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The map label for this gene is plsC [H]

Identifier: 167625703

GI number: 167625703

Start: 4614409

End: 4615137

Strand: Reverse

Name: plsC [H]

Synonym: Shal_3798

Alternate gene names: 167625703

Gene position: 4615137-4614409 (Counterclockwise)

Preceding gene: 167625704

Following gene: 167625702

Centisome position: 88.3

GC content: 43.76

Gene sequence:

>729_bases
GTGCTGTTGATCCTTAGATGTTTGATCTTGTCTGTTATGCTGCTATTCGCCTTTGTTATCGGTGGTTTAGCTTGTATTTT
ACGTCCTCGTCATCGAGATAACGTACATATGTTCGCCAAAGTATTTTCTTGGGCTGCACCCGTGCTTGGCATTAAAGTCA
TTGTGCGGAACTCGCAGCAGCAAGGCGATAAGCCGTGCATTTTCCTTGCAAACCACCAGAATAACTTCGATATGTTCACC
CATACGGCCGTTGTACCAAAAGGCACGGTGAGTTTAGGCAAGAAGAGTCTTGCTTGGATGCCGCTATTTGGACAAATTTA
CTGGTTGTCTGGCAATATTCTTATTGATCGCAAAAATCGTAGCAAAGCATTCGATACCATGGCAGCCACGGCTCGCAAGA
TAAAAGACAAGTGTTTGTCTGTGTGGATCTTCCCTGAAGGTACGCGATCTCGTGGTAAAGGCTTACTGCCATTTAAAGCT
GGCGCTTTTTATACCGCGATTGCGGCGGGTGTGCCTATGGTACCGGTATTGGCCTCAAATCAGTGTCATATCAAGTTAAA
CCGTTGGAACAATGGTGTGGTGATTATCGAAATGATGGATCCAATTGAAACGACAGGTTTTGATAAGACGCAGGTTAAAG
AACTTTCTAAGCGCATTCATACTATGATGTCTGAAAAGTTATCTCAGTTGAACCAAGAAGCTTCTGCATTAATGACTAAA
GCGGTATAA

Upstream 100 bases:

>100_bases
TACACGTGTAAACTAATGTTCATTGACATAAGTTGTATTTATATTGAGTCGCACTTGGTTGGTGGCTATACTGGCGCCAA
TTGATTCGCGGGAGATTATC

Downstream 100 bases:

>100_bases
TCGGTCGCGAAATTTTTGAGGAGTTATCGATGTCTATTGAACGCCAGTTAAAAGAACAGAAACAAGAAAACAGTGAGATC
GTTGAAGCGATCCTTGCAGA

Product: 1-acyl-sn-glycerol-3-phosphate acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT; Phosphatidic acid synthase; PA synthase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MLLILRCLILSVMLLFAFVIGGLACILRPRHRDNVHMFAKVFSWAAPVLGIKVIVRNSQQQGDKPCIFLANHQNNFDMFT
HTAVVPKGTVSLGKKSLAWMPLFGQIYWLSGNILIDRKNRSKAFDTMAATARKIKDKCLSVWIFPEGTRSRGKGLLPFKA
GAFYTAIAAGVPMVPVLASNQCHIKLNRWNNGVVIIEMMDPIETTGFDKTQVKELSKRIHTMMSEKLSQLNQEASALMTK
AV

Sequences:

>Translated_242_residues
MLLILRCLILSVMLLFAFVIGGLACILRPRHRDNVHMFAKVFSWAAPVLGIKVIVRNSQQQGDKPCIFLANHQNNFDMFT
HTAVVPKGTVSLGKKSLAWMPLFGQIYWLSGNILIDRKNRSKAFDTMAATARKIKDKCLSVWIFPEGTRSRGKGLLPFKA
GAFYTAIAAGVPMVPVLASNQCHIKLNRWNNGVVIIEMMDPIETTGFDKTQVKELSKRIHTMMSEKLSQLNQEASALMTK
AV
>Mature_242_residues
MLLILRCLILSVMLLFAFVIGGLACILRPRHRDNVHMFAKVFSWAAPVLGIKVIVRNSQQQGDKPCIFLANHQNNFDMFT
HTAVVPKGTVSLGKKSLAWMPLFGQIYWLSGNILIDRKNRSKAFDTMAATARKIKDKCLSVWIFPEGTRSRGKGLLPFKA
GAFYTAIAAGVPMVPVLASNQCHIKLNRWNNGVVIIEMMDPIETTGFDKTQVKELSKRIHTMMSEKLSQLNQEASALMTK
AV

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=216, Percent_Identity=31.4814814814815, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI15100175, Length=216, Percent_Identity=31.4814814814815, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI6041665, Length=229, Percent_Identity=32.3144104803493, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1789395, Length=239, Percent_Identity=46.0251046025105, Blast_Score=234, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17564032, Length=204, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17568319, Length=238, Percent_Identity=31.5126050420168, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6320151, Length=238, Percent_Identity=31.9327731092437, Blast_Score=127, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24641614, Length=194, Percent_Identity=35.0515463917526, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24641612, Length=194, Percent_Identity=35.0515463917526, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI281364648, Length=221, Percent_Identity=27.6018099547511, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24582856, Length=221, Percent_Identity=27.6018099547511, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24582854, Length=221, Percent_Identity=27.6018099547511, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 27032; Mature: 27032

Theoretical pI: Translated: 10.77; Mature: 10.77

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLILRCLILSVMLLFAFVIGGLACILRPRHRDNVHMFAKVFSWAAPVLGIKVIVRNSQQ
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCC
QGDKPCIFLANHQNNFDMFTHTAVVPKGTVSLGKKSLAWMPLFGQIYWLSGNILIDRKNR
CCCCCEEEEECCCCCCCEEEEEEECCCCCHHHCCCCEEEEECCCEEEEEECCEEEECCCC
SKAFDTMAATARKIKDKCLSVWIFPEGTRSRGKGLLPFKAGAFYTAIAAGVPMVPVLASN
CHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECC
QCHIKLNRWNNGVVIIEMMDPIETTGFDKTQVKELSKRIHTMMSEKLSQLNQEASALMTK
EEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AV
CC
>Mature Secondary Structure
MLLILRCLILSVMLLFAFVIGGLACILRPRHRDNVHMFAKVFSWAAPVLGIKVIVRNSQQ
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCC
QGDKPCIFLANHQNNFDMFTHTAVVPKGTVSLGKKSLAWMPLFGQIYWLSGNILIDRKNR
CCCCCEEEEECCCCCCCEEEEEEECCCCCHHHCCCCEEEEECCCEEEEEECCEEEECCCC
SKAFDTMAATARKIKDKCLSVWIFPEGTRSRGKGLLPFKAGAFYTAIAAGVPMVPVLASN
CHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECC
QCHIKLNRWNNGVVIIEMMDPIETTGFDKTQVKELSKRIHTMMSEKLSQLNQEASALMTK
EEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1557036; 9278503 [H]