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The map label for this gene is qacE [H]

Identifier: 167625936

GI number: 167625936

Start: 4912253

End: 4912579

Strand: Reverse

Name: qacE [H]

Synonym: Shal_4031

Alternate gene names: 167625936

Gene position: 4912579-4912253 (Counterclockwise)

Preceding gene: 167625937

Following gene: 167625935

Centisome position: 93.99

GC content: 50.46

Gene sequence:

>327_bases
ATGAGTTGGATTTTTCTTTTACTGGGTGTGGTGGCAGAAGCTTTGTCTCATGTGGCGCTGAAGGCAACCGATGGTTTCAG
TAAGCCGCTACCCGCGGCGCTGGTTTTACTGGGTCACTTGACTGCATTTGTTTTCCTAGGTCAGGCAATGAAAGGAATGC
CGGTTGGTGTGGTGCATGCTTTATGGGCAGGCTTGGCTATCGTGACTGTAACCTTGTTATCGGCGCTGTTTTACCGTCAG
CATCTAGATATGACTGCTTGGGTTGGCATGGCGTTGGTGGCCGCTGGTGTGATGATGATTAACTTCTCCCAAGGACACGC
TCATTAG

Upstream 100 bases:

>100_bases
TTTGTAATTTGTGCTAATTATCATTCAATTTCAAAGGAATATAATAAGCGCATTAAATAACAATAGGCATCAGCCTGACA
AACATAAGTAGGGCGTTAGC

Downstream 100 bases:

>100_bases
GTCGATAAGAGCGAATTTTATTCGCATCATTGGGCTAATGGTTTTACTCTAAAATCGCTTGGTTGTTTTTTGCGCATTCG
TTAATAAGTGCTACAGTAGA

Product: small multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant E [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSWIFLLLGVVAEALSHVALKATDGFSKPLPAALVLLGHLTAFVFLGQAMKGMPVGVVHALWAGLAIVTVTLLSALFYRQ
HLDMTAWVGMALVAAGVMMINFSQGHAH

Sequences:

>Translated_108_residues
MSWIFLLLGVVAEALSHVALKATDGFSKPLPAALVLLGHLTAFVFLGQAMKGMPVGVVHALWAGLAIVTVTLLSALFYRQ
HLDMTAWVGMALVAAGVMMINFSQGHAH
>Mature_107_residues
SWIFLLLGVVAEALSHVALKATDGFSKPLPAALVLLGHLTAFVFLGQAMKGMPVGVVHALWAGLAIVTVTLLSALFYRQH
LDMTAWVGMALVAAGVMMINFSQGHAH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=107, Percent_Identity=33.6448598130841, Blast_Score=73, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11439; Mature: 11308

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWIFLLLGVVAEALSHVALKATDGFSKPLPAALVLLGHLTAFVFLGQAMKGMPVGVVHA
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LWAGLAIVTVTLLSALFYRQHLDMTAWVGMALVAAGVMMINFSQGHAH
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SWIFLLLGVVAEALSHVALKATDGFSKPLPAALVLLGHLTAFVFLGQAMKGMPVGVVHA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LWAGLAIVTVTLLSALFYRQHLDMTAWVGMALVAAGVMMINFSQGHAH
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8494372 [H]