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The map label for this gene is dut [H]

Identifier: 169823588

GI number: 169823588

Start: 59251

End: 59679

Strand: Reverse

Name: dut [H]

Synonym: FMG_P0074

Alternate gene names: 169823588

Gene position: 59679-59251 (Counterclockwise)

Preceding gene: 169823589

Following gene: 169823587

Centisome position: 31.55

GC content: 35.66

Gene sequence:

>429_bases
ATGAAATATTTCACAGAAAAACACAACTTAAAAGTAGGAACAAAGGACAGTGCAGGAATTGATCTTCCAGCCTGTTTAGA
CGAAAAAACAACAGTAAAGGCTAAAGAATATGTAGATATCAATACGAAAATTCACGTAGAAATACCACAAGGTTGCTTCG
GAATGGTCGTTCCCCGTTCATCTATTGGAACTAAAAAACATTTAGCACTACAAAATACCGTAGGGATTATCGATTCTGAC
TATCGTGGTGCGATTAAGCTTAAATTCTTTAACTATGGTAATGAAAATATCGCTATCGAAGACGGTGAGTATGTCGCACA
AATGATTATAGTACCATATACTTCAGTTGATTTGCAAAAAGTAGATACATTAAACGAACTAAGCGAAACTGAAAGAGGTG
CTGGTGGATTTGGAAGCACAAATAGATAG

Upstream 100 bases:

>100_bases
ATCACAGTACGACAGACGAAATAGACGACATTGTCAAAATATTCGAACATATTTTTGAAATGTTAGATAAAAATTTGAAA
CAAAAATAGGAGAATAAATT

Downstream 100 bases:

>100_bases
GAATATAGGAGGAATATTATGGAAGATACAAAGAAATTAATTTCGGAAAATTTTAACATAATCAATTATAAAGCTGATCT
AATCCATTTTAACTGTTTAG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 142; Mature: 142

Protein sequence:

>142_residues
MKYFTEKHNLKVGTKDSAGIDLPACLDEKTTVKAKEYVDINTKIHVEIPQGCFGMVVPRSSIGTKKHLALQNTVGIIDSD
YRGAIKLKFFNYGNENIAIEDGEYVAQMIIVPYTSVDLQKVDTLNELSETERGAGGFGSTNR

Sequences:

>Translated_142_residues
MKYFTEKHNLKVGTKDSAGIDLPACLDEKTTVKAKEYVDINTKIHVEIPQGCFGMVVPRSSIGTKKHLALQNTVGIIDSD
YRGAIKLKFFNYGNENIAIEDGEYVAQMIIVPYTSVDLQKVDTLNELSETERGAGGFGSTNR
>Mature_142_residues
MKYFTEKHNLKVGTKDSAGIDLPACLDEKTTVKAKEYVDINTKIHVEIPQGCFGMVVPRSSIGTKKHLALQNTVGIIDSD
YRGAIKLKFFNYGNENIAIEDGEYVAQMIIVPYTSVDLQKVDTLNELSETERGAGGFGSTNR

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI4503423, Length=130, Percent_Identity=34.6153846153846, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI70906444, Length=130, Percent_Identity=34.6153846153846, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI70906441, Length=130, Percent_Identity=34.6153846153846, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790071, Length=131, Percent_Identity=37.4045801526718, Blast_Score=93, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71988561, Length=130, Percent_Identity=36.9230769230769, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319729, Length=128, Percent_Identity=35.9375, Blast_Score=82, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24583610, Length=128, Percent_Identity=33.59375, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19921126, Length=128, Percent_Identity=33.59375, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15675; Mature: 15675

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYFTEKHNLKVGTKDSAGIDLPACLDEKTTVKAKEYVDINTKIHVEIPQGCFGMVVPRS
CCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEECCCCEEEEEECC
SIGTKKHLALQNTVGIIDSDYRGAIKLKFFNYGNENIAIEDGEYVAQMIIVPYTSVDLQK
CCCCCCEEEECCCCCEEECCCCCEEEEEEEEECCCEEEEECCCEEEEEEEECCCCCCHHH
VDTLNELSETERGAGGFGSTNR
HHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKYFTEKHNLKVGTKDSAGIDLPACLDEKTTVKAKEYVDINTKIHVEIPQGCFGMVVPRS
CCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEECCCCEEEEEECC
SIGTKKHLALQNTVGIIDSDYRGAIKLKFFNYGNENIAIEDGEYVAQMIIVPYTSVDLQK
CCCCCCEEEECCCCCEEECCCCCEEEEEEEEECCCEEEEECCCEEEEEEEECCCCCCHHH
VDTLNELSETERGAGGFGSTNR
HHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA