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The map label for this gene is lytC [H]

Identifier: 169823560

GI number: 169823560

Start: 37875

End: 39548

Strand: Reverse

Name: lytC [H]

Synonym: FMG_P0046

Alternate gene names: 169823560

Gene position: 39548-37875 (Counterclockwise)

Preceding gene: 169823561

Following gene: 169823558

Centisome position: 20.91

GC content: 33.81

Gene sequence:

>1674_bases
ATGAACAAGAAAATTTTGAAATCAGTTTTAGCTTTAACATTAACTGCGTCTATGTTATCACCTTTAAATGTTTTAGCTGA
TAAAGAACACAGAATCGCAGGTCAATCAAGATTTGACACAGCTATTGAATTAGCTAAGTTAACAAAAAGTGATACAGCAG
TGGTAATGAATTATCAAAAATTCCCAGACGCTATCACAGCAACAAAAGTAGCAAATGCTAATAGCCCAATCTACTTTACA
GCAAAAGACAGAATGGATAGTAAAACTTTATATACTATTCTAAACAACCATAAAAAAGTTGTAATAGTTGGTGGTAAAAA
CGCAGTAAGCAAAACTGTTGAAAATCAATTATTAAGTCTTAACGTTGAAAGAGTTGAAGGAAACGATAGATACGAAACAA
ACGCAAAGGGTTTAACTAATACTGAAAAGTTAATCATCGTTAGTGGTGAACAATTTGCAGATGCTTTAGTAACATCTTCA
ATATCTAAGAAACTTTGCTCTGATGTAGCATTGACTCAAAAAGACAACGTGCCTAACGGTTTGAAAAACTACTTAAAGAA
CAACAAGAACTTAAAGGAAATCTTTATCGTAGGTGGTAAAGCTTCAGTTAGCCCAAAAGTTGAAAAAGAACTTAAAGCCT
ACACTAAAGCAAACATCAACAGAATCAGTGGTTATGATAGATATGAAACATCTGAAAGATTAGCTGACATAATCAAAAAC
TCTAAGTACACTATTGTAAATGGTGAACAATTTGCAGATAACTTATTAGCTTCCCCATTCTCTCAAAGAGAAAACAGAAG
TATTATCTTGACAAAAAGAGCAAAACATTCAAAATATGTTATGAACGTATTTGAAAACAAAGATTATGTTGTAGTAGGTG
GAAAAACTCAAGTAGAAATTCCAACGTTTGCTAAACCAGAAGAAAATAAACCTTCTGATGGAGATACAACTAAACCATCT
GAACAAAAACCAGAGGAAAAACCAGTTGATCCTAAACCAGAAGACAAACCTGCTGATAAACCAGAAGACAAAAAACCAGA
AGAAAAACCAACAGAGCCAGAAAAGCCTTCTGAAAAACCAGAAGAAAAACCAGTTGAAGATAAACTTTTAGACGTTGATA
GTCCAGAATTATCAGCAAAAGAAAAAGAGTTAATCAAACTTGTAAATGATTACAGAGAACAACATGGTAAGAAAAGACTA
AAAGTTAGTAAATCATTAATGAAAGTTGCTAGAACTCATGTCAACGACTTAAACATGAATTTCGATATGGCTAACCCTCC
AGTTGACTCTAGGGGGATAAAAGGAAATATGCACTCATGGTCTGATAAGGGTAATTGGACTCCAGTAGTCTATACAAAAG
ACCATAAACATGATAAATTAACAAAAATTAAACCTAAAGAAATCGCTGGCTATGATCAAACAGGCTATGAAGTAGCTGTA
AATGGTTTCTTAATTACACCTCAAAGAGCATTAGAAAAATGGAAAAACTCTCCAGGACATAATGACACAATTTTATCTCA
AAACGGTTGGGATCCTACGCCAGAAGAAATTGACCGAAGTTTCACACCATTATCCAATATGGGTGTAGCTATTAACGGTG
ACTACGCTTGTATCTGGTTTACACGTGACGACTACGGAATAGTTGATCCTATGGGATACTTCGAGTTCAACTAG

Upstream 100 bases:

>100_bases
CAATAAAGGAAAATATTTCTAAAGAAATATCGAAAATTTAGATGAATTTTGGTATATAATAATATTAACCTAGAGTAATA
GAAAAGGAGAAATAAAAAGT

Downstream 100 bases:

>100_bases
AAACAACAAAAGAGTAGACAATATTGTCTACTCTTTTTTTTATCTTAAACTCTCTAATATACTTAAATCATCAAAAAATT
CCAAATTATTATATTTATTG

Product: putative N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MNKKILKSVLALTLTASMLSPLNVLADKEHRIAGQSRFDTAIELAKLTKSDTAVVMNYQKFPDAITATKVANANSPIYFT
AKDRMDSKTLYTILNNHKKVVIVGGKNAVSKTVENQLLSLNVERVEGNDRYETNAKGLTNTEKLIIVSGEQFADALVTSS
ISKKLCSDVALTQKDNVPNGLKNYLKNNKNLKEIFIVGGKASVSPKVEKELKAYTKANINRISGYDRYETSERLADIIKN
SKYTIVNGEQFADNLLASPFSQRENRSIILTKRAKHSKYVMNVFENKDYVVVGGKTQVEIPTFAKPEENKPSDGDTTKPS
EQKPEEKPVDPKPEDKPADKPEDKKPEEKPTEPEKPSEKPEEKPVEDKLLDVDSPELSAKEKELIKLVNDYREQHGKKRL
KVSKSLMKVARTHVNDLNMNFDMANPPVDSRGIKGNMHSWSDKGNWTPVVYTKDHKHDKLTKIKPKEIAGYDQTGYEVAV
NGFLITPQRALEKWKNSPGHNDTILSQNGWDPTPEEIDRSFTPLSNMGVAINGDYACIWFTRDDYGIVDPMGYFEFN

Sequences:

>Translated_557_residues
MNKKILKSVLALTLTASMLSPLNVLADKEHRIAGQSRFDTAIELAKLTKSDTAVVMNYQKFPDAITATKVANANSPIYFT
AKDRMDSKTLYTILNNHKKVVIVGGKNAVSKTVENQLLSLNVERVEGNDRYETNAKGLTNTEKLIIVSGEQFADALVTSS
ISKKLCSDVALTQKDNVPNGLKNYLKNNKNLKEIFIVGGKASVSPKVEKELKAYTKANINRISGYDRYETSERLADIIKN
SKYTIVNGEQFADNLLASPFSQRENRSIILTKRAKHSKYVMNVFENKDYVVVGGKTQVEIPTFAKPEENKPSDGDTTKPS
EQKPEEKPVDPKPEDKPADKPEDKKPEEKPTEPEKPSEKPEEKPVEDKLLDVDSPELSAKEKELIKLVNDYREQHGKKRL
KVSKSLMKVARTHVNDLNMNFDMANPPVDSRGIKGNMHSWSDKGNWTPVVYTKDHKHDKLTKIKPKEIAGYDQTGYEVAV
NGFLITPQRALEKWKNSPGHNDTILSQNGWDPTPEEIDRSFTPLSNMGVAINGDYACIWFTRDDYGIVDPMGYFEFN
>Mature_557_residues
MNKKILKSVLALTLTASMLSPLNVLADKEHRIAGQSRFDTAIELAKLTKSDTAVVMNYQKFPDAITATKVANANSPIYFT
AKDRMDSKTLYTILNNHKKVVIVGGKNAVSKTVENQLLSLNVERVEGNDRYETNAKGLTNTEKLIIVSGEQFADALVTSS
ISKKLCSDVALTQKDNVPNGLKNYLKNNKNLKEIFIVGGKASVSPKVEKELKAYTKANINRISGYDRYETSERLADIIKN
SKYTIVNGEQFADNLLASPFSQRENRSIILTKRAKHSKYVMNVFENKDYVVVGGKTQVEIPTFAKPEENKPSDGDTTKPS
EQKPEEKPVDPKPEDKPADKPEDKKPEEKPTEPEKPSEKPEEKPVEDKLLDVDSPELSAKEKELIKLVNDYREQHGKKRL
KVSKSLMKVARTHVNDLNMNFDMANPPVDSRGIKGNMHSWSDKGNWTPVVYTKDHKHDKLTKIKPKEIAGYDQTGYEVAV
NGFLITPQRALEKWKNSPGHNDTILSQNGWDPTPEEIDRSFTPLSNMGVAINGDYACIWFTRDDYGIVDPMGYFEFN

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 62569; Mature: 62569

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKILKSVLALTLTASMLSPLNVLADKEHRIAGQSRFDTAIELAKLTKSDTAVVMNYQK
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCCEEEEEHHH
FPDAITATKVANANSPIYFTAKDRMDSKTLYTILNNHKKVVIVGGKNAVSKTVENQLLSL
CCCHHHHHEECCCCCCEEEEECCCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHEE
NVERVEGNDRYETNAKGLTNTEKLIIVSGEQFADALVTSSISKKLCSDVALTQKDNVPNG
EEEEECCCCCEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
LKNYLKNNKNLKEIFIVGGKASVSPKVEKELKAYTKANINRISGYDRYETSERLADIIKN
HHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHCC
SKYTIVNGEQFADNLLASPFSQRENRSIILTKRAKHSKYVMNVFENKDYVVVGGKTQVEI
CCEEEECCHHHHHHHHHCCHHHCCCCEEEEEECCCCHHHHHHHHCCCCEEEECCCEEEEC
PTFAKPEENKPSDGDTTKPSEQKPEEKPVDPKPEDKPADKPEDKKPEEKPTEPEKPSEKP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
EEKPVEDKLLDVDSPELSAKEKELIKLVNDYREQHGKKRLKVSKSLMKVARTHVNDLNMN
CCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
FDMANPPVDSRGIKGNMHSWSDKGNWTPVVYTKDHKHDKLTKIKPKEIAGYDQTGYEVAV
EECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHCCCCCCCCEEEE
NGFLITPQRALEKWKNSPGHNDTILSQNGWDPTPEEIDRSFTPLSNMGVAINGDYACIWF
CCEEECCHHHHHHHCCCCCCCCEEECCCCCCCCHHHHCCCCCCHHHCCEEEECCEEEEEE
TRDDYGIVDPMGYFEFN
ECCCCCCCCCCCCEECC
>Mature Secondary Structure
MNKKILKSVLALTLTASMLSPLNVLADKEHRIAGQSRFDTAIELAKLTKSDTAVVMNYQK
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCCEEEEEHHH
FPDAITATKVANANSPIYFTAKDRMDSKTLYTILNNHKKVVIVGGKNAVSKTVENQLLSL
CCCHHHHHEECCCCCCEEEEECCCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHEE
NVERVEGNDRYETNAKGLTNTEKLIIVSGEQFADALVTSSISKKLCSDVALTQKDNVPNG
EEEEECCCCCEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
LKNYLKNNKNLKEIFIVGGKASVSPKVEKELKAYTKANINRISGYDRYETSERLADIIKN
HHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHCC
SKYTIVNGEQFADNLLASPFSQRENRSIILTKRAKHSKYVMNVFENKDYVVVGGKTQVEI
CCEEEECCHHHHHHHHHCCHHHCCCCEEEEEECCCCHHHHHHHHCCCCEEEECCCEEEEC
PTFAKPEENKPSDGDTTKPSEQKPEEKPVDPKPEDKPADKPEDKKPEEKPTEPEKPSEKP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
EEKPVEDKLLDVDSPELSAKEKELIKLVNDYREQHGKKRLKVSKSLMKVARTHVNDLNMN
CCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
FDMANPPVDSRGIKGNMHSWSDKGNWTPVVYTKDHKHDKLTKIKPKEIAGYDQTGYEVAV
EECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHCCCCCCCCEEEE
NGFLITPQRALEKWKNSPGHNDTILSQNGWDPTPEEIDRSFTPLSNMGVAINGDYACIWF
CCEEECCHHHHHHHCCCCCCCCEEECCCCCCCCHHHHCCCCCCHHHCCEEEECCEEEEEE
TRDDYGIVDPMGYFEFN
ECCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]