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The map label for this gene is argH [H]

Identifier: 167625994

GI number: 167625994

Start: 4976271

End: 4977638

Strand: Reverse

Name: argH [H]

Synonym: Shal_4089

Alternate gene names: 167625994

Gene position: 4977638-4976271 (Counterclockwise)

Preceding gene: 167625995

Following gene: 167625992

Centisome position: 95.23

GC content: 47.81

Gene sequence:

>1368_bases
ATGGCATTATGGGGCGGCAGATTTAGCCAAGAGAGCAGTGCACTGTTTAAACTATTCAATGACTCTTTACCTGTGGACTT
TCGTCTCATTGAGCAAGATATTGTGGGCTCGATTGCTTGGGCGAGTGCGATCACTCAGGTGGGAATTTTAACCGAGCAAG
AGTGCAAAGATCTGCATCATGCATTGAATGAGTTGCTCGCGGAAACGATCGATAATCCACAGCTGATCATCGCATCAGGC
GCCGAAGACATACACAGCTTCGTCGAGCAGTCGCTGATCGCCAAGGTTGGGGATTTAGGCAAAAAATTACACACGGGTCG
TTCTCGCAACGATCAAGTCGCCACGGATCTTAAGCTTTGGTGTAAGAAAGAGGGCGAGCAGTTATTAGGTTTACTGGCTA
ATTTAAGAGCGGCTCTGATTGAGCTTGCCGAGCGTGAACTCGATGCGGTTATGCCGGGCTATACCCACCTGCAAAGAGCG
CAGCCAGTGGTGTTTGGTCATTGGTGCCTTGCTTATGTCGAGATGTTTGAGCGTGACATTAGCCGTCTGCAAGACGCGTT
AAAGCGCGCCGATACCTGCCCGTTAGGCACCGGGGCCTTAGCGGGTACGGCGTACCCTATGGATAGAGTCAAGCTGGCAA
AATCCTTAGGTTTTGCATCACCAACGTTAAACAGTTTAGACACGGTATCGGACAGAGACCATGTTATTGAGATCTGCAGC
GATGCTTCTATTAGCATGATGCACCTAAGCCGTATGGCAGAAGACTTAATTTTCTTTAATAGTGGTGAGGCGGGCTTTAT
CGATCTCGATGATGAAGTGACCTCAGGCTCTTCATTGATGCCACAAAAGAAAAACCCAGATGCGCTCGAGTTGATCAGAG
GCAAAACGGGTCGTGTATACGGTAGCTTAATGGGCATTTTAACCACCATGAAGGCACTGCCACTTGCGTATAACAAAGAT
ATGCAAGAGGACAAAGAAGGTCTATTCGATGTGATGGATAGCTGGTCAATTTGTCTCGAAATGGCAGCGTTAGTCTTAAG
TGGTTTAAAAGTAAATCGTGAGAAAACGCTGAGTGCAGCCAAGCAAGGTTACGCTAATTCGACAGAGCTGGCGGATTACC
TTGTGGCTAAGGGGATGCCTTTTAGAGAGGCGCATCATGTCGTAGGCGAAGCGGTTGTTAGTGCGATTGCTAAGCAAACT
CCGTTAGAAGACTTAACTCTAGAAGAGCTACAAGCATTCAGCGCTGTGATTGATGCAGATGTATATGATTGCCTCACTAT
TGAGTCTTGCTTAGCAAAACGTGAGGCGCTAGGTGGTACATCATTACCGCAGGTAAAGAGTGCGCTGGCAGTAAAACAAG
CGAGTTAG

Upstream 100 bases:

>100_bases
AGCTGAAGTTAGTGAACGCTAACATAATAGCGTTAGCGCTGTATAAACAGAAAGATAAAAGGTGGGAGTTATCCCACCTA
GCATTAGAGAGGAAGTCAAA

Downstream 100 bases:

>100_bases
CGAATACAGGCAGAGTAAAATGTCATTGTGGCTAGTTGGAATATACGCCTAAGCAATAGTATTTATTTTTAAGTGATGAA
TATAAAAAATGCGGTTATTG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MALWGGRFSQESSALFKLFNDSLPVDFRLIEQDIVGSIAWASAITQVGILTEQECKDLHHALNELLAETIDNPQLIIASG
AEDIHSFVEQSLIAKVGDLGKKLHTGRSRNDQVATDLKLWCKKEGEQLLGLLANLRAALIELAERELDAVMPGYTHLQRA
QPVVFGHWCLAYVEMFERDISRLQDALKRADTCPLGTGALAGTAYPMDRVKLAKSLGFASPTLNSLDTVSDRDHVIEICS
DASISMMHLSRMAEDLIFFNSGEAGFIDLDDEVTSGSSLMPQKKNPDALELIRGKTGRVYGSLMGILTTMKALPLAYNKD
MQEDKEGLFDVMDSWSICLEMAALVLSGLKVNREKTLSAAKQGYANSTELADYLVAKGMPFREAHHVVGEAVVSAIAKQT
PLEDLTLEELQAFSAVIDADVYDCLTIESCLAKREALGGTSLPQVKSALAVKQAS

Sequences:

>Translated_455_residues
MALWGGRFSQESSALFKLFNDSLPVDFRLIEQDIVGSIAWASAITQVGILTEQECKDLHHALNELLAETIDNPQLIIASG
AEDIHSFVEQSLIAKVGDLGKKLHTGRSRNDQVATDLKLWCKKEGEQLLGLLANLRAALIELAERELDAVMPGYTHLQRA
QPVVFGHWCLAYVEMFERDISRLQDALKRADTCPLGTGALAGTAYPMDRVKLAKSLGFASPTLNSLDTVSDRDHVIEICS
DASISMMHLSRMAEDLIFFNSGEAGFIDLDDEVTSGSSLMPQKKNPDALELIRGKTGRVYGSLMGILTTMKALPLAYNKD
MQEDKEGLFDVMDSWSICLEMAALVLSGLKVNREKTLSAAKQGYANSTELADYLVAKGMPFREAHHVVGEAVVSAIAKQT
PLEDLTLEELQAFSAVIDADVYDCLTIESCLAKREALGGTSLPQVKSALAVKQAS
>Mature_454_residues
ALWGGRFSQESSALFKLFNDSLPVDFRLIEQDIVGSIAWASAITQVGILTEQECKDLHHALNELLAETIDNPQLIIASGA
EDIHSFVEQSLIAKVGDLGKKLHTGRSRNDQVATDLKLWCKKEGEQLLGLLANLRAALIELAERELDAVMPGYTHLQRAQ
PVVFGHWCLAYVEMFERDISRLQDALKRADTCPLGTGALAGTAYPMDRVKLAKSLGFASPTLNSLDTVSDRDHVIEICSD
ASISMMHLSRMAEDLIFFNSGEAGFIDLDDEVTSGSSLMPQKKNPDALELIRGKTGRVYGSLMGILTTMKALPLAYNKDM
QEDKEGLFDVMDSWSICLEMAALVLSGLKVNREKTLSAAKQGYANSTELADYLVAKGMPFREAHHVVGEAVVSAIAKQTP
LEDLTLEELQAFSAVIDADVYDCLTIESCLAKREALGGTSLPQVKSALAVKQAS

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=459, Percent_Identity=44.2265795206972, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI68303542, Length=459, Percent_Identity=44.2265795206972, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI68303549, Length=459, Percent_Identity=42.2657952069717, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI68303547, Length=459, Percent_Identity=41.8300653594771, Blast_Score=333, Evalue=2e-91,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=68.2819383259912, Blast_Score=629, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321806, Length=442, Percent_Identity=45.0226244343891, Blast_Score=379, Evalue=1e-106,
Organism=Drosophila melanogaster, GI221473854, Length=439, Percent_Identity=42.369020501139, Blast_Score=344, Evalue=8e-95,
Organism=Drosophila melanogaster, GI78706858, Length=439, Percent_Identity=42.369020501139, Blast_Score=344, Evalue=8e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 49621; Mature: 49490

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALWGGRFSQESSALFKLFNDSLPVDFRLIEQDIVGSIAWASAITQVGILTEQECKDLHH
CCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ALNELLAETIDNPQLIIASGAEDIHSFVEQSLIAKVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CKKEGEQLLGLLANLRAALIELAERELDAVMPGYTHLQRAQPVVFGHWCLAYVEMFERDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
SRLQDALKRADTCPLGTGALAGTAYPMDRVKLAKSLGFASPTLNSLDTVSDRDHVIEICS
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHC
DASISMMHLSRMAEDLIFFNSGEAGFIDLDDEVTSGSSLMPQKKNPDALELIRGKTGRVY
CCCHHHHHHHHHHHHHEEECCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHH
GSLMGILTTMKALPLAYNKDMQEDKEGLFDVMDSWSICLEMAALVLSGLKVNREKTLSAA
HHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KQGYANSTELADYLVAKGMPFREAHHVVGEAVVSAIAKQTPLEDLTLEELQAFSAVIDAD
HHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
VYDCLTIESCLAKREALGGTSLPQVKSALAVKQAS
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
ALWGGRFSQESSALFKLFNDSLPVDFRLIEQDIVGSIAWASAITQVGILTEQECKDLHH
CCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ALNELLAETIDNPQLIIASGAEDIHSFVEQSLIAKVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CKKEGEQLLGLLANLRAALIELAERELDAVMPGYTHLQRAQPVVFGHWCLAYVEMFERDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
SRLQDALKRADTCPLGTGALAGTAYPMDRVKLAKSLGFASPTLNSLDTVSDRDHVIEICS
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHC
DASISMMHLSRMAEDLIFFNSGEAGFIDLDDEVTSGSSLMPQKKNPDALELIRGKTGRVY
CCCHHHHHHHHHHHHHEEECCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHH
GSLMGILTTMKALPLAYNKDMQEDKEGLFDVMDSWSICLEMAALVLSGLKVNREKTLSAA
HHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KQGYANSTELADYLVAKGMPFREAHHVVGEAVVSAIAKQTPLEDLTLEELQAFSAVIDAD
HHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
VYDCLTIESCLAKREALGGTSLPQVKSALAVKQAS
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA