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The map label for this gene is parC [H]

Identifier: 167625556

GI number: 167625556

Start: 4449127

End: 4451394

Strand: Reverse

Name: parC [H]

Synonym: Shal_3650

Alternate gene names: 167625556

Gene position: 4451394-4449127 (Counterclockwise)

Preceding gene: 167625557

Following gene: 167625553

Centisome position: 85.16

GC content: 47.71

Gene sequence:

>2268_bases
ATGAGTGATGCGATAGATTTAAGCCTTGATGGTGTTGAGCAGATGCCTCTACGCCGCTTCACGGAAGAGGCATATCTGAA
CTATTCCATGTATGTGATCATGGATCGAGCATTGCCACATATTGGTGATGGACTCAAACCGGTTCAGAGACGGATTATCT
ATGCCATGAGTGAGCTGGGTTTATCGGCTCAATCTAAACATAAGAAGTCGGCGCGTACAGTCGGTGACGTGCTTGGTAAA
TATCACCCTCATGGTGATAGTGCCTGTTACGAAGCGATGGTATTGATGGCGCAGCCATTCTCATACCGTTACCCGTTGGT
TGATGGCCAAGGAAACTGGGGCGCACCGGACGATCCCAAGTCATTTGCGGCGATGCGTTATACCGAAGCAAGATTATCTA
AGTTTTCAGAAGTGCTACTTAGTGAGCTCGGTCAAGGTACTGTCGATTGGGGCGTCAACTTTGATGGCACCATGAAAGAA
CCTTTGGTACTGCCTGCTCGTTTACCGCATATTTTGCTCAATGGTATTACCGGTATTGCCGTTGGTATGGCAACTGACGT
ACCGCCGCATAACGCCAAAGAGTTGGTGGGCGCGTGTGTTGAGTTACTGGATAACCCTAAAGCTGATTTAGCACGTTTGA
TGGAGTTTGTGCCAGGCCCAGATTATCCGACAGAGGCTGAGATTATTACGCCTGCGGCCGATATCACTAAAATTTATCAA
ACGGGTCGAGGCTCGATTAAGGCTCGCGCTGTTTATACCGTAGAGAACGGTGAGATCGTCATTACCGCACTGCCGCATCA
AGCCAGTAGCGGCAAAATTTTAGAACAGATCGCCAGCCAAATGCAGGCAAAGAAGTTGCCGATGGTGACAGACTTGCGTG
ATGAGTCAGATCACGAAAGCCCTGTGCGTATGATCATTGTTCCGCGCTCGAATCGTGTCGACTGTGATCAACTGATGGCG
CATCTATTCGCGACAACAGATTTACAAAAAAGTTATCGTGTTAACTTGAACGTACTTGGCCTAAATGGGCGTCCGCAAGT
TAAAGGCTTACTCGAATTATTAACTGAATGGCTTACGTTCAGAATGACAACGGTTAAGCGCCGTCTGGAATATCGACTAG
ATAAGATTTTAGCGAGACTACATATTCTAGATGCCTTGATGATTGCATTTTTGAATATTGACGAAGTGATTGAGATCATT
CGTTATAACGATGATCCCAAAGCGGAGTTAATCTCTCGATTTGCATTATCTGATAAGCAAGCTGATGCCATTCTTGATTT
GAAATTGCGTCACTTAGCCAAGCTTGAAGAGTTTAAGATTAAGGGTGAGCAAAGTGAGCTTGAAGCAGAGCGTGATAAGT
TACAATTATTACTAAGTTCTGAGCGTCGCATGAAGACGCTGATCAAGAAAGAGCTTATCAAAGATGGCGAAGATTATGGC
GATGAGCGCCGCTCACCACTGGTTGAGCGTACAGAGTCAAAAGCACTCACTCAGCAAGAACTGGTCGCAGTAGAATCTGT
CACAGTTGTACTATCAGAGAAAGGTTGGGTGCGTTGCGCTAAAGGTCATGAGGTTGACGGTCAAAGTTTATCTTACAAAG
CGGGCGATAGCTTCTTACGTTCAGCGCAGGGGCGCAGCAATCAACCTAGCGTGTTTATTGACACTTCCGGCAGGGCATTT
GCCACCGACACCCATACCTTGCCGTCAGCGCGATCTCAGGGAGAACCTATAACGACTAGGTTCAATTTAGCCCCAGGCAC
AACAATGGAGCATTTGTTATTGTCTGATGACGAGCAATGCTACCTATTAGCGTCCGACGCGGGCTACGGCTTCATCTGCG
CCAACAAAGACATGGTGTCGCGTAATAAGGCGGGTAAGGCGCTGCTAAGCTTACCTGCGAATGCTAAGGTGTTGCTGCCG
CAGAAGGTGGATAAGTCAAAACCACAGTCGATATTAGCGATCACCAATGAAGGGCGTATGTTGCTGTTCTCTCTCGATGC
GTTACCTCAGCTTTCTAAAGGTAAAGGCAATAAGATCATTGGGATCCCTGGCGAACGTGCTAAAAATCGTGAAGAGTTGC
TATTGCATTTGAATGTGATACCAGAAGACACGGCTGTAACCCTGTGGGCGGGTAAGCGCAAGCTAACCTTAAAGCCAAGT
GACTTGGAGCATTACCGTGGTGAGCGTGGCCGCCGTGGTGCTAAGTTACCGCGTGGTCTGCAGCGTGTAGACAGCGTTGA
GCTTGGTGACGGTGAGCCCGTACTCTAA

Upstream 100 bases:

>100_bases
CGCCCGATGGTGCTATGTATATTTCTGATGACCTAAAGGGCAACATATACCGTTTGTTCTATAAAGATTCAGCAAAAAAT
CAGTCACAGGATAATGATTA

Downstream 100 bases:

>100_bases
TAGCGTTACGATATAAAAAATGCAGCCAAGTGGCTGCATTTTTTATTGAAACTCGGTGTGCTTATTAAGACTAAGCCACC
TCGTAATAGTTAGGCTCGAT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 755; Mature: 754

Protein sequence:

>755_residues
MSDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELGLSAQSKHKKSARTVGDVLGK
YHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSKFSEVLLSELGQGTVDWGVNFDGTMKE
PLVLPARLPHILLNGITGIAVGMATDVPPHNAKELVGACVELLDNPKADLARLMEFVPGPDYPTEAEIITPAADITKIYQ
TGRGSIKARAVYTVENGEIVITALPHQASSGKILEQIASQMQAKKLPMVTDLRDESDHESPVRMIIVPRSNRVDCDQLMA
HLFATTDLQKSYRVNLNVLGLNGRPQVKGLLELLTEWLTFRMTTVKRRLEYRLDKILARLHILDALMIAFLNIDEVIEII
RYNDDPKAELISRFALSDKQADAILDLKLRHLAKLEEFKIKGEQSELEAERDKLQLLLSSERRMKTLIKKELIKDGEDYG
DERRSPLVERTESKALTQQELVAVESVTVVLSEKGWVRCAKGHEVDGQSLSYKAGDSFLRSAQGRSNQPSVFIDTSGRAF
ATDTHTLPSARSQGEPITTRFNLAPGTTMEHLLLSDDEQCYLLASDAGYGFICANKDMVSRNKAGKALLSLPANAKVLLP
QKVDKSKPQSILAITNEGRMLLFSLDALPQLSKGKGNKIIGIPGERAKNREELLLHLNVIPEDTAVTLWAGKRKLTLKPS
DLEHYRGERGRRGAKLPRGLQRVDSVELGDGEPVL

Sequences:

>Translated_755_residues
MSDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELGLSAQSKHKKSARTVGDVLGK
YHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSKFSEVLLSELGQGTVDWGVNFDGTMKE
PLVLPARLPHILLNGITGIAVGMATDVPPHNAKELVGACVELLDNPKADLARLMEFVPGPDYPTEAEIITPAADITKIYQ
TGRGSIKARAVYTVENGEIVITALPHQASSGKILEQIASQMQAKKLPMVTDLRDESDHESPVRMIIVPRSNRVDCDQLMA
HLFATTDLQKSYRVNLNVLGLNGRPQVKGLLELLTEWLTFRMTTVKRRLEYRLDKILARLHILDALMIAFLNIDEVIEII
RYNDDPKAELISRFALSDKQADAILDLKLRHLAKLEEFKIKGEQSELEAERDKLQLLLSSERRMKTLIKKELIKDGEDYG
DERRSPLVERTESKALTQQELVAVESVTVVLSEKGWVRCAKGHEVDGQSLSYKAGDSFLRSAQGRSNQPSVFIDTSGRAF
ATDTHTLPSARSQGEPITTRFNLAPGTTMEHLLLSDDEQCYLLASDAGYGFICANKDMVSRNKAGKALLSLPANAKVLLP
QKVDKSKPQSILAITNEGRMLLFSLDALPQLSKGKGNKIIGIPGERAKNREELLLHLNVIPEDTAVTLWAGKRKLTLKPS
DLEHYRGERGRRGAKLPRGLQRVDSVELGDGEPVL
>Mature_754_residues
SDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELGLSAQSKHKKSARTVGDVLGKY
HPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSKFSEVLLSELGQGTVDWGVNFDGTMKEP
LVLPARLPHILLNGITGIAVGMATDVPPHNAKELVGACVELLDNPKADLARLMEFVPGPDYPTEAEIITPAADITKIYQT
GRGSIKARAVYTVENGEIVITALPHQASSGKILEQIASQMQAKKLPMVTDLRDESDHESPVRMIIVPRSNRVDCDQLMAH
LFATTDLQKSYRVNLNVLGLNGRPQVKGLLELLTEWLTFRMTTVKRRLEYRLDKILARLHILDALMIAFLNIDEVIEIIR
YNDDPKAELISRFALSDKQADAILDLKLRHLAKLEEFKIKGEQSELEAERDKLQLLLSSERRMKTLIKKELIKDGEDYGD
ERRSPLVERTESKALTQQELVAVESVTVVLSEKGWVRCAKGHEVDGQSLSYKAGDSFLRSAQGRSNQPSVFIDTSGRAFA
TDTHTLPSARSQGEPITTRFNLAPGTTMEHLLLSDDEQCYLLASDAGYGFICANKDMVSRNKAGKALLSLPANAKVLLPQ
KVDKSKPQSILAITNEGRMLLFSLDALPQLSKGKGNKIIGIPGERAKNREELLLHLNVIPEDTAVTLWAGKRKLTLKPSD
LEHYRGERGRRGAKLPRGLQRVDSVELGDGEPVL

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=739, Percent_Identity=66.17050067659, Blast_Score=1035, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=615, Percent_Identity=37.0731707317073, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI212645845, Length=502, Percent_Identity=22.1115537848606, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=301, Percent_Identity=24.2524916943522, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83889; Mature: 83757

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELG
CCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEEEEHHCHHCCCCHHHHHHHHHHHHHHHC
LSAQSKHKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPK
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCH
SFAAMRYTEARLSKFSEVLLSELGQGTVDWGVNFDGTMKEPLVLPARLPHILLNGITGIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEECCHHHHHHHHHCHHHHE
VGMATDVPPHNAKELVGACVELLDNPKADLARLMEFVPGPDYPTEAEIITPAADITKIYQ
EEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHH
TGRGSIKARAVYTVENGEIVITALPHQASSGKILEQIASQMQAKKLPMVTDLRDESDHES
CCCCCEEEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCC
PVRMIIVPRSNRVDCDQLMAHLFATTDLQKSYRVNLNVLGLNGRPQVKGLLELLTEWLTF
CEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHH
RMTTVKRRLEYRLDKILARLHILDALMIAFLNIDEVIEIIRYNDDPKAELISRFALSDKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHCCCCC
ADAILDLKLRHLAKLEEFKIKGEQSELEAERDKLQLLLSSERRMKTLIKKELIKDGEDYG
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DERRSPLVERTESKALTQQELVAVESVTVVLSEKGWVRCAKGHEVDGQSLSYKAGDSFLR
HHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEECCCCCCCCCCCCCHHHHHHHH
SAQGRSNQPSVFIDTSGRAFATDTHTLPSARSQGEPITTRFNLAPGTTMEHLLLSDDEQC
HCCCCCCCCCEEEECCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCCCE
YLLASDAGYGFICANKDMVSRNKAGKALLSLPANAKVLLPQKVDKSKPQSILAITNEGRM
EEEECCCCCEEEECCCHHHHCCCCCCEEEECCCCCEEECCCCCCCCCCCEEEEEECCCCE
LLFSLDALPQLSKGKGNKIIGIPGERAKNREELLLHLNVIPEDTAVTLWAGKRKLTLKPS
EEEECCCCCCCCCCCCCEEEECCCCCCCCHHHEEEEEEECCCCCEEEEEECCEEEEECCC
DLEHYRGERGRRGAKLPRGLQRVDSVELGDGEPVL
HHHHHCCCCCCCCCCCHHHHHHHCCEECCCCCCCC
>Mature Secondary Structure 
SDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELG
CCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEEEEHHCHHCCCCHHHHHHHHHHHHHHHC
LSAQSKHKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPK
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCH
SFAAMRYTEARLSKFSEVLLSELGQGTVDWGVNFDGTMKEPLVLPARLPHILLNGITGIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEECCHHHHHHHHHCHHHHE
VGMATDVPPHNAKELVGACVELLDNPKADLARLMEFVPGPDYPTEAEIITPAADITKIYQ
EEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHH
TGRGSIKARAVYTVENGEIVITALPHQASSGKILEQIASQMQAKKLPMVTDLRDESDHES
CCCCCEEEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCC
PVRMIIVPRSNRVDCDQLMAHLFATTDLQKSYRVNLNVLGLNGRPQVKGLLELLTEWLTF
CEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHH
RMTTVKRRLEYRLDKILARLHILDALMIAFLNIDEVIEIIRYNDDPKAELISRFALSDKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHCCCCC
ADAILDLKLRHLAKLEEFKIKGEQSELEAERDKLQLLLSSERRMKTLIKKELIKDGEDYG
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DERRSPLVERTESKALTQQELVAVESVTVVLSEKGWVRCAKGHEVDGQSLSYKAGDSFLR
HHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEECCCCCCCCCCCCCHHHHHHHH
SAQGRSNQPSVFIDTSGRAFATDTHTLPSARSQGEPITTRFNLAPGTTMEHLLLSDDEQC
HCCCCCCCCCEEEECCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCCCE
YLLASDAGYGFICANKDMVSRNKAGKALLSLPANAKVLLPQKVDKSKPQSILAITNEGRM
EEEECCCCCEEEECCCHHHHCCCCCCEEEECCCCCEEECCCCCCCCCCCEEEEEECCCCE
LLFSLDALPQLSKGKGNKIIGIPGERAKNREELLLHLNVIPEDTAVTLWAGKRKLTLKPS
EEEECCCCCCCCCCCCCEEEECCCCCCCCHHHEEEEEEECCCCCEEEEEECCEEEEECCC
DLEHYRGERGRRGAKLPRGLQRVDSVELGDGEPVL
HHHHHCCCCCCCCCCCHHHHHHHCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]