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The map label for this gene is parE [H]

Identifier: 167625558

GI number: 167625558

Start: 4452582

End: 4454477

Strand: Reverse

Name: parE [H]

Synonym: Shal_3652

Alternate gene names: 167625558

Gene position: 4454477-4452582 (Counterclockwise)

Preceding gene: 167625559

Following gene: 167625557

Centisome position: 85.22

GC content: 46.89

Gene sequence:

>1896_bases
ATGTGTGCCATGACAAACCAATACACCTCAGATGCTATTGAAGTCCTAAATGGACTCGACCCTGTAAAACGTCGCCCCGG
TATGTATACCGATACTTCGCGCCCGAACCACTTAGGACAGGAAGTCATAGATAATAGTGTCGATGAGGCATTAGCCGGGC
ACGCCAGCCGTATCGACGTTATTTTGCATGCCGATAACTCCTTAGAAGTCACCGATGACGGCCGTGGTATGCCTGTCGAT
ATTCACCCTGAAGAGGGGATCCCAGGTGTCGAGCTTATTTTAACTAAGCTGCATGCGGGCGGTAAGTTCTCCAATAAAAA
CTATCAGTTTTCAGGTGGTCTTCACGGTGTGGGGATCTCAGTTGTAAACGCGCTTTCAAGTCGTGTTGAAATAACCGTGA
GACGTAATGCCGAAGTCTATGAGATGGCTTTTGAGCACGGTGAAAAAGTTGAAGACTTACATGTAACGGGCACCTGTGGC
CGCCGTAATACGGGTACCAGCGTTCATTTCTGGCCAGACCCTAGTTACTTTGATTCTGGTAATTTCTCAATTAGTAAATT
GACCTATTTACTAAAAGCCAAAGCGGTACTTTGCCCCGGCCTGCGAATTAAATTTGTTAATAAACAAACTAATGAAACCC
AAGAGTGGTTTTATGAGAGTGGTTTAGAAGATTACTTAAAATCGTCTATCAATGGTGTGCCTACACTGCCTGAAGTACCG
TTTGTTGGTAGCTTTGCTGGCAATCTAGAGGCGGCGGATTGGGCGATTACCTGGTTGCCAGAAGGTGGCGACTATCTAAA
TGAAAGTTATGTAAACCTTATTCCAACACCGCTTGGCGGTACGCACGTAAACGGCTTTAGGCAAGGTTTGCTTGAGTCTA
TGCGTGAGTTTTGTGAGTTCAGAAATTTGATGCCGCGTGGCATTAAGTTAACGCCTGAAGATATCTGGGATCGCAGCACC
TTTATCTTATCGATTAAGATGCAAGACCCACAGTTTGCAGGCCAAACCAAAGAGAAGCTATCAAGCAGGCAGTGTGCTGC
GTTTGTATCGGGTATCGTTCGCGATGCATTTAGCCTCTGGTTAAACACCAATACTGAGCAAGCAGAAGCCTTAGCCGATA
TGTGCATTAACAATGCACAAAAGCGATTAAAAGCAGCCAAGAAAGTGGCGCGTAAGCGTATTACGTCTGGCCCAGCACTG
CCGGGTAAGCTAACAGATTGTAGCGGTCAAGACCCGATGCGAGGCGAGCTATTCTTGGTGGAGGGTGACTCTGCGGGCGG
TAGTGCCAAACAGGCTCGCGATCGCGAGTTTCAAGCGATTATGCCGCTGCGCGGTAAGATCTTAAATACATGGGAAGTCG
ATGCTTCTCAGGTACTGGCATCGCAAGAAGTACATGATATTTCGGTTGCGATTGGTTGCGACCCTGATAGTGCGGATATC
TCTGAGCTGAGATACGGTAAAATCTGTATCCTTGCCGATGCGGACTCGGATGGTCTGCATATTGCGACACTCTTATGTGC
GCTATTTATGAAGCATTACCGGGTGCTGGTGGAGCAGGGACATATTTATGTCGCTATGCCGCCGCTGTTCCGTATCGATA
TTGGTAAAGATGTGTTCTACGCCCTCGATGAGGCTGAGAAAAACGGTATTCTAGACAGAATCACCGCAGAAAAACGGAAA
GGAAAAGTCCAAGTAACACGATTCAAGGGATTGGGTGAGATGAATCCACTGCAATTACGTGAAACCACTATGGACCCAAA
TACGCGTCGATTAGTGCAATTAACCATAGATGATGCCGATGATACAATGGCTCTGATGGATATGCTTTTAGCCAAGAAAC
GCTCTGGAGACAGAAAAACTTGGTTAGAGGCTAAGGGTGATATTGCCCAGCTCTAA

Upstream 100 bases:

>100_bases
TTTATCGGCTACGAGGACCAACTTGCTTCTATCTGTGAATATCTGTTTTCTTGACAAATAGACCCGTAGGGCCGCAACAT
GGCCTGAATAACAAAAAAAT

Downstream 100 bases:

>100_bases
TCGGCAGTTTGAGATGAATGATTATAATCAGACAAAAGAATAATAATGACGTTTGAAAACTATCGAAATCAAATAGCTGT
TGGGATGTCGCTGCTTTGCG

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MCAMTNQYTSDAIEVLNGLDPVKRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHASRIDVILHADNSLEVTDDGRGMPVD
IHPEEGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSSRVEITVRRNAEVYEMAFEHGEKVEDLHVTGTCG
RRNTGTSVHFWPDPSYFDSGNFSISKLTYLLKAKAVLCPGLRIKFVNKQTNETQEWFYESGLEDYLKSSINGVPTLPEVP
FVGSFAGNLEAADWAITWLPEGGDYLNESYVNLIPTPLGGTHVNGFRQGLLESMREFCEFRNLMPRGIKLTPEDIWDRST
FILSIKMQDPQFAGQTKEKLSSRQCAAFVSGIVRDAFSLWLNTNTEQAEALADMCINNAQKRLKAAKKVARKRITSGPAL
PGKLTDCSGQDPMRGELFLVEGDSAGGSAKQARDREFQAIMPLRGKILNTWEVDASQVLASQEVHDISVAIGCDPDSADI
SELRYGKICILADADSDGLHIATLLCALFMKHYRVLVEQGHIYVAMPPLFRIDIGKDVFYALDEAEKNGILDRITAEKRK
GKVQVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDADDTMALMDMLLAKKRSGDRKTWLEAKGDIAQL

Sequences:

>Translated_631_residues
MCAMTNQYTSDAIEVLNGLDPVKRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHASRIDVILHADNSLEVTDDGRGMPVD
IHPEEGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSSRVEITVRRNAEVYEMAFEHGEKVEDLHVTGTCG
RRNTGTSVHFWPDPSYFDSGNFSISKLTYLLKAKAVLCPGLRIKFVNKQTNETQEWFYESGLEDYLKSSINGVPTLPEVP
FVGSFAGNLEAADWAITWLPEGGDYLNESYVNLIPTPLGGTHVNGFRQGLLESMREFCEFRNLMPRGIKLTPEDIWDRST
FILSIKMQDPQFAGQTKEKLSSRQCAAFVSGIVRDAFSLWLNTNTEQAEALADMCINNAQKRLKAAKKVARKRITSGPAL
PGKLTDCSGQDPMRGELFLVEGDSAGGSAKQARDREFQAIMPLRGKILNTWEVDASQVLASQEVHDISVAIGCDPDSADI
SELRYGKICILADADSDGLHIATLLCALFMKHYRVLVEQGHIYVAMPPLFRIDIGKDVFYALDEAEKNGILDRITAEKRK
GKVQVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDADDTMALMDMLLAKKRSGDRKTWLEAKGDIAQL
>Mature_631_residues
MCAMTNQYTSDAIEVLNGLDPVKRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHASRIDVILHADNSLEVTDDGRGMPVD
IHPEEGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSSRVEITVRRNAEVYEMAFEHGEKVEDLHVTGTCG
RRNTGTSVHFWPDPSYFDSGNFSISKLTYLLKAKAVLCPGLRIKFVNKQTNETQEWFYESGLEDYLKSSINGVPTLPEVP
FVGSFAGNLEAADWAITWLPEGGDYLNESYVNLIPTPLGGTHVNGFRQGLLESMREFCEFRNLMPRGIKLTPEDIWDRST
FILSIKMQDPQFAGQTKEKLSSRQCAAFVSGIVRDAFSLWLNTNTEQAEALADMCINNAQKRLKAAKKVARKRITSGPAL
PGKLTDCSGQDPMRGELFLVEGDSAGGSAKQARDREFQAIMPLRGKILNTWEVDASQVLASQEVHDISVAIGCDPDSADI
SELRYGKICILADADSDGLHIATLLCALFMKHYRVLVEQGHIYVAMPPLFRIDIGKDVFYALDEAEKNGILDRITAEKRK
GKVQVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDADDTMALMDMLLAKKRSGDRKTWLEAKGDIAQL

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=579, Percent_Identity=24.3523316062176, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI19913406, Length=617, Percent_Identity=23.5008103727715, Blast_Score=120, Evalue=4e-27,
Organism=Escherichia coli, GI1789408, Length=630, Percent_Identity=74.4444444444444, Blast_Score=1019, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=556, Percent_Identity=38.8489208633094, Blast_Score=380, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17535065, Length=643, Percent_Identity=23.7947122861586, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI212645845, Length=596, Percent_Identity=24.1610738255034, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI212645657, Length=229, Percent_Identity=26.6375545851528, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=624, Percent_Identity=23.8782051282051, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17136538, Length=591, Percent_Identity=23.1810490693739, Blast_Score=123, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 69847; Mature: 69847

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCAMTNQYTSDAIEVLNGLDPVKRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHASRIDV
CCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
ILHADNSLEVTDDGRGMPVDIHPEEGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGIS
EEECCCCEEECCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHH
VVNALSSRVEITVRRNAEVYEMAFEHGEKVEDLHVTGTCGRRNTGTSVHFWPDPSYFDSG
HHHHHCCCEEEEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCC
NFSISKLTYLLKAKAVLCPGLRIKFVNKQTNETQEWFYESGLEDYLKSSINGVPTLPEVP
CCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCC
FVGSFAGNLEAADWAITWLPEGGDYLNESYVNLIPTPLGGTHVNGFRQGLLESMREFCEF
CCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHH
RNLMPRGIKLTPEDIWDRSTFILSIKMQDPQFAGQTKEKLSSRQCAAFVSGIVRDAFSLW
HHCCCCCCEECHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LNTNTEQAEALADMCINNAQKRLKAAKKVARKRITSGPALPGKLTDCSGQDPMRGELFLV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEE
EGDSAGGSAKQARDREFQAIMPLRGKILNTWEVDASQVLASQEVHDISVAIGCDPDSADI
ECCCCCCCHHHHHCCHHHEECCCCCCEEEEECCCHHHHHHHCCCEEEEEEEECCCCCCCH
SELRYGKICILADADSDGLHIATLLCALFMKHYRVLVEQGHIYVAMPPLFRIDIGKDVFY
HHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCHHHH
ALDEAEKNGILDRITAEKRKGKVQVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDAD
HHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCEEEEEEEECCCC
DTMALMDMLLAKKRSGDRKTWLEAKGDIAQL
HHHHHHHHHHHHHCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure
MCAMTNQYTSDAIEVLNGLDPVKRRPGMYTDTSRPNHLGQEVIDNSVDEALAGHASRIDV
CCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
ILHADNSLEVTDDGRGMPVDIHPEEGIPGVELILTKLHAGGKFSNKNYQFSGGLHGVGIS
EEECCCCEEECCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHH
VVNALSSRVEITVRRNAEVYEMAFEHGEKVEDLHVTGTCGRRNTGTSVHFWPDPSYFDSG
HHHHHCCCEEEEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCC
NFSISKLTYLLKAKAVLCPGLRIKFVNKQTNETQEWFYESGLEDYLKSSINGVPTLPEVP
CCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCC
FVGSFAGNLEAADWAITWLPEGGDYLNESYVNLIPTPLGGTHVNGFRQGLLESMREFCEF
CCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHH
RNLMPRGIKLTPEDIWDRSTFILSIKMQDPQFAGQTKEKLSSRQCAAFVSGIVRDAFSLW
HHCCCCCCEECHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LNTNTEQAEALADMCINNAQKRLKAAKKVARKRITSGPALPGKLTDCSGQDPMRGELFLV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEE
EGDSAGGSAKQARDREFQAIMPLRGKILNTWEVDASQVLASQEVHDISVAIGCDPDSADI
ECCCCCCCHHHHHCCHHHEECCCCCCEEEEECCCHHHHHHHCCCEEEEEEEECCCCCCCH
SELRYGKICILADADSDGLHIATLLCALFMKHYRVLVEQGHIYVAMPPLFRIDIGKDVFY
HHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCHHHH
ALDEAEKNGILDRITAEKRKGKVQVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDAD
HHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCEEEEEEEECCCC
DTMALMDMLLAKKRSGDRKTWLEAKGDIAQL
HHHHHHHHHHHHHCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]