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The map label for this gene is csrD [H]

Identifier: 167625763

GI number: 167625763

Start: 4679031

End: 4680938

Strand: Reverse

Name: csrD [H]

Synonym: Shal_3858

Alternate gene names: 167625763

Gene position: 4680938-4679031 (Counterclockwise)

Preceding gene: 167625764

Following gene: 167625762

Centisome position: 89.55

GC content: 43.34

Gene sequence:

>1908_bases
ATGAAACTGACTCGAATTCTGACTAAAAAATTGACTAGCTTTTGGCTTATGTCACTCGCAGGTGTCGCATTCATCTGCTT
TTTGACCGCTATGGTCAGCTTTTTTCAACTTACCTATACCTTTCAGCAACAAAAAGTCACTGAATTAGAAAACCTTATTG
AGCAGCAGCTTTCGCAACAAAGTAGTGGCCAGCTTGACGCTTGGTTACCGCCATTGCTTAAAGGATATCGAGCTCATTCT
TTTACGTTATCTAAAGGTAATCAATCTCTTTTTGAGTATCAGTCTCCGGTTCCTCAGGGAAGTGGCGTTAATTATAAGAG
TCAACTTGCTGGTGGAAAGTTATTGATGACGCTGACTTTACCGCAACCTTTTAGTCAGGGGGATATTGGTTGGCATGAGG
TCTTGATTATCATAATTGGTTGCGCCGCCGTATTCTTGTTTGTCCGTTTCGGTTTTCGTTGGTTCTCGATGCATCTTGAG
GGCATCGAGCACTTAGCACAACGCTCAAGCCTTATCCTATCGGGTAAGTATGATAAGGCGTTGGCAGAAAAGGGGCATGG
CAAACCTAGGTTAATCAACCGTGCGCTAACCCATCTGTTGCTAGAGCTAGATGATGCCCATAAAGAGCGTGCTCGTTTCG
ATCAATTTATTCGCTCGAATACATTTCTAGACGCAGGTACAGGGATAGGCAATCGACTGTTTTTGAAAAACCGACTCGAT
GCTCTCAGTAACCATTTAGGCATGATGACGCCGGGTGTGCTGTATCTATTTGAAATGGAAGATTTGGATTTATTCAGTAA
AGAGCTTACTGAGCAAGAAGTTGATGAGCTGTTATCACAGCTGATAAGTACCATAAATCAAATCCTGGCCAACAAGGCAA
ACTGTATATTTTCGAGGCGATCATATAATCAGTTTGCGGTAGTGGTGCCACAAATTTCACAACTAGAAGCGGACCAACTT
GCCGCTAAGTTACTGCGTTTAAGCCTTAATCAGATTAATACCTTGGTTCAGCTGCCTGATGACTTTATGCATTTAGGCGG
GGCATATTTTAAAGTTGGTGATGATAAAGATGCATTAGTTGAAGAAGCTGAACTCGCGTTGCGTTCAGCTCAGTTCCAAG
GGGGAAGTAGCTGGTTTATGTATGATAAGGGCTCTGTTGATGGTGAACTGTCAAAAGGCTCTGTGCGTTGGCGAAGTTTT
CTTGAGAATGTGTTGGTTAGCAAAAGAGTATTCCTTTTTTCGCAGCCAGTCGTTGACAGTGACTCCCACGCTCATCACCA
AGAGGTGACCTGTCGCTTGCGAGATACGCAGGGAAACCTTGTTAGAGCAACCTTGTTTTTGCCTATGGCGATAAAGTGCG
GCCTAACACCACAGATAGAACGGCAAGTCATCGAGATGGTGATGTTTGATCTGTTGCCAAAACATAAAGATAACAGCCTA
AAATTTAGTATTAACCTGAGCTTAGATACCTTAACTAGCCGTGCCTTTGTACGCTGGTTGAAAACCACGCTACTTGAATA
TCGTCATTTAGCCCCAAGGCTTATCTTTGAGGTGAATGAAGATATTTTAGTCAACCATCAGAAACAGCTTATAGCGCCGT
TGGATATGATCAATAAAATGGGCGCGAGTATCTGTGTCGATCGTGTTGGTCAACAAGTCGTGAGTACCGAATATATTCAC
CATTATCCTATCTCGCTAATCAAACTTCATCGTTCTATTGTTAATCAAATCCATCTGCGAGCAGAGAACCAACTGTTTGT
TCGAAGCCTGATTGCAGGTCTATACCGCACCGATGTACAGGTGTGTGCAGAGGGAGTGGAAGTATTCGAAGAATGGCAAA
CATTACAGATTTTAGGCGTTAGTGCTGGCCAAGGGAGCTTCTTTAGCGAACCGATCGAAGAGGTATAG

Upstream 100 bases:

>100_bases
GTTATTAAGCTAAGGCTGGCTTTATCATTATTCTCTACTGTGGCGGTGAAGAGTATGATGATTTAGGTGTAATAAAAAAG
ATCCTGCAGGAAGCGGACTG

Downstream 100 bases:

>100_bases
TTTGTTCTGGTTTTGTTGGTGATTGTTGCGGATTATTCCTAAAATGAGGTTTTATCTATATTAATCAGGGATAACTCGCT
ACACTGATGGCATAATAAGA

Product: regulatory protein CsrD

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MKLTRILTKKLTSFWLMSLAGVAFICFLTAMVSFFQLTYTFQQQKVTELENLIEQQLSQQSSGQLDAWLPPLLKGYRAHS
FTLSKGNQSLFEYQSPVPQGSGVNYKSQLAGGKLLMTLTLPQPFSQGDIGWHEVLIIIIGCAAVFLFVRFGFRWFSMHLE
GIEHLAQRSSLILSGKYDKALAEKGHGKPRLINRALTHLLLELDDAHKERARFDQFIRSNTFLDAGTGIGNRLFLKNRLD
ALSNHLGMMTPGVLYLFEMEDLDLFSKELTEQEVDELLSQLISTINQILANKANCIFSRRSYNQFAVVVPQISQLEADQL
AAKLLRLSLNQINTLVQLPDDFMHLGGAYFKVGDDKDALVEEAELALRSAQFQGGSSWFMYDKGSVDGELSKGSVRWRSF
LENVLVSKRVFLFSQPVVDSDSHAHHQEVTCRLRDTQGNLVRATLFLPMAIKCGLTPQIERQVIEMVMFDLLPKHKDNSL
KFSINLSLDTLTSRAFVRWLKTTLLEYRHLAPRLIFEVNEDILVNHQKQLIAPLDMINKMGASICVDRVGQQVVSTEYIH
HYPISLIKLHRSIVNQIHLRAENQLFVRSLIAGLYRTDVQVCAEGVEVFEEWQTLQILGVSAGQGSFFSEPIEEV

Sequences:

>Translated_635_residues
MKLTRILTKKLTSFWLMSLAGVAFICFLTAMVSFFQLTYTFQQQKVTELENLIEQQLSQQSSGQLDAWLPPLLKGYRAHS
FTLSKGNQSLFEYQSPVPQGSGVNYKSQLAGGKLLMTLTLPQPFSQGDIGWHEVLIIIIGCAAVFLFVRFGFRWFSMHLE
GIEHLAQRSSLILSGKYDKALAEKGHGKPRLINRALTHLLLELDDAHKERARFDQFIRSNTFLDAGTGIGNRLFLKNRLD
ALSNHLGMMTPGVLYLFEMEDLDLFSKELTEQEVDELLSQLISTINQILANKANCIFSRRSYNQFAVVVPQISQLEADQL
AAKLLRLSLNQINTLVQLPDDFMHLGGAYFKVGDDKDALVEEAELALRSAQFQGGSSWFMYDKGSVDGELSKGSVRWRSF
LENVLVSKRVFLFSQPVVDSDSHAHHQEVTCRLRDTQGNLVRATLFLPMAIKCGLTPQIERQVIEMVMFDLLPKHKDNSL
KFSINLSLDTLTSRAFVRWLKTTLLEYRHLAPRLIFEVNEDILVNHQKQLIAPLDMINKMGASICVDRVGQQVVSTEYIH
HYPISLIKLHRSIVNQIHLRAENQLFVRSLIAGLYRTDVQVCAEGVEVFEEWQTLQILGVSAGQGSFFSEPIEEV
>Mature_635_residues
MKLTRILTKKLTSFWLMSLAGVAFICFLTAMVSFFQLTYTFQQQKVTELENLIEQQLSQQSSGQLDAWLPPLLKGYRAHS
FTLSKGNQSLFEYQSPVPQGSGVNYKSQLAGGKLLMTLTLPQPFSQGDIGWHEVLIIIIGCAAVFLFVRFGFRWFSMHLE
GIEHLAQRSSLILSGKYDKALAEKGHGKPRLINRALTHLLLELDDAHKERARFDQFIRSNTFLDAGTGIGNRLFLKNRLD
ALSNHLGMMTPGVLYLFEMEDLDLFSKELTEQEVDELLSQLISTINQILANKANCIFSRRSYNQFAVVVPQISQLEADQL
AAKLLRLSLNQINTLVQLPDDFMHLGGAYFKVGDDKDALVEEAELALRSAQFQGGSSWFMYDKGSVDGELSKGSVRWRSF
LENVLVSKRVFLFSQPVVDSDSHAHHQEVTCRLRDTQGNLVRATLFLPMAIKCGLTPQIERQVIEMVMFDLLPKHKDNSL
KFSINLSLDTLTSRAFVRWLKTTLLEYRHLAPRLIFEVNEDILVNHQKQLIAPLDMINKMGASICVDRVGQQVVSTEYIH
HYPISLIKLHRSIVNQIHLRAENQLFVRSLIAGLYRTDVQVCAEGVEVFEEWQTLQILGVSAGQGSFFSEPIEEV

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=500, Percent_Identity=31.2, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1787541, Length=438, Percent_Identity=24.6575342465753, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI87081921, Length=452, Percent_Identity=22.5663716814159, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1788849, Length=241, Percent_Identity=26.5560165975104, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1790496, Length=237, Percent_Identity=27.8481012658228, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081845, Length=230, Percent_Identity=23.9130434782609, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 71973; Mature: 71973

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTRILTKKLTSFWLMSLAGVAFICFLTAMVSFFQLTYTFQQQKVTELENLIEQQLSQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSGQLDAWLPPLLKGYRAHSFTLSKGNQSLFEYQSPVPQGSGVNYKSQLAGGKLLMTLTL
CCCCCHHCCHHHHHCCCCCEEEECCCCHHHHHHCCCCCCCCCCCHHHHCCCCEEEEEEEC
PQPFSQGDIGWHEVLIIIIGCAAVFLFVRFGFRWFSMHLEGIEHLAQRSSLILSGKYDKA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHH
LAEKGHGKPRLINRALTHLLLELDDAHKERARFDQFIRSNTFLDAGTGIGNRLFLKNRLD
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHH
ALSNHLGMMTPGVLYLFEMEDLDLFSKELTEQEVDELLSQLISTINQILANKANCIFSRR
HHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECC
SYNQFAVVVPQISQLEADQLAAKLLRLSLNQINTLVQLPDDFMHLGGAYFKVGDDKDALV
CCCCEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECCCHHHHH
EEAELALRSAQFQGGSSWFMYDKGSVDGELSKGSVRWRSFLENVLVSKRVFLFSQPVVDS
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCC
DSHAHHQEVTCRLRDTQGNLVRATLFLPMAIKCGLTPQIERQVIEMVMFDLLPKHKDNSL
CCCCCCHHEEEEEECCCCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCE
KFSINLSLDTLTSRAFVRWLKTTLLEYRHLAPRLIFEVNEDILVNHQKQLIAPLDMINKM
EEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHCCHHHHHHHHHHHHHH
GASICVDRVGQQVVSTEYIHHYPISLIKLHRSIVNQIHLRAENQLFVRSLIAGLYRTDVQ
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VCAEGVEVFEEWQTLQILGVSAGQGSFFSEPIEEV
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHCC
>Mature Secondary Structure
MKLTRILTKKLTSFWLMSLAGVAFICFLTAMVSFFQLTYTFQQQKVTELENLIEQQLSQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSGQLDAWLPPLLKGYRAHSFTLSKGNQSLFEYQSPVPQGSGVNYKSQLAGGKLLMTLTL
CCCCCHHCCHHHHHCCCCCEEEECCCCHHHHHHCCCCCCCCCCCHHHHCCCCEEEEEEEC
PQPFSQGDIGWHEVLIIIIGCAAVFLFVRFGFRWFSMHLEGIEHLAQRSSLILSGKYDKA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHH
LAEKGHGKPRLINRALTHLLLELDDAHKERARFDQFIRSNTFLDAGTGIGNRLFLKNRLD
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHH
ALSNHLGMMTPGVLYLFEMEDLDLFSKELTEQEVDELLSQLISTINQILANKANCIFSRR
HHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECC
SYNQFAVVVPQISQLEADQLAAKLLRLSLNQINTLVQLPDDFMHLGGAYFKVGDDKDALV
CCCCEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECCCHHHHH
EEAELALRSAQFQGGSSWFMYDKGSVDGELSKGSVRWRSFLENVLVSKRVFLFSQPVVDS
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCC
DSHAHHQEVTCRLRDTQGNLVRATLFLPMAIKCGLTPQIERQVIEMVMFDLLPKHKDNSL
CCCCCCHHEEEEEECCCCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCE
KFSINLSLDTLTSRAFVRWLKTTLLEYRHLAPRLIFEVNEDILVNHQKQLIAPLDMINKM
EEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHCCHHHHHHHHHHHHHH
GASICVDRVGQQVVSTEYIHHYPISLIKLHRSIVNQIHLRAENQLFVRSLIAGLYRTDVQ
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VCAEGVEVFEEWQTLQILGVSAGQGSFFSEPIEEV
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]