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The map label for this gene is caiT [H]

Identifier: 167625230

GI number: 167625230

Start: 4047834

End: 4049432

Strand: Reverse

Name: caiT [H]

Synonym: Shal_3318

Alternate gene names: 167625230

Gene position: 4049432-4047834 (Counterclockwise)

Preceding gene: 167625231

Following gene: 167625229

Centisome position: 77.47

GC content: 45.47

Gene sequence:

>1599_bases
ATGAATTTCAAGAATCTTGATCATAAGCTGTTTTGGCCGGCCATCAGCTTTACTTTTTTAAGTTTGGCGTTGGCTGTATT
TTTTCCGGAAAGCTCTAAAAATGTCGCGCATGCAGGTATGAAGTGGGTGACCAATGATATTGGCTGGTTTATCCAATTAG
CCGGATTTGGTGCGCTTGTATTTTTGATGTGGATTGCCTTTAGCCGTTTTGGTCATATTAAACTGGGGGACGACAATGAT
GCCCCTGAGTTCACCTATGCAACCTATTCATTTATGATCTTTACCGCGGGTGTGGGCGCAGCATTGATTTTCTGGGCCGT
AGGTGAGCCCATGTACTATATGCAGAGTCCGCCGATGTTTGCTGAAGCAGGCAGTGCAGAGGCTTCTCAGTGGCTTATCA
CTTATACCTTGTTCCATTGGGGACCGATAGGTTGGGCTATTTTCTGTTTGCCAGCAGTGCCTTACGCTTACTATCTACAT
AAGAAAAAGAAGCGTAACCTACGTCTATCTAACTTACTAGAAGATGTGATTGGTGAGAAGAATGCTAATGGTCCGCTAGG
CTATTTCATCAACATTATCGCTATTTTTGGTACCTTGGGCGCCTTCTCTACCTCTATGGGATTGGCTGTTGACCTTATCG
GTTCGGGTATTGAGAAAGTCACTGGTTTACCTAATGATATCTGGCTTCAAGTTGGCTTGATTGCACTGTTTATTGTCTTC
TATGCCGTGGTGATGTTGGCGGGAATGAAGAAGGGCGTTGCTAAGCTTGCTAACTGGTGTGTGTATGCCGCGTTTGCCTT
AGGTATTTTCATCTTATTGTCAGGTCCAACCGCGTTTATTCTGTCTTATTTCTTCGACAGCTTGAGCGTGATGGTTGATA
ACTTTGTCCGCATGAGTTTCTGGAGTGATCCAGTAGAAAAGTCAGGTTTCCCACAAGCGTGGACCATGTACTACTGGGCT
TGGTATTTTGCTTACCTTGTGATGATGGGCATTTTCTTAGCGCGAATCTCTAAGGGACGCACGATTAAAGAGTTGGTATT
GACCACGATATTCTTTGGTTCGGCAGGTTGTGCTTTCTTCATCGCTATCTTCGGTAGTTACTCGGTATTCAGTGAGTTAA
CGGGTGCGTTGCCTGTGCTTGAGTGGATGAATGAGGCTGGGGTCTCCATGGCCGTGATTGAGGTGATTAATGCACTGCCT
TTTGGTGCGGCCATTTTGATTGTTTTTCTTATCGTTGAGTTCTTCCTGATGTCGACAACGATGACGTCGGCTGCGGTGTC
CATCTCTATGATGACCACCAAGGAACTGGATGCTGATGCAGATCCGGATGTCTCGGTAAGACTGATTTGGGCATTAGGGA
TCGGTGCGGTTTCGATGGCAGCCTTCTTTATGGGGGGCAGTATCGACACGATTAAGTCCATGTGTATTATCGTTGGTTTA
CCGATGATCTTCTTGAATATCTTGATGGTGGTGTGTTTGATGAAGTGGATTAGAAAAGATCACCCAGAATTAATCAAATC
AACAGCAACACCGGCTGTAAAAGCCAACGCCGAACAGGCTGAGCCTGCTCATGCCGAATTAGCCAAAGTTGAGGTATAA

Upstream 100 bases:

>100_bases
AACCCAATATAACTCGCCGCAGAGATTATGCTAACAGCATAAGGCGGCATCAAGCTGGTTCCTTTAAATGTAAGACAAAG
GAGCAGCGTGGAATTTACCT

Downstream 100 bases:

>100_bases
CGAGATGGGCGCAAATATTGTTTCAGTGGAGTTTATTCCGGTAAACGTGGCCGCGACTAACTGGAGTGAAAACACCGTTA
TCGTTAAGGTTACCGATGAA

Product: BCCT transporter

Products: Proton [Cytoplasm]; L-carnitine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MNFKNLDHKLFWPAISFTFLSLALAVFFPESSKNVAHAGMKWVTNDIGWFIQLAGFGALVFLMWIAFSRFGHIKLGDDND
APEFTYATYSFMIFTAGVGAALIFWAVGEPMYYMQSPPMFAEAGSAEASQWLITYTLFHWGPIGWAIFCLPAVPYAYYLH
KKKKRNLRLSNLLEDVIGEKNANGPLGYFINIIAIFGTLGAFSTSMGLAVDLIGSGIEKVTGLPNDIWLQVGLIALFIVF
YAVVMLAGMKKGVAKLANWCVYAAFALGIFILLSGPTAFILSYFFDSLSVMVDNFVRMSFWSDPVEKSGFPQAWTMYYWA
WYFAYLVMMGIFLARISKGRTIKELVLTTIFFGSAGCAFFIAIFGSYSVFSELTGALPVLEWMNEAGVSMAVIEVINALP
FGAAILIVFLIVEFFLMSTTMTSAAVSISMMTTKELDADADPDVSVRLIWALGIGAVSMAAFFMGGSIDTIKSMCIIVGL
PMIFLNILMVVCLMKWIRKDHPELIKSTATPAVKANAEQAEPAHAELAKVEV

Sequences:

>Translated_532_residues
MNFKNLDHKLFWPAISFTFLSLALAVFFPESSKNVAHAGMKWVTNDIGWFIQLAGFGALVFLMWIAFSRFGHIKLGDDND
APEFTYATYSFMIFTAGVGAALIFWAVGEPMYYMQSPPMFAEAGSAEASQWLITYTLFHWGPIGWAIFCLPAVPYAYYLH
KKKKRNLRLSNLLEDVIGEKNANGPLGYFINIIAIFGTLGAFSTSMGLAVDLIGSGIEKVTGLPNDIWLQVGLIALFIVF
YAVVMLAGMKKGVAKLANWCVYAAFALGIFILLSGPTAFILSYFFDSLSVMVDNFVRMSFWSDPVEKSGFPQAWTMYYWA
WYFAYLVMMGIFLARISKGRTIKELVLTTIFFGSAGCAFFIAIFGSYSVFSELTGALPVLEWMNEAGVSMAVIEVINALP
FGAAILIVFLIVEFFLMSTTMTSAAVSISMMTTKELDADADPDVSVRLIWALGIGAVSMAAFFMGGSIDTIKSMCIIVGL
PMIFLNILMVVCLMKWIRKDHPELIKSTATPAVKANAEQAEPAHAELAKVEV
>Mature_532_residues
MNFKNLDHKLFWPAISFTFLSLALAVFFPESSKNVAHAGMKWVTNDIGWFIQLAGFGALVFLMWIAFSRFGHIKLGDDND
APEFTYATYSFMIFTAGVGAALIFWAVGEPMYYMQSPPMFAEAGSAEASQWLITYTLFHWGPIGWAIFCLPAVPYAYYLH
KKKKRNLRLSNLLEDVIGEKNANGPLGYFINIIAIFGTLGAFSTSMGLAVDLIGSGIEKVTGLPNDIWLQVGLIALFIVF
YAVVMLAGMKKGVAKLANWCVYAAFALGIFILLSGPTAFILSYFFDSLSVMVDNFVRMSFWSDPVEKSGFPQAWTMYYWA
WYFAYLVMMGIFLARISKGRTIKELVLTTIFFGSAGCAFFIAIFGSYSVFSELTGALPVLEWMNEAGVSMAVIEVINALP
FGAAILIVFLIVEFFLMSTTMTSAAVSISMMTTKELDADADPDVSVRLIWALGIGAVSMAAFFMGGSIDTIKSMCIIVGL
PMIFLNILMVVCLMKWIRKDHPELIKSTATPAVKANAEQAEPAHAELAKVEV

Specific function: Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786224, Length=490, Percent_Identity=30.2040816326531, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1788102, Length=447, Percent_Identity=28.4116331096197, Blast_Score=258, Evalue=8e-70,
Organism=Escherichia coli, GI1786506, Length=470, Percent_Identity=28.7234042553192, Blast_Score=204, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 58678; Mature: 58678

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFKNLDHKLFWPAISFTFLSLALAVFFPESSKNVAHAGMKWVTNDIGWFIQLAGFGALV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FLMWIAFSRFGHIKLGDDNDAPEFTYATYSFMIFTAGVGAALIFWAVGEPMYYMQSPPMF
HHHHHHHHHCCCEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCH
AEAGSAEASQWLITYTLFHWGPIGWAIFCLPAVPYAYYLHKKKKRNLRLSNLLEDVIGEK
HCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
NANGPLGYFINIIAIFGTLGAFSTSMGLAVDLIGSGIEKVTGLPNDIWLQVGLIALFIVF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHH
YAVVMLAGMKKGVAKLANWCVYAAFALGIFILLSGPTAFILSYFFDSLSVMVDNFVRMSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
WSDPVEKSGFPQAWTMYYWAWYFAYLVMMGIFLARISKGRTIKELVLTTIFFGSAGCAFF
CCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHH
IAIFGSYSVFSELTGALPVLEWMNEAGVSMAVIEVINALPFGAAILIVFLIVEFFLMSTT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
MTSAAVSISMMTTKELDADADPDVSVRLIWALGIGAVSMAAFFMGGSIDTIKSMCIIVGL
HHHHHHEEEEEEHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
PMIFLNILMVVCLMKWIRKDHPELIKSTATPAVKANAEQAEPAHAELAKVEV
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MNFKNLDHKLFWPAISFTFLSLALAVFFPESSKNVAHAGMKWVTNDIGWFIQLAGFGALV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FLMWIAFSRFGHIKLGDDNDAPEFTYATYSFMIFTAGVGAALIFWAVGEPMYYMQSPPMF
HHHHHHHHHCCCEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCH
AEAGSAEASQWLITYTLFHWGPIGWAIFCLPAVPYAYYLHKKKKRNLRLSNLLEDVIGEK
HCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
NANGPLGYFINIIAIFGTLGAFSTSMGLAVDLIGSGIEKVTGLPNDIWLQVGLIALFIVF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHH
YAVVMLAGMKKGVAKLANWCVYAAFALGIFILLSGPTAFILSYFFDSLSVMVDNFVRMSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
WSDPVEKSGFPQAWTMYYWAWYFAYLVMMGIFLARISKGRTIKELVLTTIFFGSAGCAFF
CCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHH
IAIFGSYSVFSELTGALPVLEWMNEAGVSMAVIEVINALPFGAAILIVFLIVEFFLMSTT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
MTSAAVSISMMTTKELDADADPDVSVRLIWALGIGAVSMAAFFMGGSIDTIKSMCIIVGL
HHHHHHEEEEEEHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
PMIFLNILMVVCLMKWIRKDHPELIKSTATPAVKANAEQAEPAHAELAKVEV
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-carnitine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-carnitine [Periplasm] = Proton [Cytoplasm] + L-carnitine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA