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The map label for this gene is ung [H]

Identifier: 167625300

GI number: 167625300

Start: 4135274

End: 4135942

Strand: Reverse

Name: ung [H]

Synonym: Shal_3389

Alternate gene names: 167625300

Gene position: 4135942-4135274 (Counterclockwise)

Preceding gene: 167625304

Following gene: 167625294

Centisome position: 79.13

GC content: 49.78

Gene sequence:

>669_bases
ATGACGGCGCATTCTAGCTGGTTATCTTTTATCGAAGATCAACAGCAACAAAGTTATTTTCAATCGGTACAGCAGTTTGT
CAAAGCTGAGCGCGCAGCTGGGAAAGCGATTTATCCGCCAGAGAGTGAAGTGTTCGCCGCATTTGATTCGACACCGCTAA
ACAAGGTACGTGTGGTGCTTATTGGGCAAGATCCTTACCATGGGCCAAACCAAGCTCATGGCCTGTGTTTCTCGGTGAAA
CATGGGGTCAAGACGCCACCGTCGCTGGTAAATATGTATAAAGAGTTGGCTAGCGACATTGACGGCTTTACCATCCCTGA
ACATGGCAACTTGAGCCACTGGGCCGAGCAGGGGGTCTTGATGCTAAACACGGTACTCACCGTAGAGCAGGGTAAGGCTC
ACTCTCACGCCAAATCAGGCTGGGAATCTTTTACCGCTAATGCTCTAGCACTACTAAACGAGCAATCTCAGCCAATCATC
TTTGTTCTCTGGGGGGCTCATGCCATTAAAAAAGGCAAAGGTATTAACGCGCCGCAACACCAAGTGATTTCAGGGCCACA
TCCATCGCCGTTATCGGCCTACCGAGGCTTCTTCGGCTGTAAGCATTTCTCTAAAATTAATGAGCTCTTGCAAGCAAGGG
GCGAGCGGGCCATCGATTGGCAGGTATAG

Upstream 100 bases:

>100_bases
CTATTGAAGCCGTGGCGGTCTTAATGAATTTATCCTAGGAGATTGCAAGCAATGTCACGACCTTTTAAGCTTAGGCAAAT
TTTTATCTTAAGGTCAGATC

Downstream 100 bases:

>100_bases
CTTGGCAGGTATAGCTTGGCAGCTATAGTCTGGCTGGTATGCCTGGAGCATATTCATATAAAAAGAGCGCCTTGCGCTCT
TTTTTATTTAAGCTCAGATA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MTAHSSWLSFIEDQQQQSYFQSVQQFVKAERAAGKAIYPPESEVFAAFDSTPLNKVRVVLIGQDPYHGPNQAHGLCFSVK
HGVKTPPSLVNMYKELASDIDGFTIPEHGNLSHWAEQGVLMLNTVLTVEQGKAHSHAKSGWESFTANALALLNEQSQPII
FVLWGAHAIKKGKGINAPQHQVISGPHPSPLSAYRGFFGCKHFSKINELLQARGERAIDWQV

Sequences:

>Translated_222_residues
MTAHSSWLSFIEDQQQQSYFQSVQQFVKAERAAGKAIYPPESEVFAAFDSTPLNKVRVVLIGQDPYHGPNQAHGLCFSVK
HGVKTPPSLVNMYKELASDIDGFTIPEHGNLSHWAEQGVLMLNTVLTVEQGKAHSHAKSGWESFTANALALLNEQSQPII
FVLWGAHAIKKGKGINAPQHQVISGPHPSPLSAYRGFFGCKHFSKINELLQARGERAIDWQV
>Mature_221_residues
TAHSSWLSFIEDQQQQSYFQSVQQFVKAERAAGKAIYPPESEVFAAFDSTPLNKVRVVLIGQDPYHGPNQAHGLCFSVKH
GVKTPPSLVNMYKELASDIDGFTIPEHGNLSHWAEQGVLMLNTVLTVEQGKAHSHAKSGWESFTANALALLNEQSQPIIF
VLWGAHAIKKGKGINAPQHQVISGPHPSPLSAYRGFFGCKHFSKINELLQARGERAIDWQV

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=51.8518518518518, Blast_Score=236, Evalue=1e-62,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=51.8518518518518, Blast_Score=236, Evalue=1e-62,
Organism=Escherichia coli, GI1788934, Length=220, Percent_Identity=55, Blast_Score=264, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=49.0740740740741, Blast_Score=227, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=45.5696202531646, Blast_Score=203, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24525; Mature: 24394

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAHSSWLSFIEDQQQQSYFQSVQQFVKAERAAGKAIYPPESEVFAAFDSTPLNKVRVVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCEEEEEE
IGQDPYHGPNQAHGLCFSVKHGVKTPPSLVNMYKELASDIDGFTIPEHGNLSHWAEQGVL
ECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCEE
MLNTVLTVEQGKAHSHAKSGWESFTANALALLNEQSQPIIFVLWGAHAIKKGKGINAPQH
EEHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCCCCCCCH
QVISGPHPSPLSAYRGFFGCKHFSKINELLQARGERAIDWQV
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TAHSSWLSFIEDQQQQSYFQSVQQFVKAERAAGKAIYPPESEVFAAFDSTPLNKVRVVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCEEEEEE
IGQDPYHGPNQAHGLCFSVKHGVKTPPSLVNMYKELASDIDGFTIPEHGNLSHWAEQGVL
ECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCEE
MLNTVLTVEQGKAHSHAKSGWESFTANALALLNEQSQPIIFVLWGAHAIKKGKGINAPQH
EEHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCCCCCCCH
QVISGPHPSPLSAYRGFFGCKHFSKINELLQARGERAIDWQV
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]