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The map label for this gene is gppA [H]

Identifier: 167625796

GI number: 167625796

Start: 4723639

End: 4724550

Strand: Reverse

Name: gppA [H]

Synonym: Shal_3891

Alternate gene names: 167625796

Gene position: 4724550-4723639 (Counterclockwise)

Preceding gene: 167625797

Following gene: 167625795

Centisome position: 90.39

GC content: 43.86

Gene sequence:

>912_bases
ATGACAACACCTCTTTATGCAGCCATTACGTTAGGCTCAAATAGTTTTAATATGTTGGTTGCTCAAACAGCGGTTCAACA
GCCTAAAGTTATTGCGAAGTACAAACGTAAAGTCCGCTTGGCCGAAGGCATTCAAGCCGATGGTTCGCTGAGTGAAGAGG
TGTTATTACGGGGGTTAGACTGTTTGGCGATGTTTGCCAATATGCTAGAAAAAGAAGGGGTTTCTTTCGAAAATGTTGCA
GTCATCGCAACGGCAACATTAAGAAGTATCTCTAACTCGGATGACTTCTGTCGTCGAGCCTTACCCATATTGGGGCACCC
AATCGAGATTATCTCAGGCATGCGCGAAGCAGAGCTGATTTATCAAGGTATGGTGGCGACAACTGCAGGCGAAGGGCGTC
GGCTTGTTATCGATATTGGTGGTGCTAGTACCGAGTTTATTATCGGTGATGGCAACAATGTTCTACTAAAAACCAGCTTG
CCCATGGGCTGCGTCACTTTTAATGAGGCATTTTTTAGCAGCTTTCCACTTCAACACTTAGATTTTGACGATGCTAAAGC
TAAGGTGAAAGAAATACTGGGTCAACACTTAACCGAGCTTAAAACCTTAGGTTGGCATTGTGTTGTTGGAGCTTCTGGTA
GTGTGCAGTCAGTTGTGGAACTACTAAATCATCGCAATCAGTCTTCTACTATTACCCTAGATGTTTTACTGAGTTTAAAA
CAAGAAGTCTTAGCGCAAAAGAACCCATCTATGCTCGCAATTTTCGGCTTGAATCATGAAAGGGCGCCTACATTTTGCGC
CGGAGTGTCGATTCTTCTCGCTCTATTTGAGCTACTTGAAATTGAAAAGTTATCTCTTTCTGGTGGCGCCCTGCGTGAAG
GAGTATTGCAGACATTAGCGAGTAACCTTTAA

Upstream 100 bases:

>100_bases
AATACCCGAGACCGTGGTGCAAGTCGTCCACAAGGTGGTCAGCGCAGTGGCCCGCGTCGTCACGACAGAACGCGTAGACA
TTCATAGGCGATAACGCTTA

Downstream 100 bases:

>100_bases
CTTATTAATATCATTTTTACTTTATATTCAACTCTTAATATCTCTTTCTATTATTTATATTCAATTCTATTGTGCCGTAT
TCGAGTGTCAATTAACTCAA

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTTPLYAAITLGSNSFNMLVAQTAVQQPKVIAKYKRKVRLAEGIQADGSLSEEVLLRGLDCLAMFANMLEKEGVSFENVA
VIATATLRSISNSDDFCRRALPILGHPIEIISGMREAELIYQGMVATTAGEGRRLVIDIGGASTEFIIGDGNNVLLKTSL
PMGCVTFNEAFFSSFPLQHLDFDDAKAKVKEILGQHLTELKTLGWHCVVGASGSVQSVVELLNHRNQSSTITLDVLLSLK
QEVLAQKNPSMLAIFGLNHERAPTFCAGVSILLALFELLEIEKLSLSGGALREGVLQTLASNL

Sequences:

>Translated_303_residues
MTTPLYAAITLGSNSFNMLVAQTAVQQPKVIAKYKRKVRLAEGIQADGSLSEEVLLRGLDCLAMFANMLEKEGVSFENVA
VIATATLRSISNSDDFCRRALPILGHPIEIISGMREAELIYQGMVATTAGEGRRLVIDIGGASTEFIIGDGNNVLLKTSL
PMGCVTFNEAFFSSFPLQHLDFDDAKAKVKEILGQHLTELKTLGWHCVVGASGSVQSVVELLNHRNQSSTITLDVLLSLK
QEVLAQKNPSMLAIFGLNHERAPTFCAGVSILLALFELLEIEKLSLSGGALREGVLQTLASNL
>Mature_302_residues
TTPLYAAITLGSNSFNMLVAQTAVQQPKVIAKYKRKVRLAEGIQADGSLSEEVLLRGLDCLAMFANMLEKEGVSFENVAV
IATATLRSISNSDDFCRRALPILGHPIEIISGMREAELIYQGMVATTAGEGRRLVIDIGGASTEFIIGDGNNVLLKTSLP
MGCVTFNEAFFSSFPLQHLDFDDAKAKVKEILGQHLTELKTLGWHCVVGASGSVQSVVELLNHRNQSSTITLDVLLSLKQ
EVLAQKNPSMLAIFGLNHERAPTFCAGVSILLALFELLEIEKLSLSGGALREGVLQTLASNL

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=295, Percent_Identity=44.4067796610169, Blast_Score=234, Evalue=5e-63,
Organism=Escherichia coli, GI1788848, Length=292, Percent_Identity=40.4109589041096, Blast_Score=213, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 32674; Mature: 32543

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPLYAAITLGSNSFNMLVAQTAVQQPKVIAKYKRKVRLAEGIQADGSLSEEVLLRGLD
CCCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CLAMFANMLEKEGVSFENVAVIATATLRSISNSDDFCRRALPILGHPIEIISGMREAELI
HHHHHHHHHHHCCCCCCCEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCHHHHHH
YQGMVATTAGEGRRLVIDIGGASTEFIIGDGNNVLLKTSLPMGCVTFNEAFFSSFPLQHL
HHHHHHEECCCCCEEEEEECCCCEEEEEECCCCEEEEECCCCCEEEHHHHHHHCCCCCCC
DFDDAKAKVKEILGQHLTELKTLGWHCVVGASGSVQSVVELLNHRNQSSTITLDVLLSLK
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCCCCEEHHHHHHHHH
QEVLAQKNPSMLAIFGLNHERAPTFCAGVSILLALFELLEIEKLSLSGGALREGVLQTLA
HHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
SNL
HCC
>Mature Secondary Structure 
TTPLYAAITLGSNSFNMLVAQTAVQQPKVIAKYKRKVRLAEGIQADGSLSEEVLLRGLD
CCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CLAMFANMLEKEGVSFENVAVIATATLRSISNSDDFCRRALPILGHPIEIISGMREAELI
HHHHHHHHHHHCCCCCCCEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCHHHHHH
YQGMVATTAGEGRRLVIDIGGASTEFIIGDGNNVLLKTSLPMGCVTFNEAFFSSFPLQHL
HHHHHHEECCCCCEEEEEECCCCEEEEEECCCCEEEEECCCCCEEEHHHHHHHCCCCCCC
DFDDAKAKVKEILGQHLTELKTLGWHCVVGASGSVQSVVELLNHRNQSSTITLDVLLSLK
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCCCCEEHHHHHHHHH
QEVLAQKNPSMLAIFGLNHERAPTFCAGVSILLALFELLEIEKLSLSGGALREGVLQTLA
HHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
SNL
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA