGYIKRISTDAYKVQHRGGRGVNAMGMKDGDFIKDMFATTTHQDLLFFTNKGK
VYSLKAYEVPEASRTARGSNIINLIQIDADENVTQVLALDKEKENDQFIIFITKKGKVKKTSLSLYENIRKTGIIAIKFD
EGDELIDVKLVEKNEEVIIVTKKGMSLQFNVDQLRDLSRNAIGVKAITLNKDDEVISFDLVKDNEFLAVISENGYGKKTE
LSNYTTQNRGGKGIRTYKIAKKTGDVACAKALKKDDEILLISKQAEVIRIKAEGISTLSRNTSGVLLKNTDKGEDAIVAV
AKYFEE
>Mature_805_residues
TERKLNIKPADLKREMESAYLDYSMSVIVSRALPDVRDGLKPVHRRIIYGMQQQGLFPDRKYSKSARLVGEVMGKYHPHG
DSAIYDAVVRLAQDFNMRYPLVDGQGNFGSIDGDGAAAPRYTELRMDKLALEMLRDINKDTVDFQDNYDGEEQEPVVLPS
RFPNLIVNGSSGIAVGMATNMAPHNLGETIDALIATIDNPNITIEELMKYIKAPDFPTGGNIMGLEEVKNAYTTGRGKVR
LRAEARIEESKGRFKIIVTEIPYQVNKSNLIKKIADLVKQKKIEGISDLRDESDRKGMRIVIETKRDANPNIVLNNLYKY
TQMQTTFGIINLALVNGVPKVLTLKQLIDHYLVHQEIVVRRRTQFDLNKAKARIHIVEGLLKAIDNIDEIIHIIRTSYDD
ALEKLMERFGFSEIQAQAILDMRLKRLQGLEKEKLQNEFDELSALIEKLTEILNNRHMLLEIIKDELSEIRTKYADDRRT
KILRDDGDFEDMELLEEEDMFITITNKGYIKRISTDAYKVQHRGGRGVNAMGMKDGDFIKDMFATTTHQDLLFFTNKGKV
YSLKAYEVPEASRTARGSNIINLIQIDADENVTQVLALDKEKENDQFIIFITKKGKVKKTSLSLYENIRKTGIIAIKFDE
GDELIDVKLVEKNEEVIIVTKKGMSLQFNVDQLRDLSRNAIGVKAITLNKDDEVISFDLVKDNEFLAVISENGYGKKTEL
SNYTTQNRGGKGIRTYKIAKKTGDVACAKALKKDDEILLISKQAEVIRIKAEGISTLSRNTSGVLLKNTDKGEDAIVAVA
KYFEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=178, Percent_Identity=28.0898876404494, Blast_Score=71, Evalue=5e-12,
Organism=Escherichia coli, GI1788562, Length=835, Percent_Identity=45.8682634730539, Blast_Score=741, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=672, Percent_Identity=35.7142857142857, Blast_Score=412, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI212645845, Length=397, Percent_Identity=24.1813602015113, Blast_Score=73, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=249, Percent_Identity=26.9076305220884, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136538, Length=284, Percent_Identity=25.7042253521127, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 91308; Mature: 91177

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERKLNIKPADLKREMESAYLDYSMSVIVSRALPDVRDGLKPVHRRIIYGMQQQGLFPD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
RKYSKSARLVGEVMGKYHPHGDSAIYDAVVRLAQDFNMRYPLVDGQGNFGSIDGDGAAAP
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCC
RYTELRMDKLALEMLRDINKDTVDFQDNYDGEEQEPVVLPSRFPNLIVNGSSGIAVGMAT
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCEEEECCCCEEEEEEC
NMAPHNLGETIDALIATIDNPNITIEELMKYIKAPDFPTGGNIMGLEEVKNAYTTGRGKV
CCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCCCCCCCEEEHHHHHHHHCCCCCEE
RLRAEARIEESKGRFKIIVTEIPYQVNKSNLIKKIADLVKQKKIEGISDLRDESDRKGMR
EEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCE
IVIETKRDANPNIVLNNLYKYTQMQTTFGIINLALVNGVPKVLTLKQLIDHYLVHQEIVV
EEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
RRRTQFDLNKAKARIHIVEGLLKAIDNIDEIIHIIRTSYDDALEKLMERFGFSEIQAQAI
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHH
LDMRLKRLQGLEKEKLQNEFDELSALIEKLTEILNNRHMLLEIIKDELSEIRTKYADDRR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHH
TKILRDDGDFEDMELLEEEDMFITITNKGYIKRISTDAYKVQHRGGRGVNAMGMKDGDFI
HEEECCCCCCHHHHHHCCCCEEEEEECCCEEEEECCCCEEEECCCCCCCCCCCCCCCHHH
KDMFATTTHQDLLFFTNKGKVYSLKAYEVPEASRTARGSNIINLIQIDADENVTQVLALD
HHHHHCCCCCCEEEEECCCCEEEEEEECCCCCHHCCCCCCEEEEEEECCCCCCEEHEEEC
KEKENDQFIIFITKKGKVKKTSLSLYENIRKTGIIAIKFDEGDELIDVKLVEKNEEVIIV
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCEEEEEEECCCCCEEEEEEEECCCCEEEE
TKKGMSLQFNVDQLRDLSRNAIGVKAITLNKDDEVISFDLVKDNEFLAVISENGYGKKTE
EECCCEEEECHHHHHHCCCCCCEEEEEEECCCCCEEEEEEEECCCEEEEEECCCCCCCCC
LSNYTTQNRGGKGIRTYKIAKKTGDVACAKALKKDDEILLISKQAEVIRIKAEGISTLSR
CCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCEEEEECCCEEEEEECCCCHHHCC
NTSGVLLKNTDKGEDAIVAVAKYFEE
CCCEEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TERKLNIKPADLKREMESAYLDYSMSVIVSRALPDVRDGLKPVHRRIIYGMQQQGLFPD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
RKYSKSARLVGEVMGKYHPHGDSAIYDAVVRLAQDFNMRYPLVDGQGNFGSIDGDGAAAP
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCC
RYTELRMDKLALEMLRDINKDTVDFQDNYDGEEQEPVVLPSRFPNLIVNGSSGIAVGMAT
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCEEEECCCCEEEEEEC
NMAPHNLGETIDALIATIDNPNITIEELMKYIKAPDFPTGGNIMGLEEVKNAYTTGRGKV
CCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCCCCCCCEEEHHHHHHHHCCCCCEE
RLRAEARIEESKGRFKIIVTEIPYQVNKSNLIKKIADLVKQKKIEGISDLRDESDRKGMR
EEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCE
IVIETKRDANPNIVLNNLYKYTQMQTTFGIINLALVNGVPKVLTLKQLIDHYLVHQEIVV
EEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
RRRTQFDLNKAKARIHIVEGLLKAIDNIDEIIHIIRTSYDDALEKLMERFGFSEIQAQAI
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHH
LDMRLKRLQGLEKEKLQNEFDELSALIEKLTEILNNRHMLLEIIKDELSEIRTKYADDRR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHH
TKILRDDGDFEDMELLEEEDMFITITNKGYIKRISTDAYKVQHRGGRGVNAMGMKDGDFI
HEEECCCCCCHHHHHHCCCCEEEEEECCCEEEEECCCCEEEECCCCCCCCCCCCCCCHHH
KDMFATTTHQDLLFFTNKGKVYSLKAYEVPEASRTARGSNIINLIQIDADENVTQVLALD
HHHHHCCCCCCEEEEECCCCEEEEEEECCCCCHHCCCCCCEEEEEEECCCCCCEEHEEEC
KEKENDQFIIFITKKGKVKKTSLSLYENIRKTGIIAIKFDEGDELIDVKLVEKNEEVIIV
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCEEEEEEECCCCCEEEEEEEECCCCEEEE
TKKGMSLQFNVDQLRDLSRNAIGVKAITLNKDDEVISFDLVKDNEFLAVISENGYGKKTE
EECCCEEEECHHHHHHCCCCCCEEEEEEECCCCCEEEEEEEECCCEEEEEECCCCCCCCC
LSNYTTQNRGGKGIRTYKIAKKTGDVACAKALKKDDEILLISKQAEVIRIKAEGISTLSR
CCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCEEEEECCCEEEEEECCCCHHHCC
NTSGVLLKNTDKGEDAIVAVAKYFEE
CCCEEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]