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The map label for this gene is zraS [C]

Identifier: 167625596

GI number: 167625596

Start: 4492991

End: 4494385

Strand: Reverse

Name: zraS [C]

Synonym: Shal_3691

Alternate gene names: 167625596

Gene position: 4494385-4492991 (Counterclockwise)

Preceding gene: 167625597

Following gene: 167625595

Centisome position: 85.99

GC content: 46.02

Gene sequence:

>1395_bases
ATGCCTGTTTTTGTGACTTTCAATATCTACCTTTTTTACGGCCTCGTGTTTTTTTCGATGGGCTGCGTAGTGGTATTTCG
AAATTTTCGCTACAGTCAATTAAAAGTAGCCCCAACGCTTTGGGCGCTCGCGGTGTTTGGTTTCTCCCATGCTTTTCATG
AGTGGTCTGAGCTATATGTACTCATTTTTACAGACCATATCACCCCCCAATATCGCCTGCTGACCCAGTGGCTCTGTTTA
GCCAAGTTATTTTTATCTTATGCCGCCTTAATGGTATTTGCCTGGCAGATTTTAACCATCACCAATAAGCGTCTAGCGCA
TATCGGTCACGGTGTAATTATCACTCTGTTACTGTGCTATGCCTACCTAGTGATCCCCGATCTTCATCACCTCGCGGTTA
ATCAAACCGGTTTCGAAGAGGCCAGTCAGTTCACTCGGATATTGATAGGGTTTGGCAGCGCGATGCTAGCTGGAGTGGGA
ATGGTGGTCTACGGCAACAGCTTGCGCCAAGAAGAGCATAGCTACGGACTTTACTTTGCTCTCAGCGGTGTCGGTCTAAT
GGTTTATGGCGTGCTTTCTGGGCTAGTGCCGACAGAGTACCACTATAGCGTACCAATCTATCGAACATTGGCTGGTGGAG
TCATTTTAGTTGCTCTATTTAAGGCGCTTAAAGTATTTGATCTAGAGAAGGAGCAAAAGACTGCCGCTAAACTGAAACGT
GCTATCGAGGCAGATAAGTACAAGGCGATAGGCCAGTTAGCAATGGGAGTCGCTCATGAGATCAATAACCCTCTAGCATC
GTCCACTTTAGCGCTGGATCTGTGGGAGCGAAAACATCCTCAGCTGTCGGATTCAGAAGCAAACTACCTAAGCCGCGTTC
GCTTGGGGATTGAACGCGCATCATCGATTAGTAAAGAGCTACTCAGTTACGCAAGGCCCGCTTCGGGTAAGCGCTGTTTT
GTTGCTCTGAGAGAGGTTTTAGACTCCGGTGTGAAGTTACTGTCACACCGCACTAAGCAGTATAATATTCAGTTGGATTG
CAGTGAAAATATCGTCTTATATGCCGAGAGAATCAAACTAGAAGAGTTGTTCATCAATCTTCTGTGTAATGCTATTGATG
CATCACCGACGAATAGTTCGATTATCGTGAGTGCGACTCAGGATGAGCATAAAGTCAGTGTGTCTATAGAGGACTCTGGT
TGTGGTATGAGCCAAGTAGAGTTATCTCGCGCAACAGAATTGTTTTATTCGACTAAGGCTGTCGGTCAAGGTACGGGGCT
GGGTTTGGCGATTTGTGAACAGATAGTCACACTACATAATGGCAAGATGCATATTACGAGTAGTAAAGAGAAGGGCACTC
GTGTGGAACTCACTTTTTATCGGGAGCAGCATTGA

Upstream 100 bases:

>100_bases
TTAAATGGCTTTTTTGTTTTATGAGCTAGCGCAAGTTACAGCCTAACAAAATAGGAAGCAGATCAAATCATAGCTCGGAG
CCAGATGTTATGTTGGCGAT

Downstream 100 bases:

>100_bases
TGATCACTATTCTATTGGCGGAAGACGACGTTGAACTTAGGCTAAATATGGTTGAGATTCTAGAGCTTGAGGGTTTTAGT
GTCACCGCTGTTGAAAGCGC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MPVFVTFNIYLFYGLVFFSMGCVVVFRNFRYSQLKVAPTLWALAVFGFSHAFHEWSELYVLIFTDHITPQYRLLTQWLCL
AKLFLSYAALMVFAWQILTITNKRLAHIGHGVIITLLLCYAYLVIPDLHHLAVNQTGFEEASQFTRILIGFGSAMLAGVG
MVVYGNSLRQEEHSYGLYFALSGVGLMVYGVLSGLVPTEYHYSVPIYRTLAGGVILVALFKALKVFDLEKEQKTAAKLKR
AIEADKYKAIGQLAMGVAHEINNPLASSTLALDLWERKHPQLSDSEANYLSRVRLGIERASSISKELLSYARPASGKRCF
VALREVLDSGVKLLSHRTKQYNIQLDCSENIVLYAERIKLEELFINLLCNAIDASPTNSSIIVSATQDEHKVSVSIEDSG
CGMSQVELSRATELFYSTKAVGQGTGLGLAICEQIVTLHNGKMHITSSKEKGTRVELTFYREQH

Sequences:

>Translated_464_residues
MPVFVTFNIYLFYGLVFFSMGCVVVFRNFRYSQLKVAPTLWALAVFGFSHAFHEWSELYVLIFTDHITPQYRLLTQWLCL
AKLFLSYAALMVFAWQILTITNKRLAHIGHGVIITLLLCYAYLVIPDLHHLAVNQTGFEEASQFTRILIGFGSAMLAGVG
MVVYGNSLRQEEHSYGLYFALSGVGLMVYGVLSGLVPTEYHYSVPIYRTLAGGVILVALFKALKVFDLEKEQKTAAKLKR
AIEADKYKAIGQLAMGVAHEINNPLASSTLALDLWERKHPQLSDSEANYLSRVRLGIERASSISKELLSYARPASGKRCF
VALREVLDSGVKLLSHRTKQYNIQLDCSENIVLYAERIKLEELFINLLCNAIDASPTNSSIIVSATQDEHKVSVSIEDSG
CGMSQVELSRATELFYSTKAVGQGTGLGLAICEQIVTLHNGKMHITSSKEKGTRVELTFYREQH
>Mature_463_residues
PVFVTFNIYLFYGLVFFSMGCVVVFRNFRYSQLKVAPTLWALAVFGFSHAFHEWSELYVLIFTDHITPQYRLLTQWLCLA
KLFLSYAALMVFAWQILTITNKRLAHIGHGVIITLLLCYAYLVIPDLHHLAVNQTGFEEASQFTRILIGFGSAMLAGVGM
VVYGNSLRQEEHSYGLYFALSGVGLMVYGVLSGLVPTEYHYSVPIYRTLAGGVILVALFKALKVFDLEKEQKTAAKLKRA
IEADKYKAIGQLAMGVAHEINNPLASSTLALDLWERKHPQLSDSEANYLSRVRLGIERASSISKELLSYARPASGKRCFV
ALREVLDSGVKLLSHRTKQYNIQLDCSENIVLYAERIKLEELFINLLCNAIDASPTNSSIIVSATQDEHKVSVSIEDSGC
GMSQVELSRATELFYSTKAVGQGTGLGLAICEQIVTLHNGKMHITSSKEKGTRVELTFYREQH

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=31.7391304347826, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1788549, Length=236, Percent_Identity=29.2372881355932, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790861, Length=237, Percent_Identity=28.2700421940928, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788393, Length=131, Percent_Identity=32.824427480916, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786600, Length=210, Percent_Identity=25.7142857142857, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789149, Length=253, Percent_Identity=24.5059288537549, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790551, Length=218, Percent_Identity=27.9816513761468, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786783, Length=98, Percent_Identity=36.734693877551, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1786912, Length=325, Percent_Identity=23.0769230769231, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51851; Mature: 51720

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVFVTFNIYLFYGLVFFSMGCVVVFRNFRYSQLKVAPTLWALAVFGFSHAFHEWSELYV
CCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHEEE
LIFTDHITPQYRLLTQWLCLAKLFLSYAALMVFAWQILTITNKRLAHIGHGVIITLLLCY
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHH
AYLVIPDLHHLAVNQTGFEEASQFTRILIGFGSAMLAGVGMVVYGNSLRQEEHSYGLYFA
HHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHCCCEEEE
LSGVGLMVYGVLSGLVPTEYHYSVPIYRTLAGGVILVALFKALKVFDLEKEQKTAAKLKR
EHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AIEADKYKAIGQLAMGVAHEINNPLASSTLALDLWERKHPQLSDSEANYLSRVRLGIERA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEHHHCCCCCCCCCHHHHHHHHHHHHHHH
SSISKELLSYARPASGKRCFVALREVLDSGVKLLSHRTKQYNIQLDCSENIVLYAERIKL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEHHHHHH
EELFINLLCNAIDASPTNSSIIVSATQDEHKVSVSIEDSGCGMSQVELSRATELFYSTKA
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
VGQGTGLGLAICEQIVTLHNGKMHITSSKEKGTRVELTFYREQH
CCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
PVFVTFNIYLFYGLVFFSMGCVVVFRNFRYSQLKVAPTLWALAVFGFSHAFHEWSELYV
CEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHEEE
LIFTDHITPQYRLLTQWLCLAKLFLSYAALMVFAWQILTITNKRLAHIGHGVIITLLLCY
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHH
AYLVIPDLHHLAVNQTGFEEASQFTRILIGFGSAMLAGVGMVVYGNSLRQEEHSYGLYFA
HHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHCCCEEEE
LSGVGLMVYGVLSGLVPTEYHYSVPIYRTLAGGVILVALFKALKVFDLEKEQKTAAKLKR
EHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AIEADKYKAIGQLAMGVAHEINNPLASSTLALDLWERKHPQLSDSEANYLSRVRLGIERA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEHHHCCCCCCCCCHHHHHHHHHHHHHHH
SSISKELLSYARPASGKRCFVALREVLDSGVKLLSHRTKQYNIQLDCSENIVLYAERIKL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEHHHHHH
EELFINLLCNAIDASPTNSSIIVSATQDEHKVSVSIEDSGCGMSQVELSRATELFYSTKA
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
VGQGTGLGLAICEQIVTLHNGKMHITSSKEKGTRVELTFYREQH
CCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]